Project
ENCODE cell lines, expression (Ernst 2011)
Navigation
Downloads
Results for TBP
Z-value: 2.61
Motif logo
Transcription factors associated with TBP
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBP | hg19_v2_chr6_+_170863421_170863484 | -0.32 | 2.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TBP
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_56685796 | 10.23 |
ENST00000334346.2 ENST00000562399.1 |
MT1B |
metallothionein 1B |
| chr12_-_52845910 | 9.98 |
ENST00000252252.3 |
KRT6B |
keratin 6B |
| chr12_-_52867569 | 8.35 |
ENST00000252250.6 |
KRT6C |
keratin 6C |
| chr10_+_54074033 | 7.40 |
ENST00000373970.3 |
DKK1 |
dickkopf WNT signaling pathway inhibitor 1 |
| chr17_-_39780819 | 7.30 |
ENST00000311208.8 |
KRT17 |
keratin 17 |
| chr1_+_153003671 | 7.00 |
ENST00000307098.4 |
SPRR1B |
small proline-rich protein 1B |
| chr1_-_59043166 | 6.54 |
ENST00000371225.2 |
TACSTD2 |
tumor-associated calcium signal transducer 2 |
| chr1_-_153538011 | 6.36 |
ENST00000368707.4 |
S100A2 |
S100 calcium binding protein A2 |
| chr1_-_153363452 | 6.02 |
ENST00000368732.1 ENST00000368733.3 |
S100A8 |
S100 calcium binding protein A8 |
| chr17_-_39674668 | 5.98 |
ENST00000393981.3 |
KRT15 |
keratin 15 |
Gene Ontology Analysis
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 33.1 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.6 | 28.2 | GO:0045095 | keratin filament(GO:0045095) |
| 0.4 | 20.9 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.2 | 16.8 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.2 | 12.8 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.1 | 7.6 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.1 | 7.6 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 6.7 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 6.7 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.2 | 6.6 | GO:0009925 | basal plasma membrane(GO:0009925) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 16.1 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 15.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 8.2 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 6.4 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 5.5 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 5.3 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.2 | 4.6 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 4.4 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 3.1 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 3.0 | PID ALK1 PATHWAY | ALK1 signaling events |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 62.0 | GO:0070268 | cornification(GO:0070268) |
| 1.2 | 33.7 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 1.7 | 10.4 | GO:0055064 | chloride ion homeostasis(GO:0055064) |
| 2.5 | 7.4 | GO:0009996 | negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) negative regulation of cell fate specification(GO:0009996) Wnt signaling pathway involved in somitogenesis(GO:0090244) |
| 0.8 | 6.5 | GO:0090191 | negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191) |
| 0.4 | 6.1 | GO:0060712 | spongiotrophoblast layer development(GO:0060712) |
| 1.0 | 6.0 | GO:0032119 | sequestering of zinc ion(GO:0032119) |
| 1.1 | 5.7 | GO:0060356 | leucine import(GO:0060356) |
| 0.4 | 5.7 | GO:0001542 | ovulation from ovarian follicle(GO:0001542) |
| 0.0 | 5.4 | GO:0043542 | endothelial cell migration(GO:0043542) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 28.3 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.1 | 18.9 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 18.3 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.1 | 13.4 | GO:0002020 | protease binding(GO:0002020) |
| 3.8 | 11.5 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 0.6 | 10.8 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.0 | 10.3 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.7 | 7.4 | GO:0039706 | co-receptor binding(GO:0039706) |
| 1.5 | 7.3 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.1 | 6.9 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 10.8 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.1 | 5.7 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 4.7 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.2 | 4.6 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.2 | 4.5 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.1 | 4.0 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.0 | 3.9 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 2.8 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 2.7 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.0 | 2.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |