ISMARA results: SP1

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ENCODE cell lines, expression (Ernst 2011)

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Results for SP1

Z-value: 2.08

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Transcription factors associated with SP1

Gene Symbol	Gene ID	Gene Info
SP1 Ensembl NCBI GeneCards UniProt	ENSG00000185591.5	SP1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SP1	hg19_v2_chr12_+_53774423_53774658	-0.62	1.1e-02	Click!

Activity profile of SP1 motif

Sorted Z-values of SP1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SP1

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Promoter	Score	Transcript	Gene	Gene Info
chr3_-_149688655	6.65	ENST00000461930.1 ENST00000423691.2 ENST00000490975.1 ENST00000461868.1 ENST00000452853.2	PFN2	profilin 2
chr19_-_50143452	6.58	ENST00000246792.3	RRAS	related RAS viral (r-ras) oncogene homolog
chr9_-_35691017	5.99	ENST00000378292.3	TPM2	tropomyosin 2 (beta)
chr10_-_126849588	5.80	ENST00000411419.2	CTBP2	C-terminal binding protein 2
chr2_+_30369859	5.75	ENST00000402003.3	YPEL5	yippee-like 5 (Drosophila)
chr17_-_1619535	5.72	ENST00000573075.1 ENST00000574306.1	MIR22HG	MIR22 host gene (non-protein coding)
chr19_+_41725088	5.57	ENST00000301178.4	AXL	AXL receptor tyrosine kinase
chr17_-_1619491	5.38	ENST00000570416.1 ENST00000575626.1 ENST00000610106.1 ENST00000608198.1 ENST00000609442.1 ENST00000334146.3 ENST00000576489.1 ENST00000608245.1 ENST00000609398.1 ENST00000608913.1 ENST00000574016.1 ENST00000571091.1 ENST00000573127.1 ENST00000609990.1 ENST00000576749.1	MIR22HG	MIR22 host gene (non-protein coding)
chr2_+_30369807	5.04	ENST00000379520.3 ENST00000379519.3 ENST00000261353.4	YPEL5	yippee-like 5 (Drosophila)
chr3_-_149688502	5.00	ENST00000481767.1 ENST00000475518.1	PFN2	profilin 2

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	35.1	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.5	23.8	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.6	21.9	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.3	19.9	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.6	19.3	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.1	16.7	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.6	16.0	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.5	13.6	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.4	13.4	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.3	12.7	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions

Showing 1 to 10 of 136 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	18.5	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.2	12.3	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.2	7.7	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	6.8	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.3	6.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.1	6.0	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.3	5.5	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.2	5.2	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.2	4.4	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.1	3.9	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions

Showing 1 to 10 of 64 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	15.5	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.2	12.5	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.2	11.4	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.4	10.2	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.1	9.3	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1	8.0	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.1	7.4	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.2	7.3	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.1	7.3	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.2	5.2	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway

Showing 1 to 10 of 52 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	5.1	GO:0035692	macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0	4.2	GO:0000790	nuclear chromatin(GO:0000790)
0.0	3.5	GO:0045121	membrane raft(GO:0045121)
0.0	3.2	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.1	2.9	GO:0002102	podosome(GO:0002102)
0.2	2.5	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.1	2.2	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.1	2.0	GO:0005916	fascia adherens(GO:0005916)
0.0	2.0	GO:0016459	myosin complex(GO:0016459)
0.0	1.9	GO:0045171	intercellular bridge(GO:0045171)

Showing 1 to 10 of 80 entries

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	22.4	GO:0031581	hemidesmosome assembly(GO:0031581)
0.8	16.6	GO:0000052	citrulline metabolic process(GO:0000052)
1.3	15.4	GO:1900028	negative regulation of ruffle assembly(GO:1900028)
0.8	12.5	GO:0051639	actin filament network formation(GO:0051639)
1.5	12.0	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.2	11.8	GO:0030574	collagen catabolic process(GO:0030574)
0.2	11.6	GO:1901016	regulation of potassium ion transmembrane transporter activity(GO:1901016)
1.4	11.3	GO:0003065	positive regulation of heart rate by epinephrine(GO:0003065)
0.4	10.9	GO:0071294	cellular response to zinc ion(GO:0071294)
1.5	10.7	GO:0070294	renal sodium ion absorption(GO:0070294)

Showing 1 to 10 of 965 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	15.5	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1	9.4	GO:0043195	terminal bouton(GO:0043195)
0.2	7.7	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.1	7.7	GO:0043204	perikaryon(GO:0043204)
0.1	7.5	GO:0002102	podosome(GO:0002102)
0.6	6.9	GO:0005614	interstitial matrix(GO:0005614)
0.1	6.6	GO:0005796	Golgi lumen(GO:0005796)
0.0	6.4	GO:0055037	recycling endosome(GO:0055037)
0.1	6.2	GO:0005913	cell-cell adherens junction(GO:0005913)
1.9	5.7	GO:0034676	integrin alpha6-beta4 complex(GO:0034676)

Showing 1 to 10 of 118 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.8	GO:0003785	actin monomer binding(GO:0003785)
0.2	5.4	GO:0005540	hyaluronic acid binding(GO:0005540)
1.4	4.3	GO:0047757	chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.1	3.9	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.1	3.4	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	2.9	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	2.7	GO:0051219	phosphoprotein binding(GO:0051219)
0.0	2.6	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
0.1	2.5	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1	2.1	GO:0042813	Wnt-activated receptor activity(GO:0042813)

Showing 1 to 10 of 126 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	64.9	GO:0005925	focal adhesion(GO:0005925)
0.2	44.7	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.0	32.7	GO:0005783	endoplasmic reticulum(GO:0005783)
0.3	29.4	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.2	28.9	GO:0043202	lysosomal lumen(GO:0043202)
0.3	28.0	GO:0005604	basement membrane(GO:0005604)
1.2	23.0	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.2	20.1	GO:0032432	actin filament bundle(GO:0032432)
0.2	18.5	GO:0030175	filopodium(GO:0030175)
0.1	16.2	GO:0005578	proteinaceous extracellular matrix(GO:0005578)

Showing 1 to 10 of 332 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	5.1	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	4.3	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	3.4	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.1	2.5	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	2.3	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1	1.4	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	1.4	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	1.4	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.0	1.2	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.0	1.1	PID HIF2PATHWAY	HIF-2-alpha transcription factor network

Showing 1 to 10 of 21 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	48.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	36.7	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.4	25.5	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.4	23.5	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.4	22.1	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.5	16.4	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2	15.4	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.1	13.3	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.6	12.9	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.2	12.1	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction

Showing 1 to 10 of 97 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	40.5	GO:0008307	structural constituent of muscle(GO:0008307)
0.1	34.5	GO:0045296	cadherin binding(GO:0045296)
0.9	34.1	GO:0043236	laminin binding(GO:0043236)
0.1	23.4	GO:0003779	actin binding(GO:0003779)
0.2	22.7	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.6	22.0	GO:0003785	actin monomer binding(GO:0003785)
0.3	21.1	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.4	14.4	GO:0050840	extracellular matrix binding(GO:0050840)
0.1	14.3	GO:0044325	ion channel binding(GO:0044325)
0.2	13.0	GO:0005518	collagen binding(GO:0005518)

Showing 1 to 10 of 520 entries

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	6.1	GO:2000483	negative regulation of interleukin-8 secretion(GO:2000483)
0.6	5.1	GO:1900625	regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.6	3.9	GO:0051414	response to cortisol(GO:0051414)
0.2	3.9	GO:0030208	dermatan sulfate biosynthetic process(GO:0030208)
0.1	3.4	GO:0003334	keratinocyte development(GO:0003334)
0.4	3.0	GO:0032596	protein transport within lipid bilayer(GO:0032594) protein transport into membrane raft(GO:0032596)
0.2	2.7	GO:0035372	protein localization to microtubule(GO:0035372)
0.4	2.6	GO:1902957	negative regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902957)
0.2	2.5	GO:0035986	senescence-associated heterochromatin focus assembly(GO:0035986)
0.6	2.2	GO:0001971	negative regulation of activation of membrane attack complex(GO:0001971)

Showing 1 to 10 of 160 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.5	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.3	5.1	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.1	3.1	REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0	2.5	REACTOME G1 PHASE	Genes involved in G1 Phase
0.1	2.0	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.0	1.7	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.2	1.6	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.1	1.4	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.0	1.4	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.0	1.3	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex

Showing 1 to 10 of 36 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.2	15.5	GO:0070320	inward rectifier potassium channel inhibitor activity(GO:0070320)
0.2	14.8	GO:0008307	structural constituent of muscle(GO:0008307)
2.6	10.5	GO:0004598	peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.2	8.1	GO:0003785	actin monomer binding(GO:0003785)
0.1	7.9	GO:0008201	heparin binding(GO:0008201)
0.2	7.5	GO:0046875	ephrin receptor binding(GO:0046875)
0.1	7.5	GO:0005178	integrin binding(GO:0005178)
0.3	7.3	GO:0051371	muscle alpha-actinin binding(GO:0051371)
1.2	6.2	GO:0016403	dimethylargininase activity(GO:0016403)
1.5	5.9	GO:0017089	glycolipid transporter activity(GO:0017089)

Showing 1 to 10 of 203 entries

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.2	15.5	GO:1900085	negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.5	15.2	GO:0008045	motor neuron axon guidance(GO:0008045)
0.9	10.9	GO:1900028	negative regulation of ruffle assembly(GO:1900028)
2.6	10.5	GO:0001519	peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179)
0.0	8.2	GO:0043687	post-translational protein modification(GO:0043687)
0.7	7.8	GO:0009414	response to water deprivation(GO:0009414)
0.5	7.6	GO:0035878	nail development(GO:0035878)
0.4	6.2	GO:0006527	arginine catabolic process(GO:0006527)
0.8	5.9	GO:0046836	glycolipid transport(GO:0046836)
0.3	5.9	GO:0003334	keratinocyte development(GO:0003334)

Showing 1 to 10 of 301 entries

Results for SP1

Z-value: 2.08

Motif logo

Transcription factors associated with SP1

Activity-expression correlation:

Activity profile of SP1 motif

Sorted Z-values of SP1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SP1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in biological_process category: