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ENCODE cell lines, expression (Ernst 2011)
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Results for TP63
Z-value: 1.90
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Transcription factors associated with TP63
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TP63 | hg19_v2_chr3_+_189349162_189349305 | 0.71 | 2.3e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TP63
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_51504411 | 7.62 |
ENST00000593490.1 |
KLK8 |
kallikrein-related peptidase 8 |
| chr6_+_121756809 | 7.13 |
ENST00000282561.3 |
GJA1 |
gap junction protein, alpha 1, 43kDa |
| chr12_-_52887034 | 6.95 |
ENST00000330722.6 |
KRT6A |
keratin 6A |
| chr18_+_61143994 | 6.74 |
ENST00000382771.4 |
SERPINB5 |
serpin peptidase inhibitor, clade B (ovalbumin), member 5 |
| chr1_-_209824643 | 6.34 |
ENST00000391911.1 ENST00000415782.1 |
LAMB3 |
laminin, beta 3 |
| chr3_+_122044084 | 6.17 |
ENST00000264474.3 ENST00000479204.1 |
CSTA |
cystatin A (stefin A) |
| chr12_-_52845910 | 6.06 |
ENST00000252252.3 |
KRT6B |
keratin 6B |
| chr2_-_151344172 | 5.37 |
ENST00000375734.2 ENST00000263895.4 ENST00000454202.1 |
RND3 |
Rho family GTPase 3 |
| chr16_+_57653989 | 5.03 |
ENST00000567835.1 ENST00000569372.1 ENST00000563548.1 ENST00000562003.1 |
GPR56 |
G protein-coupled receptor 56 |
| chr1_-_153588334 | 4.99 |
ENST00000476873.1 |
S100A14 |
S100 calcium binding protein A14 |
Gene Ontology Analysis
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.8 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 10.2 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.3 | 6.3 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 5.1 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 4.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 4.1 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 3.4 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 3.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 3.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 2.7 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 12.7 | GO:0045095 | keratin filament(GO:0045095) |
| 0.6 | 9.6 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 8.6 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 8.1 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 8.0 | GO:0045178 | basal part of cell(GO:0045178) |
| 0.6 | 6.5 | GO:0097413 | Lewy body(GO:0097413) |
| 0.8 | 6.3 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.1 | 5.7 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 4.6 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.1 | 4.1 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.8 | GO:0032732 | positive regulation of interleukin-1 production(GO:0032732) |
| 0.3 | 8.1 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 1.0 | 7.6 | GO:0031642 | negative regulation of myelination(GO:0031642) |
| 2.4 | 7.1 | GO:0010652 | regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652) |
| 2.3 | 6.9 | GO:0051710 | regulation of cytolysis in other organism(GO:0051710) |
| 0.1 | 6.2 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.2 | 6.0 | GO:0060512 | prostate gland morphogenesis(GO:0060512) |
| 0.2 | 5.7 | GO:0007398 | ectoderm development(GO:0007398) |
| 1.4 | 5.5 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 1.0 | 5.0 | GO:0009608 | response to symbiont(GO:0009608) response to symbiotic bacterium(GO:0009609) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 9.6 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.1 | 8.5 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.5 | 5.0 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.0 | 5.0 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 4.3 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.2 | 4.1 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.1 | 3.7 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.1 | 3.3 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 2.9 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 2.7 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.8 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 10.7 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 8.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 7.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 1.4 | 7.1 | GO:0086075 | gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) |
| 0.6 | 5.5 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.0 | 5.1 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.2 | 5.0 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.1 | 5.0 | GO:0042379 | chemokine receptor binding(GO:0042379) |
| 0.3 | 4.7 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |