Motif ID: NANOG.p2

Z-value: 1.329


Transcription factors associated with NANOG.p2:

Gene SymbolEntrez IDGene Name
NANOG 79923 Nanog homeobox



Activity profile for motif NANOG.p2.

activity profile for motif NANOG.p2


Sorted Z-values histogram for motif NANOG.p2

Sorted Z-values for motif NANOG.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NANOG.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_17861266 5.742 NM_001105569
MSGN1
mesogenin 1
chr14_+_51025604 3.509 NM_001042481
FRMD6
FERM domain containing 6
chr2_+_157822355 3.148 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr10_-_13789628 1.883 FRMD4A
FERM domain containing 4A
chr15_+_38849450 1.676 NM_001130448
C15orf62
chromosome 15 open reading frame 62
chr18_+_19826734 1.646 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr10_-_105835525 1.626 COL17A1
collagen, type XVII, alpha 1
chr12_-_15005761 1.595 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr2_+_170742900 1.567 NM_001083615
NM_001171642
NM_138995
MYO3B


myosin IIIB


chr7_-_13992351 1.535 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr6_-_26343139 1.466 NM_005320
HIST1H1D
histone cluster 1, H1d
chr10_-_105835609 1.463 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr13_-_40491405 1.460 ELF1
E74-like factor 1 (ets domain transcription factor)
chr6_+_34314545 1.418 NM_145905
HMGA1
high mobility group AT-hook 1
chr12_-_51114372 1.398 NM_004693
KRT75
keratin 75
chr13_-_40491491 1.382 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr10_+_82290554 1.321 NM_001145719
SH2D4B
SH2 domain containing 4B
chr2_+_108604111 1.219 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr11_+_58146721 1.204 NM_000614
CNTF
ciliary neurotrophic factor
chr7_+_63411813 1.168 ZNF736
zinc finger protein 736
chr22_-_39189369 1.084 MKL1
megakaryoblastic leukemia (translocation) 1
chrX_+_134482212 1.006 NM_182540
DDX26B
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr10_+_11246934 1.000 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr6_-_32605898 0.976 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr11_-_123353607 0.974 NM_001004474
OR10S1
olfactory receptor, family 10, subfamily S, member 1
chr11_-_58736897 0.971 NM_001039396
MPEG1
macrophage expressed 1
chr12_+_25096472 0.957 NM_006152
LRMP
lymphoid-restricted membrane protein
chr16_-_21221872 0.954 NM_001014444
NM_001888
CRYM

crystallin, mu

chr12_-_51200347 0.938 NM_000424
KRT5
keratin 5
chr11_-_56951628 0.911 NM_017611
SLC43A3
solute carrier family 43, member 3
chrX_+_55951280 0.898


chr1_+_165565006 0.888 POU2F1
POU class 2 homeobox 1
chr1_+_165564904 0.887 NM_001198783
POU2F1
POU class 2 homeobox 1
chr7_+_50318801 0.883 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr15_+_56217686 0.872 NM_020980
AQP9
aquaporin 9
chr8_-_10550026 0.841 NM_178857
RP1L1
retinitis pigmentosa 1-like 1
chr6_+_34312906 0.815 HMGA1
high mobility group AT-hook 1
chr11_+_10433241 0.800 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr6_-_161614962 0.794 NM_020133
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr3_+_123279439 0.787 NM_006889
CD86
CD86 molecule
chr17_-_78391178 0.775 NM_024702
ZNF750
zinc finger protein 750
chr3_-_145049853 0.767 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr7_+_113853790 0.757 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr6_-_32665409 0.738 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr12_+_25096755 0.725 LRMP
lymphoid-restricted membrane protein
chr1_+_196874839 0.718 PTPRC
protein tyrosine phosphatase, receptor type, C
chr12_+_14429499 0.702 ATF7IP
activating transcription factor 7 interacting protein
chr3_-_57209319 0.691 NM_003865
HESX1
HESX homeobox 1
chrX_+_134482387 0.691 DDX26B
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr18_+_55718171 0.686 NM_021127
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr7_+_128802719 0.685 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr6_+_50894397 0.673 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr1_+_196874759 0.669 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr6_-_112033752 0.652 TRAF3IP2
TRAF3 interacting protein 2
chr2_+_113542017 0.641 NM_173161
IL1F10
interleukin 1 family, member 10 (theta)
chr3_+_154362726 0.622 RAP2B
RAP2B, member of RAS oncogene family
chr11_-_110755112 0.620 POU2AF1
POU class 2 associating factor 1
chr10_-_32707549 0.620 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr3_-_110155237 0.619 NM_005459
GUCA1C
guanylate cyclase activator 1C
chr7_+_116447527 0.600 ST7
suppression of tumorigenicity 7
chr3_-_152517204 0.599 NM_023915
GPR87
G protein-coupled receptor 87
chr6_-_112033775 0.597 TRAF3IP2
TRAF3 interacting protein 2
chr18_+_27281729 0.576 NM_001944
DSG3
desmoglein 3
chr19_-_46504831 0.574


chr13_-_93929719 0.563 NM_001129889
NM_001922
DCT

dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)

chr11_+_7574992 0.558 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr2_-_55090759 0.557 NM_007008
RTN4
reticulon 4
chr18_-_26996742 0.551 NM_004948
NM_024421
DSC1

desmocollin 1

chr5_-_56814310 0.539 NM_001017992
ACTBL2
actin, beta-like 2
chr5_+_125786975 0.531 GRAMD3
GRAM domain containing 3
chr16_+_51690564 0.526 CHD9
chromodomain helicase DNA binding protein 9
chr3_-_139315011 0.525 NM_001170538
DZIP1L
DAZ interacting protein 1-like
chr18_+_54039730 0.525 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr3_+_138132006 0.524 NM_001190796
NCK1
NCK adaptor protein 1
chr13_+_108079570 0.522 NM_001198950
MYO16
myosin XVI
chr18_+_13601664 0.520 NM_001003674
NM_001003675
C18orf1

chromosome 18 open reading frame 1

chr6_+_147568795 0.517 STXBP5
syntaxin binding protein 5 (tomosyn)
chr15_-_75259714 0.507 PEAK1
NKF3 kinase family member
chr3_+_157877146 0.500 NM_001184718
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr17_-_39094787 0.496 NM_001040002
MEOX1
mesenchyme homeobox 1
chr12_+_52105131 0.492 AMHR2
anti-Mullerian hormone receptor, type II
chr8_+_37714524 0.490


chr11_+_59979857 0.477 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr6_-_112034166 0.475 NM_001164281
NM_147686
TRAF3IP2

TRAF3 interacting protein 2

chr18_+_54039779 0.467 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr14_+_77939845 0.466 NM_004796
NRXN3
neurexin 3
chr7_-_41709191 0.465 NM_002192
INHBA
inhibin, beta A
chr6_+_34312633 0.454 HMGA1
high mobility group AT-hook 1
chr19_+_40632456 0.449 NM_005306
FFAR2
free fatty acid receptor 2
chr3_+_190990142 0.446 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr1_-_116185215 0.443 NM_005599
NHLH2
nescient helix loop helix 2
chr11_-_83071084 0.439 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr1_-_115060956 0.439 NM_002524
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr10_+_49279647 0.438 NM_002750
NM_139046
NM_139047
NM_139049
MAPK8



mitogen-activated protein kinase 8



chr7_-_112545840 0.437 LOC401397
hypothetical LOC401397
chr5_-_112658200 0.434 MCC
mutated in colorectal cancers
chr22_+_38903825 0.434 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr10_-_123346148 0.432 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr12_+_45896511 0.430 FAM113B
family with sequence similarity 113, member B
chr7_-_107930170 0.414 PNPLA8
patatin-like phospholipase domain containing 8
chr6_+_34312979 0.410 HMGA1
high mobility group AT-hook 1
chr6_-_74284522 0.408 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr9_-_5294579 0.402 NM_005059
NM_134441
RLN2

relaxin 2

chr12_-_107551783 0.400 NM_003006
SELPLG
selectin P ligand
chr19_+_17440577 0.400 SLC27A1
solute carrier family 27 (fatty acid transporter), member 1
chr5_+_125786717 0.395 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr9_-_132759045 0.394 NM_198180
QRFP
pyroglutamylated RFamide peptide
chr1_-_115060904 0.393 NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr8_-_102029997 0.392 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr3_+_69895310 0.390 NM_001184967
MITF
microphthalmia-associated transcription factor
chr6_+_32713160 0.388 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr8_+_26206648 0.387 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr1_-_149004852 0.386 CTSS
cathepsin S
chr13_-_98708549 0.385 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr5_+_169713458 0.382 NM_001034838
KCNIP1
Kv channel interacting protein 1
chr1_+_154386358 0.378 NM_001193301
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr6_-_32742265 0.377 NM_002123
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr12_-_9913199 0.376 CLEC2B
C-type lectin domain family 2, member B
chr17_-_74244539 0.376


chrX_-_19727828 0.376 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chr1_-_30977931 0.375 LAPTM5
lysosomal protein transmembrane 5
chr10_+_47216925 0.374 NM_001630
ANXA8L2
ANXA8
annexin A8-like 2
annexin A8
chr6_+_34312641 0.370 HMGA1
high mobility group AT-hook 1
chr7_-_92615593 0.369 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr6_-_24827265 0.369 NM_030939
C6orf62
chromosome 6 open reading frame 62
chr1_-_153109349 0.363 NM_002249
KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr12_-_101398451 0.362 IGF1
insulin-like growth factor 1 (somatomedin C)
chr6_+_135544214 0.360 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr12_+_45896318 0.353 NM_138371
FAM113B
family with sequence similarity 113, member B
chr12_-_107551744 0.350 SELPLG
selectin P ligand
chr17_+_22823151 0.347 NM_014238
KSR1
kinase suppressor of ras 1
chr7_-_104696678 0.346 NM_182691
SRPK2
SRSF protein kinase 2
chr6_-_116973465 0.345 NM_001139444
BET3L
BET3 like (S. cerevisiae)
chr4_-_151990061 0.345 LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr1_-_115060857 0.344 NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr3_-_126325132 0.342 SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr7_-_30032649 0.339 NM_017946
FKBP14
FK506 binding protein 14, 22 kDa
chr11_-_26550243 0.337 NM_001135091
NM_001135092
NM_145650
MUC15


mucin 15, cell surface associated


chr5_+_176786279 0.334 NM_001004105
NM_001004106
NM_002082
GRK6


G protein-coupled receptor kinase 6


chr1_-_42157077 0.332 NM_001127714
NM_024503
HIVEP3

human immunodeficiency virus type I enhancer binding protein 3

chr3_-_180467483 0.331 NM_001163677
NM_171828
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr3_-_74652952 0.330 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chr1_+_158636987 0.328 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chr6_+_34312625 0.325 NM_145901
NM_145902
HMGA1

high mobility group AT-hook 1

chr2_-_215711313 0.324 NM_173076
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr15_+_64481270 0.323 MAP2K1
mitogen-activated protein kinase kinase 1
chr12_+_103204842 0.321 NM_003330
NM_182729
NM_182742
NM_182743
TXNRD1



thioredoxin reductase 1



chr18_+_59726183 0.320 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr18_+_74841262 0.316 NM_171999
SALL3
sal-like 3 (Drosophila)
chr12_-_101398470 0.315 IGF1
insulin-like growth factor 1 (somatomedin C)
chr20_+_58004811 0.314 NM_021810
CDH26
cadherin 26
chr7_-_92686773 0.310 NM_198151
HEPACAM2
HEPACAM family member 2
chr1_+_42920635 0.309 NM_004559
YBX1
Y box binding protein 1
chr11_+_20005704 0.309 NAV2
neuron navigator 2
chr1_-_149004916 0.307 NM_004079
CTSS
cathepsin S
chr12_-_101398503 0.304 NM_000618
NM_001111283
NM_001111285
IGF1


insulin-like growth factor 1 (somatomedin C)


chr9_+_81377419 0.303 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr3_+_2528272 0.302 CNTN4
contactin 4
chr2_+_96269703 0.302 NM_001037228
LOC285033
hypothetical protein LOC285033
chr18_+_54039818 0.300 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr12_-_101398429 0.300 IGF1
insulin-like growth factor 1 (somatomedin C)
chr10_+_44726635 0.296 NM_001123376
TMEM72
transmembrane protein 72
chr11_-_57173823 0.296 NM_145008
YPEL4
yippee-like 4 (Drosophila)
chr4_+_77575276 0.294 NM_020859
SHROOM3
shroom family member 3
chr3_+_69895651 0.294 NM_006722
MITF
microphthalmia-associated transcription factor
chrX_-_19727775 0.293 SH3KBP1
SH3-domain kinase binding protein 1
chr3_-_120861959 0.291 NM_022135
POPDC2
popeye domain containing 2
chr3_+_154362714 0.288 NM_002886
RAP2B
RAP2B, member of RAS oncogene family
chr10_+_70517863 0.288 SRGN
serglycin
chr1_-_108032645 0.285 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr10_+_35524835 0.284 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chr9_-_116151099 0.284 AKNA
AT-hook transcription factor
chr19_+_7874701 0.280 MAP2K7
mitogen-activated protein kinase kinase 7
chr3_+_161040439 0.277 SCHIP1
schwannomin interacting protein 1
chr21_-_30460841 0.276 NM_012131
CLDN17
claudin 17
chr17_-_53849888 0.273 RNF43
ring finger protein 43
chr3_-_122862391 0.271 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr7_+_129693938 0.268 NM_001869
CPA2
carboxypeptidase A2 (pancreatic)
chr13_+_110637173 0.265 NM_001113513
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr2_+_113546365 0.264 NM_032556
IL1F10
interleukin 1 family, member 10 (theta)
chr12_-_120725210 0.264 LOC338799
hypothetical LOC338799
chr11_+_65164167 0.260 NM_153253
SIPA1
signal-induced proliferation-associated 1
chr3_-_122862447 0.259 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr6_+_34313007 0.256 HMGA1
high mobility group AT-hook 1
chr19_-_7874426 0.255


chr17_-_1195096 0.255 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr7_+_28418668 0.253 NM_182898
CREB5
cAMP responsive element binding protein 5
chr22_+_20715340 0.253


chr7_-_112545847 0.251 LOC401397
hypothetical LOC401397
chr12_-_101398288 0.250 IGF1
insulin-like growth factor 1 (somatomedin C)
chr5_-_169657395 0.249 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr21_-_31049566 0.248 NM_181619
KRTAP21-1
keratin associated protein 21-1
chr4_-_57242492 0.248 NM_001145460
NM_032495
NM_139212
HOPX


HOP homeobox


chr3_+_89239494 0.247 EPHA3
EPH receptor A3
chr5_-_112658456 0.246 NM_002387
MCC
mutated in colorectal cancers
chr14_+_69307914 0.245 SRSF5
serine/arginine-rich splicing factor 5
chr6_+_134800533 0.245 LOC154092
hypothetical LOC154092
chr10_+_11247467 0.244 CELF2
CUGBP, Elav-like family member 2
chr12_+_50981915 0.241 NM_002284
KRT86
keratin 86
chr5_-_168204430 0.241



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.37 7.36e-06 GO:0032501 multicellular organismal process
1.63 1.39e-03 GO:0003008 system process
1.35 4.42e-02 GO:0007275 multicellular organismal development
1.39 4.52e-02 GO:0048731 system development
9.19 4.57e-02 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
5.21 1.41e-05 GO:0045095 keratin filament
3.37 2.86e-05 GO:0045111 intermediate filament cytoskeleton
3.59 2.99e-05 GO:0005882 intermediate filament
1.32 1.29e-03 GO:0071944 cell periphery
1.32 1.67e-03 GO:0005886 plasma membrane
11.16 2.00e-03 GO:0042613 MHC class II protein complex
1.58 2.81e-03 GO:0005856 cytoskeleton
5.70 4.81e-02 GO:0042611 MHC protein complex

Nothing significant found in function category.