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ENCODE cell lines, expression (Ernst 2011)
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Results for SPIC
Z-value: 2.33
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Transcription factors associated with SPIC
Network of associatons between targets according to the STRING database.
First level regulatory network of SPIC
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_-_98031310 | 10.72 |
ENST00000427367.2 ENST00000413476.2 |
BLNK |
B-cell linker |
| chr10_-_98031265 | 10.07 |
ENST00000224337.5 ENST00000371176.2 |
BLNK |
B-cell linker |
| chr16_+_81812863 | 7.03 |
ENST00000359376.3 |
PLCG2 |
phospholipase C, gamma 2 (phosphatidylinositol-specific) |
| chr1_-_160681593 | 6.53 |
ENST00000368045.3 ENST00000368046.3 |
CD48 |
CD48 molecule |
| chr13_-_46756351 | 6.38 |
ENST00000323076.2 |
LCP1 |
lymphocyte cytosolic protein 1 (L-plastin) |
| chr12_+_25205666 | 6.03 |
ENST00000547044.1 |
LRMP |
lymphoid-restricted membrane protein |
| chr22_+_23247030 | 6.02 |
ENST00000390324.2 |
IGLJ3 |
immunoglobulin lambda joining 3 |
| chr12_+_25205568 | 5.94 |
ENST00000548766.1 ENST00000556887.1 |
LRMP |
lymphoid-restricted membrane protein |
| chr6_-_32557610 | 5.83 |
ENST00000360004.5 |
HLA-DRB1 |
major histocompatibility complex, class II, DR beta 1 |
| chr3_-_121379739 | 5.56 |
ENST00000428394.2 ENST00000314583.3 |
HCLS1 |
hematopoietic cell-specific Lyn substrate 1 |
Gene Ontology Analysis
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 37.7 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.5 | 21.1 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.2 | 16.7 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 11.2 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.2 | 10.4 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.2 | 9.6 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 9.0 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 7.7 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 5.7 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 5.4 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 22.7 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 1.1 | 21.1 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 1.8 | 12.6 | GO:0005353 | fructose transmembrane transporter activity(GO:0005353) |
| 1.7 | 12.1 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.6 | 10.4 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.9 | 10.2 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
| 0.9 | 9.0 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.1 | 9.0 | GO:0030295 | protein kinase activator activity(GO:0030295) |
| 0.4 | 7.8 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.6 | 7.5 | GO:0008429 | phosphatidylethanolamine binding(GO:0008429) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 14.9 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.7 | 13.7 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.2 | 12.2 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 1.4 | 11.4 | GO:0032010 | phagolysosome(GO:0032010) |
| 0.1 | 10.4 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.7 | 9.6 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 9.4 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.8 | 9.3 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.1 | 8.3 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 8.1 | GO:0001772 | immunological synapse(GO:0001772) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 35.5 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.2 | 16.3 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 13.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.6 | 12.6 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.3 | 12.0 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.2 | 9.4 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.2 | 8.9 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 8.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.6 | 7.6 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.4 | 7.6 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 27.3 | GO:0030183 | B cell differentiation(GO:0030183) |
| 2.7 | 21.7 | GO:0050859 | negative regulation of B cell receptor signaling pathway(GO:0050859) |
| 0.1 | 14.4 | GO:0007338 | single fertilization(GO:0007338) |
| 1.8 | 12.6 | GO:0098704 | fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539) |
| 4.0 | 11.9 | GO:0002316 | follicular B cell differentiation(GO:0002316) |
| 0.3 | 10.6 | GO:0045730 | respiratory burst(GO:0045730) |
| 0.5 | 10.4 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 1.7 | 10.2 | GO:1990822 | basic amino acid transmembrane transport(GO:1990822) |
| 2.2 | 9.0 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 0.4 | 7.8 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |