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ENCODE cell lines, expression (Ernst 2011)
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Results for SP4_PML
Z-value: 2.06
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Transcription factors associated with SP4_PML
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP4 | hg19_v2_chr7_+_21467642_21467671 | -0.50 | 4.8e-02 | Click! |
| PML | hg19_v2_chr15_+_74287118_74287144 | -0.43 | 9.7e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SP4_PML
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_235860616 | 12.40 |
ENST00000392011.2 |
SH3BP4 |
SH3-domain binding protein 4 |
| chr12_-_106641728 | 10.59 |
ENST00000378026.4 |
CKAP4 |
cytoskeleton-associated protein 4 |
| chr3_-_149688502 | 8.86 |
ENST00000481767.1 ENST00000475518.1 |
PFN2 |
profilin 2 |
| chr3_-_149688655 | 8.57 |
ENST00000461930.1 ENST00000423691.2 ENST00000490975.1 ENST00000461868.1 ENST00000452853.2 |
PFN2 |
profilin 2 |
| chr14_-_53417732 | 8.55 |
ENST00000399304.3 ENST00000395631.2 ENST00000341590.3 ENST00000343279.4 |
FERMT2 |
fermitin family member 2 |
| chr1_-_20812690 | 8.26 |
ENST00000375078.3 |
CAMK2N1 |
calcium/calmodulin-dependent protein kinase II inhibitor 1 |
| chr4_-_177713788 | 8.07 |
ENST00000280193.2 |
VEGFC |
vascular endothelial growth factor C |
| chr11_-_12030629 | 7.80 |
ENST00000396505.2 |
DKK3 |
dickkopf WNT signaling pathway inhibitor 3 |
| chr2_-_161264385 | 7.78 |
ENST00000409972.1 |
RBMS1 |
RNA binding motif, single stranded interacting protein 1 |
| chr10_-_15413035 | 7.77 |
ENST00000378116.4 ENST00000455654.1 |
FAM171A1 |
family with sequence similarity 171, member A1 |
Gene Ontology Analysis
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 42.4 | GO:0005178 | integrin binding(GO:0005178) |
| 0.5 | 40.3 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 1.0 | 36.6 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.7 | 34.1 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.3 | 30.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.3 | 23.9 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.3 | 21.4 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.2 | 20.7 | GO:0008201 | heparin binding(GO:0008201) |
| 0.1 | 19.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 19.3 | GO:0045296 | cadherin binding(GO:0045296) |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 30.7 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 0.9 | 25.1 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.5 | 19.0 | GO:0035329 | hippo signaling(GO:0035329) |
| 1.9 | 17.0 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.3 | 16.2 | GO:0007190 | activation of adenylate cyclase activity(GO:0007190) |
| 0.2 | 15.5 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.7 | 14.7 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 1.8 | 14.5 | GO:0003065 | positive regulation of heart rate by epinephrine(GO:0003065) |
| 1.1 | 14.0 | GO:0038089 | positive regulation of cell migration by vascular endothelial growth factor signaling pathway(GO:0038089) |
| 0.6 | 13.9 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 99.6 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.3 | 84.1 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.5 | 46.0 | GO:0005604 | basement membrane(GO:0005604) |
| 0.3 | 26.6 | GO:0042641 | actomyosin(GO:0042641) |
| 0.2 | 25.0 | GO:0001726 | ruffle(GO:0001726) |
| 1.3 | 24.1 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.8 | 23.4 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.1 | 23.1 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.3 | 22.6 | GO:0030175 | filopodium(GO:0030175) |
| 0.3 | 19.2 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 51.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 45.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.7 | 37.7 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.2 | 36.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.7 | 30.3 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.5 | 28.3 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.3 | 25.9 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.6 | 23.0 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.4 | 22.2 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.3 | 21.1 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 49.3 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.6 | 37.3 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 24.3 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.9 | 24.0 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.3 | 21.5 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.8 | 20.4 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.6 | 14.9 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.7 | 14.0 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.7 | 13.6 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.5 | 13.4 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |