ISMARA results: ZBTB18

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ENCODE cell lines, expression (Ernst 2011)

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Results for ZBTB18

Z-value: 1.70

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Transcription factors associated with ZBTB18

Gene Symbol	Gene ID	Gene Info
ZBTB18 Ensembl NCBI GeneCards UniProt	ENSG00000179456.9	ZBTB18

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ZBTB18	hg19_v2_chr1_+_244214577_244214593	0.37	1.6e-01	Click!

Activity profile of ZBTB18 motif

Sorted Z-values of ZBTB18 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB18

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr2_+_189839046	7.99	ENST00000304636.3 ENST00000317840.5	COL3A1	collagen, type III, alpha 1
chr8_-_49834299	6.39	ENST00000396822.1	SNAI2	snail family zinc finger 2
chr8_-_49833978	5.99	ENST00000020945.1	SNAI2	snail family zinc finger 2
chr10_-_95241951	5.69	ENST00000358334.5 ENST00000359263.4 ENST00000371488.3	MYOF	myoferlin
chr10_-_95242044	5.64	ENST00000371501.4 ENST00000371502.4 ENST00000371489.1	MYOF	myoferlin
chr2_-_163099885	5.06	ENST00000443424.1	FAP	fibroblast activation protein, alpha
chr2_-_163100045	4.86	ENST00000188790.4	FAP	fibroblast activation protein, alpha
chr8_+_1772132	4.70	ENST00000349830.3 ENST00000520359.1 ENST00000518288.1 ENST00000398560.1	ARHGEF10	Rho guanine nucleotide exchange factor (GEF) 10
chr1_-_153518270	4.62	ENST00000354332.4 ENST00000368716.4	S100A4	S100 calcium binding protein A4
chrX_-_101771645	4.00	ENST00000289373.4	TMSB15A	thymosin beta 15a

Showing 1 to 10 of 109 entries

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	12.5	GO:0000790	nuclear chromatin(GO:0000790)
0.1	11.3	GO:0005901	caveola(GO:0005901)
0.9	9.9	GO:0071438	invadopodium membrane(GO:0071438)
0.7	8.0	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.6	7.2	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.2	7.1	GO:0043218	compact myelin(GO:0043218)
0.3	5.5	GO:0043205	microfibril(GO:0001527) fibril(GO:0043205)
0.0	2.6	GO:0005882	intermediate filament(GO:0005882)
0.0	2.5	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.0	2.3	GO:0005796	Golgi lumen(GO:0005796)

Showing 1 to 10 of 25 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	12.4	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1	11.3	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.0	9.8	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	8.0	NABA COLLAGENS	Genes encoding collagen proteins
0.1	4.7	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.1	4.6	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	3.9	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	3.8	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.1	2.8	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0	2.7	WNT SIGNALING	Genes related to Wnt-mediated signal transduction

Showing 1 to 10 of 18 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	8.0	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	7.2	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.1	4.2	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0	2.5	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.0	2.4	REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	Genes involved in Phase 1 - Functionalization of compounds
0.0	2.0	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	1.6	REACTOME ACTIVATION OF GENES BY ATF4	Genes involved in Activation of Genes by ATF4
0.0	1.5	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.1	0.9	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.0	0.8	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation

Showing 1 to 10 of 18 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	13.4	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.5	9.9	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	9.5	GO:0005543	phospholipid binding(GO:0005543)
0.7	8.0	GO:0048407	platelet-derived growth factor binding(GO:0048407)
1.1	5.5	GO:0050436	microfibril binding(GO:0050436)
0.1	4.7	GO:0019894	kinesin binding(GO:0019894)
0.2	4.6	GO:0050786	RAGE receptor binding(GO:0050786)
0.1	4.1	GO:0005109	frizzled binding(GO:0005109)
0.1	4.0	GO:0003785	actin monomer binding(GO:0003785)
0.1	3.9	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)

Showing 1 to 10 of 43 entries

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.1	12.4	GO:0070563	negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.9	11.3	GO:0001778	plasma membrane repair(GO:0001778)
2.5	9.9	GO:0097325	melanocyte proliferation(GO:0097325)
1.0	8.0	GO:0060414	aorta smooth muscle tissue morphogenesis(GO:0060414)
0.6	7.2	GO:2000680	rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
0.2	6.2	GO:0032292	myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.6	5.5	GO:0035583	sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.1	4.6	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	4.2	GO:0001837	epithelial to mesenchymal transition(GO:0001837)
0.3	3.8	GO:0070307	lens fiber cell development(GO:0070307)

Showing 1 to 10 of 53 entries

Results for ZBTB18

Z-value: 1.70

Motif logo

Transcription factors associated with ZBTB18

Activity-expression correlation:

Activity profile of ZBTB18 motif

Sorted Z-values of ZBTB18 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB18

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in biological_process category: