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ENCODE cell lines, expression (Ernst 2011)
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Results for RARG
Z-value: 1.79
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Transcription factors associated with RARG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RARG | hg19_v2_chr12_-_53625958_53626036 | 0.21 | 4.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RARG
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_156647189 | 4.28 |
ENST00000368223.3 |
NES |
nestin |
| chr15_+_33010175 | 4.21 |
ENST00000300177.4 ENST00000560677.1 ENST00000560830.1 |
GREM1 |
gremlin 1, DAN family BMP antagonist |
| chr7_-_107642348 | 3.72 |
ENST00000393561.1 |
LAMB1 |
laminin, beta 1 |
| chr11_+_117073850 | 3.62 |
ENST00000529622.1 |
TAGLN |
transgelin |
| chr8_-_108510224 | 3.42 |
ENST00000517746.1 ENST00000297450.3 |
ANGPT1 |
angiopoietin 1 |
| chr9_-_130637244 | 3.33 |
ENST00000373156.1 |
AK1 |
adenylate kinase 1 |
| chr12_-_91576429 | 3.26 |
ENST00000552145.1 ENST00000546745.1 |
DCN |
decorin |
| chr11_-_111784005 | 2.71 |
ENST00000527899.1 |
CRYAB |
crystallin, alpha B |
| chr1_+_196621002 | 2.66 |
ENST00000367429.4 ENST00000439155.2 |
CFH |
complement factor H |
| chr8_+_70404996 | 2.66 |
ENST00000402687.4 ENST00000419716.3 |
SULF1 |
sulfatase 1 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 8.8 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 1.2 | 6.9 | GO:0030421 | defecation(GO:0030421) |
| 0.4 | 6.6 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.1 | 6.0 | GO:0030049 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 2.0 | 5.9 | GO:1901202 | negative regulation of extracellular matrix assembly(GO:1901202) |
| 0.1 | 5.2 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.2 | 4.4 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
| 1.4 | 4.2 | GO:1900158 | negative regulation of osteoclast proliferation(GO:0090291) negative regulation of bone mineralization involved in bone maturation(GO:1900158) |
| 1.0 | 4.0 | GO:0009956 | radial pattern formation(GO:0009956) |
| 0.4 | 4.0 | GO:0060020 | Bergmann glial cell differentiation(GO:0060020) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 10.1 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.1 | 9.3 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 6.7 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 6.1 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.2 | 5.8 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 5.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 5.4 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 4.2 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 4.1 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 3.7 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 12.4 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 10.6 | GO:0005924 | cell-substrate adherens junction(GO:0005924) |
| 0.5 | 7.3 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.1 | 7.3 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 5.8 | GO:0043034 | costamere(GO:0043034) |
| 0.1 | 5.2 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 5.0 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.1 | 4.8 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.2 | 4.4 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.1 | 4.4 | GO:0005859 | muscle myosin complex(GO:0005859) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 24.3 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.2 | 10.2 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 9.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 6.0 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 6.0 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 4.6 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 4.5 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 4.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 3.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 3.4 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.7 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 9.4 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 8.1 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.2 | 6.8 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 6.3 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 6.0 | GO:0008201 | heparin binding(GO:0008201) |
| 0.2 | 5.4 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.1 | 4.8 | GO:0005518 | collagen binding(GO:0005518) |
| 0.5 | 4.3 | GO:0019215 | intermediate filament binding(GO:0019215) |
| 0.4 | 4.3 | GO:0030274 | LIM domain binding(GO:0030274) |