Motif ID: ESR1.p2

Z-value: 1.975


Transcription factors associated with ESR1.p2:

Gene SymbolEntrez IDGene Name
ESR1 2099 estrogen receptor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ESR1chr6_+_1521703780.185.0e-01Click!


Activity profile for motif ESR1.p2.

activity profile for motif ESR1.p2


Sorted Z-values histogram for motif ESR1.p2

Sorted Z-values for motif ESR1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESR1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_24068759 2.433 NM_001144942
NM_031934
RAB34

RAB34, member RAS oncogene family

chr19_+_15079141 2.255 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr2_+_36436316 2.013 CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr16_+_54072969 1.712 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr22_+_36632242 1.682 NM_033386
MICALL1
MICAL-like 1
chr2_-_233501069 1.675 NM_001114090
NGEF
neuronal guanine nucleotide exchange factor
chr6_+_148705646 1.659 SASH1
SAM and SH3 domain containing 1
chr17_-_7238546 1.630 NM_020360
PLSCR3
phospholipid scramblase 3
chr6_+_148705421 1.434 NM_015278
SASH1
SAM and SH3 domain containing 1
chr1_+_15955719 1.337 FBLIM1
filamin binding LIM protein 1
chr16_-_1341766 1.307 NM_001001410
C16orf42
chromosome 16 open reading frame 42
chr9_+_136673464 1.303 NM_000093
COL5A1
collagen, type V, alpha 1
chr7_+_2638156 1.293 TTYH3
tweety homolog 3 (Drosophila)
chr10_+_115428924 1.278 NM_033340
CASP7
caspase 7, apoptosis-related cysteine peptidase
chr7_+_99919485 1.267 NM_173564
C7orf51
chromosome 7 open reading frame 51
chr9_-_139202855 1.264 NM_013366
ANAPC2
anaphase promoting complex subunit 2
chr19_+_47521600 1.219 NM_001410
MEGF8
multiple EGF-like-domains 8
chr19_-_60802663 1.215 NM_032836
FIZ1
FLT3-interacting zinc finger 1
chr17_-_3518568 1.208 TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr22_-_18309312 1.208 TXNRD2
thioredoxin reductase 2
chr2_+_100802923 1.199 NM_002518
NPAS2
neuronal PAS domain protein 2
chr7_-_47588160 1.192 TNS3
tensin 3
chr19_-_15172773 1.179 NM_000435
NOTCH3
notch 3
chr16_-_73842884 1.177 NM_001170717
NM_014567
BCAR1

breast cancer anti-estrogen resistance 1

chr20_+_4077466 1.167 SMOX
spermine oxidase
chr1_+_31659246 1.159 NM_001199039
NM_018565
SERINC2

serine incorporator 2

chr5_-_156935283 1.157


chr9_-_139202831 1.142 ANAPC2
anaphase promoting complex subunit 2
chr9_-_83493415 1.130 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr2_+_236067424 1.112 NM_001037131
NM_014914
AGAP1

ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

chr12_-_123023312 1.110 CCDC92
coiled-coil domain containing 92
chr22_-_36245155 1.071 NM_014550
CARD10
caspase recruitment domain family, member 10
chr19_-_4509471 1.070 NM_032108
SEMA6B
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr2_-_1727247 1.056 PXDN
peroxidasin homolog (Drosophila)
chr22_+_42651018 1.050 PNPLA3
patatin-like phospholipase domain containing 3
chr16_+_559970 1.036 NM_004204
NM_148920
PIGQ

phosphatidylinositol glycan anchor biosynthesis, class Q

chr12_-_123023052 1.035 NM_025140
CCDC92
coiled-coil domain containing 92
chr20_+_4077409 1.023 NM_175839
NM_175840
NM_175841
NM_175842
SMOX



spermine oxidase



chr22_-_41446740 1.010 NM_017436
A4GALT
alpha 1,4-galactosyltransferase
chr9_-_85342868 1.007 NM_174938
FRMD3
FERM domain containing 3
chr9_-_21999270 1.004 NM_004936
NM_078487
CDKN2B

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

chr2_+_242398954 1.002 NEU4
sialidase 4
chr1_+_1256585 0.998 NM_152228
TAS1R3
taste receptor, type 1, member 3
chr4_+_4912272 0.985 NM_002448
MSX1
msh homeobox 1
chr17_-_3518654 0.978 NM_014604
TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr21_-_45786709 0.975 NM_194255
SLC19A1
solute carrier family 19 (folate transporter), member 1
chr19_-_14447163 0.967 NM_000955
PTGER1
prostaglandin E receptor 1 (subtype EP1), 42kDa
chr1_+_31658549 0.963 NM_178865
SERINC2
serine incorporator 2
chr17_-_40401138 0.961 NM_006688
C1QL1
complement component 1, q subcomponent-like 1
chr22_+_42650951 0.954 NM_025225
PNPLA3
patatin-like phospholipase domain containing 3
chr14_+_92188546 0.952 RIN3
Ras and Rab interactor 3
chr22_+_41877502 0.946 TSPO
translocator protein (18kDa)
chr14_+_104244998 0.946 INF2
inverted formin, FH2 and WH2 domain containing
chr13_+_112670757 0.942 NM_001112732
MCF2L
MCF.2 cell line derived transforming sequence-like
chr17_+_77261401 0.937 NM_004712
HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr9_+_136673534 0.934 COL5A1
collagen, type V, alpha 1
chr10_+_102748062 0.918 LZTS2
leucine zipper, putative tumor suppressor 2
chr22_+_42651007 0.917 PNPLA3
patatin-like phospholipase domain containing 3
chr13_+_109757593 0.916 NM_001846
COL4A2
collagen, type IV, alpha 2
chr16_+_88512769 0.914 MC1R
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
chr14_+_73073570 0.914 NM_001037161
ACOT1
acyl-CoA thioesterase 1
chr10_+_50492088 0.914 NM_001142929
NM_001142933
NM_001142934
NM_020549
CHAT



choline O-acetyltransferase



chr2_-_1727220 0.913 PXDN
peroxidasin homolog (Drosophila)
chr13_-_32822759 0.911 STARD13
StAR-related lipid transfer (START) domain containing 13
chr5_-_1165106 0.907 NM_006598
SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chr16_-_4105703 0.905 ADCY9
adenylate cyclase 9
chr22_+_41877470 0.901 NM_000714
NM_007311
TSPO

translocator protein (18kDa)

chr3_+_52464657 0.898 NISCH
nischarin
chr12_+_50631734 0.894 ACVR1B
activin A receptor, type IB
chr4_+_151218862 0.893 NM_001040260
NM_001040261
DCLK2

doublecortin-like kinase 2

chr2_+_85213884 0.889 NM_031283
TCF7L1
transcription factor 7-like 1 (T-cell specific, HMG-box)
chr7_+_44110470 0.884 NM_001129
AEBP1
AE binding protein 1
chr11_-_1549719 0.879 NM_004420
DUSP8
dual specificity phosphatase 8
chr19_-_10091534 0.854 NM_003755
EIF3G
eukaryotic translation initiation factor 3, subunit G
chr22_+_36472201 0.854 TRIOBP
TRIO and F-actin binding protein
chr11_-_70641267 0.850 SHANK2
SH3 and multiple ankyrin repeat domains 2
chr20_+_25176698 0.842 NM_002862
PYGB
phosphorylase, glycogen; brain
chr22_-_19122047 0.833 SCARF2
scavenger receptor class F, member 2
chr16_+_14976422 0.826 PDXDC1
pyridoxal-dependent decarboxylase domain containing 1
chr4_-_118226119 0.824 NM_152402
TRAM1L1
translocation associated membrane protein 1-like 1
chr19_-_4351357 0.818 SH3GL1
SH3-domain GRB2-like 1
chr15_-_76890626 0.816 NM_014272
ADAMTS7
ADAM metallopeptidase with thrombospondin type 1 motif, 7
chr9_-_130980302 0.814 IER5L
immediate early response 5-like
chr17_-_24069299 0.813 NM_001142624
NM_001142625
NM_001144943
RAB34


RAB34, member RAS oncogene family


chr7_+_1536847 0.812 NM_002360
MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr2_+_106048543 0.810 NM_032411
C2orf40
chromosome 2 open reading frame 40
chr9_-_137731139 0.800 NM_001012415
NM_001101677
SOHLH1

spermatogenesis and oogenesis specific basic helix-loop-helix 1

chr6_+_148705817 0.794 SASH1
SAM and SH3 domain containing 1
chr16_+_88616508 0.790 NM_001481
GAS8
growth arrest-specific 8
chr5_-_172594691 0.786 NM_001166175
NM_001166176
NM_004387
NKX2-5


NK2 transcription factor related, locus 5 (Drosophila)


chr18_+_18003401 0.785 NM_005257
GATA6
GATA binding protein 6
chr19_-_11234117 0.782 NM_020812
DOCK6
dedicator of cytokinesis 6
chr9_-_16860664 0.776 BNC2
basonuclin 2
chr5_-_141041933 0.771 ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr16_+_4361775 0.759 NM_138440
VASN
vasorin
chr22_-_49413326 0.759 NM_000487
NM_001085425
NM_001085426
NM_001085427
NM_001085428
ARSA




arylsulfatase A




chr17_+_77261477 0.758 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr17_-_75808680 0.756 NM_000199
SGSH
N-sulfoglucosamine sulfohydrolase
chr19_-_41397396 0.752 NM_152477
ZNF565
zinc finger protein 565
chr9_-_130980359 0.746 NM_203434
IER5L
immediate early response 5-like
chr19_-_4486202 0.744 NM_001013706
PLIN5
perilipin 5
chr7_-_47588266 0.744 TNS3
tensin 3
chr19_-_50963942 0.742


chr19_-_5742198 0.739 NM_001161619
NM_020175
DUS3L

dihydrouridine synthase 3-like (S. cerevisiae)

chr17_-_34635446 0.739 NM_198993
STAC2
SH3 and cysteine rich domain 2
chr16_+_550394 0.737 NM_145270
C16orf11
chromosome 16 open reading frame 11
chr3_-_129690056 0.736 NM_001145661
GATA2
GATA binding protein 2
chr6_-_117193505 0.729 NM_001085480
FAM162B
family with sequence similarity 162, member B
chr5_-_141041982 0.725 NM_022481
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr19_+_42517337 0.725 NM_181786
HKR1
HKR1, GLI-Kruppel zinc finger family member
chr17_-_3518628 0.721 TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr19_+_4255590 0.721 NM_024333
FSD1
fibronectin type III and SPRY domain containing 1
chr9_-_138560058 0.716 NM_017617
NOTCH1
notch 1
chr2_-_42574587 0.715 NM_133329
NM_172344
KCNG3

potassium voltage-gated channel, subfamily G, member 3

chr22_-_19122107 0.713 NM_153334
NM_182895
SCARF2

scavenger receptor class F, member 2

chr19_+_3457264 0.713 NM_016263
FZR1
fizzy/cell division cycle 20 related 1 (Drosophila)
chr22_+_36472176 0.712 NM_007032
NM_138632
TRIOBP

TRIO and F-actin binding protein

chr18_+_74841262 0.712 NM_171999
SALL3
sal-like 3 (Drosophila)
chr9_-_139042526 0.709 NM_001606
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr17_+_6288457 0.707 NM_001195228
NM_019013
FAM64A

family with sequence similarity 64, member A

chr19_+_7874764 0.705 NM_145185
MAP2K7
mitogen-activated protein kinase kinase 7
chr19_+_7834124 0.703 EVI5L
ecotropic viral integration site 5-like
chr22_-_18309447 0.698 TXNRD2
thioredoxin reductase 2
chr16_-_68657221 0.696 PDXDC2P
pyridoxal-dependent decarboxylase domain containing 2, pseudogene
chr11_-_605998 0.688 NM_001572
NM_004029
IRF7

interferon regulatory factor 7

chr20_+_61963009 0.686 NM_080622
ABHD16B
abhydrolase domain containing 16B
chr2_-_1727292 0.685 NM_012293
PXDN
peroxidasin homolog (Drosophila)
chr1_+_22909916 0.684 NM_004442
NM_017449
EPHB2

EPH receptor B2

chr7_-_100262971 0.683 NM_004444
EPHB4
EPH receptor B4
chr11_+_128266460 0.679 NM_000890
KCNJ5
potassium inwardly-rectifying channel, subfamily J, member 5
chr14_-_103251497 0.678 NM_001100118
NM_001100119
NM_005432
XRCC3


X-ray repair complementing defective repair in Chinese hamster cells 3


chr19_+_7874765 0.675 MAP2K7
mitogen-activated protein kinase kinase 7
chr5_+_176446425 0.673 NM_002011
NM_213647
FGFR4

fibroblast growth factor receptor 4

chr11_+_832821 0.671 NM_001025238
NM_001025239
NM_003271
NM_001025235
NM_001025236
TSPAN4




tetraspanin 4




chr10_-_133995323 0.664 STK32C
serine/threonine kinase 32C
chr2_+_242398832 0.660 NM_001167600
NM_001167601
NEU4

sialidase 4

chr2_+_236067687 0.659 AGAP1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr17_+_77261440 0.659 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr14_+_105012106 0.658 NM_001312
CRIP2
cysteine-rich protein 2
chr12_+_50631704 0.658 NM_004302
NM_020328
ACVR1B

activin A receptor, type IB

chr16_+_1143738 0.654 CACNA1H
calcium channel, voltage-dependent, T type, alpha 1H subunit
chr16_+_1974017 0.650 NM_005262
GFER
growth factor, augmenter of liver regeneration
chr1_+_77520190 0.647 AK5
adenylate kinase 5
chr2_-_20714303 0.645 NM_022460
HS1BP3
HCLS1 binding protein 3
chr19_-_41397822 0.644 NM_001042474
ZNF565
zinc finger protein 565
chr19_-_14062230 0.642 NM_138352
SAMD1
sterile alpha motif domain containing 1
chr17_+_77261457 0.639


chr7_-_130069399 0.638 NM_138693
KLF14
Kruppel-like factor 14
chr11_-_116213511 0.638 NM_000039
APOA1
apolipoprotein A-I
chr20_+_30161173 0.631 TM9SF4
transmembrane 9 superfamily protein member 4
chr17_+_77261447 0.630 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr9_-_139042416 0.629 ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr4_-_41579325 0.629


chr11_+_47227009 0.628 NM_001130102
NR1H3
nuclear receptor subfamily 1, group H, member 3
chr1_+_15352800 0.628 NM_001136218
NM_018022
TMEM51

transmembrane protein 51

chr16_-_2125825 0.625 NM_000296
NM_001009944
PKD1

polycystic kidney disease 1 (autosomal dominant)

chr12_+_50592379 0.624 NM_001077401
ACVRL1
activin A receptor type II-like 1
chr7_+_128615948 0.620 NM_005631
SMO
smoothened homolog (Drosophila)
chr10_+_26545241 0.616 NM_000818
NM_001134366
GAD2

glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)

chr11_+_61204392 0.614 NM_006133
DAGLA
diacylglycerol lipase, alpha
chr1_-_151852128 0.614 NM_080388
S100A16
S100 calcium binding protein A16
chr11_+_57554977 0.613 NM_001005186
OR6Q1
olfactory receptor, family 6, subfamily Q, member 1
chr20_+_23279372 0.610 NM_013248
NXT1
NTF2-like export factor 1
chr9_+_111850698 0.608 NM_001004065
NM_001198656
AKAP2

A kinase (PRKA) anchor protein 2

chr8_+_144428083 0.605 GLI4
GLI family zinc finger 4
chr1_-_199742871 0.605 NM_001193570
NM_004078
CSRP1

cysteine and glycine-rich protein 1

chr14_+_105063975 0.603 NM_025268
TMEM121
transmembrane protein 121
chr16_+_1143241 0.602 NM_001005407
NM_021098
CACNA1H

calcium channel, voltage-dependent, T type, alpha 1H subunit

chr22_+_28329544 0.602 NM_000268
NM_016418
NM_181825
NM_181828
NM_181829
NM_181830
NM_181831
NM_181832
NM_181833
NF2








neurofibromin 2 (merlin)








chr1_-_199742864 0.602 CSRP1
cysteine and glycine-rich protein 1
chr19_-_14447122 0.601 PTGER1
prostaglandin E receptor 1 (subtype EP1), 42kDa
chr16_+_64958060 0.599 CDH5
cadherin 5, type 2 (vascular endothelium)
chr19_-_5742177 0.597 DUS3L
dihydrouridine synthase 3-like (S. cerevisiae)
chr1_+_54780515 0.594 ACOT11
acyl-CoA thioesterase 11
chr19_-_5741913 0.591 DUS3L
dihydrouridine synthase 3-like (S. cerevisiae)
chr9_-_139047112 0.591 NM_004479
FUT7
fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
chr1_+_179148935 0.587 NM_020950
KIAA1614
KIAA1614
chr19_+_7874762 0.585 MAP2K7
mitogen-activated protein kinase kinase 7
chr22_+_22445035 0.584 NM_005940
MMP11
matrix metallopeptidase 11 (stromelysin 3)
chr19_+_62703136 0.581 ZNF773
zinc finger protein 773
chr19_+_58733144 0.580 NM_001079906
ZNF331
zinc finger protein 331
chr19_+_4423149 0.579 NM_001001520
NM_032631
HDGFRP2

hepatoma-derived growth factor-related protein 2

chr1_-_94475504 0.576 ARHGAP29
Rho GTPase activating protein 29
chr2_+_219354948 0.576 CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr5_-_156935317 0.575 NM_033274
ADAM19
ADAM metallopeptidase domain 19
chr1_+_3360880 0.575 NM_014448
ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr22_-_18309333 0.574 NM_006440
TXNRD2
thioredoxin reductase 2
chr15_-_88034857 0.571 NM_003847
PEX11A
peroxisomal biogenesis factor 11 alpha
chr13_+_112681626 0.569 NM_024979
MCF2L
MCF.2 cell line derived transforming sequence-like
chr20_-_36322587 0.569 NM_001029864
KIAA1755
KIAA1755
chr13_-_109757442 0.569 NM_001845
COL4A1
collagen, type IV, alpha 1
chr2_-_242096673 0.568 NM_006374
STK25
serine/threonine kinase 25
chr2_-_216008689 0.567 FN1
fibronectin 1
chr22_-_18309250 0.563 TXNRD2
thioredoxin reductase 2
chr19_+_3884100 0.562 NM_170678
ITGB1BP3
integrin beta 1 binding protein 3
chr1_-_155374756 0.558 ETV3
ets variant 3
chr22_-_35113876 0.558 MYH9
myosin, heavy chain 9, non-muscle
chr2_-_1727324 0.557 PXDN
peroxidasin homolog (Drosophila)
chr7_+_44110527 0.557 AEBP1
AE binding protein 1
chr11_-_605649 0.557 NM_004031
IRF7
interferon regulatory factor 7

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.47 2.11e-05 GO:0009966 regulation of signal transduction
1.41 1.71e-04 GO:0023051 regulation of signaling
1.22 3.50e-03 GO:0023052 signaling
1.71 3.68e-03 GO:0072358 cardiovascular system development
1.71 3.68e-03 GO:0072359 circulatory system development
1.89 8.04e-03 GO:0001944 vasculature development
1.89 1.95e-02 GO:0001568 blood vessel development
1.21 2.55e-02 GO:0007165 signal transduction
1.13 2.74e-02 GO:0050794 regulation of cellular process
1.34 3.23e-02 GO:0009653 anatomical structure morphogenesis
5.68 4.78e-02 GO:0060411 cardiac septum morphogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.10 2.29e-02 GO:0005737 cytoplasm
1.49 2.99e-02 GO:0030054 cell junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.17 1.09e-06 GO:0005515 protein binding
1.07 7.77e-03 GO:0005488 binding
1.69 3.72e-02 GO:0003779 actin binding
1.56 4.79e-02 GO:0060589 nucleoside-triphosphatase regulator activity