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ENCODE cell lines, expression (Ernst 2011)
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Results for TFAP2C
Z-value: 1.60
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Transcription factors associated with TFAP2C
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TFAP2C | hg19_v2_chr20_+_55204351_55204377 | 0.82 | 1.0e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TFAP2C
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_39264072 | 3.92 |
ENST00000599035.1 ENST00000378626.4 |
LGALS7 |
lectin, galactoside-binding, soluble, 7 |
| chr19_+_39279838 | 3.76 |
ENST00000314980.4 |
LGALS7B |
lectin, galactoside-binding, soluble, 7B |
| chr12_-_28123206 | 2.99 |
ENST00000542963.1 ENST00000535992.1 |
PTHLH |
parathyroid hormone-like hormone |
| chr1_-_209979375 | 2.74 |
ENST00000367021.3 |
IRF6 |
interferon regulatory factor 6 |
| chr10_-_126849068 | 2.59 |
ENST00000494626.2 ENST00000337195.5 |
CTBP2 |
C-terminal binding protein 2 |
| chr18_+_21269404 | 2.51 |
ENST00000313654.9 |
LAMA3 |
laminin, alpha 3 |
| chr12_-_52887034 | 2.45 |
ENST00000330722.6 |
KRT6A |
keratin 6A |
| chr18_-_28622774 | 2.34 |
ENST00000434452.1 |
DSC3 |
desmocollin 3 |
| chr16_+_22825475 | 2.27 |
ENST00000261374.3 |
HS3ST2 |
heparan sulfate (glucosamine) 3-O-sulfotransferase 2 |
| chr10_+_124221036 | 2.26 |
ENST00000368984.3 |
HTRA1 |
HtrA serine peptidase 1 |
Gene Ontology Analysis
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 5.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 5.7 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.8 | 5.5 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.1 | 5.2 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.5 | 4.3 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 0.0 | 4.3 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 4.1 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.1 | 3.4 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.2 | 3.2 | GO:0045499 | chemorepellent activity(GO:0045499) |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.8 | GO:0070268 | cornification(GO:0070268) |
| 0.2 | 7.1 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.9 | 5.6 | GO:0002225 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) |
| 0.6 | 5.5 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.1 | 5.3 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.5 | 4.3 | GO:0086073 | cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073) |
| 0.1 | 3.8 | GO:0042347 | negative regulation of NF-kappaB import into nucleus(GO:0042347) |
| 0.3 | 3.5 | GO:0009414 | response to water deprivation(GO:0009414) |
| 0.1 | 3.2 | GO:0032331 | negative regulation of chondrocyte differentiation(GO:0032331) |
| 0.2 | 2.6 | GO:0060753 | regulation of mast cell chemotaxis(GO:0060753) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 6.9 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 6.8 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.2 | 4.7 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 4.2 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 4.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 3.3 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
| 0.1 | 3.0 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 2.5 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.1 | 2.4 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.4 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.0 | 5.0 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 4.4 | REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS | Genes involved in TGF-beta receptor signaling activates SMADs |
| 0.1 | 3.4 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 3.2 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 3.1 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 3.0 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.1 | 2.8 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 2.8 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 0.0 | 2.7 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.7 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 6.3 | GO:0005912 | adherens junction(GO:0005912) anchoring junction(GO:0070161) |
| 0.5 | 6.1 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.2 | 6.1 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.8 | 5.6 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.5 | 4.3 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.7 | 4.0 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.2 | 3.3 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.0 | 3.1 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.1 | 2.8 | GO:0031258 | lamellipodium membrane(GO:0031258) |