Motif ID: EN1,2.p2

Z-value: 2.027


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
EN1 2019 engrailed homeobox 1
EN2 2020 engrailed homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EN1chr2_-_1193222280.421.0e-01Click!
EN2chr7_+_1549434660.312.4e-01Click!


Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_50318801 2.470 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr2_+_234265059 2.211 NM_205862
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr2_+_68855436 2.123 NM_001166276
NM_014882
ARHGAP25

Rho GTPase activating protein 25

chr2_+_102401580 2.072 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr22_+_38627031 2.025 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr11_+_123639909 2.011 NM_001005198
OR8G5
olfactory receptor, family 8, subfamily G, member 5
chr16_-_20271530 1.954 NM_001008389
NM_003361
UMOD

uromodulin

chr2_-_158008763 1.935 NM_004288
CYTIP
cytohesin 1 interacting protein
chr17_-_36928604 1.898 NM_002275
KRT15
keratin 15
chr1_+_169421011 1.889 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr1_+_159032551 1.854 NM_001033667
NM_002348
LY9

lymphocyte antigen 9

chr11_+_59979857 1.799 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr13_+_112349358 1.764 NM_207440
C13orf35
chromosome 13 open reading frame 35
chr3_-_184756101 1.709 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr16_-_79811475 1.647 NM_001076780
NM_052892
PKD1L2

polycystic kidney disease 1-like 2

chr6_+_32515596 1.640 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr2_+_234333653 1.571 NM_000463
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1
chr6_+_160247962 1.568 NM_002377
MAS1
MAS1 oncogene
chr6_+_28601767 1.567 NM_001509
NM_003996
GPX5

glutathione peroxidase 5 (epididymal androgen-related protein)

chr1_+_246635918 1.566 NM_030904
OR2T1
olfactory receptor, family 2, subfamily T, member 1
chr1_+_173111306 1.540 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr4_+_71235259 1.510 NM_033122
CABS1
calcium-binding protein, spermatid-specific 1
chr10_-_48036698 1.495 NM_016204
GDF2
growth differentiation factor 2
chr9_-_34719463 1.495 NM_001141917
C9orf144B
transmembrane protein C9orf144B
chr14_+_75907442 1.485 NM_004452
ESRRB
estrogen-related receptor beta
chr7_+_149104063 1.474 NM_198455
SSPO
SCO-spondin homolog (Bos taurus)
chr4_-_80466177 1.375 NM_032693
NAA11
N(alpha)-acetyltransferase 11, NatA catalytic subunit
chr11_+_55617328 1.363 NM_001003750
OR8I2
olfactory receptor, family 8, subfamily I, member 2
chr17_+_41278035 1.356 NM_175882
IMP5
intramembrane protease 5
chr10_-_98021144 1.326 NM_001114094
NM_013314
BLNK

B-cell linker

chr6_-_2580296 1.289 NM_152554
C6orf195
chromosome 6 open reading frame 195
chr18_+_27210737 1.278 NM_001134453
NM_177986
DSG4

desmoglein 4

chrX_+_65152004 1.269


chr4_-_47831002 1.268 NM_003328
TXK
TXK tyrosine kinase
chr15_-_78050515 1.255 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr3_+_99733432 1.246 NM_005290
GPR15
G protein-coupled receptor 15
chr17_-_64649608 1.212 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr3_+_171022403 1.207 NM_001080460
LRRIQ4
leucine-rich repeats and IQ motif containing 4
chr6_-_33085290 1.204 HLA-DOA
major histocompatibility complex, class II, DO alpha
chr17_+_43165608 1.195 NM_013351
TBX21
T-box 21
chr2_-_142605739 1.180 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr1_+_246591505 1.170 NM_001004696
OR2T4
olfactory receptor, family 2, subfamily T, member 4
chr6_-_32121784 1.154 NM_032470
TNXB
tenascin XB
chr4_-_38710376 1.133 NM_024943
TMEM156
transmembrane protein 156
chr6_-_30188845 1.093 NM_007028
TRIM31
tripartite motif containing 31
chr1_+_159943385 1.091 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chr17_-_31441390 1.089 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chrX_+_50670474 1.069 NM_005448
BMP15
bone morphogenetic protein 15
chr1_-_150353179 1.067 NM_007113
TCHH
trichohyalin
chr14_+_87541220 1.065 NM_003608
GPR65
G protein-coupled receptor 65
chr11_+_5367182 1.049 NM_001004756
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr4_-_40211324 1.047 RBM47
RNA binding motif protein 47
chr11_-_123182266 1.026 NM_001005325
OR6M1
olfactory receptor, family 6, subfamily M, member 1
chr5_-_135729062 1.026 NM_001167576
NM_001167577
NM_020389
TRPC7


transient receptor potential cation channel, subfamily C, member 7


chr3_+_99592199 1.025 NM_001005516
OR5K3
olfactory receptor, family 5, subfamily K, member 3
chr11_+_6762823 1.011 NM_001004489
OR2AG1
olfactory receptor, family 2, subfamily AG, member 1
chr5_-_22889487 1.009 NM_004061
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr1_+_246718487 0.983 NM_001004697
OR2T5
olfactory receptor, family 2, subfamily T, member 5
chrX_+_30171768 0.981 NM_002363
NM_177415
MAGEB1

melanoma antigen family B, 1

chr10_-_7722747 0.981 ITIH5
inter-alpha (globulin) inhibitor H5
chrX_+_18618965 0.980 NM_006240
NM_152224
NM_152226
PPEF1


protein phosphatase, EF-hand calcium binding domain 1


chr16_-_20323533 0.977 NM_174924
PDILT
protein disulfide isomerase-like, testis expressed
chr16_+_56567839 0.947 NM_199046
NM_199456
TEPP

testis, prostate and placenta expressed

chr3_-_152517204 0.944 NM_023915
GPR87
G protein-coupled receptor 87
chr14_+_22581215 0.942 NM_001099780
PSMB11
proteasome (prosome, macropain) subunit, beta type, 11
chr1_+_69998445 0.940 NM_020794
LRRC7
leucine rich repeat containing 7
chr6_+_30212488 0.925 NM_138700
TRIM40
tripartite motif containing 40
chr2_-_208763017 0.908 NM_001099334
C2orf80
chromosome 2 open reading frame 80
chr11_-_6870306 0.904 NM_003700
OR2D2
olfactory receptor, family 2, subfamily D, member 2
chr11_-_62508946 0.902 NM_004790
NM_153276
NM_153277
NM_153278
SLC22A6



solute carrier family 22 (organic anion transporter), member 6



chr19_-_15779935 0.898 NM_013940
OR10H1
olfactory receptor, family 10, subfamily H, member 1
chr22_+_38627129 0.897 GRAP2
GRB2-related adaptor protein 2
chr12_+_54316910 0.897 NM_206899
OR10P1
olfactory receptor, family 10, subfamily P, member 1
chr10_-_69095362 0.893 NM_001127384
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr11_-_56015421 0.879 NM_001005282
OR5M8
olfactory receptor, family 5, subfamily M, member 8
chr6_+_32713160 0.869 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr1_+_86707113 0.865 NM_001285
CLCA1
chloride channel accessory 1
chr11_+_123625632 0.865 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr1_-_47468029 0.862 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr5_-_176258920 0.832 NM_002115
HK3
hexokinase 3 (white cell)
chr19_-_56026559 0.823 NM_017509
NM_138563
NM_138564
KLK15


kallikrein-related peptidase 15


chr1_-_180822686 0.811 NM_021133
RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr3_-_46224791 0.794 NM_001295
CCR1
chemokine (C-C motif) receptor 1
chr12_+_21417068 0.786 NM_000415
IAPP
islet amyloid polypeptide
chr6_+_49575629 0.783 NM_001010904
GLYATL3
glycine-N-acyltransferase-like 3
chr11_+_55096179 0.780 NM_001004701
OR4C16
olfactory receptor, family 4, subfamily C, member 16
chr3_-_18455207 0.778 NM_001131010
SATB1
SATB homeobox 1
chr18_-_13905534 0.773 NM_000529
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr15_+_56217686 0.765 NM_020980
AQP9
aquaporin 9
chr11_+_55884266 0.760 NM_001005205
OR8J1
olfactory receptor, family 8, subfamily J, member 1
chr11_-_5037432 0.755 NM_001005164
OR52E2
olfactory receptor, family 52, subfamily E, member 2
chr1_+_157526127 0.755 NM_002001
FCER1A
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
chr14_-_91111135 0.752 NM_001080113
C14orf184
chromosome 14 open reading frame 184
chr1_-_154484341 0.750 NM_198406
NM_024897
PAQR6

