Motif ID: ATF2.p2

Z-value: 0.920


Transcription factors associated with ATF2.p2:

Gene SymbolEntrez IDGene Name
ATF2 1386 activating transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ATF2chr2_-_175741096-0.146.0e-01Click!


Activity profile for motif ATF2.p2.

activity profile for motif ATF2.p2


Sorted Z-values histogram for motif ATF2.p2

Sorted Z-values for motif ATF2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_-_42589543 1.385 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chr4_-_187884721 0.997


chr8_+_70567581 0.970 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr5_-_99898788 0.959


chr2_+_220116986 0.899 NM_001005209
TMEM198
transmembrane protein 198
chr8_+_70567634 0.885 SULF1
sulfatase 1
chr4_-_186693574 0.843 NM_001114107
NM_014476
PDLIM3

PDZ and LIM domain 3

chr6_+_39868116 0.832


chr13_-_51276231 0.828 NM_001031719
NM_024705
DHRS12

dehydrogenase/reductase (SDR family) member 12

chr1_+_29435534 0.820 NM_001195001
NM_005704
NM_133177
NM_133178
PTPRU



protein tyrosine phosphatase, receptor type, U



chr6_+_39868126 0.789 DAAM2
dishevelled associated activator of morphogenesis 2
chr4_-_111777584 0.784 PITX2
paired-like homeodomain 2
chr2_+_220117009 0.765 TMEM198
transmembrane protein 198
chr11_+_12652427 0.748 NM_021961
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr20_-_43853945 0.729 NM_080614
WFDC3
WAP four-disulfide core domain 3
chr2_-_224175339 0.721 SCG2
secretogranin II
chr2_-_220116508 0.714 NM_024536
CHPF
chondroitin polymerizing factor
chr1_+_26368969 0.684 NM_015871
ZNF593
zinc finger protein 593
chr4_-_111777651 0.680 PITX2
paired-like homeodomain 2
chr2_-_224175293 0.667 SCG2
secretogranin II
chr9_-_19023183 0.625 NM_153707
FAM154A
family with sequence similarity 154, member A
chr11_+_61204392 0.618 NM_006133
DAGLA
diacylglycerol lipase, alpha
chr19_-_5291700 0.610 NM_002850
NM_130853
NM_130854
NM_130855
PTPRS



protein tyrosine phosphatase, receptor type, S



chr4_+_658250 0.584 MYL5
myosin, light chain 5, regulatory
chr2_-_237987509 0.564 COL6A3
collagen, type VI, alpha 3
chr2_-_237987554 0.552 COL6A3
collagen, type VI, alpha 3
chr8_+_40130143 0.542 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr3_+_141136691 0.534 NM_022131
CLSTN2
calsyntenin 2
chr2_+_154436670 0.527 NM_052917
GALNT13
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)
chr17_-_13445942 0.526 NM_006042
HS3ST3A1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
chr2_-_237987579 0.504 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr1_+_165330710 0.499 NM_001080426
DUSP27
dual specificity phosphatase 27 (putative)
chr5_-_158690047 0.487 NM_002187
IL12B
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
chr14_+_31868229 0.485 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr17_+_7402788 0.475 TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr2_-_237987545 0.473 COL6A3
collagen, type VI, alpha 3
chr10_-_95350949 0.472 NM_006744
RBP4
retinol binding protein 4, plasma
chr8_-_67253234 0.459 NM_000756
CRH
corticotropin releasing hormone
chr15_-_81412354 0.451 NM_004839
NM_199330
NM_199331
NM_199332
HOMER2



homer homolog 2 (Drosophila)



chr9_+_110664366 0.451 NM_006687
ACTL7A
actin-like 7A
chr8_-_95343716 0.447 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr18_+_57308754 0.441 NM_031891
CDH20
cadherin 20, type 2
chr10_-_102663070 0.440


chr1_-_1283770 0.439 NM_032348
MXRA8
matrix-remodelling associated 8
chr5_+_140747586 0.438 NM_003736
NM_032098
PCDHGB4

protocadherin gamma subfamily B, 4

chr16_+_66252296 0.437 NM_001037281
NM_016948
PARD6A

par-6 partitioning defective 6 homolog alpha (C. elegans)

chr2_-_224175386 0.435 NM_003469
SCG2
secretogranin II
chr17_-_53976681 0.423 NM_001038704
C17orf47
chromosome 17 open reading frame 47
chr22_-_27787793 0.420 NM_015370
C22orf31
chromosome 22 open reading frame 31
chr3_+_189354167 0.419 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr19_+_18584666 0.417 NM_012109
TMEM59L
transmembrane protein 59-like
chr4_+_85723080 0.414 NM_001263
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr2_-_237987553 0.412 COL6A3
collagen, type VI, alpha 3
chr3_+_8518508 0.412 NM_014583
LMCD1
LIM and cysteine-rich domains 1
chr3_-_21767819 0.408 NM_024697
ZNF385D
zinc finger protein 385D
chr7_+_30140868 0.403 NM_152793
C7orf41
chromosome 7 open reading frame 41
chr20_+_19863716 0.399 RIN2
Ras and Rab interactor 2
chr3_-_64186151 0.392 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr7_-_45095017 0.392 NM_001146334
NACAD
NAC alpha domain containing
chr2_+_38031099 0.392 NM_001170793
NM_144713
FAM82A1

family with sequence similarity 82, member A1

chr8_-_95343696 0.382 GEM
GTP binding protein overexpressed in skeletal muscle
chr13_+_51275921 0.380


chr6_-_127822227 0.378 NM_014702
KIAA0408
KIAA0408
chr1_-_42157077 0.376 NM_001127714
NM_024503
HIVEP3

human immunodeficiency virus type I enhancer binding protein 3

chr4_-_23500706 0.372 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr2_-_70167569 0.371 LOC400960
hypothetical LOC400960
chr13_+_75232797 0.370 NM_015842
LMO7
LIM domain 7
chr10_+_24023680 0.366 NM_001098500
KIAA1217
KIAA1217
chr13_+_31503436 0.366 NM_023037
FRY
furry homolog (Drosophila)
chr2_-_206790871 0.364 NM_001098199
NM_005279
GPR1

G protein-coupled receptor 1

chr4_+_120167264 0.364 SYNPO2
synaptopodin 2
chr3_-_126136261 0.363 NM_033049
MUC13
mucin 13, cell surface associated
chr1_+_99502655 0.359 LPPR4
lipid phosphate phosphatase-related protein type 4
chr2_+_5750229 0.357 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chr12_+_70119785 0.353 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr2_-_224611568 0.352 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr11_+_76516957 0.351 NM_000260
NM_001127179
NM_001127180
MYO7A


myosin VIIA


chr14_+_20568184 0.349 NM_173846
TPPP2
tubulin polymerization-promoting protein family member 2
chr11_+_56862395 0.349 NM_002559
P2RX3
purinergic receptor P2X, ligand-gated ion channel, 3
chr1_+_17404206 0.348 NM_013358
PADI1
peptidyl arginine deiminase, type I
chr7_-_37923040 0.345 NM_003014
SFRP4
secreted frizzled-related protein 4
chr5_+_36642424 0.341 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr14_-_79748273 0.332 NM_000793
NM_013989
DIO2

deiodinase, iodothyronine, type II

chr1_+_109090817 0.329 STXBP3
syntaxin binding protein 3
chr9_+_36159384 0.325 NM_005893
CCIN
calicin
chr1_+_119484529 0.325


chr1_+_99502435 0.324 NM_001166252
NM_014839
LPPR4

lipid phosphate phosphatase-related protein type 4

chr19_-_55671273 0.324 FAM71E1
family with sequence similarity 71, member E1
chrX_-_83644054 0.320 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr6_-_56515640 0.320


chr11_+_108798047 0.318 NM_207645
C11orf87
chromosome 11 open reading frame 87
chr14_+_92459197 0.315 NM_001275
CHGA
chromogranin A (parathyroid secretory protein 1)
chr2_+_176680251 0.313 NM_021192
HOXD11
homeobox D11
chr20_+_9236446 0.312 NM_000933
PLCB4
phospholipase C, beta 4
chr5_+_32747194 0.312 NM_000908
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr16_+_27320983 0.311 NM_181078
NM_181079
IL21R

interleukin 21 receptor

chr3_+_141879555 0.310 NM_152616
TRIM42
tripartite motif containing 42
chr5_-_132976094 0.308 FSTL4
follistatin-like 4
chr9_+_102987137 0.307 NM_017753
LPPR1
lipid phosphate phosphatase-related protein type 1
chr6_-_106880300 0.304 NM_004849
ATG5
ATG5 autophagy related 5 homolog (S. cerevisiae)
chr22_-_28972683 0.303 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr7_+_128099581 0.301 NM_001012454
NM_001128926
FAM71F2

family with sequence similarity 71, member F2

chr7_-_100595552 0.300 NM_003378
VGF
VGF nerve growth factor inducible
chr12_+_52680143 0.298 NM_006897
HOXC9
homeobox C9
chr7_-_6354933 0.297 NM_001037163
C7orf70
chromosome 7 open reading frame 70
chr7_-_37922902 0.296 SFRP4
secreted frizzled-related protein 4
chr17_+_39213328 0.295 NM_001136483
C17orf105
chromosome 17 open reading frame 105
chr21_-_42060266 0.294 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr21_+_38550739 0.294 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr10_-_1769669 0.292 NM_018702
ADARB2
adenosine deaminase, RNA-specific, B2
chr5_+_36642213 0.290 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr2_-_216009015 0.289 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
FN1





fibronectin 1





chr12_-_31773210 0.288 AMN1
antagonist of mitotic exit network 1 homolog (S. cerevisiae)
chr21_-_42060334 0.287 RIPK4
receptor-interacting serine-threonine kinase 4
chr2_+_10969513 0.286 NM_002236
KCNF1
potassium voltage-gated channel, subfamily F, member 1
chr7_+_73080362 0.286 NM_000501
NM_001081752
NM_001081753
NM_001081754
NM_001081755
ELN




elastin




chrX_-_128485121 0.285 SMARCA1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr11_+_116575249 0.283 NM_001001522
NM_003186
TAGLN

transgelin

chr19_+_40716153 0.282 NM_014364
GAPDHS
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr17_+_38831874 0.282 NM_001661
ARL4D
ADP-ribosylation factor-like 4D
chr2_-_142605010 0.280 LRP1B
low density lipoprotein receptor-related protein 1B
chr3_+_141136896 0.279 CLSTN2
calsyntenin 2
chr20_+_2621193 0.279 NM_001110514
EBF4
early B-cell factor 4
chrX_+_84385649 0.278 NM_021998
ZNF711
zinc finger protein 711
chr4_-_171161486 0.276 NM_001009554
MFAP3L
microfibrillar-associated protein 3-like
chr17_+_7402315 0.275 NM_001198622
NM_001198623
NM_001198624
NM_003808
NM_172087
NM_172088
TNFSF13





tumor necrosis factor (ligand) superfamily, member 13





chr3_+_8518539 0.275 LMCD1
LIM and cysteine-rich domains 1
chr11_-_66367279 0.273


chr4_+_120276386 0.271 NM_016599
MYOZ2
myozenin 2
chr13_+_28900776 0.269 NM_015233
MTUS2
microtubule associated tumor suppressor candidate 2
chr22_+_49272078 0.268 NM_017584
MIOX
myo-inositol oxygenase
chr20_+_16676997 0.268 NM_020157
OTOR
otoraplin
chr11_-_67032675 0.268 NM_005851
CDK2AP2
cyclin-dependent kinase 2 associated protein 2
chr3_+_120984246 0.267 NM_022002
NR1I2
nuclear receptor subfamily 1, group I, member 2
chr19_+_60487345 0.266 NM_032430
BRSK1
BR serine/threonine kinase 1
chr5_-_95794416 0.264 NM_000439
PCSK1
proprotein convertase subtilisin/kexin type 1
chr11_-_8849485 0.264 ST5
suppression of tumorigenicity 5
chr16_-_3485421 0.263 NM_001080524
C16orf90
chromosome 16 open reading frame 90
chr4_+_88939725 0.263 NM_004967
IBSP
integrin-binding sialoprotein
chr20_+_32610161 0.262 NM_032514
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr21_-_30796278 0.260 NM_181611
KRTAP19-5
keratin associated protein 19-5
chr14_+_92721048 0.259 NM_015676
NM_001098621
C14orf109

chromosome 14 open reading frame 109

chr16_+_415606 0.258 RAB11FIP3
RAB11 family interacting protein 3 (class II)
chr11_-_65550425 0.258 NM_053054
CATSPER1
cation channel, sperm associated 1
chr2_+_170370290 0.258 SSB
Sjogren syndrome antigen B (autoantigen La)
chr17_+_72047709 0.256 NM_001077620
PRCD
progressive rod-cone degeneration
chr21_+_38550533 0.255 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr12_+_52665196 0.254 NM_017409
HOXC10
homeobox C10
chr5_-_139992621 0.254 NM_000591
CD14
CD14 molecule
chr4_+_88790477 0.253 NM_001079911
NM_004407
DMP1

dentin matrix acidic phosphoprotein 1

chr2_-_213723298 0.253 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr6_+_89848229 0.251 PNRC1
proline-rich nuclear receptor coactivator 1
chr1_+_154297588 0.251 NM_020387
RAB25
RAB25, member RAS oncogene family
chr9_+_15542871 0.250 NM_173550
C9orf93
chromosome 9 open reading frame 93
chr2_+_219991342 0.250 NM_001927
DES
desmin
chr6_+_134800533 0.250 LOC154092
hypothetical LOC154092
chr6_-_24491498 0.249 NM_001195610
DCDC2
doublecortin domain containing 2
chr7_-_41709191 0.248 NM_002192
INHBA
inhibin, beta A
chr3_-_113842652 0.247 NM_199511
NM_199512
CCDC80

coiled-coil domain containing 80

chr8_+_134272463 0.247 NM_003882
NM_080838
WISP1

WNT1 inducible signaling pathway protein 1

chr11_-_85107569 0.245 NM_206929
SYTL2
synaptotagmin-like 2
chr11_-_62213577 0.245 LRRN4CL
LRRN4 C-terminal like
chr5_-_95323353 0.245 NM_012081
ELL2
elongation factor, RNA polymerase II, 2
chr19_+_57540493 0.240 NM_173530
ZNF610
zinc finger protein 610
chr8_-_22022757 0.240 NM_024815
NUDT18
nudix (nucleoside diphosphate linked moiety X)-type motif 18
chr8_-_124818754 0.239 NM_001003954
NM_004306
ANXA13

annexin A13

chr9_-_113585593 0.239 NM_173521
C9orf84
chromosome 9 open reading frame 84
chr4_+_3341521 0.238 NM_198227
RGS12
regulator of G-protein signaling 12
chr6_-_46566969 0.237 RCAN2
regulator of calcineurin 2
chr15_+_36776090 0.236 NM_207444
C15orf53
chromosome 15 open reading frame 53
chr12_-_90029328 0.235 LUM
lumican
chr20_+_10147455 0.235 NM_003081
NM_130811
SNAP25

synaptosomal-associated protein, 25kDa

chr21_-_35343500 0.235 RUNX1
runt-related transcription factor 1
chr2_-_27384617 0.235 NM_003353
UCN
urocortin
chr2_-_216008689 0.234 FN1
fibronectin 1
chr9_-_110658030 0.233 NM_006686
ACTL7B
actin-like 7B
chr1_-_32600430 0.233 NM_001167676
LOC100128071
hypothetical LOC100128071
chr19_-_56919032 0.232 NM_001523
HAS1
hyaluronan synthase 1
chr4_-_52578542 0.232 NM_001024611
LRRC66
leucine rich repeat containing 66
chr4_-_156517394 0.231 MAP9
microtubule-associated protein 9
chr9_+_100745531 0.230 NM_001855
COL15A1
collagen, type XV, alpha 1
chr17_+_36515166 0.230 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr12_-_115803614 0.229 NM_003806
HRK
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr19_+_60487578 0.228 BRSK1
BR serine/threonine kinase 1
chr2_+_148319033 0.228 NM_001616
ACVR2A
activin A receptor, type IIA
chr19_+_50196526 0.227 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr20_-_33489383 0.227 NM_000557
GDF5
growth differentiation factor 5
chr20_+_5839973 0.226 NM_001819
CHGB
chromogranin B (secretogranin 1)
chr14_-_49399317 0.226 RN7SL2
RNA, 7SL, cytoplasmic 2
chr3_+_108578877 0.226 NM_032600
CCDC54
coiled-coil domain containing 54
chr21_+_46369617 0.225 COL6A2
collagen, type VI, alpha 2
chr19_-_52679287 0.224 NM_007059
KPTN
kaptin (actin binding protein)
chr5_-_176760242 0.224 NM_001029886
PFN3
profilin 3
chr4_-_156517423 0.223 MAP9
microtubule-associated protein 9
chr7_+_73080387 0.223 ELN
elastin
chr12_-_49076658 0.223 NM_001145475
FAM186A
family with sequence similarity 186, member A
chr3_-_55496370 0.221 NM_003392
WNT5A
wingless-type MMTV integration site family, member 5A
chr16_-_3008162 0.220 NM_021195
CLDN6
claudin 6
chr20_+_49008754 0.219 NM_014484
MOCS3
molybdenum cofactor synthesis 3
chr3_+_101019357 0.218 NM_032359
C3orf26
chromosome 3 open reading frame 26

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.55 1.79e-08 GO:0048731 system development
1.51 2.26e-08 GO:0048856 anatomical structure development
1.40 5.74e-06 GO:0032502 developmental process
1.42 7.30e-06 GO:0007275 multicellular organismal development
1.27 3.81e-04 GO:0032501 multicellular organismal process
1.57 2.95e-03 GO:0007399 nervous system development
1.39 3.83e-03 GO:0048518 positive regulation of biological process
1.40 6.94e-03 GO:0048522 positive regulation of cellular process
1.83 7.54e-03 GO:0030182 neuron differentiation
1.46 1.13e-02 GO:0048513 organ development
1.57 1.48e-02 GO:0051239 regulation of multicellular organismal process
2.24 1.54e-02 GO:0001501 skeletal system development
1.85 3.51e-02 GO:0048666 neuron development
1.49 3.95e-02 GO:0009653 anatomical structure morphogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.68 3.71e-04 GO:0044421 extracellular region part
1.73 2.01e-03 GO:0005615 extracellular space
2.16 4.88e-03 GO:0005578 proteinaceous extracellular matrix
1.99 1.49e-02 GO:0031012 extracellular matrix

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.76 1.91e-02 GO:0005198 structural molecule activity