ISMARA results: SPI1

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ENCODE cell lines, expression (Ernst 2011)

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Results for SPI1

Z-value: 3.10

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Transcription factors associated with SPI1

Gene Symbol	Gene ID	Gene Info
SPI1 Ensembl NCBI GeneCards UniProt	ENSG00000066336.7	SPI1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SPI1	hg19_v2_chr11_-_47399942_47399961, hg19_v2_chr11_-_47400078_47400127	0.76	5.8e-04	Click!

Activity profile of SPI1 motif

Sorted Z-values of SPI1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SPI1

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Promoter	Score	Transcript	Gene	Gene Info
chr13_-_46756351	12.92	ENST00000323076.2	LCP1	lymphocyte cytosolic protein 1 (L-plastin)
chr1_+_198608146	11.93	ENST00000367376.2 ENST00000352140.3 ENST00000594404.1 ENST00000598951.1 ENST00000530727.1 ENST00000442510.2 ENST00000367367.4 ENST00000348564.6 ENST00000367364.1 ENST00000413409.2	PTPRC	protein tyrosine phosphatase, receptor type, C
chr10_-_98031310	10.02	ENST00000427367.2 ENST00000413476.2	BLNK	B-cell linker
chr10_-_98031265	9.70	ENST00000224337.5 ENST00000371176.2	BLNK	B-cell linker
chr3_-_121379739	8.91	ENST00000428394.2 ENST00000314583.3	HCLS1	hematopoietic cell-specific Lyn substrate 1
chr12_-_15114492	8.65	ENST00000541546.1	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta
chr12_-_15114603	8.58	ENST00000228945.4	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta
chr11_+_60223225	8.11	ENST00000524807.1 ENST00000345732.4	MS4A1	membrane-spanning 4-domains, subfamily A, member 1
chr11_+_60223312	8.10	ENST00000532491.1 ENST00000532073.1 ENST00000534668.1 ENST00000528313.1 ENST00000533306.1	MS4A1	membrane-spanning 4-domains, subfamily A, member 1
chr1_-_207095324	7.93	ENST00000530505.1 ENST00000367091.3 ENST00000442471.2	FAIM3	Fas apoptotic inhibitory molecule 3

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	26.7	GO:0009897	external side of plasma membrane(GO:0009897)
1.0	20.1	GO:0001891	phagocytic cup(GO:0001891)
0.1	18.8	GO:0032993	protein-DNA complex(GO:0032993)
0.0	18.6	GO:0016607	nuclear speck(GO:0016607)
2.2	17.8	GO:0032010	phagolysosome(GO:0032010)
0.1	17.3	GO:0045121	membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2	13.8	GO:0035577	azurophil granule membrane(GO:0035577)
1.8	12.4	GO:0043196	varicosity(GO:0043196)
2.2	10.9	GO:0034666	integrin alpha2-beta1 complex(GO:0034666)
0.2	9.8	GO:0001772	immunological synapse(GO:0001772)

Showing 1 to 10 of 136 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	51.4	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.8	33.6	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.5	30.7	PID BCR 5PATHWAY	BCR signaling pathway
0.3	24.0	PID RAC1 PATHWAY	RAC1 signaling pathway
0.5	22.1	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.5	22.0	PID CD40 PATHWAY	CD40/CD40L signaling
0.2	18.5	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.2	17.3	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.4	14.5	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.1	13.3	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling

Showing 1 to 10 of 64 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	24.8	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
1.5	19.1	GO:0001011	transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
2.7	18.7	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.6	17.4	GO:0023026	MHC class II protein complex binding(GO:0023026)
1.7	17.2	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.6	16.4	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.8	15.3	GO:0005522	profilin binding(GO:0005522)
0.9	14.8	GO:0003680	AT DNA binding(GO:0003680)
1.1	12.4	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.1	12.4	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)

Showing 1 to 10 of 213 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	39.5	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.6	31.5	REACTOME MYOGENESIS	Genes involved in Myogenesis
1.4	26.8	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.9	25.1	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.5	23.3	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.7	16.2	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.4	16.2	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.4	14.8	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.1	14.5	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.1	13.1	REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)

Showing 1 to 10 of 90 entries

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	25.6	GO:0042100	B cell proliferation(GO:0042100)
0.8	25.3	GO:0045730	respiratory burst(GO:0045730)
0.3	21.4	GO:0030183	B cell differentiation(GO:0030183)
2.5	19.9	GO:0050859	negative regulation of B cell receptor signaling pathway(GO:0050859)
4.3	17.2	GO:0071461	cellular response to redox state(GO:0071461)
0.1	16.2	GO:0065004	protein-DNA complex assembly(GO:0065004)
0.1	15.4	GO:0002433	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.1	14.6	GO:0006903	vesicle targeting(GO:0006903)
3.6	14.5	GO:0003138	primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.1	14.2	GO:0002223	stimulatory C-type lectin receptor signaling pathway(GO:0002223)

Showing 1 to 10 of 292 entries

Results for SPI1

Z-value: 3.10

Motif logo

Transcription factors associated with SPI1

Activity-expression correlation:

Activity profile of SPI1 motif

Sorted Z-values of SPI1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SPI1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in biological_process category: