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ENCODE cell lines, expression (Ernst 2011)
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Results for POU2F2_POU3F1
Z-value: 2.83
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Transcription factors associated with POU2F2_POU3F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU2F2 | hg19_v2_chr19_-_42636617_42636632 | 0.69 | 3.1e-03 | Click! |
| POU3F1 | hg19_v2_chr1_-_38512450_38512474 | 0.01 | 9.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU2F2_POU3F1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_23847339 | 27.11 |
ENST00000303531.7 |
PRKCB |
protein kinase C, beta |
| chr16_+_23847267 | 23.27 |
ENST00000321728.7 |
PRKCB |
protein kinase C, beta |
| chr16_+_32077386 | 15.46 |
ENST00000354689.6 |
IGHV3OR16-9 |
immunoglobulin heavy variable 3/OR16-9 (non-functional) |
| chr14_-_106692191 | 12.21 |
ENST00000390607.2 |
IGHV3-21 |
immunoglobulin heavy variable 3-21 |
| chr14_-_106573756 | 10.46 |
ENST00000390601.2 |
IGHV3-11 |
immunoglobulin heavy variable 3-11 (gene/pseudogene) |
| chr1_+_228645796 | 10.41 |
ENST00000369160.2 |
HIST3H2BB |
histone cluster 3, H2bb |
| chr8_+_56792355 | 10.32 |
ENST00000519728.1 |
LYN |
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog |
| chr6_+_26124373 | 10.15 |
ENST00000377791.2 ENST00000602637.1 |
HIST1H2AC |
histone cluster 1, H2ac |
| chr6_-_27114577 | 9.36 |
ENST00000356950.1 ENST00000396891.4 |
HIST1H2BK |
histone cluster 1, H2bk |
| chr6_-_26124138 | 9.23 |
ENST00000314332.5 ENST00000396984.1 |
HIST1H2BC |
histone cluster 1, H2bc |
Gene Ontology Analysis
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 79.7 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.4 | 74.0 | GO:0003823 | antigen binding(GO:0003823) |
| 0.1 | 68.0 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 16.8 | 50.4 | GO:0035403 | histone kinase activity (H3-T6 specific)(GO:0035403) |
| 2.8 | 19.5 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 0.4 | 7.8 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.6 | 7.7 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.3 | 7.0 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.6 | 6.1 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.4 | 5.9 | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 80.7 | GO:0000786 | nucleosome(GO:0000786) |
| 1.6 | 79.7 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 3.9 | 19.4 | GO:0034666 | integrin alpha2-beta1 complex(GO:0034666) |
| 0.1 | 8.0 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.1 | 7.6 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.1 | 7.0 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.2 | 4.1 | GO:0042627 | chylomicron(GO:0042627) |
| 0.0 | 3.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 2.9 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.1 | 2.1 | GO:0016580 | Sin3 complex(GO:0016580) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 99.1 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 1.8 | 50.8 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 1.1 | 19.4 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.3 | 7.8 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.0 | 7.0 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 6.1 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 5.5 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.2 | 4.1 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 3.4 | REACTOME TOLL RECEPTOR CASCADES | Genes involved in Toll Receptor Cascades |
| 0.1 | 3.2 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 51.1 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.9 | 22.4 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.3 | 7.8 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.1 | 3.3 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 1.9 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.7 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.6 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 1.6 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 1.4 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 1.3 | PID ATM PATHWAY | ATM pathway |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 77.6 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.6 | 63.4 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 16.8 | 50.4 | GO:0035408 | histone H3-T6 phosphorylation(GO:0035408) |
| 0.3 | 31.2 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.3 | 26.6 | GO:0006342 | chromatin silencing(GO:0006342) |
| 1.2 | 22.9 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 6.5 | 19.4 | GO:0070668 | positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668) |
| 0.1 | 11.3 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.1 | 9.0 | GO:0016239 | positive regulation of macroautophagy(GO:0016239) |
| 0.1 | 7.9 | GO:0030183 | B cell differentiation(GO:0030183) |