Motif ID: CRX.p2

Z-value: 1.149


Transcription factors associated with CRX.p2:

Gene SymbolEntrez IDGene Name
CRX 1406 cone-rod homeobox

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
CRXchr19_+_53016910-0.107.1e-01Click!


Activity profile for motif CRX.p2.

activity profile for motif CRX.p2


Sorted Z-values histogram for motif CRX.p2

Sorted Z-values for motif CRX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CRX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_559129 2.264


chr16_+_56567839 1.650 NM_199046
NM_199456
TEPP

testis, prostate and placenta expressed

chr1_+_559618 1.299


chr5_-_134290789 1.141


chr18_-_13905534 0.992 NM_000529
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr12_-_112058403 0.806 NM_001193520
NM_004658
RASAL1

RAS protein activator like 1 (GAP1 like)

chr19_+_13848949 0.742 NM_001098622
NANOS3
nanos homolog 3 (Drosophila)
chr10_-_76538859 0.736 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chr1_+_61319976 0.729 NM_001145512
NFIA
nuclear factor I/A
chr1_+_166812466 0.725 NM_002995
XCL1
chemokine (C motif) ligand 1
chr3_+_161877640 0.712 NM_025047
ARL14
ADP-ribosylation factor-like 14
chr4_-_191185390 0.710 NM_001005217
FRG2B
FRG2
FSHD region gene 2 family, member B
FSHD region gene 2
chr16_-_46823682 0.701 NM_033151
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr4_+_187424336 0.687 F11
coagulation factor XI
chr17_+_53670785 0.643 NM_001160102
NM_006151
LPO

lactoperoxidase

chr10_-_118670968 0.631 KIAA1598
KIAA1598
chr12_-_51528983 0.628 NM_173352
KRT78
keratin 78
chr11_-_7917642 0.626 NM_001003745
OR10A3
olfactory receptor, family 10, subfamily A, member 3
chr18_+_27210737 0.611 NM_001134453
NM_177986
DSG4

desmoglein 4

chr16_+_56286212 0.582 NM_032269
CCDC135
coiled-coil domain containing 135
chr7_-_122126422 0.579 NM_139175
RNF133
ring finger protein 133
chr6_+_10693964 0.577 NM_145655
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr12_+_47009029 0.543 NM_181788
H1FNT
H1 histone family, member N, testis-specific
chr10_-_82039158 0.539 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr6_+_32515596 0.529 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr5_-_95794416 0.525 NM_000439
PCSK1
proprotein convertase subtilisin/kexin type 1
chr20_-_43440290 0.519 NM_014477
TP53TG5
TP53 target 5
chr6_-_49712483 0.517 NM_000324
RHAG
Rh-associated glycoprotein
chr21_-_43903755 0.512 NM_007031
HSF2BP
heat shock transcription factor 2 binding protein
chr7_-_138014329 0.512 NM_001139456
SVOPL
SVOP-like
chr11_+_55343658 0.511 NM_001001952
OR5D18
olfactory receptor, family 5, subfamily D, member 18
chr1_+_12774132 0.506 NM_023013
PRAMEF1
PRAME family member 1
chr11_-_36576352 0.494 NM_000536
RAG2
recombination activating gene 2
chr11_-_6148131 0.494 NM_001004052
OR52B2
olfactory receptor, family 52, subfamily B, member 2
chr6_-_52217185 0.494 NM_052872
IL17F
interleukin 17F
chr6_-_35588613 0.481 NM_003322
TULP1
tubby like protein 1
chr21_-_42060334 0.480 RIPK4
receptor-interacting serine-threonine kinase 4
chr7_-_150352484 0.477 NM_173681
ATG9B
ATG9 autophagy related 9 homolog B (S. cerevisiae)
chr3_+_123526700 0.472 NM_005213
CSTA
cystatin A (stefin A)
chr12_-_16649211 0.467 LMO3
LIM domain only 3 (rhombotin-like 2)
chr7_-_115458064 0.464 TFEC
transcription factor EC
chr19_-_12858956 0.462 NM_006563
KLF1
Kruppel-like factor 1 (erythroid)
chr6_+_46869052 0.457 NM_005588
MEP1A
meprin A, alpha (PABA peptide hydrolase)
chr12_+_8557402 0.456 NM_080387
CLEC4D
C-type lectin domain family 4, member D
chr14_+_20580224 0.449 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr1_+_201729893 0.440 NM_014359
OPTC
opticin
chr14_-_20128228 0.435 NM_145250
RNASE11
ribonuclease, RNase A family, 11 (non-active)
chr21_+_44729875 0.434


chr19_-_63177713 0.432 NM_152474
C19orf18
chromosome 19 open reading frame 18
chr1_-_156923111 0.431 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr16_-_76026431 0.426 NM_199355
ADAMTS18
ADAM metallopeptidase with thrombospondin type 1 motif, 18
chr16_-_3362283 0.425 NM_001190476
MTRNR2L4
MT-RNR2-like 4
chr4_+_25267183 0.420 NM_001177999
SLC34A2
solute carrier family 34 (sodium phosphate), member 2
chr6_+_132000134 0.420 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr7_+_37746520 0.417 NM_181791
GPR141
G protein-coupled receptor 141
chr18_+_27281729 0.410 NM_001944
DSG3
desmoglein 3
chrX_+_144710557 0.410 NM_001144006
NM_001144008
NM_001144009
NM_001144010
SLITRK2



SLIT and NTRK-like family, member 2



chr22_+_21359175 0.405 IGLV3-25
immunoglobulin lambda variable 3-25
chr1_-_156635879 0.396 NM_001004475
OR10T2
olfactory receptor, family 10, subfamily T, member 2
chr6_-_11887265 0.395 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr3_+_82117978 0.394


chr1_-_26266571 0.393 NM_032588
TRIM63
tripartite motif containing 63
chr10_+_99322187 0.391 NM_001129981
NM_020349
ANKRD2

ankyrin repeat domain 2 (stretch responsive muscle)

chr1_-_160613203 0.391 NM_182581
C1orf111
chromosome 1 open reading frame 111
chr3_+_185300660 0.390 NM_182589
HTR3E
5-hydroxytryptamine (serotonin) receptor 3, family member E
chr15_-_96875133 0.387 NM_182562
FAM169B
family with sequence similarity 169, member B
chr1_-_246045653 0.387 NM_001001966
OR14A16
olfactory receptor, family 14, subfamily A, member 16
chr2_-_73781974 0.386 NM_016347
NAT8B
N-acetyltransferase 8B (GCN5-related, putative, gene/pseudogene)
chrX_-_6156655 0.382 NM_181332
NLGN4X
neuroligin 4, X-linked
chr1_+_151209751 0.380 NM_173080
SPRR4
small proline-rich protein 4
chr1_-_153272859 0.378 NM_144622
DCST2
DC-STAMP domain containing 2
chr7_-_115458010 0.372 NM_001018058
NM_012252
TFEC

transcription factor EC

chr21_+_30690165 0.366 NM_181599
KRTAP13-1
keratin associated protein 13-1
chr9_-_103237851 0.355 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr1_+_65492679 0.354 LOC645195
DNAJC6
hypothetical LOC645195
DnaJ (Hsp40) homolog, subfamily C, member 6
chr19_-_60360768 0.351 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr9_-_103185621 0.347 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr2_+_108360798 0.341 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr12_-_88269884 0.341 DUSP6
dual specificity phosphatase 6
chr2_+_101974737 0.338 NM_004633
IL1R2
interleukin 1 receptor, type II
chr2_+_204440753 0.338 NM_001037631
NM_005214
CTLA4

cytotoxic T-lymphocyte-associated protein 4

chr21_-_44506526 0.337 NM_013369
NM_175867
DNMT3L

DNA (cytosine-5-)-methyltransferase 3-like

chr3_+_98641143 0.337 NM_173655
EPHA6
EPH receptor A6
chr1_-_153537362 0.330 NM_181871
PKLR
pyruvate kinase, liver and RBC
chr7_-_142369519 0.326 KEL
Kell blood group, metallo-endopeptidase
chr6_+_12825818 0.323 NM_030948
PHACTR1
phosphatase and actin regulator 1
chr6_+_55300225 0.323 NM_207410
GFRAL
GDNF family receptor alpha like
chr20_+_42417752 0.322 NM_001030003
NM_001030004
NM_175914
HNF4A


hepatocyte nuclear factor 4, alpha


chr1_+_18830086 0.322 NM_001135254
NM_002584
NM_013945
PAX7


paired box 7


chr8_-_30826074 0.321 NM_031271
TEX15
testis expressed 15
chr19_+_43616167 0.320 NM_000540
NM_001042723
RYR1

ryanodine receptor 1 (skeletal)

chr2_-_183095308 0.320 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr6_-_139654807 0.320 NM_153235
TXLNB
taxilin beta
chr2_-_224175339 0.318 SCG2
secretogranin II
chr4_-_187114407 0.318 SORBS2
sorbin and SH3 domain containing 2
chr7_+_150321771 0.316 NM_001160109
NM_001160110
NM_001160111
NOS3


nitric oxide synthase 3 (endothelial cell)


chr2_+_113601608 0.316 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr7_+_142692165 0.315 NM_153345
TMEM139
transmembrane protein 139
chr15_+_21361546 0.314 NM_005664
MKRN3
makorin ring finger protein 3
chr11_-_55460451 0.312 NM_006637
OR5I1
olfactory receptor, family 5, subfamily I, member 1
chr8_-_95289945 0.311 NM_004063
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr11_-_59369501 0.310 NM_005142
GIF
gastric intrinsic factor (vitamin B synthesis)
chr8_-_134156437 0.310 SLA
Src-like-adaptor
chr14_+_20568184 0.308 NM_173846
TPPP2
tubulin polymerization-promoting protein family member 2
chr11_+_45899747 0.307 NM_152312
GYLTL1B
glycosyltransferase-like 1B
chr2_-_224175293 0.306 SCG2
secretogranin II
chr3_-_69254226 0.306 NM_198271
LMOD3
leiomodin 3 (fetal)
chr19_+_50693570 0.303 NM_001080401
PPM1N
protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)
chr14_+_57964148 0.302


chr14_+_22911857 0.301 NM_172314
NM_022789
IL25

interleukin 25

chr12_-_69434330 0.300 PTPRR
protein tyrosine phosphatase, receptor type, R
chr18_+_13601664 0.299 NM_001003674
NM_001003675
C18orf1

chromosome 18 open reading frame 1

chr2_-_224175386 0.298 NM_003469
SCG2
secretogranin II
chr11_-_123772456 0.297 NM_001005467
OR8B3
olfactory receptor, family 8, subfamily B, member 3
chr17_-_36113502 0.297 NM_019016
KRT24
keratin 24
chr12_-_51298599 0.295 NM_175068
KRT73
keratin 73
chr5_-_22248630 0.295 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr11_-_5110383 0.294 NM_001005160
OR52A5
olfactory receptor, family 52, subfamily A, member 5
chr10_-_62431203 0.294 RHOBTB1
Rho-related BTB domain containing 1
chr7_-_142369534 0.293 NM_000420
KEL
Kell blood group, metallo-endopeptidase
chr5_+_147672181 0.292 NM_032566
SPINK7
serine peptidase inhibitor, Kazal type 7 (putative)
chr11_+_120478584 0.292 NM_005422
TECTA
tectorin alpha
chr11_+_89341319 0.289 NM_001136486
TRIM64
tripartite motif containing 64
chr11_-_62668268 0.289 NM_001136506
SLC22A24
solute carrier family 22, member 24
chrX_+_56606686 0.285 NM_013444
UBQLN2
ubiquilin 2
chr21_+_46094301 0.285 NM_001130141
NM_020528
PCBP3

poly(rC) binding protein 3

chr3_+_185536376 0.284 NM_001171093
FAM131A
family with sequence similarity 131, member A
chr6_-_149847809 0.283 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr1_+_86662356 0.282 NM_006536
CLCA2
chloride channel accessory 2
chr2_+_113601616 0.281 IL1RN
interleukin 1 receptor antagonist
chr3_+_160269836 0.281 IQCJ
IQ motif containing J
chr18_+_53865455 0.280 NM_001144964
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr12_+_100512877 0.278 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr12_+_10015274 0.278 NM_138337
NM_201623
CLEC12A

C-type lectin domain family 12, member A

chr12_+_53809731 0.275 NM_001005243
OR9K2
olfactory receptor, family 9, subfamily K, member 2
chr11_-_123182266 0.275 NM_001005325
OR6M1
olfactory receptor, family 6, subfamily M, member 1
chr1_-_155053124 0.273 NM_001161441
NM_001161442
NM_001161444
NM_003975
SH2D2A



SH2 domain containing 2A



chr1_+_45250503 0.272 UROD
uroporphyrinogen decarboxylase
chr1_-_202595666 0.272 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr12_-_14740694 0.269 NM_004963
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr3_+_141879555 0.267 NM_152616
TRIM42
tripartite motif containing 42
chr3_-_148605996 0.267 NM_001168379
ZIC4
Zic family member 4
chr3_+_160269734 0.267 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr8_-_10550026 0.266 NM_178857
RP1L1
retinitis pigmentosa 1-like 1
chr7_-_115458047 0.266 TFEC
transcription factor EC
chr14_-_60817946 0.264


chr13_-_60887210 0.264 PCDH20
protocadherin 20
chr15_+_57691272 0.263 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr3_+_138159396 0.260 NM_144717
IL20RB
interleukin 20 receptor beta
chr5_-_74568458 0.259 NM_001164443
ANKRD31
ankyrin repeat domain 31
chr4_-_155753249 0.259 FGG
fibrinogen gamma chain
chr12_-_21379098 0.258 NM_021094
SLCO1A2
solute carrier organic anion transporter family, member 1A2
chr16_-_20246309 0.255 NM_001007240
NM_001007241
NM_001007242
NM_001502
GP2



glycoprotein 2 (zymogen granule membrane)



chr11_+_48303047 0.255 NM_001004702
OR4C3
olfactory receptor, family 4, subfamily C, member 3
chr17_-_54124374 0.255 NM_031272
NM_198393
TEX14

testis expressed 14

chr17_+_40332667 0.254 NM_213607
CCDC103
coiled-coil domain containing 103
chr2_+_170742900 0.254 NM_001083615
NM_001171642
NM_138995
MYO3B


myosin IIIB


chr4_-_64957595 0.254 NM_001010874
TECRL
trans-2,3-enoyl-CoA reductase-like
chr12_-_7487989 0.253 NM_174941
CD163L1
CD163 molecule-like 1
chr12_+_108690199 0.253 C12orf34
chromosome 12 open reading frame 34
chr17_-_23151601 0.252 NM_000625
NOS2
nitric oxide synthase 2, inducible
chr7_-_99115454 0.251 NM_000777
NM_001190484
CYP3A5

cytochrome P450, family 3, subfamily A, polypeptide 5

chr11_-_26700121 0.251 NM_178498
SLC5A12
solute carrier family 5 (sodium/glucose cotransporter), member 12
chr1_+_92190296 0.251 NM_001726
BRDT
bromodomain, testis-specific
chr19_-_4253389 0.250 NM_001169126
NM_144615
TMIGD2

transmembrane and immunoglobulin domain containing 2

chr17_-_31528027 0.250 NM_001001417
TBC1D3B
TBC1D3C
TBC1D3G
TBC1D3F
TBC1 domain family, member 3B
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3F
chr2_-_88208650 0.249 NM_001443
FABP1
fatty acid binding protein 1, liver
chr20_+_41621079 0.248 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr6_-_80303822 0.246 NM_001122769
NM_181714
LCA5

Leber congenital amaurosis 5

chr2_+_169634330 0.245 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr7_-_50740491 0.245 NM_001001550
GRB10
growth factor receptor-bound protein 10
chr14_-_22722680 0.244 NM_012244
SLC7A8
solute carrier family 7 (amino acid transporter, L-type), member 8
chr3_+_46423682 0.240 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr11_-_7906784 0.239 NM_001004461
OR10A6
olfactory receptor, family 10, subfamily A, member 6
chr6_-_24597717 0.238 NM_177483
NM_001503
GPLD1

glycosylphosphatidylinositol specific phospholipase D1

chr6_+_47732181 0.238 NM_153839
GPR111
G protein-coupled receptor 111
chr19_-_59452869 0.237 NM_001081442
NM_001081443
NM_006840
LILRB5


leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5


chr7_-_138133388 0.237 NM_020632
NM_130840
ATP6V0A4

ATPase, H+ transporting, lysosomal V0 subunit a4

chr11_-_4747722 0.237 NM_001004752
OR51F1
olfactory receptor, family 51, subfamily F, member 1
chr14_-_22516271 0.237 NM_198086
JUB
jub, ajuba homolog (Xenopus laevis)
chr1_-_175400573 0.236 NM_004319
NM_207108
ASTN1

astrotactin 1

chr6_-_138935359 0.236 NM_020464
NHSL1
NHS-like 1
chr9_-_8723893 0.236 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr21_-_38792173 0.235 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr17_+_52689372 0.235 NM_170721
MSI2
musashi homolog 2 (Drosophila)
chr10_-_30958631 0.234 NM_183058
LYZL2
lysozyme-like 2
chr16_-_31390926 0.234


chr17_+_3065661 0.233 NM_014565
OR1A1
olfactory receptor, family 1, subfamily A, member 1
chr5_+_140154627 0.232 NM_018905
NM_031495
PCDHA2

protocadherin alpha 2

chr4_-_155753207 0.231 FGG
fibrinogen gamma chain
chr20_+_43531806 0.231 NM_006103
WFDC2
WAP four-disulfide core domain 2
chr10_+_57028755 0.230 NM_001190478
MTRNR2L5
MT-RNR2-like 5
chr20_+_41621119 0.228 SGK2
serum/glucocorticoid regulated kinase 2
chr1_-_155336223 0.228 NM_001004341
ETV3L
ets variant 3-like
chr2_-_160765008 0.228 ITGB6
integrin, beta 6
chr12_-_88270375 0.224 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr4_-_186969041 0.223 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr11_-_34491878 0.222 NM_001422
ELF5
E74-like factor 5 (ets domain transcription factor)
chr12_+_8499788 0.222 NM_001007033
CLEC6A
C-type lectin domain family 6, member A
chr19_-_60241424 0.221 NM_001083899
NM_016363
GP6

glycoprotein VI (platelet)


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.18 7.77e-15 GO:0007600 sensory perception
1.70 2.41e-12 GO:0003008 system process
2.40 7.34e-11 GO:0007606 sensory perception of chemical stimulus
2.49 8.90e-11 GO:0007608 sensory perception of smell
1.75 1.16e-10 GO:0050877 neurological system process
1.20 3.12e-03 GO:0032501 multicellular organismal process
2.13 2.45e-02 GO:0007601 visual perception
2.13 2.45e-02 GO:0050953 sensory perception of light stimulus
2.49 3.95e-02 GO:0051346 negative regulation of hydrolase activity

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.54 5.54e-10 GO:0005576 extracellular region
1.25 7.75e-08 GO:0031224 intrinsic to membrane
1.22 1.95e-07 GO:0044425 membrane part
1.24 4.73e-07 GO:0016021 integral to membrane
1.28 1.17e-06 GO:0071944 cell periphery
1.27 5.68e-06 GO:0005886 plasma membrane
1.53 5.33e-04 GO:0044421 extracellular region part
1.13 1.54e-03 GO:0016020 membrane
5.26 2.35e-03 GO:0001750 photoreceptor outer segment
1.75 2.39e-02 GO:0031012 extracellular matrix

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.50 4.97e-11 GO:0004984 olfactory receptor activity
1.58 4.47e-09 GO:0004872 receptor activity
1.68 7.61e-09 GO:0004888 transmembrane receptor activity
1.81 1.25e-07 GO:0004930 G-protein coupled receptor activity
1.47 3.08e-07 GO:0004871 signal transducer activity
1.47 3.08e-07 GO:0060089 molecular transducer activity
12.62 2.42e-02 GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity