ISMARA results: SPIB

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ENCODE cell lines, expression (Ernst 2011)

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Results for SPIB

Z-value: 3.64

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Transcription factors associated with SPIB

Gene Symbol	Gene ID	Gene Info
SPIB Ensembl NCBI GeneCards UniProt	ENSG00000269404.2	SPIB

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SPIB	hg19_v2_chr19_+_50922187_50922215	0.84	4.5e-05	Click!

Activity profile of SPIB motif

Sorted Z-values of SPIB motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SPIB

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Promoter	Score	Transcript	Gene	Gene Info
chr12_-_15114492	20.45	ENST00000541546.1	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta
chr1_-_160681593	16.29	ENST00000368045.3 ENST00000368046.3	CD48	CD48 molecule
chr10_-_121302195	12.14	ENST00000369103.2	RGS10	regulator of G-protein signaling 10
chr12_-_15114603	11.91	ENST00000228945.4	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta
chr1_-_31230650	11.72	ENST00000294507.3	LAPTM5	lysosomal protein transmembrane 5
chr10_-_98031310	10.49	ENST00000427367.2 ENST00000413476.2	BLNK	B-cell linker
chr10_-_98031265	9.96	ENST00000224337.5 ENST00000371176.2	BLNK	B-cell linker
chr3_-_121379739	9.07	ENST00000428394.2 ENST00000314583.3	HCLS1	hematopoietic cell-specific Lyn substrate 1
chr16_+_30194916	8.92	ENST00000570045.1 ENST00000565497.1 ENST00000570244.1	CORO1A	coronin, actin binding protein, 1A
chr2_+_143886877	8.79	ENST00000295095.6	ARHGAP15	Rho GTPase activating protein 15

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	41.9	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.4	32.4	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.5	24.0	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.3	22.8	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.3	16.7	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.0	12.5	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	10.7	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.1	9.4	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.2	9.0	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.1	6.5	PID IL4 2PATHWAY	IL4-mediated signaling events

Showing 1 to 10 of 33 entries

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
8.1	32.4	GO:0071461	cellular response to redox state(GO:0071461)
0.2	27.9	GO:0030183	B cell differentiation(GO:0030183)
0.1	18.3	GO:0007338	single fertilization(GO:0007338)
5.3	15.8	GO:0045404	interleukin-4 biosynthetic process(GO:0042097) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.1	15.6	GO:0008360	regulation of cell shape(GO:0008360)
2.4	14.5	GO:0045588	positive regulation of gamma-delta T cell differentiation(GO:0045588)
0.2	14.1	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.7	13.4	GO:0007213	G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.6	12.0	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1	11.6	GO:1990823	response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)

Showing 1 to 10 of 148 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	45.4	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.2	37.6	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.3	24.4	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2	22.4	REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	Genes involved in Cell surface interactions at the vascular wall
0.4	12.6	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.6	12.0	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.3	10.6	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.6	10.0	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.5	7.6	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.1	7.1	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex

Showing 1 to 10 of 56 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.2	32.4	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
1.3	24.3	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	20.0	GO:0004872	receptor activity(GO:0004872) molecular transducer activity(GO:0060089)
0.1	17.3	GO:0001085	RNA polymerase II transcription factor binding(GO:0001085)
0.0	15.0	GO:0003924	GTPase activity(GO:0003924)
0.3	14.4	GO:0001784	phosphotyrosine binding(GO:0001784)
0.4	13.8	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.2	12.2	GO:0016278	lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.6	12.0	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.2	10.9	GO:0015026	coreceptor activity(GO:0015026)

Showing 1 to 10 of 126 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	34.5	GO:0031226	intrinsic component of plasma membrane(GO:0031226)
0.0	17.6	GO:0005667	transcription factor complex(GO:0005667)
0.1	17.5	GO:0043197	dendritic spine(GO:0043197)
2.3	16.4	GO:0019815	B cell receptor complex(GO:0019815)
0.7	13.4	GO:0001891	phagocytic cup(GO:0001891)
0.0	12.7	GO:0098852	lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.2	11.9	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.2	11.9	GO:0035577	azurophil granule membrane(GO:0035577)
0.1	10.7	GO:0005913	cell-cell adherens junction(GO:0005913)
0.1	9.5	GO:0031225	anchored component of membrane(GO:0031225)

Showing 1 to 10 of 90 entries

Results for SPIB

Z-value: 3.64

Motif logo

Transcription factors associated with SPIB

Activity-expression correlation:

Activity profile of SPIB motif

Sorted Z-values of SPIB motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SPIB

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in C2:CP category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in cellular_component category: