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ENCODE cell lines, expression (Ernst 2011)
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Results for TCF12_ASCL2
Z-value: 2.34
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Transcription factors associated with TCF12_ASCL2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TCF12 | hg19_v2_chr15_+_57210961_57211030 | -0.18 | 4.9e-01 | Click! |
| ASCL2 | hg19_v2_chr11_-_2292182_2292212 | 0.14 | 6.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TCF12_ASCL2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_23847339 | 16.73 |
ENST00000303531.7 |
PRKCB |
protein kinase C, beta |
| chr16_+_23847267 | 15.97 |
ENST00000321728.7 |
PRKCB |
protein kinase C, beta |
| chr22_+_23241661 | 8.26 |
ENST00000390322.2 |
IGLJ2 |
immunoglobulin lambda joining 2 |
| chr16_-_89043377 | 7.10 |
ENST00000436887.2 ENST00000448839.1 ENST00000360302.2 |
CBFA2T3 |
core-binding factor, runt domain, alpha subunit 2; translocated to, 3 |
| chr16_+_32077386 | 6.66 |
ENST00000354689.6 |
IGHV3OR16-9 |
immunoglobulin heavy variable 3/OR16-9 (non-functional) |
| chr17_+_76164639 | 6.18 |
ENST00000225777.3 ENST00000585591.1 ENST00000589711.1 ENST00000588282.1 ENST00000589168.1 |
SYNGR2 |
synaptogyrin 2 |
| chr17_+_76165213 | 6.15 |
ENST00000590201.1 |
SYNGR2 |
synaptogyrin 2 |
| chr15_+_89182178 | 5.96 |
ENST00000559876.1 |
ISG20 |
interferon stimulated exonuclease gene 20kDa |
| chr20_+_37434329 | 5.81 |
ENST00000299824.1 ENST00000373331.2 |
PPP1R16B |
protein phosphatase 1, regulatory subunit 16B |
| chr15_+_89181974 | 5.56 |
ENST00000306072.5 |
ISG20 |
interferon stimulated exonuclease gene 20kDa |
Gene Ontology Analysis
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 34.0 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 13.3 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.2 | 10.9 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.2 | 9.3 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 8.1 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.2 | 7.4 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.1 | 7.0 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.1 | 6.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 5.0 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.1 | 4.3 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 47.3 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.7 | 35.2 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.2 | 16.8 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 13.1 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 12.5 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.1 | 10.7 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.1 | 8.1 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 8.1 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.4 | 7.9 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 5.8 | GO:0005759 | mitochondrial matrix(GO:0005759) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 32.5 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.2 | 17.7 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 12.8 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.5 | 11.5 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.4 | 10.6 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |
| 0.2 | 5.8 | REACTOME REGULATION OF KIT SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.1 | 5.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.2 | 5.7 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.2 | 5.4 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.2 | 5.3 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 34.9 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 10.9 | 32.7 | GO:0035403 | histone kinase activity (H3-T6 specific)(GO:0035403) |
| 0.0 | 18.2 | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) |
| 5.6 | 16.9 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.1 | 15.7 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.1 | 14.7 | GO:0003823 | antigen binding(GO:0003823) |
| 1.7 | 12.2 | GO:0005353 | fructose transmembrane transporter activity(GO:0005353) |
| 1.1 | 7.6 | GO:0031726 | CCR1 chemokine receptor binding(GO:0031726) |
| 0.4 | 6.2 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.1 | 5.7 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 33.6 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 10.9 | 32.7 | GO:0035408 | histone H3-T6 phosphorylation(GO:0035408) |
| 5.6 | 16.9 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 1.7 | 12.2 | GO:1990539 | fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539) |
| 1.5 | 12.0 | GO:1903715 | regulation of aerobic respiration(GO:1903715) |
| 0.1 | 10.9 | GO:0002455 | humoral immune response mediated by circulating immunoglobulin(GO:0002455) |
| 0.1 | 8.7 | GO:0050853 | B cell receptor signaling pathway(GO:0050853) |
| 1.1 | 7.6 | GO:2000503 | positive regulation of natural killer cell chemotaxis(GO:2000503) |
| 0.1 | 6.8 | GO:0002260 | lymphocyte homeostasis(GO:0002260) |
| 0.1 | 6.2 | GO:0006383 | transcription from RNA polymerase III promoter(GO:0006383) |