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ENCODE cell lines, expression (Ernst 2011)
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Results for SOX5
Z-value: 1.82
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Transcription factors associated with SOX5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX5 | hg19_v2_chr12_-_24103954_24103972, hg19_v2_chr12_-_23737534_23737550 | 0.37 | 1.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX5
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_6233828 | 4.90 |
ENST00000572068.1 ENST00000261405.5 |
VWF |
von Willebrand factor |
| chr7_-_111846435 | 4.35 |
ENST00000437633.1 ENST00000428084.1 |
DOCK4 |
dedicator of cytokinesis 4 |
| chr6_+_12290586 | 3.97 |
ENST00000379375.5 |
EDN1 |
endothelin 1 |
| chr11_+_46402583 | 3.13 |
ENST00000359803.3 |
MDK |
midkine (neurite growth-promoting factor 2) |
| chr1_-_86043921 | 2.92 |
ENST00000535924.2 |
DDAH1 |
dimethylarginine dimethylaminohydrolase 1 |
| chrY_+_15016013 | 2.86 |
ENST00000360160.4 ENST00000454054.1 |
DDX3Y |
DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked |
| chrX_+_15525426 | 2.84 |
ENST00000342014.6 |
BMX |
BMX non-receptor tyrosine kinase |
| chr11_+_46402744 | 2.78 |
ENST00000533952.1 |
MDK |
midkine (neurite growth-promoting factor 2) |
| chr3_-_99594948 | 2.76 |
ENST00000471562.1 ENST00000495625.2 |
FILIP1L |
filamin A interacting protein 1-like |
| chr3_-_99595037 | 2.58 |
ENST00000383694.2 |
FILIP1L |
filamin A interacting protein 1-like |
Gene Ontology Analysis
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.0 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 6.0 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 4.6 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.1 | 4.2 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 3.2 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.0 | 3.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.0 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 1.4 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 1.3 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 1.3 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.4 | GO:0036464 | cytoplasmic ribonucleoprotein granule(GO:0036464) |
| 0.1 | 5.7 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 5.0 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.4 | 4.9 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.1 | 4.4 | GO:0032420 | stereocilium(GO:0032420) |
| 1.0 | 4.0 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
| 0.0 | 3.9 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.0 | 2.8 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.2 | 2.7 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 2.5 | GO:0032433 | filopodium tip(GO:0032433) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.9 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.1 | 4.9 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 3.8 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 3.1 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 2.6 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 2.6 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.0 | 2.0 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 1.7 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.0 | 1.4 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 1.3 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.9 | GO:0008201 | heparin binding(GO:0008201) |
| 0.1 | 5.7 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.2 | 5.2 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.2 | 4.9 | GO:0019865 | immunoglobulin binding(GO:0019865) |
| 0.4 | 4.7 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 4.4 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.8 | 4.0 | GO:0031708 | endothelin B receptor binding(GO:0031708) |
| 0.0 | 3.8 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 0.6 | 2.9 | GO:0016403 | dimethylargininase activity(GO:0016403) |
| 0.0 | 2.9 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 8.0 | GO:0030421 | defecation(GO:0030421) |
| 0.9 | 5.7 | GO:1903756 | regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758) |
| 0.0 | 4.5 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 0.9 | 4.4 | GO:0045906 | negative regulation of vasoconstriction(GO:0045906) |
| 1.3 | 4.0 | GO:0060585 | regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585) |
| 0.2 | 3.7 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.2 | 3.7 | GO:0007597 | blood coagulation, intrinsic pathway(GO:0007597) |
| 0.0 | 3.5 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.4 | 2.9 | GO:0031087 | deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) |
| 0.2 | 2.9 | GO:1900038 | negative regulation of cellular response to hypoxia(GO:1900038) |