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ENCODE cell lines, expression (Ernst 2011)
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Results for RCOR1_MTA3
Z-value: 2.17
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Transcription factors associated with RCOR1_MTA3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RCOR1 | hg19_v2_chr14_+_103058948_103059005 | 0.12 | 6.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RCOR1_MTA3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_12030629 | 12.27 |
ENST00000396505.2 |
DKK3 |
dickkopf WNT signaling pathway inhibitor 3 |
| chr8_+_54793425 | 11.37 |
ENST00000522225.1 |
RGS20 |
regulator of G-protein signaling 20 |
| chr14_-_105420241 | 11.28 |
ENST00000557457.1 |
AHNAK2 |
AHNAK nucleoprotein 2 |
| chr19_-_51504852 | 10.62 |
ENST00000391806.2 ENST00000347619.4 ENST00000291726.7 ENST00000320838.5 |
KLK8 |
kallikrein-related peptidase 8 |
| chr8_+_54793454 | 10.61 |
ENST00000276500.4 |
RGS20 |
regulator of G-protein signaling 20 |
| chr19_+_35609380 | 10.35 |
ENST00000604621.1 |
FXYD3 |
FXYD domain containing ion transport regulator 3 |
| chr5_-_127873659 | 9.83 |
ENST00000262464.4 |
FBN2 |
fibrillin 2 |
| chr19_+_35645618 | 9.81 |
ENST00000392218.2 ENST00000543307.1 ENST00000392219.2 ENST00000541435.2 ENST00000590686.1 ENST00000342879.3 ENST00000588699.1 |
FXYD5 |
FXYD domain containing ion transport regulator 5 |
| chr7_-_93519471 | 9.69 |
ENST00000451238.1 |
TFPI2 |
tissue factor pathway inhibitor 2 |
| chr19_+_35645817 | 9.65 |
ENST00000423817.3 |
FXYD5 |
FXYD domain containing ion transport regulator 5 |
Gene Ontology Analysis
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 50.9 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.4 | 45.4 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.2 | 43.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 1.8 | 40.9 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.8 | 36.6 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.4 | 28.9 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.4 | 28.0 | PID NOTCH PATHWAY | Notch signaling pathway |
| 1.3 | 27.8 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.4 | 24.6 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.7 | 23.8 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 55.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 52.3 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.4 | 44.1 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.3 | 44.0 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 35.6 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.6 | 33.8 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.4 | 28.7 | GO:0019003 | GDP binding(GO:0019003) |
| 0.6 | 25.1 | GO:0050699 | WW domain binding(GO:0050699) |
| 3.5 | 24.5 | GO:0030267 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.1 | 23.4 | GO:0005509 | calcium ion binding(GO:0005509) |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 67.3 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.5 | 50.3 | GO:0070268 | cornification(GO:0070268) |
| 5.9 | 35.4 | GO:0002760 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) |
| 0.6 | 33.7 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 1.3 | 32.0 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 2.8 | 25.0 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 5.4 | 21.6 | GO:1902612 | regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262) |
| 7.1 | 21.2 | GO:0046586 | regulation of calcium-dependent cell-cell adhesion(GO:0046586) |
| 0.3 | 20.3 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 6.6 | 19.9 | GO:1900085 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 89.4 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.4 | 38.1 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 5.3 | 37.1 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 1.6 | 36.6 | GO:0030056 | hemidesmosome(GO:0030056) |
| 3.8 | 30.4 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 1.0 | 29.7 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.6 | 28.8 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.6 | 28.5 | GO:0045095 | keratin filament(GO:0045095) |
| 2.1 | 26.8 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.1 | 25.7 | GO:0098857 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 66.4 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.5 | 34.3 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 1.1 | 32.2 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.9 | 28.9 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.7 | 27.0 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.3 | 24.6 | REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | Genes involved in Cyclin E associated events during G1/S transition |
| 0.5 | 23.9 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.6 | 22.8 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.3 | 21.0 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.3 | 20.6 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |