ISMARA results: STAT1_STAT3

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ENCODE cell lines, expression (Ernst 2011)

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Results for STAT1_STAT3_BCL6

Z-value: 2.17

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Transcription factors associated with STAT1_STAT3_BCL6

Gene Symbol	Gene ID	Gene Info
STAT1 Ensembl NCBI GeneCards UniProt	ENSG00000115415.14	STAT1
STAT3 Ensembl NCBI GeneCards UniProt	ENSG00000168610.10	STAT3
BCL6 Ensembl NCBI GeneCards UniProt	ENSG00000113916.13	BCL6

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
STAT1	hg19_v2_chr2_-_191885686_191885750	-0.68	3.9e-03	Click!
STAT3	hg19_v2_chr17_-_40540484_40540537	-0.44	9.1e-02	Click!
BCL6	hg19_v2_chr3_-_187454281_187454357	0.22	4.2e-01	Click!

Activity profile of STAT1_STAT3_BCL6 motif

Sorted Z-values of STAT1_STAT3_BCL6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT1_STAT3_BCL6

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Promoter	Score	Transcript	Gene	Gene Info
chr11_-_102668879	8.42	ENST00000315274.6	MMP1	matrix metallopeptidase 1 (interstitial collagenase)
chr8_-_27469196	7.30	ENST00000546343.1 ENST00000560566.1	CLU	clusterin
chr7_+_134464414	7.11	ENST00000361901.2	CALD1	caldesmon 1
chr1_-_68299130	6.87	ENST00000370982.3	GNG12	guanine nucleotide binding protein (G protein), gamma 12
chr3_-_93692781	6.34	ENST00000394236.3	PROS1	protein S (alpha)
chr17_+_32582293	6.25	ENST00000580907.1 ENST00000225831.4	CCL2	chemokine (C-C motif) ligand 2
chr9_-_117880477	6.13	ENST00000534839.1 ENST00000340094.3 ENST00000535648.1 ENST00000346706.3 ENST00000345230.3 ENST00000350763.4	TNC	tenascin C
chr8_-_27468842	6.08	ENST00000523500.1	CLU	clusterin
chr7_+_134464376	5.68	ENST00000454108.1 ENST00000361675.2	CALD1	caldesmon 1
chr8_-_27468945	5.38	ENST00000405140.3	CLU	clusterin

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	18.8	GO:0051787	misfolded protein binding(GO:0051787)
0.4	12.5	GO:0005523	tropomyosin binding(GO:0005523)
0.9	8.6	GO:0045545	syndecan binding(GO:0045545)
0.1	7.8	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.6	6.8	GO:0042301	phosphate ion binding(GO:0042301)
2.1	6.3	GO:0031727	CCR2 chemokine receptor binding(GO:0031727)
0.0	6.3	GO:0005178	integrin binding(GO:0005178)
0.0	5.4	GO:0004866	endopeptidase inhibitor activity(GO:0004866)
0.1	5.1	GO:0008307	structural constituent of muscle(GO:0008307)
0.1	5.0	GO:0005201	extracellular matrix structural constituent(GO:0005201)

Showing 1 to 10 of 135 entries

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.1	18.8	GO:0061518	macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
2.9	8.6	GO:0060447	bud outgrowth involved in lung branching(GO:0060447)
0.3	8.5	GO:0032461	positive regulation of protein oligomerization(GO:0032461)
0.4	7.7	GO:2001046	positive regulation of integrin-mediated signaling pathway(GO:2001046)
0.4	7.2	GO:0018214	peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.1	7.0	GO:0071377	cellular response to glucagon stimulus(GO:0071377)
2.1	6.2	GO:1901624	negative regulation of lymphocyte chemotaxis(GO:1901624)
0.7	5.3	GO:0003065	positive regulation of heart rate by epinephrine(GO:0003065)
1.3	5.2	GO:1903224	regulation of endodermal cell differentiation(GO:1903224)
0.1	5.1	GO:0000188	inactivation of MAPK activity(GO:0000188)

Showing 1 to 10 of 188 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	18.3	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.2	17.0	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.2	9.6	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.1	9.3	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	7.9	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	7.0	PID IGF1 PATHWAY	IGF1 pathway
0.1	5.2	NABA COLLAGENS	Genes encoding collagen proteins
0.2	3.5	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.1	3.5	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.1	2.8	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III

Showing 1 to 10 of 46 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	18.8	GO:0097418	neurofibrillary tangle(GO:0097418)
0.9	13.7	GO:0030478	actin cap(GO:0030478)
0.0	10.6	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.8	8.7	GO:0005614	interstitial matrix(GO:0005614)
0.1	8.3	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.1	6.8	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.3	5.3	GO:0032059	bleb(GO:0032059)
1.7	5.2	GO:0005588	collagen type V trimer(GO:0005588)
0.1	4.4	GO:0000421	autophagosome membrane(GO:0000421)
0.9	4.3	GO:0044352	pinosome(GO:0044352) macropinosome(GO:0044354)

Showing 1 to 10 of 92 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	24.6	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.4	23.1	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.4	8.9	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.5	8.4	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.1	7.5	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.3	6.8	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta
0.2	5.8	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.2	5.6	REACTOME ACTIVATION OF GENES BY ATF4	Genes involved in Activation of Genes by ATF4
0.2	5.3	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.1	5.2	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions

Showing 1 to 10 of 53 entries

Results for STAT1_STAT3_BCL6

Z-value: 2.17

Motif logo

Transcription factors associated with STAT1_STAT3_BCL6

Activity-expression correlation:

Activity profile of STAT1_STAT3_BCL6 motif

Sorted Z-values of STAT1_STAT3_BCL6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT1_STAT3_BCL6

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in molecular_function category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in C2:CP:REACTOME category: