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ENCODE cell lines, expression (Ernst 2011)
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Results for ZEB1
Z-value: 5.10
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Transcription factors associated with ZEB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZEB1 | hg19_v2_chr10_+_31608054_31608156 | -0.87 | 1.3e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZEB1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_38755042 | 18.26 |
ENST00000301244.7 |
SPINT2 |
serine peptidase inhibitor, Kunitz type, 2 |
| chr19_+_38755203 | 18.15 |
ENST00000587090.1 ENST00000454580.3 |
SPINT2 |
serine peptidase inhibitor, Kunitz type, 2 |
| chr17_-_39942940 | 15.28 |
ENST00000310706.5 ENST00000393931.3 ENST00000424457.1 ENST00000591690.1 |
JUP |
junction plakoglobin |
| chr8_+_95653427 | 13.51 |
ENST00000454170.2 |
ESRP1 |
epithelial splicing regulatory protein 1 |
| chr8_+_95653373 | 12.94 |
ENST00000358397.5 |
ESRP1 |
epithelial splicing regulatory protein 1 |
| chr8_+_95653302 | 12.92 |
ENST00000423620.2 ENST00000433389.2 |
ESRP1 |
epithelial splicing regulatory protein 1 |
| chr1_-_209979375 | 12.48 |
ENST00000367021.3 |
IRF6 |
interferon regulatory factor 6 |
| chr19_+_35606692 | 12.46 |
ENST00000406242.3 ENST00000454903.2 |
FXYD3 |
FXYD domain containing ion transport regulator 3 |
| chr16_-_4987065 | 11.56 |
ENST00000590782.2 ENST00000345988.2 |
PPL |
periplakin |
| chr16_+_68678739 | 11.55 |
ENST00000264012.4 |
CDH3 |
cadherin 3, type 1, P-cadherin (placental) |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 64.4 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 6.0 | 53.8 | GO:0086042 | cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073) |
| 0.5 | 48.4 | GO:0070268 | cornification(GO:0070268) |
| 10.8 | 43.2 | GO:0060671 | epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672) |
| 0.3 | 39.1 | GO:0008543 | fibroblast growth factor receptor signaling pathway(GO:0008543) |
| 6.9 | 34.4 | GO:1904274 | tricellular tight junction assembly(GO:1904274) |
| 0.5 | 32.7 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 10.0 | 30.0 | GO:0051796 | regulation of monophenol monooxygenase activity(GO:0032771) positive regulation of monophenol monooxygenase activity(GO:0032773) negative regulation of catagen(GO:0051796) regulation of hair cycle by canonical Wnt signaling pathway(GO:0060901) positive regulation of melanosome transport(GO:1902910) |
| 1.6 | 21.2 | GO:0070863 | positive regulation of protein exit from endoplasmic reticulum(GO:0070863) |
| 1.0 | 21.2 | GO:0090026 | positive regulation of monocyte chemotaxis(GO:0090026) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 54.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 6.0 | 53.8 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 0.7 | 40.2 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 36.2 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.1 | 34.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 28.8 | GO:0045296 | cadherin binding(GO:0045296) |
| 2.1 | 27.9 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.4 | 24.0 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.8 | 21.9 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.0 | 18.3 | GO:0005509 | calcium ion binding(GO:0005509) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 49.8 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 2.0 | 45.6 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 1.0 | 33.3 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 23.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.6 | 20.7 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.3 | 16.5 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.2 | 15.7 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.5 | 15.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.2 | 13.4 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.4 | 11.7 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 39.0 | GO:0016604 | nuclear body(GO:0016604) |
| 2.5 | 37.3 | GO:0005916 | fascia adherens(GO:0005916) |
| 1.3 | 36.7 | GO:0030057 | desmosome(GO:0030057) |
| 0.4 | 36.1 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 5.7 | 34.4 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.7 | 30.1 | GO:0045095 | keratin filament(GO:0045095) |
| 0.4 | 28.8 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.5 | 19.5 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.2 | 19.5 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.2 | 16.7 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 44.4 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 1.9 | 35.5 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.4 | 32.8 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.6 | 13.7 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.4 | 13.0 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.1 | 12.0 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.4 | 11.6 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.2 | 8.6 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.6 | 8.0 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.3 | 6.9 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |