ISMARA results: TEAD3

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ENCODE cell lines, expression (Ernst 2011)

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Results for TEAD3_TEAD1

Z-value: 4.78

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Transcription factors associated with TEAD3_TEAD1

Gene Symbol	Gene ID	Gene Info
TEAD3 Ensembl NCBI GeneCards UniProt	ENSG00000007866.14	TEAD3
TEAD1 Ensembl NCBI GeneCards UniProt	ENSG00000187079.10	TEAD1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TEAD1	hg19_v2_chr11_+_12695944_12695989, hg19_v2_chr11_+_12696102_12696164, hg19_v2_chr11_+_12766583_12766592	0.94	1.1e-07	Click!
TEAD3	hg19_v2_chr6_-_35464817_35464894, hg19_v2_chr6_-_35464727_35464738	0.64	7.2e-03	Click!

Activity profile of TEAD3_TEAD1 motif

Sorted Z-values of TEAD3_TEAD1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TEAD3_TEAD1

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Promoter	Score	Transcript	Gene	Gene Info
chr6_-_132272504	48.89	ENST00000367976.3	CTGF	connective tissue growth factor
chr5_-_39425068	33.20	ENST00000515700.1 ENST00000339788.6	DAB2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr2_-_161264385	18.94	ENST00000409972.1	RBMS1	RNA binding motif, single stranded interacting protein 1
chr7_+_134464414	18.86	ENST00000361901.2	CALD1	caldesmon 1
chr6_-_128841503	18.55	ENST00000368215.3 ENST00000532331.1 ENST00000368213.5 ENST00000368207.3 ENST00000525459.1 ENST00000368210.3 ENST00000368226.4 ENST00000368227.3	PTPRK	protein tyrosine phosphatase, receptor type, K
chr10_-_90712520	17.95	ENST00000224784.6	ACTA2	actin, alpha 2, smooth muscle, aorta
chr1_+_86046433	17.72	ENST00000451137.2	CYR61	cysteine-rich, angiogenic inducer, 61
chr5_-_39425222	16.82	ENST00000320816.6	DAB2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr15_+_39873268	16.64	ENST00000397591.2 ENST00000260356.5	THBS1	thrombospondin 1
chr5_-_39425290	16.38	ENST00000545653.1	DAB2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	75.7	GO:0006936	muscle contraction(GO:0006936)
16.6	66.4	GO:0035026	leading edge cell differentiation(GO:0035026)
16.3	48.9	GO:0070318	positive regulation of G0 to G1 transition(GO:0070318)
1.9	34.3	GO:0007021	tubulin complex assembly(GO:0007021)
0.7	30.4	GO:0035329	hippo signaling(GO:0035329)
7.2	21.7	GO:1900075	regulation of neuromuscular synaptic transmission(GO:1900073) positive regulation of neuromuscular synaptic transmission(GO:1900075)
7.1	21.4	GO:1903609	negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
3.6	21.3	GO:0090131	mesenchyme migration(GO:0090131)
1.5	21.1	GO:0010839	negative regulation of keratinocyte proliferation(GO:0010839)
0.6	18.8	GO:0060216	definitive hemopoiesis(GO:0060216)

Showing 1 to 10 of 181 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.1	67.2	GO:0098748	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.7	65.3	GO:0008307	structural constituent of muscle(GO:0008307)
2.5	61.0	GO:0001968	fibronectin binding(GO:0001968)
2.1	58.1	GO:0005523	tropomyosin binding(GO:0005523)
1.1	34.0	GO:0005212	structural constituent of eye lens(GO:0005212)
0.3	30.8	GO:0005201	extracellular matrix structural constituent(GO:0005201)
1.1	21.7	GO:0033130	acetylcholine receptor binding(GO:0033130)
7.1	21.4	GO:0070320	inward rectifier potassium channel inhibitor activity(GO:0070320)
0.8	20.5	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
1.0	18.5	GO:0045295	gamma-catenin binding(GO:0045295)

Showing 1 to 10 of 130 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	140.0	PID TGFBR PATHWAY	TGF-beta receptor signaling
1.3	35.3	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.6	32.8	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.2	19.1	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.3	18.0	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
0.2	15.9	PID NOTCH PATHWAY	Notch signaling pathway
0.2	14.9	PID SHP2 PATHWAY	SHP2 signaling
0.2	12.1	PID ILK PATHWAY	Integrin-linked kinase signaling
0.0	9.0	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	8.4	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling

Showing 1 to 10 of 44 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	91.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
3.7	66.4	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
1.7	64.9	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.9	24.8	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.9	22.2	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.3	15.8	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.1	14.8	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.5	14.6	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.5	11.8	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.3	8.4	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions

Showing 1 to 10 of 54 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
7.4	66.4	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.8	48.4	GO:0005801	cis-Golgi network(GO:0005801)
3.2	47.3	GO:0030478	actin cap(GO:0030478)
2.8	45.4	GO:0097512	cardiac myofibril(GO:0097512)
2.2	29.2	GO:0005577	fibrinogen complex(GO:0005577)
0.8	28.9	GO:0005859	muscle myosin complex(GO:0005859)
0.1	26.8	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
1.0	22.9	GO:0001527	microfibril(GO:0001527) fibril(GO:0043205)
1.8	21.7	GO:0099634	postsynaptic specialization membrane(GO:0099634)
1.4	19.3	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)

Showing 1 to 10 of 82 entries

Results for TEAD3_TEAD1

Z-value: 4.78

Motif logo

Transcription factors associated with TEAD3_TEAD1

Activity-expression correlation:

Activity profile of TEAD3_TEAD1 motif

Sorted Z-values of TEAD3_TEAD1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TEAD3_TEAD1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in cellular_component category: