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ENCODE cell lines, expression (Ernst 2011)
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Results for TWIST1_SNAI1
Z-value: 1.44
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Transcription factors associated with TWIST1_SNAI1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TWIST1 | hg19_v2_chr7_-_19157248_19157295 | -0.35 | 1.8e-01 | Click! |
| SNAI1 | hg19_v2_chr20_+_48599506_48599536 | -0.23 | 4.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TWIST1_SNAI1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_111314230 | 4.28 |
ENST00000317012.4 |
ZBED2 |
zinc finger, BED-type containing 2 |
| chr1_+_35247859 | 4.07 |
ENST00000373362.3 |
GJB3 |
gap junction protein, beta 3, 31kDa |
| chr18_+_29077990 | 3.67 |
ENST00000261590.8 |
DSG2 |
desmoglein 2 |
| chr19_+_35609380 | 3.17 |
ENST00000604621.1 |
FXYD3 |
FXYD domain containing ion transport regulator 3 |
| chr17_-_39677971 | 2.95 |
ENST00000393976.2 |
KRT15 |
keratin 15 |
| chrX_+_105969893 | 2.94 |
ENST00000255499.2 |
RNF128 |
ring finger protein 128, E3 ubiquitin protein ligase |
| chr12_+_52626898 | 2.43 |
ENST00000331817.5 |
KRT7 |
keratin 7 |
| chr2_+_47596287 | 2.41 |
ENST00000263735.4 |
EPCAM |
epithelial cell adhesion molecule |
| chr19_-_51456198 | 2.26 |
ENST00000594846.1 |
KLK5 |
kallikrein-related peptidase 5 |
| chr19_+_38755042 | 2.13 |
ENST00000301244.7 |
SPINT2 |
serine peptidase inhibitor, Kunitz type, 2 |
Gene Ontology Analysis
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 10.2 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 5.6 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 5.2 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.3 | 4.3 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 4.0 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 4.0 | GO:0005923 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.0 | 3.7 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.1 | 2.9 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.0 | 2.4 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.3 | 2.3 | GO:0097209 | epidermal lamellar body(GO:0097209) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 7.9 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 0.1 | 5.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 5.5 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.2 | 5.3 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.0 | 4.6 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.3 | 4.3 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.1 | 4.2 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 2.6 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.0 | 2.2 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.4 | 2.1 | GO:0047179 | platelet-activating factor acetyltransferase activity(GO:0047179) |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.3 | GO:0070268 | cornification(GO:0070268) |
| 0.9 | 7.9 | GO:0086073 | cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073) |
| 0.1 | 5.3 | GO:2000249 | regulation of actin cytoskeleton reorganization(GO:2000249) |
| 0.1 | 4.9 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 1.6 | 4.7 | GO:0051796 | regulation of monophenol monooxygenase activity(GO:0032771) positive regulation of monophenol monooxygenase activity(GO:0032773) negative regulation of catagen(GO:0051796) regulation of hair cycle by canonical Wnt signaling pathway(GO:0060901) positive regulation of melanosome transport(GO:1902910) |
| 0.9 | 3.8 | GO:0060672 | epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672) |
| 0.0 | 3.5 | GO:0071300 | cellular response to retinoic acid(GO:0071300) |
| 0.3 | 2.8 | GO:1904352 | positive regulation of protein catabolic process in the vacuole(GO:1904352) |
| 0.2 | 2.6 | GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162) |
| 0.8 | 2.4 | GO:2000048 | negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 8.5 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.3 | 4.3 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.1 | 3.5 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 2.9 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 2.7 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 1.9 | REACTOME GRB2 EVENTS IN ERBB2 SIGNALING | Genes involved in GRB2 events in ERBB2 signaling |
| 0.0 | 1.9 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 1.7 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.1 | 1.6 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 1.6 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.8 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 3.5 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 3.2 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 2.1 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 2.0 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 2.0 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 1.9 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 1.9 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.0 | 1.5 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 1.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |