ISMARA results: WT1_MTF1

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ENCODE cell lines, expression (Ernst 2011)

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Results for WT1_MTF1_ZBTB7B

Z-value: 3.19

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Transcription factors associated with WT1_MTF1_ZBTB7B

Gene Symbol	Gene ID	Gene Info
WT1 Ensembl NCBI GeneCards UniProt	ENSG00000184937.8	WT1
MTF1 Ensembl NCBI GeneCards UniProt	ENSG00000188786.9	MTF1
ZBTB7B Ensembl NCBI GeneCards UniProt	ENSG00000160685.9	ZBTB7B

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
WT1	hg19_v2_chr11_-_32452357_32452363, hg19_v2_chr11_-_32457176_32457193, hg19_v2_chr11_-_32456891_32456906	-0.74	1.1e-03	Click!
MTF1	hg19_v2_chr1_-_38325256_38325292	-0.33	2.1e-01	Click!
ZBTB7B	hg19_v2_chr1_+_154975258_154975330	-0.19	4.7e-01	Click!

Activity profile of WT1_MTF1_ZBTB7B motif

Sorted Z-values of WT1_MTF1_ZBTB7B motif

Network of associatons between targets according to the STRING database.

First level regulatory network of WT1_MTF1_ZBTB7B

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Promoter	Score	Transcript	Gene	Gene Info
chr2_+_235860616	22.26	ENST00000392011.2	SH3BP4	SH3-domain binding protein 4
chr1_-_20812690	18.55	ENST00000375078.3	CAMK2N1	calcium/calmodulin-dependent protein kinase II inhibitor 1
chr3_-_185542817	16.16	ENST00000382199.2	IGF2BP2	insulin-like growth factor 2 mRNA binding protein 2
chr3_-_185542761	15.60	ENST00000457616.2 ENST00000346192.3	IGF2BP2	insulin-like growth factor 2 mRNA binding protein 2
chr12_-_124457257	14.60	ENST00000545891.1	CCDC92	coiled-coil domain containing 92
chr16_+_56642489	13.70	ENST00000561491.1	MT2A	metallothionein 2A
chr3_-_149688655	12.84	ENST00000461930.1 ENST00000423691.2 ENST00000490975.1 ENST00000461868.1 ENST00000452853.2	PFN2	profilin 2
chr14_-_53417732	12.72	ENST00000399304.3 ENST00000395631.2 ENST00000341590.3 ENST00000343279.4	FERMT2	fermitin family member 2
chr17_-_882966	12.35	ENST00000336868.3	NXN	nucleoredoxin
chr3_-_149688502	12.15	ENST00000481767.1 ENST00000475518.1	PFN2	profilin 2

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	56.2	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.7	55.8	GO:0008307	structural constituent of muscle(GO:0008307)
1.2	52.5	GO:0003785	actin monomer binding(GO:0003785)
0.6	50.7	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.4	47.7	GO:0005178	integrin binding(GO:0005178)
0.4	44.6	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.1	41.3	GO:0045296	cadherin binding(GO:0045296)
0.9	40.9	GO:0030546	receptor activator activity(GO:0030546)
0.2	33.6	GO:0017137	Rab GTPase binding(GO:0017137)
2.0	33.2	GO:0017154	semaphorin receptor activity(GO:0017154)

Showing 1 to 10 of 683 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	71.9	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.8	52.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
1.7	46.6	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.7	43.5	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.3	42.9	REACTOME DIABETES PATHWAYS	Genes involved in Diabetes pathways
1.6	41.1	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.9	36.4	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.3	31.3	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
1.5	27.9	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.3	25.9	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression

Showing 1 to 10 of 156 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	126.7	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.4	94.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.1	59.9	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.8	57.7	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.6	43.8	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.9	43.6	NABA COLLAGENS	Genes encoding collagen proteins
0.3	43.5	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.7	42.7	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.8	37.1	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.5	34.7	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins

Showing 1 to 10 of 103 entries

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.4	61.2	GO:0071294	cellular response to zinc ion(GO:0071294)
3.3	39.3	GO:1900028	negative regulation of ruffle assembly(GO:1900028)
1.1	32.5	GO:0031581	hemidesmosome assembly(GO:0031581)
0.7	31.9	GO:0035329	hippo signaling(GO:0035329)
0.1	29.5	GO:0043062	extracellular structure organization(GO:0043062)
1.7	27.4	GO:0051639	actin filament network formation(GO:0051639)
0.7	25.8	GO:0032007	negative regulation of TOR signaling(GO:0032007)
2.8	25.0	GO:0048386	positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
4.7	23.3	GO:1990169	detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
2.6	23.2	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)

Showing 1 to 10 of 1,177 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	117.1	GO:0005924	cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925)
0.4	113.6	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.8	78.4	GO:0005604	basement membrane(GO:0005604)
0.4	66.0	GO:0001726	ruffle(GO:0001726)
0.0	49.2	GO:0005783	endoplasmic reticulum(GO:0005783)
0.1	47.5	GO:0048471	perinuclear region of cytoplasm(GO:0048471)
0.4	46.7	GO:0043202	lysosomal lumen(GO:0043202)
0.6	46.3	GO:0001725	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.5	46.1	GO:0031093	platelet alpha granule lumen(GO:0031093)
2.7	41.2	GO:0005916	fascia adherens(GO:0005916)

Showing 1 to 10 of 362 entries

Results for WT1_MTF1_ZBTB7B

Z-value: 3.19

Motif logo

Transcription factors associated with WT1_MTF1_ZBTB7B

Activity-expression correlation:

Activity profile of WT1_MTF1_ZBTB7B motif

Sorted Z-values of WT1_MTF1_ZBTB7B motif

Network of associatons between targets according to the STRING database.

First level regulatory network of WT1_MTF1_ZBTB7B

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category: