Project
ENCODE cell lines, expression (Ernst 2011)
Navigation
Downloads
Results for TLX1_NFIC
Z-value: 2.44
Motif logo
Transcription factors associated with TLX1_NFIC
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFIC | hg19_v2_chr19_+_3359561_3359681 | 0.77 | 4.8e-04 | Click! |
| TLX1 | hg19_v2_chr10_+_102891048_102891078 | -0.39 | 1.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TLX1_NFIC
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_116165038 | 11.91 |
ENST00000393470.1 |
CAV1 |
caveolin 1, caveolae protein, 22kDa |
| chr12_+_13349650 | 10.51 |
ENST00000256951.5 ENST00000431267.2 ENST00000542474.1 ENST00000544053.1 |
EMP1 |
epithelial membrane protein 1 |
| chr8_-_42065187 | 9.02 |
ENST00000270189.6 ENST00000352041.3 ENST00000220809.4 |
PLAT |
plasminogen activator, tissue |
| chr8_-_42065075 | 7.90 |
ENST00000429089.2 ENST00000519510.1 ENST00000429710.2 ENST00000524009.1 |
PLAT |
plasminogen activator, tissue |
| chrX_+_102631844 | 7.28 |
ENST00000372634.1 ENST00000299872.7 |
NGFRAP1 |
nerve growth factor receptor (TNFRSF16) associated protein 1 |
| chrX_+_102631248 | 7.01 |
ENST00000361298.4 ENST00000372645.3 ENST00000372635.1 |
NGFRAP1 |
nerve growth factor receptor (TNFRSF16) associated protein 1 |
| chr7_+_102553430 | 6.87 |
ENST00000339431.4 ENST00000249377.4 |
LRRC17 |
leucine rich repeat containing 17 |
| chr1_+_151512775 | 6.39 |
ENST00000368849.3 ENST00000392712.3 ENST00000353024.3 ENST00000368848.2 ENST00000538902.1 |
TUFT1 |
tuftelin 1 |
| chr14_+_85996471 | 5.64 |
ENST00000330753.4 |
FLRT2 |
fibronectin leucine rich transmembrane protein 2 |
| chr7_+_143079000 | 5.45 |
ENST00000392910.2 |
ZYX |
zyxin |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 16.9 | GO:0031639 | plasminogen activation(GO:0031639) |
| 2.5 | 15.1 | GO:0061518 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.1 | 14.9 | GO:0007229 | integrin-mediated signaling pathway(GO:0007229) |
| 4.0 | 11.9 | GO:1903609 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
| 0.5 | 10.5 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.5 | 9.9 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 1.5 | 9.1 | GO:0061343 | cell adhesion involved in heart morphogenesis(GO:0061343) |
| 0.1 | 7.9 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.7 | 7.7 | GO:0060020 | Bergmann glial cell differentiation(GO:0060020) |
| 1.4 | 6.9 | GO:0048539 | bone marrow development(GO:0048539) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.7 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.7 | 14.9 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 4.0 | 11.9 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
| 0.4 | 10.4 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.6 | 9.1 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.1 | 8.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.7 | 8.2 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 1.3 | 7.7 | GO:1990254 | keratin filament binding(GO:1990254) |
| 0.2 | 6.8 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.8 | 6.5 | GO:0005534 | galactose binding(GO:0005534) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 52.8 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 17.5 | GO:0005615 | extracellular space(GO:0005615) |
| 1.0 | 16.3 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.1 | 14.9 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.9 | 11.9 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.6 | 9.9 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.1 | 8.4 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.6 | 7.9 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 2.2 | 6.5 | GO:0072563 | endothelial microparticle(GO:0072563) |
| 0.5 | 6.5 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 19.2 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.2 | 18.9 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.4 | 18.5 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.3 | 15.4 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 13.5 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.3 | 9.2 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.3 | 9.1 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.1 | 7.7 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.2 | 5.5 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 24.1 | REACTOME SIGNALING BY PDGF | Genes involved in Signaling by PDGF |
| 0.2 | 21.2 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 13.0 | REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE | Genes involved in Cell death signalling via NRAGE, NRIF and NADE |
| 0.4 | 12.7 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.3 | 10.4 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.3 | 8.2 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.2 | 4.3 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 4.1 | REACTOME SIGNAL TRANSDUCTION BY L1 | Genes involved in Signal transduction by L1 |
| 0.2 | 3.5 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 3.3 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |