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ENCODE cell lines, expression (Ernst 2011)
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Results for SP3
Z-value: 1.24
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Transcription factors associated with SP3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP3 | hg19_v2_chr2_-_174830430_174830563, hg19_v2_chr2_-_174828892_174828972 | -0.05 | 8.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SP3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_+_6309517 | 2.99 |
ENST00000382519.4 ENST00000009180.4 |
CD9 |
CD9 molecule |
| chr11_-_6677018 | 2.43 |
ENST00000299441.3 |
DCHS1 |
dachsous cadherin-related 1 |
| chr10_-_126849068 | 2.40 |
ENST00000494626.2 ENST00000337195.5 |
CTBP2 |
C-terminal binding protein 2 |
| chr9_+_139560197 | 2.21 |
ENST00000371698.3 |
EGFL7 |
EGF-like-domain, multiple 7 |
| chr7_-_38670957 | 2.12 |
ENST00000325590.5 ENST00000428293.2 |
AMPH |
amphiphysin |
| chr10_-_15210615 | 2.06 |
ENST00000378150.1 |
NMT2 |
N-myristoyltransferase 2 |
| chr4_-_25864581 | 2.06 |
ENST00000399878.3 |
SEL1L3 |
sel-1 suppressor of lin-12-like 3 (C. elegans) |
| chr13_+_42031679 | 2.02 |
ENST00000379359.3 |
RGCC |
regulator of cell cycle |
| chr18_-_500692 | 2.02 |
ENST00000400256.3 |
COLEC12 |
collectin sub-family member 12 |
| chr5_-_127873659 | 1.97 |
ENST00000262464.4 |
FBN2 |
fibrillin 2 |
Gene Ontology Analysis
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 28.0 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.3 | 10.1 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.1 | 9.0 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 8.4 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 6.9 | GO:0000776 | kinetochore(GO:0000776) |
| 0.0 | 6.7 | GO:0042581 | specific granule(GO:0042581) |
| 0.1 | 6.5 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.5 | 6.4 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.0 | 6.2 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.5 | 5.8 | GO:0097443 | sorting endosome(GO:0097443) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.5 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
| 0.6 | 6.8 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
| 0.0 | 6.5 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 6.3 | GO:0019003 | GDP binding(GO:0019003) |
| 0.8 | 5.6 | GO:0030267 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.9 | 5.3 | GO:0039552 | RIG-I binding(GO:0039552) |
| 0.0 | 5.3 | GO:0005178 | integrin binding(GO:0005178) |
| 0.2 | 5.2 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.7 | 4.5 | GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 0.1 | 4.5 | GO:0005484 | SNAP receptor activity(GO:0005484) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.7 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.4 | 7.4 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 7.0 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 5.4 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.1 | 5.4 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.5 | 5.2 | REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 0.2 | 5.0 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 5.0 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.0 | 4.7 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 4.6 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 6.8 | GO:0009414 | response to water deprivation(GO:0009414) |
| 0.1 | 6.0 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.5 | 5.5 | GO:0039536 | negative regulation of RIG-I signaling pathway(GO:0039536) |
| 0.6 | 5.4 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 1.0 | 4.8 | GO:0097102 | vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) endothelial tip cell fate specification(GO:0097102) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040) |
| 0.5 | 4.8 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 0.8 | 4.5 | GO:0030421 | defecation(GO:0030421) |
| 0.7 | 4.5 | GO:0003273 | cell migration involved in endocardial cushion formation(GO:0003273) |
| 0.4 | 4.4 | GO:0001955 | blood vessel maturation(GO:0001955) |
| 0.5 | 4.3 | GO:0097350 | neutrophil clearance(GO:0097350) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 9.0 | PID FOXO PATHWAY | FoxO family signaling |
| 0.1 | 8.9 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 8.9 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.4 | 8.0 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.1 | 7.0 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 6.7 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.1 | 6.2 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 6.0 | SIG BCR SIGNALING PATHWAY | Members of the BCR signaling pathway |
| 0.2 | 5.2 | PID S1P S1P1 PATHWAY | S1P1 pathway |