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ENCODE cell lines, expression (Ernst 2011)
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Results for TCF3_MYOG
Z-value: 1.53
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Transcription factors associated with TCF3_MYOG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MYOG | hg19_v2_chr1_-_203055129_203055164 | 0.75 | 9.0e-04 | Click! |
| TCF3 | hg19_v2_chr19_-_1650666_1650744 | 0.18 | 5.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TCF3_MYOG
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_+_45286706 | 6.48 |
ENST00000393450.1 ENST00000572303.1 |
MYL4 |
myosin, light chain 4, alkali; atrial, embryonic |
| chr17_+_45286387 | 6.16 |
ENST00000572316.1 ENST00000354968.1 ENST00000576874.1 ENST00000536623.2 |
MYL4 |
myosin, light chain 4, alkali; atrial, embryonic |
| chr9_-_35689900 | 5.32 |
ENST00000378300.5 ENST00000329305.2 ENST00000360958.2 |
TPM2 |
tropomyosin 2 (beta) |
| chr6_+_44184653 | 4.10 |
ENST00000573382.2 ENST00000576476.1 |
RP1-302G2.5 |
RP1-302G2.5 |
| chr1_-_201391149 | 3.99 |
ENST00000555948.1 ENST00000556362.1 |
TNNI1 |
troponin I type 1 (skeletal, slow) |
| chr21_+_30502806 | 3.94 |
ENST00000399928.1 ENST00000399926.1 |
MAP3K7CL |
MAP3K7 C-terminal like |
| chr16_+_30383613 | 3.77 |
ENST00000568749.1 |
MYLPF |
myosin light chain, phosphorylatable, fast skeletal muscle |
| chr3_-_87040233 | 3.65 |
ENST00000398399.2 |
VGLL3 |
vestigial like 3 (Drosophila) |
| chr2_-_152590946 | 3.41 |
ENST00000172853.10 |
NEB |
nebulin |
| chr8_+_98788003 | 3.41 |
ENST00000521545.2 |
LAPTM4B |
lysosomal protein transmembrane 4 beta |
Gene Ontology Analysis
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.0 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 5.2 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 5.0 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 4.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 3.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 3.3 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 3.0 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.1 | 2.9 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 2.8 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.0 | 2.6 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 21.2 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 3.2 | 12.6 | GO:0032038 | myosin II heavy chain binding(GO:0032038) |
| 0.3 | 6.3 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
| 0.0 | 6.2 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.5 | 5.6 | GO:0031013 | troponin I binding(GO:0031013) |
| 0.0 | 5.5 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.1 | 4.4 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.2 | 3.5 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 1.1 | 3.3 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
| 0.3 | 3.3 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 32.6 | GO:0030049 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 2.0 | 6.0 | GO:1900075 | regulation of neuromuscular synaptic transmission(GO:1900073) positive regulation of neuromuscular synaptic transmission(GO:1900075) |
| 0.4 | 5.9 | GO:0031272 | regulation of pseudopodium assembly(GO:0031272) |
| 0.0 | 4.4 | GO:0007519 | skeletal muscle tissue development(GO:0007519) |
| 1.0 | 4.0 | GO:0032972 | regulation of muscle filament sliding speed(GO:0032972) |
| 0.2 | 3.5 | GO:0045199 | maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199) |
| 0.9 | 3.4 | GO:0007525 | somatic muscle development(GO:0007525) |
| 0.2 | 3.4 | GO:0035020 | regulation of Rac protein signal transduction(GO:0035020) |
| 0.0 | 3.4 | GO:0010507 | negative regulation of autophagy(GO:0010507) |
| 1.1 | 3.3 | GO:1900085 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.3 | GO:0030018 | Z disc(GO:0030018) |
| 0.3 | 16.3 | GO:0031672 | A band(GO:0031672) |
| 0.4 | 7.6 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.4 | 7.5 | GO:0005861 | troponin complex(GO:0005861) |
| 0.4 | 7.0 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.0 | 7.0 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.5 | 6.4 | GO:0099634 | postsynaptic specialization membrane(GO:0099634) |
| 0.4 | 4.6 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.7 | 4.0 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
| 0.2 | 3.8 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 35.9 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 4.6 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 3.9 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 3.5 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 3.4 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.1 | 2.4 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 2.3 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 2.1 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 1.9 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 1.7 | REACTOME DESTABILIZATION OF MRNA BY KSRP | Genes involved in Destabilization of mRNA by KSRP |