progestin and adipoQ receptor family member VI

chr11_-_47356562 0.739 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr12_+_91620749 0.738 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr6_+_97117144 0.738 NM_001170807
NM_020482
FHL5

four and a half LIM domains 5

chr11_+_94398069 0.736 NM_001161630
KDM4DL
lysine (K)-specific demethylase 4D-like
chr17_-_23151601 0.735 NM_000625
NOS2
nitric oxide synthase 2, inducible
chr18_-_22699650 0.722 NM_001650
AQP4
aquaporin 4
chr1_-_240679380 0.715 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr6_-_123999640 0.713 NM_006073
TRDN
triadin
chr6_+_14032655 0.713 NM_001165034
RNF182
ring finger protein 182
chr22_+_49333327 0.712 NM_138433
KLHDC7B
kelch domain containing 7B
chr16_+_28850760 0.710 NM_001178098
NM_001770
CD19

CD19 molecule

chr11_-_123918759 0.709 NM_001005195
OR8B12
olfactory receptor, family 8, subfamily B, member 12
chr2_-_113310796 0.709 NM_000576
IL1B
interleukin 1, beta
chr1_-_28392966 0.706 NM_001164722
NM_001164721
PTAFR

platelet-activating factor receptor

chr7_+_106293112 0.706 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr3_+_120375053 0.704 NM_006952
UPK1B
uroplakin 1B
chr1_-_150328153 0.703 NM_001008536
TCHHL1
trichohyalin-like 1
chr5_+_79651545 0.702 NM_032567
SPZ1
spermatogenic leucine zipper 1
chr8_+_128497038 0.702 NM_001159542
POU5F1B
POU class 5 homeobox 1B
chr18_+_41560915 0.694 NM_001146037
SLC14A1
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chr5_+_57823017 0.693 NM_152687
GAPT
GRB2-binding adaptor protein, transmembrane
chr22_-_48865907 0.686 NM_139202
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr10_+_118370441 0.684 NM_005396
PNLIPRP2
pancreatic lipase-related protein 2
chr14_-_20340830 0.683 NM_002933
NM_198234
NM_198235
RNASE1


ribonuclease, RNase A family, 1 (pancreatic)


chr3_+_129124591 0.683 NM_207335
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr10_-_72032519 0.683 NM_001083116
NM_005041
PRF1

perforin 1 (pore forming protein)

chr11_+_54891935 0.680 NM_001005275
OR4A15
olfactory receptor, family 4, subfamily A, member 15
chr22_-_48865864 0.680 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr7_-_115458010 0.679 NM_001018058
NM_012252
TFEC

transcription factor EC

chr12_-_46883341 0.677 NM_001004134
OR10AD1
olfactory receptor, family 10, subfamily AD, member 1
chrX_+_134803450 0.675 NM_018666
SAGE1
sarcoma antigen 1
chr2_+_68445936 0.673 PLEK
pleckstrin
chr4_-_47678187 0.673 NM_001142564
CNGA1
cyclic nucleotide gated channel alpha 1
chr12_+_111829191 0.671 OAS1
2',5'-oligoadenylate synthetase 1, 40/46kDa
chr11_-_55518675 0.669 NM_003697
OR5F1
olfactory receptor, family 5, subfamily F, member 1
chr6_+_106653429 0.668 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr14_+_69993969 0.664 NM_003813
ADAM21
ADAM metallopeptidase domain 21
chr21_+_24722913 0.664 FLJ42200
FLJ42200 protein
chr10_-_72032447 0.662 PRF1
perforin 1 (pore forming protein)
chr4_-_100575313 0.659 NM_001166504
NM_000673
ADH7

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

chr11_+_123600553 0.657 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chr11_-_5099422 0.656 NM_001005222
OR52A4
olfactory receptor, family 52, subfamily A, member 4
chr6_-_33085329 0.652 NM_002119
HLA-DOA
major histocompatibility complex, class II, DO alpha
chr16_+_29734785 0.645 C16orf53
chromosome 16 open reading frame 53
chr1_+_86662356 0.641 NM_006536
CLCA2
chloride channel accessory 2
chr18_-_56190980 0.640 NM_005912
MC4R
melanocortin 4 receptor
chr11_+_55078358 0.634 NM_001001920
OR4C15
olfactory receptor, family 4, subfamily C, member 15
chr6_+_47732181 0.626 NM_153839
GPR111
G protein-coupled receptor 111
chr14_-_20340377 0.624 NM_198232
RNASE1
ribonuclease, RNase A family, 1 (pancreatic)
chrX_+_130505630 0.620 NM_001004486
OR13H1
olfactory receptor, family 13, subfamily H, member 1
chr11_+_22316242 0.619 NM_020346
SLC17A6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr1_-_27573882 0.619 NM_003665
NM_173452
FCN3

ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)

chr17_+_36493927 0.614 NM_033061
KRTAP4-7
keratin associated protein 4-7
chrX_-_110400406 0.607 NM_014289
CAPN6
calpain 6
chr1_+_210275752 0.605 DTL
denticleless homolog (Drosophila)
chr5_-_22889192 0.605 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr17_+_44643067 0.601 ABI3
ABI family, member 3
chr1_+_24518501 0.596 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr14_-_19252330 0.593 NM_001197287
OR11H2
olfactory receptor, family 11, subfamily H, member 2
chr16_+_49288550 0.592 NM_022162
NOD2
nucleotide-binding oligomerization domain containing 2
chr17_+_44642587 0.587 NM_001135186
NM_016428
ABI3

ABI family, member 3

chrX_+_12834659 0.586 NM_138636
TLR8
toll-like receptor 8
chr3_+_185253528 0.583 NM_130770
HTR3C
5-hydroxytryptamine (serotonin) receptor 3, family member C
chr19_-_46048033 0.582 NM_000762
CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
chr19_-_56164628 0.582 NM_002774
KLK6
kallikrein-related peptidase 6
chr5_+_132021763 0.581 NM_002188
IL13
interleukin 13
chr6_+_29534109 0.581 NM_030883
OR2H1
olfactory receptor, family 2, subfamily H, member 1
chr19_-_60941551 0.576 NM_176820
NLRP9
NLR family, pyrin domain containing 9
chr1_-_159306037 0.574 ARHGAP30
Rho GTPase activating protein 30
chr6_+_116889248 0.570 NM_001010919
FAM26F
family with sequence similarity 26, member F
chr16_-_1761504 0.569 NME3
non-metastatic cells 3, protein expressed in
chr2_+_234266250 0.568 NM_001072
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr1_+_47674275 0.565 NM_004474
FOXD2
forkhead box D2
chrX_+_27674846 0.563 NM_001136533
DCAF8L2
DDB1 and CUL4 associated factor 8-like 2
chr2_-_49235059 0.561 NM_000145
NM_181446
FSHR

follicle stimulating hormone receptor

chr19_+_10820105 0.559 NM_001136482
C19orf38
chromosome 19 open reading frame 38
chr7_+_143457083 0.558 NM_001001659
OR2A14
olfactory receptor, family 2, subfamily A, member 14
chr11_+_4965996 0.558 NM_021801
MMP26
matrix metallopeptidase 26
chr17_-_53764867 0.556


chr11_+_123315459 0.553 NM_001001965
OR4D5
olfactory receptor, family 4, subfamily D, member 5
chr11_+_62231741 0.552 GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr17_+_22996461 0.550 LGALS9
lectin, galactoside-binding, soluble, 9
chrX_-_100015783 0.548 NM_007052
NM_013955
NOX1

NADPH oxidase 1

chr5_-_112798436 0.547 NM_032028
TSSK1B
testis-specific serine kinase 1B
chr3_+_63613383 0.547 NM_001080537
SNTN
sentan, cilia apical structure protein
chr1_+_210275541 0.546 NM_016448
DTL
denticleless homolog (Drosophila)
chr5_-_180560535 0.545 NM_203297
TRIM7
tripartite motif containing 7
chr3_+_188568861 0.542 NM_022147
RTP4
receptor (chemosensory) transporter protein 4
chr2_+_68726457 0.541 NM_138964
PROKR1
prokineticin receptor 1
chr19_-_44518465 0.541 GMFG
glia maturation factor, gamma
chr4_+_157044296 0.540 NM_005651
TDO2
tryptophan 2,3-dioxygenase
chr11_-_6746763 0.538 NM_001004490
OR2AG2
olfactory receptor, family 2, subfamily AG, member 2
chr2_+_96355661 0.537 NM_178495
NM_001163524
ITPRIPL1

inositol 1,4,5-triphosphate receptor interacting protein-like 1

chr7_+_106897737 0.537 NM_005295
GPR22
G protein-coupled receptor 22
chr11_+_20577521 0.536 NM_004211
SLC6A5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
chr1_+_246617532 0.535 NM_001005471
OR2T6
olfactory receptor, family 2, subfamily T, member 6
chr21_-_31123797 0.534 NM_181606
KRTAP7-1
keratin associated protein 7-1 (gene/pseudogene)
chr22_-_29197944 0.533 NM_174975
SEC14L3
SEC14-like 3 (S. cerevisiae)
chr7_-_25234582 0.532 NM_022150
NPVF
neuropeptide VF precursor
chr17_-_29507663 0.529 NM_001094
ACCN1
amiloride-sensitive cation channel 1, neuronal
chrX_+_30158473 0.524 NM_002365
MAGEB3
melanoma antigen family B, 3
chrX_-_27909486 0.520 NM_001017930
DCAF8L1
DDB1 and CUL4 associated factor 8-like 1
chr7_+_141054621 0.520 NM_001105558
WEE2
WEE1 homolog 2 (S. pombe)
chr4_+_39874921 0.518 NM_004310
RHOH
ras homolog gene family, member H
chr7_-_115458064 0.513 TFEC
transcription factor EC
chr10_-_108448990 0.512 SORCS1
sortilin-related VPS10 domain containing receptor 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
4.82 3.94e-53 GO:0007608 sensory perception of smell
4.54 1.59e-52 GO:0007606 sensory perception of chemical stimulus
3.22 5.20e-42 GO:0007600 sensory perception
2.34 6.43e-29 GO:0050877 neurological system process
2.13 2.69e-27 GO:0003008 system process
1.35 5.37e-15 GO:0050896 response to stimulus
1.38 2.57e-13 GO:0032501 multicellular organismal process
2.07 3.10e-09 GO:0006955 immune response
1.69 1.78e-06 GO:0002376 immune system process
1.87 2.73e-06 GO:0006952 defense response
2.23 4.46e-05 GO:0045087 innate immune response
3.21 1.82e-02 GO:0034341 response to interferon-gamma

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.62 1.97e-28 GO:0071944 cell periphery
1.62 5.69e-28 GO:0005886 plasma membrane
1.45 2.75e-22 GO:0031224 intrinsic to membrane
1.45 1.34e-21 GO:0016021 integral to membrane
1.35 4.77e-17 GO:0044425 membrane part
1.24 2.31e-11 GO:0016020 membrane
1.55 7.08e-09 GO:0005576 extracellular region
2.44 4.82e-04 GO:0045111 intermediate filament cytoskeleton
2.57 5.01e-04 GO:0005882 intermediate filament
1.63 1.23e-03 GO:0005615 extracellular space
2.59 3.16e-03 GO:0009897 external side of plasma membrane
1.47 3.61e-03 GO:0005887 integral to plasma membrane
1.45 5.36e-03 GO:0031226 intrinsic to plasma membrane
1.49 7.52e-03 GO:0044421 extracellular region part
1.29 2.85e-02 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.98 9.05e-55 GO:0004984 olfactory receptor activity
3.21 3.46e-44 GO:0004930 G-protein coupled receptor activity
2.68 4.68e-43 GO:0004888 transmembrane receptor activity
2.32 1.69e-38 GO:0004872 receptor activity
2.08 2.65e-33 GO:0004871 signal transducer activity
2.08 2.65e-33 GO:0060089 molecular transducer activity
2.30 4.19e-03 GO:0005125 cytokine activity
4.04 5.50e-03 GO:0008009 chemokine activity
3.64 1.86e-02 GO:0042379 chemokine receptor binding