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ENCODE cell lines, expression (Ernst 2011)
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Results for SRF
Z-value: 4.00
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Transcription factors associated with SRF
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SRF | hg19_v2_chr6_+_43139037_43139094 | -0.23 | 3.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SRF
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_+_35169885 | 31.81 |
ENST00000279022.2 ENST00000346786.2 |
MYL9 |
myosin, light chain 9, regulatory |
| chr15_-_35088340 | 22.47 |
ENST00000290378.4 |
ACTC1 |
actin, alpha, cardiac muscle 1 |
| chr9_-_35691017 | 17.27 |
ENST00000378292.3 |
TPM2 |
tropomyosin 2 (beta) |
| chr2_+_74120094 | 15.97 |
ENST00000409731.3 ENST00000345517.3 ENST00000409918.1 ENST00000442912.1 ENST00000409624.1 |
ACTG2 |
actin, gamma 2, smooth muscle, enteric |
| chr12_+_75874460 | 13.20 |
ENST00000266659.3 |
GLIPR1 |
GLI pathogenesis-related 1 |
| chr1_-_86043921 | 13.20 |
ENST00000535924.2 |
DDAH1 |
dimethylarginine dimethylaminohydrolase 1 |
| chr12_+_75874580 | 12.83 |
ENST00000456650.3 |
GLIPR1 |
GLI pathogenesis-related 1 |
| chr6_+_151561506 | 12.32 |
ENST00000253332.1 |
AKAP12 |
A kinase (PRKA) anchor protein 12 |
| chr6_+_151561085 | 12.27 |
ENST00000402676.2 |
AKAP12 |
A kinase (PRKA) anchor protein 12 |
| chr11_+_117070037 | 10.35 |
ENST00000392951.4 ENST00000525531.1 ENST00000278968.6 |
TAGLN |
transgelin |
Gene Ontology Analysis
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 101.4 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.4 | 52.8 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 11.1 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.2 | 6.8 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.2 | 6.4 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 5.5 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 5.4 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.0 | 4.9 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 4.4 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.4 | 4.3 | REACTOME PROSTANOID LIGAND RECEPTORS | Genes involved in Prostanoid ligand receptors |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 27.7 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 1.7 | 27.6 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.4 | 26.8 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 1.5 | 24.6 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.3 | 22.9 | GO:0017022 | myosin binding(GO:0017022) |
| 3.7 | 18.6 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.0 | 17.6 | GO:0005524 | ATP binding(GO:0005524) |
| 0.1 | 16.8 | GO:0051015 | actin filament binding(GO:0051015) |
| 2.6 | 13.2 | GO:0016403 | dimethylargininase activity(GO:0016403) |
| 0.5 | 8.4 | GO:0016641 | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 44.7 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.5 | 41.5 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.8 | 26.8 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 19.3 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.2 | 11.9 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.2 | 10.7 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.2 | 8.8 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 7.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 6.8 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
| 0.1 | 6.4 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.0 | 53.9 | GO:0090131 | mesenchyme migration(GO:0090131) |
| 0.4 | 31.8 | GO:0045652 | regulation of megakaryocyte differentiation(GO:0045652) |
| 5.4 | 26.8 | GO:0055014 | atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014) |
| 1.6 | 24.6 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.3 | 23.7 | GO:0030049 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 0.1 | 23.7 | GO:0007160 | cell-matrix adhesion(GO:0007160) |
| 2.3 | 18.6 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.0 | 14.7 | GO:0019216 | regulation of lipid metabolic process(GO:0019216) |
| 1.1 | 13.2 | GO:1900038 | negative regulation of cellular response to hypoxia(GO:1900038) |
| 1.9 | 11.2 | GO:1900756 | protein processing in phagocytic vesicle(GO:1900756) regulation of protein processing in phagocytic vesicle(GO:1903921) positive regulation of protein processing in phagocytic vesicle(GO:1903923) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 40.7 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 1.0 | 36.0 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 3.4 | 27.4 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 5.4 | 27.0 | GO:0042643 | actomyosin, actin portion(GO:0042643) |
| 0.7 | 26.4 | GO:0031430 | M band(GO:0031430) |
| 0.3 | 26.0 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.1 | 25.2 | GO:0005938 | cell cortex(GO:0005938) |
| 1.2 | 23.6 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 2.7 | 16.0 | GO:0032982 | myosin filament(GO:0032982) |
| 0.0 | 11.1 | GO:0000139 | Golgi membrane(GO:0000139) |