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ENCODE cell lines, expression (Ernst 2011)
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Results for SMAD4
Z-value: 1.49
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Transcription factors associated with SMAD4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMAD4 | hg19_v2_chr18_+_48494361_48494426 | 0.49 | 5.2e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SMAD4
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_+_117070037 | 6.47 |
ENST00000392951.4 ENST00000525531.1 ENST00000278968.6 |
TAGLN |
transgelin |
| chr1_-_153599732 | 3.89 |
ENST00000392623.1 |
S100A13 |
S100 calcium binding protein A13 |
| chr10_+_75670862 | 3.65 |
ENST00000446342.1 ENST00000372764.3 ENST00000372762.4 |
PLAU |
plasminogen activator, urokinase |
| chr1_-_153538292 | 3.42 |
ENST00000497140.1 ENST00000368708.3 |
S100A2 |
S100 calcium binding protein A2 |
| chr7_+_94023873 | 3.35 |
ENST00000297268.6 |
COL1A2 |
collagen, type I, alpha 2 |
| chr11_+_86511569 | 3.13 |
ENST00000441050.1 |
PRSS23 |
protease, serine, 23 |
| chr12_+_75874984 | 2.96 |
ENST00000550491.1 |
GLIPR1 |
GLI pathogenesis-related 1 |
| chr1_-_153522562 | 2.92 |
ENST00000368714.1 |
S100A4 |
S100 calcium binding protein A4 |
| chr12_+_75874460 | 2.74 |
ENST00000266659.3 |
GLIPR1 |
GLI pathogenesis-related 1 |
| chr3_+_159557637 | 2.72 |
ENST00000445224.2 |
SCHIP1 |
schwannomin interacting protein 1 |
Gene Ontology Analysis
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 9.9 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
| 0.0 | 7.7 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 6.3 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 5.7 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 5.2 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 4.5 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.2 | 3.5 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 3.5 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.0 | 3.0 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.9 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 6.4 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 5.7 | REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE | Genes involved in Cell death signalling via NRAGE, NRIF and NADE |
| 0.1 | 4.1 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.1 | 4.1 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 4.0 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.2 | 3.7 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 3.1 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 3.0 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 2.8 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.0 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 8.3 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.2 | 6.6 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.4 | 6.5 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.1 | 6.3 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.3 | 6.1 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.3 | 4.5 | GO:0030478 | actin cap(GO:0030478) |
| 0.2 | 4.0 | GO:0005861 | troponin complex(GO:0005861) |
| 0.3 | 3.4 | GO:0005583 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.1 | 3.3 | GO:0031258 | lamellipodium membrane(GO:0031258) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 9.5 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.0 | 9.0 | GO:0003779 | actin binding(GO:0003779) |
| 0.0 | 6.7 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.2 | 6.4 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 5.6 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 5.2 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.2 | 4.8 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.4 | 3.9 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.0 | 3.8 | GO:0005518 | collagen binding(GO:0005518) |
| 0.2 | 3.7 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 6.5 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.4 | 4.1 | GO:0050703 | interleukin-1 alpha secretion(GO:0050703) |
| 0.1 | 4.1 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
| 0.3 | 4.0 | GO:0014883 | transition between fast and slow fiber(GO:0014883) |
| 0.2 | 3.9 | GO:0003334 | keratinocyte development(GO:0003334) |
| 1.2 | 3.7 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 0.4 | 3.5 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.2 | 3.4 | GO:0043589 | skin morphogenesis(GO:0043589) |
| 0.6 | 3.1 | GO:2000035 | regulation of stem cell division(GO:2000035) |
| 0.1 | 3.1 | GO:0015949 | nucleobase-containing small molecule interconversion(GO:0015949) |