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ENCODE cell lines, expression (Ernst 2011)
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Results for SMAD1
Z-value: 2.46
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Transcription factors associated with SMAD1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMAD1 | hg19_v2_chr4_+_146402925_146402957 | 0.12 | 6.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SMAD1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_102608306 | 13.21 |
ENST00000332549.3 |
IL1R2 |
interleukin 1 receptor, type II |
| chr6_-_33048483 | 8.00 |
ENST00000419277.1 |
HLA-DPA1 |
major histocompatibility complex, class II, DP alpha 1 |
| chr14_-_106209368 | 7.18 |
ENST00000390548.2 ENST00000390549.2 ENST00000390542.2 |
IGHG1 |
immunoglobulin heavy constant gamma 1 (G1m marker) |
| chr22_+_23077065 | 5.89 |
ENST00000390310.2 |
IGLV2-18 |
immunoglobulin lambda variable 2-18 |
| chr18_-_11148587 | 5.38 |
ENST00000302079.6 ENST00000580640.1 ENST00000503781.3 |
PIEZO2 |
piezo-type mechanosensitive ion channel component 2 |
| chr11_+_121461097 | 5.17 |
ENST00000527934.1 |
SORL1 |
sortilin-related receptor, L(DLR class) A repeats containing |
| chr22_+_23040274 | 4.91 |
ENST00000390306.2 |
IGLV2-23 |
immunoglobulin lambda variable 2-23 |
| chr22_+_23247030 | 4.91 |
ENST00000390324.2 |
IGLJ3 |
immunoglobulin lambda joining 3 |
| chr14_-_106111127 | 4.78 |
ENST00000390545.2 |
IGHG2 |
immunoglobulin heavy constant gamma 2 (G2m marker) |
| chr14_-_106092403 | 4.56 |
ENST00000390543.2 |
IGHG4 |
immunoglobulin heavy constant gamma 4 (G4m marker) |
Gene Ontology Analysis
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 62.2 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.2 | 34.0 | GO:0003823 | antigen binding(GO:0003823) |
| 0.8 | 24.1 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 1.5 | 20.4 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 3.7 | 18.6 | GO:0004910 | interleukin-1, Type II, blocking receptor activity(GO:0004910) |
| 3.7 | 11.0 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.2 | 10.9 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.2 | 10.5 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 1.3 | 8.9 | GO:0030369 | ICAM-3 receptor activity(GO:0030369) |
| 0.5 | 8.2 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 57.0 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 1.4 | 29.7 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 1.4 | 14.9 | GO:0042611 | MHC protein complex(GO:0042611) MHC class I protein complex(GO:0042612) |
| 0.1 | 14.4 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.2 | 12.2 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 9.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 1.5 | 9.0 | GO:0034687 | integrin alphaL-beta2 complex(GO:0034687) |
| 0.1 | 7.2 | GO:0016235 | aggresome(GO:0016235) |
| 1.0 | 7.0 | GO:0019815 | B cell receptor complex(GO:0019815) |
| 0.5 | 6.9 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 38.2 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 0.4 | 21.5 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.3 | 20.7 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 1.5 | 14.8 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.2 | 14.4 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.2 | 12.0 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.1 | 5.5 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.2 | 5.3 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.3 | 5.0 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.1 | 5.0 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 22.1 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.3 | 19.0 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.2 | 18.0 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.2 | 13.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 12.0 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.2 | 10.1 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.1 | 9.1 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.4 | 7.4 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.2 | 6.3 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.2 | 5.8 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 62.5 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.3 | 36.8 | GO:0060333 | interferon-gamma-mediated signaling pathway(GO:0060333) |
| 0.3 | 26.6 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 4.7 | 18.7 | GO:0050712 | negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712) |
| 0.3 | 16.8 | GO:0050853 | B cell receptor signaling pathway(GO:0050853) |
| 1.5 | 15.3 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 3.7 | 11.0 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 2.6 | 7.7 | GO:1902955 | regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246) |
| 0.5 | 7.6 | GO:1901748 | leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750) |
| 0.1 | 6.9 | GO:0002377 | immunoglobulin production(GO:0002377) |