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ENCODE cell lines, expression (Ernst 2011)
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Results for ZNF263
Z-value: 2.86
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Transcription factors associated with ZNF263
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF263 | hg19_v2_chr16_+_3313791_3313834 | -0.61 | 1.2e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF263
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_102268628 | 9.49 |
ENST00000323055.6 ENST00000512215.1 ENST00000394854.3 |
PPP3CA |
protein phosphatase 3, catalytic subunit, alpha isozyme |
| chr19_-_51504852 | 6.74 |
ENST00000391806.2 ENST00000347619.4 ENST00000291726.7 ENST00000320838.5 |
KLK8 |
kallikrein-related peptidase 8 |
| chr8_-_49834299 | 6.49 |
ENST00000396822.1 |
SNAI2 |
snail family zinc finger 2 |
| chr17_+_60704762 | 6.41 |
ENST00000303375.5 |
MRC2 |
mannose receptor, C type 2 |
| chr8_-_49833978 | 6.10 |
ENST00000020945.1 |
SNAI2 |
snail family zinc finger 2 |
| chr15_-_63674034 | 5.67 |
ENST00000344366.3 ENST00000422263.2 |
CA12 |
carbonic anhydrase XII |
| chr12_-_106641728 | 5.63 |
ENST00000378026.4 |
CKAP4 |
cytoskeleton-associated protein 4 |
| chr11_-_6341844 | 5.53 |
ENST00000303927.3 |
PRKCDBP |
protein kinase C, delta binding protein |
| chr12_+_52626898 | 5.43 |
ENST00000331817.5 |
KRT7 |
keratin 7 |
| chr3_-_127542051 | 5.32 |
ENST00000398104.1 |
MGLL |
monoglyceride lipase |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 14.0 | GO:0034465 | response to carbon monoxide(GO:0034465) |
| 2.0 | 13.8 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 1.2 | 13.0 | GO:0035986 | senescence-associated heterochromatin focus assembly(GO:0035986) |
| 4.3 | 12.8 | GO:1905205 | positive regulation of connective tissue replacement(GO:1905205) |
| 0.4 | 12.7 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 4.2 | 12.6 | GO:0070563 | negative regulation of vitamin D receptor signaling pathway(GO:0070563) |
| 0.0 | 11.3 | GO:0043687 | post-translational protein modification(GO:0043687) |
| 1.6 | 9.8 | GO:0055064 | chloride ion homeostasis(GO:0055064) |
| 1.5 | 8.8 | GO:0031585 | regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031585) |
| 0.1 | 8.7 | GO:0070268 | cornification(GO:0070268) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 14.6 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.2 | 14.2 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.2 | 13.9 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.1 | 13.9 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.5 | 13.8 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.6 | 8.5 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.2 | 8.4 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.3 | 7.9 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.1 | 7.8 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 7.7 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.8 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 17.0 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.1 | 16.9 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.8 | 14.3 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 2.0 | 14.0 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 1.1 | 13.8 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.1 | 13.8 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 1.2 | 12.0 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 1.9 | 11.2 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.2 | 8.1 | GO:0003785 | actin monomer binding(GO:0003785) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 24.1 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.2 | 18.1 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 14.6 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 1.2 | 13.0 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 1.4 | 12.8 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.1 | 11.0 | GO:0005901 | caveola(GO:0005901) |
| 0.1 | 9.7 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 9.4 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 9.3 | GO:0043195 | terminal bouton(GO:0043195) |
| 1.1 | 9.2 | GO:0005610 | laminin-5 complex(GO:0005610) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 17.9 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.3 | 15.6 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 13.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.5 | 11.7 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 11.5 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.5 | 11.3 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.2 | 11.2 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.2 | 10.7 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.3 | 9.3 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 7.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |