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ENCODE cell lines, expression (Ernst 2011)
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Results for XBP1
Z-value: 2.21
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Transcription factors associated with XBP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| XBP1 | hg19_v2_chr22_-_29196030_29196121 | -0.29 | 2.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of XBP1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_94023873 | 21.01 |
ENST00000297268.6 |
COL1A2 |
collagen, type I, alpha 2 |
| chr10_+_89419370 | 7.45 |
ENST00000361175.4 ENST00000456849.1 |
PAPSS2 |
3'-phosphoadenosine 5'-phosphosulfate synthase 2 |
| chr5_-_121413974 | 6.26 |
ENST00000231004.4 |
LOX |
lysyl oxidase |
| chr22_+_38864041 | 5.84 |
ENST00000216014.4 ENST00000409006.3 |
KDELR3 |
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 |
| chr12_-_106641728 | 5.72 |
ENST00000378026.4 |
CKAP4 |
cytoskeleton-associated protein 4 |
| chr11_+_69455855 | 5.44 |
ENST00000227507.2 ENST00000536559.1 |
CCND1 |
cyclin D1 |
| chr5_+_119799927 | 3.92 |
ENST00000407149.2 ENST00000379551.2 |
PRR16 |
proline rich 16 |
| chr15_-_60690932 | 3.85 |
ENST00000559818.1 |
ANXA2 |
annexin A2 |
| chr3_-_149688502 | 3.84 |
ENST00000481767.1 ENST00000475518.1 |
PFN2 |
profilin 2 |
| chr3_-_149688896 | 3.81 |
ENST00000239940.7 |
PFN2 |
profilin 2 |
Gene Ontology Analysis
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 21.0 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.1 | 9.8 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 9.4 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 7.7 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.6 | 7.1 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.1 | 6.3 | GO:0005581 | collagen trimer(GO:0005581) |
| 1.2 | 5.8 | GO:0044354 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 0.1 | 5.4 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 4.7 | GO:0030016 | myofibril(GO:0030016) |
| 0.2 | 4.6 | GO:0042599 | lamellar body(GO:0042599) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 21.0 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 9.8 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.0 | 8.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 7.7 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.3 | 5.4 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 5.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 4.1 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.1 | 4.0 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 3.2 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.3 | 3.1 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 21.0 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.1 | 10.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 9.7 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 7.7 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.3 | 7.4 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.3 | 6.1 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.1 | 3.5 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 3.1 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.1 | 2.5 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 2.3 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 21.0 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.4 | 9.2 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.2 | 9.1 | GO:0003785 | actin monomer binding(GO:0003785) |
| 1.1 | 8.6 | GO:0046923 | ER retention sequence binding(GO:0046923) |
| 0.0 | 8.4 | GO:0005509 | calcium ion binding(GO:0005509) |
| 2.5 | 7.4 | GO:0004020 | adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781) |
| 0.0 | 6.4 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.4 | 6.3 | GO:0016641 | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641) |
| 1.0 | 5.8 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 0.2 | 5.4 | GO:0070064 | proline-rich region binding(GO:0070064) |
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 21.0 | GO:0043589 | skin morphogenesis(GO:0043589) |
| 0.0 | 10.7 | GO:0043687 | post-translational protein modification(GO:0043687) |
| 0.9 | 9.8 | GO:0031584 | activation of phospholipase D activity(GO:0031584) apical protein localization(GO:0045176) |
| 0.8 | 8.6 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 0.6 | 7.7 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 1.9 | 7.4 | GO:0000103 | sulfate assimilation(GO:0000103) |
| 0.5 | 6.3 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 1.9 | 5.8 | GO:0032804 | negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804) |
| 0.5 | 5.4 | GO:0033327 | Leydig cell differentiation(GO:0033327) |
| 0.0 | 4.1 | GO:0007224 | smoothened signaling pathway(GO:0007224) |