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ENCODE cell lines, expression (Ernst 2011)
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Results for SOX4
Z-value: 1.50
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Transcription factors associated with SOX4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX4 | hg19_v2_chr6_+_21593972_21594071 | 0.46 | 7.0e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX4
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_1748214 | 6.87 |
ENST00000433670.1 ENST00000425171.1 ENST00000252804.4 |
PXDN |
peroxidasin homolog (Drosophila) |
| chr13_-_110959478 | 6.19 |
ENST00000543140.1 ENST00000375820.4 |
COL4A1 |
collagen, type IV, alpha 1 |
| chr5_-_39425222 | 4.65 |
ENST00000320816.6 |
DAB2 |
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) |
| chr10_+_17272608 | 4.59 |
ENST00000421459.2 |
VIM |
vimentin |
| chr5_-_39425290 | 4.54 |
ENST00000545653.1 |
DAB2 |
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) |
| chrX_+_12993336 | 4.11 |
ENST00000380635.1 |
TMSB4X |
thymosin beta 4, X-linked |
| chr5_-_39425068 | 4.05 |
ENST00000515700.1 ENST00000339788.6 |
DAB2 |
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) |
| chr2_+_33172221 | 3.86 |
ENST00000354476.3 |
LTBP1 |
latent transforming growth factor beta binding protein 1 |
| chrX_+_12993202 | 3.67 |
ENST00000451311.2 ENST00000380636.1 |
TMSB4X |
thymosin beta 4, X-linked |
| chr7_+_134551583 | 3.54 |
ENST00000435928.1 |
CALD1 |
caldesmon 1 |
Gene Ontology Analysis
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 13.2 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.1 | 7.8 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.5 | 7.1 | GO:0030478 | actin cap(GO:0030478) |
| 0.3 | 6.3 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.8 | 6.2 | GO:0005587 | collagen type IV trimer(GO:0005587) |
| 0.0 | 5.9 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 4.7 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 3.6 | GO:0043204 | perikaryon(GO:0043204) |
| 0.3 | 3.5 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.1 | 3.1 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 13.2 | GO:0035026 | leading edge cell differentiation(GO:0035026) |
| 1.1 | 7.8 | GO:2000483 | negative regulation of interleukin-8 secretion(GO:2000483) |
| 0.2 | 6.6 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.0 | 6.4 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.7 | 6.3 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 1.5 | 6.2 | GO:0061304 | retinal blood vessel morphogenesis(GO:0061304) |
| 1.3 | 5.2 | GO:0050928 | negative regulation of positive chemotaxis(GO:0050928) |
| 0.1 | 5.1 | GO:0042744 | hydrogen peroxide catabolic process(GO:0042744) |
| 0.4 | 4.6 | GO:0060020 | Bergmann glial cell differentiation(GO:0060020) |
| 0.9 | 3.6 | GO:0031179 | peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 13.2 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.1 | 9.2 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 7.8 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 6.4 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 4.9 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 4.4 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 3.5 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.0 | 3.1 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 2.7 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 1.7 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 13.2 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.2 | 7.8 | GO:0003785 | actin monomer binding(GO:0003785) |
| 1.4 | 6.9 | GO:0005152 | interleukin-1 receptor antagonist activity(GO:0005152) |
| 0.2 | 6.8 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.1 | 6.6 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 1.3 | 6.3 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.8 | 6.2 | GO:0030023 | extracellular matrix constituent conferring elasticity(GO:0030023) |
| 0.8 | 4.6 | GO:1990254 | keratin filament binding(GO:1990254) |
| 0.1 | 4.6 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.9 | 3.6 | GO:0004598 | peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.2 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 13.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 7.7 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 5.1 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 4.1 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.1 | 3.4 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 3.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.2 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.0 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |