Motif ID: FEV.p2

Z-value: 2.301


Transcription factors associated with FEV.p2:

Gene SymbolEntrez IDGene Name
FEV 54738 FEV (ETS oncogene family)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FEVchr2_-_2195585170.097.3e-01Click!


Activity profile for motif FEV.p2.

activity profile for motif FEV.p2


Sorted Z-values histogram for motif FEV.p2

Sorted Z-values for motif FEV.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FEV.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_35586950 2.554 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr10_+_49562866 2.271 WDFY4
WDFY family member 4
chr7_+_106292975 2.235 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr7_+_106292932 2.122 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr3_+_114733907 2.088 NM_017699
SIDT1
SID1 transmembrane family, member 1
chr10_-_98021144 1.980 NM_001114094
NM_013314
BLNK

B-cell linker

chr3_-_122862391 1.936 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr3_-_122862447 1.897 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr12_-_6668880 1.814 NM_001039917
NM_001039919
NM_001039920
NM_001135734
ZNF384



zinc finger protein 384



chr3_+_120495906 1.813 NM_020754
ARHGAP31
Rho GTPase activating protein 31
chr3_-_46224791 1.803 NM_001295
CCR1
chemokine (C-C motif) receptor 1
chr7_+_106293112 1.744 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr12_-_6668680 1.697 ZNF384
zinc finger protein 384
chr11_+_63498590 1.603 NM_004074
COX8A
cytochrome c oxidase subunit VIIIA (ubiquitous)
chr12_-_6668787 1.584 NM_001039918
NM_133476
ZNF384

zinc finger protein 384

chr6_-_42527760 1.583 NM_033502
TRERF1
transcriptional regulating factor 1
chr18_-_59137488 1.566 NM_000633
NM_000657
BCL2

B-cell CLL/lymphoma 2

chr19_-_61324456 1.555 NM_001002836
ZNF787
zinc finger protein 787
chr17_-_16816113 1.517 NM_012452
TNFRSF13B
tumor necrosis factor receptor superfamily, member 13B
chr1_+_32512298 1.511 NM_001042771
LCK
lymphocyte-specific protein tyrosine kinase
chr3_-_184756101 1.502 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr19_-_55071645 1.465 AKT1S1
AKT1 substrate 1 (proline-rich)
chr3_+_120799411 1.429 NM_015900
PLA1A
phospholipase A1 member A
chr11_+_2378559 1.418 TSSC4
tumor suppressing subtransferable candidate 4
chr22_+_36008465 1.400 CYTH4
cytohesin 4
chr19_-_51820133 1.390 NM_000960
PTGIR
prostaglandin I2 (prostacyclin) receptor (IP)
chr2_-_175207521 1.384 NM_003387
WIPF1
WAS/WASL interacting protein family, member 1
chr16_-_30993004 1.374 NM_024706
ZNF668
zinc finger protein 668
chr6_-_32268267 1.371 GPSM3
G-protein signaling modulator 3
chr19_+_17281374 1.362 DDA1
DET1 and DDB1 associated 1
chr10_+_49563520 1.326 NM_020945
WDFY4
WDFY family member 4
chr17_+_44642587 1.320 NM_001135186
NM_016428
ABI3

ABI family, member 3

chr17_+_64922420 1.315 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chrX_+_128741562 1.313 NM_018990
SASH3
SAM and SH3 domain containing 3
chr1_-_149004879 1.306 CTSS
cathepsin S
chr14_+_101097440 1.301 NM_001362
DIO3
deiodinase, iodothyronine, type III
chr22_+_25398690 1.294 LOC388889
hypothetical LOC388889
chr1_+_196874867 1.285 PTPRC
protein tyrosine phosphatase, receptor type, C
chr11_-_76059435 1.284 NM_001128922
LRRC32
leucine rich repeat containing 32
chr11_-_62146144 1.270 B3GAT3
beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
chr16_-_65818401 1.265 NM_001004055
LRRC29
leucine rich repeat containing 29
chr12_-_56157898 1.263 NM_001080156
ARHGAP9
Rho GTPase activating protein 9
chr2_+_33514896 1.231 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr6_-_32268615 1.222 GPSM3
G-protein signaling modulator 3
chr4_+_54790020 1.221 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr4_-_153820535 1.216 NM_152680
TMEM154
transmembrane protein 154
chr1_+_32489426 1.210 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr6_-_154719560 1.209 NM_001130700
NM_015553
IPCEF1

interaction protein for cytohesin exchange factors 1

chr1_+_43410587 1.205 NM_001167965
NM_152498
NM_001167966
WDR65


WD repeat domain 65


chr16_-_30992574 1.194 ZNF668
zinc finger protein 668
chr19_+_55571493 1.189 NM_007121
NR1H2
nuclear receptor subfamily 1, group H, member 2
chr16_+_56134037 1.183 GPR114
G protein-coupled receptor 114
chr16_+_30391460 1.176 NM_001114380
NM_002209
ITGAL

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

chr15_-_68971665 1.165 NM_020147
THAP10
THAP domain containing 10
chrX_+_128741578 1.158 SASH3
SAM and SH3 domain containing 3
chr11_+_46679140 1.154 NM_001184751
ZNF408
zinc finger protein 408
chr16_+_30391550 1.150 ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr3_-_114176401 1.148 NM_138806
NM_138939
NM_138940
NM_170780
CD200R1



CD200 receptor 1



chr22_+_36008511 1.144 CYTH4
cytohesin 4
chrX_+_12795111 1.139 NM_016562
TLR7
toll-like receptor 7
chr7_-_3049872 1.136 NM_032415
CARD11
caspase recruitment domain family, member 11
chr19_-_6432765 1.130 NM_024898
DENND1C
DENN/MADD domain containing 1C
chr22_+_36008369 1.125 NM_013385
CYTH4
cytohesin 4
chr1_-_246869181 1.092 NM_001001827
OR2T35
olfactory receptor, family 2, subfamily T, member 35
chr21_-_14840506 1.089 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr10_+_26767657 1.089 APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr12_-_56159631 1.085 NM_001080157
ARHGAP9
Rho GTPase activating protein 9
chr2_+_233633279 1.082 NM_001017915
NM_005541
INPP5D

inositol polyphosphate-5-phosphatase, 145kDa

chr5_+_180582880 1.073 TRIM41
tripartite motif containing 41
chr22_-_35970230 1.072 NM_002872
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr12_-_14982708 1.067 NM_152321
ERP27
endoplasmic reticulum protein 27
chr15_-_38387410 1.064 NM_004573
PLCB2
phospholipase C, beta 2
chr13_-_42464301 1.062 NM_001002264
NM_033255
EPSTI1

epithelial stromal interaction 1 (breast)

chr10_+_26767698 1.053 APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr6_+_31661934 1.035 NM_205838
NM_205839
LST1

leukocyte specific transcript 1

chr13_+_48178620 1.035 NM_020377
CYSLTR2
cysteinyl leukotriene receptor 2
chr15_-_38387164 1.033 PLCB2
phospholipase C, beta 2
chr1_-_155788775 1.030 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr2_+_45732416 1.025 NM_005400
PRKCE
protein kinase C, epsilon
chr16_-_85099941 1.022 LOC400550
hypothetical LOC400550
chr12_+_11694172 1.020 ETV6
ets variant 6
chr16_+_75782870 1.015 MON1B
MON1 homolog B (yeast)
chr11_+_65164167 1.009 NM_153253
SIPA1
signal-induced proliferation-associated 1
chr12_+_25096472 1.007 NM_006152
LRMP
lymphoid-restricted membrane protein
chr15_-_38387317 1.003 PLCB2
phospholipase C, beta 2
chrX_-_44945025 1.000 NM_024689
NM_176819
CXorf36

chromosome X open reading frame 36

chr14_-_37795290 0.986 NM_175060
CLEC14A
C-type lectin domain family 14, member A
chr11_-_62145952 0.981 NM_012200
B3GAT3
beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
chr7_-_44985202 0.980 NM_033054
MYO1G
myosin IG
chr11_+_63864263 0.977 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr9_+_263025 0.972 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr2_+_233633348 0.968 INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr22_-_16080265 0.964 CECR1
cat eye syndrome chromosome region, candidate 1
chr5_-_156468614 0.961 NM_032782
HAVCR2
hepatitis A virus cellular receptor 2
chr3_+_120496180 0.952 ARHGAP31
Rho GTPase activating protein 31
chr6_+_153060722 0.948 NM_025107
MYCT1
myc target 1
chr19_+_52451642 0.947 CCDC9
coiled-coil domain containing 9
chrX_-_110542040 0.946 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr2_+_31310485 0.944 EHD3
EH-domain containing 3
chr14_+_68934855 0.943 SLC39A9
solute carrier family 39 (zinc transporter), member 9
chr20_+_2743613 0.940 NM_080739
C20orf141
chromosome 20 open reading frame 141
chr12_+_25096755 0.939 LRMP
lymphoid-restricted membrane protein
chr1_+_196874839 0.934 PTPRC
protein tyrosine phosphatase, receptor type, C
chr19_+_52451570 0.933 NM_015603
CCDC9
coiled-coil domain containing 9
chr11_-_110755112 0.930 POU2AF1
POU class 2 associating factor 1
chr12_-_6103945 0.926 NM_000552
VWF
von Willebrand factor
chr7_-_143523582 0.914 NM_001003702
ARHGEF35
Rho guanine nucleotide exchange factor (GEF) 35
chr1_+_196874759 0.911 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr11_-_57054756 0.911 NM_012456
TIMM10
translocase of inner mitochondrial membrane 10 homolog (yeast)
chr4_+_54790190 0.905 PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr16_-_49272617 0.903 SNX20
sorting nexin 20
chr1_-_158815850 0.900 CD84
CD84 molecule
chr16_-_29664765 0.896 NM_175900
C16orf54
chromosome 16 open reading frame 54
chr11_-_64641700 0.894 NM_014205
ZNHIT2
zinc finger, HIT-type containing 2
chr11_-_46678715 0.890 ARHGAP1
Rho GTPase activating protein 1
chr16_+_56134077 0.886 NM_153837
GPR114
G protein-coupled receptor 114
chr19_+_17281352 0.886 DDA1
DET1 and DDB1 associated 1
chr19_-_59019240 0.885 NM_144687
NLRP12
NLR family, pyrin domain containing 12
chr1_+_111544469 0.885


chr13_-_27967215 0.876 NM_001159920
NM_001160030
NM_001160031
NM_002019
FLT1



fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)



chr13_-_45654327 0.875 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr5_-_169657312 0.874 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr7_-_44985175 0.867 MYO1G
myosin IG
chr19_-_56567602 0.866 NM_005601
NKG7
natural killer cell group 7 sequence
chr13_-_45654296 0.864 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr19_-_44518465 0.859 GMFG
glia maturation factor, gamma
chrX_-_102234606 0.858 NM_022052
NXF3
nuclear RNA export factor 3
chr19_-_17349096 0.855 NM_031310
PLVAP
plasmalemma vesicle associated protein
chr17_-_4783943 0.848 NM_001165417
NM_001165418
NM_003562
SLC25A11


solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11


chr9_-_90983501 0.846 NM_016848
SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr17_-_31441390 0.846 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr1_+_202000906 0.832 NM_001136190
NM_017773
LAX1

lymphocyte transmembrane adaptor 1

chr7_-_44985084 0.824 MYO1G
myosin IG
chr3_-_150533948 0.824 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr1_-_158815895 0.823 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr19_+_10820105 0.818 NM_001136482
C19orf38
chromosome 19 open reading frame 38
chr1_-_181826292 0.818 NM_000433
NM_001190789
NM_001190794
NCF2


neutrophil cytosolic factor 2


chr7_+_143683365 0.812 NM_005435
ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr18_+_21967813 0.806 NM_001025096
NM_001025097
NM_144662
PSMA8


proteasome (prosome, macropain) subunit, alpha type, 8


chr20_+_2224612 0.805 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr19_-_47328399 0.802 NM_002698
POU2F2
POU class 2 homeobox 2
chr5_-_66528330 0.801 NM_005582
CD180
CD180 molecule
chr12_+_11693909 0.800 ETV6
ets variant 6
chr1_-_181826086 0.796 NCF2
neutrophil cytosolic factor 2
chr16_+_2145810 0.794 TRAF7
TNF receptor-associated factor 7
chr12_+_11693993 0.791 NM_001987
ETV6
ets variant 6
chr9_+_94766379 0.788 FGD3
FYVE, RhoGEF and PH domain containing 3
chr17_+_6858779 0.787 NM_001142798
NM_001142799
NM_174893
C17orf49


chromosome 17 open reading frame 49


chr11_-_110755366 0.785 NM_006235
POU2AF1
POU class 2 associating factor 1
chr1_-_149004852 0.781 CTSS
cathepsin S
chr14_+_62740878 0.779 NM_020663
RHOJ
ras homolog gene family, member J
chr4_-_10295412 0.777 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr6_+_10663934 0.775 NM_001491
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr1_+_159943385 0.772 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chr3_-_166397142 0.772 NM_014926
SLITRK3
SLIT and NTRK-like family, member 3
chr19_-_15436333 0.771 NM_022904
RASAL3
RAS protein activator like 3
chr12_-_56422120 0.770 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr9_-_116190038 0.764 AKNA
AT-hook transcription factor
chr11_+_63362922 0.764 NM_001039469
NM_001163296
NM_001163297
NM_004954
MARK2



MAP/microtubule affinity-regulating kinase 2



chr1_-_155834357 0.762 NM_031282
FCRL4
Fc receptor-like 4
chr16_+_75782556 0.759 MON1B
MON1 homolog B (yeast)
chr5_+_180582905 0.757 NM_033549
NM_201627
TRIM41

tripartite motif containing 41

chr16_+_2145765 0.757 NM_032271
TRAF7
TNF receptor-associated factor 7
chr20_+_44180355 0.757 CD40
CD40 molecule, TNF receptor superfamily member 5
chr1_+_43539239 0.756 NM_005424
TIE1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr5_-_54317102 0.755 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr21_-_38792173 0.754 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr17_-_77422526 0.749 ARHGDIA
Rho GDP dissociation inhibitor (GDI) alpha
chr5_-_38881636 0.748


chr2_-_215605054 0.747 NM_015657
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr19_+_14412087 0.743 PKN1
protein kinase N1
chr1_-_159306210 0.741 ARHGAP30
Rho GTPase activating protein 30
chr4_+_100957003 0.740 NM_014395
DAPP1
dual adaptor of phosphotyrosine and 3-phosphoinositides
chrX_-_128616594 0.738 NM_017413
APLN
apelin
chr14_+_68935172 0.734 SLC39A9
solute carrier family 39 (zinc transporter), member 9
chr7_+_149842850 0.731 NM_153236
GIMAP7
GTPase, IMAP family member 7
chr7_-_143622188 0.731 ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr11_+_46678892 0.727 NM_024741
ZNF408
zinc finger protein 408
chr4_+_2783764 0.726 SH3BP2
SH3-domain binding protein 2
chr13_-_45654292 0.723 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr16_+_75782595 0.722 MON1B
MON1 homolog B (yeast)
chr11_+_123398929 0.718 NM_001001953
OR10G9
olfactory receptor, family 10, subfamily G, member 9
chr5_+_180583315 0.718 TRIM41
tripartite motif containing 41
chr16_-_49272741 0.716 NM_001144972
NM_153337
NM_182854
SNX20


sorting nexin 20


chr2_-_73373956 0.714 NM_001965
EGR4
early growth response 4
chr17_-_18890963 0.710 NM_006613
GRAP
GRB2-related adaptor protein
chr17_-_59451662 0.710 NM_001099786
NM_001099787
NM_001099788
NM_001099789
ICAM2



intercellular adhesion molecule 2



chr17_+_4283967 0.704 NM_182538
SPNS3
spinster homolog 3 (Drosophila)
chr12_+_106692291 0.700 NM_203436
ASCL4
achaete-scute complex homolog 4 (Drosophila)
chr16_+_29582069 0.699 NM_003123
SPN
sialophorin
chr1_+_179719338 0.699 NM_000721
CACNA1E
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr3_+_123817151 0.697 NM_152615
PARP15
poly (ADP-ribose) polymerase family, member 15
chr2_-_213724577 0.694 NM_001079526
IKZF2
IKAROS family zinc finger 2 (Helios)
chr11_+_59979857 0.691 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr14_-_104602784 0.689 NM_013345
GPR132
G protein-coupled receptor 132
chr5_-_169657192 0.688 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr11_-_74818685 0.688 KLHL35
kelch-like 35 (Drosophila)
chr19_-_10166536 0.686 DNMT1
DNA (cytosine-5-)-methyltransferase 1
chr12_+_47162552 0.685 NM_152319
C12orf54
chromosome 12 open reading frame 54
chr14_-_104602809 0.684 GPR132
G protein-coupled receptor 132

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.61 1.30e-13 GO:0006955 immune response
1.44 4.03e-12 GO:0002376 immune system process
1.73 1.12e-10 GO:0050776 regulation of immune response
1.33 4.09e-10 GO:0048583 regulation of response to stimulus
1.55 1.84e-09 GO:0002682 regulation of immune system process
1.63 9.18e-09 GO:0001775 cell activation
1.21 1.85e-08 GO:0007165 signal transduction
1.66 1.85e-08 GO:0002684 positive regulation of immune system process
1.14 3.66e-08 GO:0050896 response to stimulus
1.87 1.35e-07 GO:0002694 regulation of leukocyte activation
1.98 1.74e-07 GO:0050867 positive regulation of cell activation
1.99 1.77e-07 GO:0002696 positive regulation of leukocyte activation
2.03 1.83e-07 GO:0051251 positive regulation of lymphocyte activation
1.83 2.89e-07 GO:0050865 regulation of cell activation
1.19 4.69e-07 GO:0023052 signaling
1.88 4.85e-07 GO:0051249 regulation of lymphocyte activation
1.90 7.30e-06 GO:0002764 immune response-regulating signaling pathway
2.24 1.44e-05 GO:0050851 antigen receptor-mediated signaling pathway
1.16 1.62e-05 GO:0051716 cellular response to stimulus
2.15 1.84e-05 GO:0002768 immune response-regulating cell surface receptor signaling pathway
1.87 3.82e-05 GO:0002757 immune response-activating signal transduction
1.73 4.55e-05 GO:0045321 leukocyte activation
1.39 4.74e-05 GO:0006952 defense response
1.93 5.34e-05 GO:0002697 regulation of immune effector process
1.25 6.35e-05 GO:0007166 cell surface receptor linked signaling pathway
2.92 6.68e-05 GO:0030888 regulation of B cell proliferation
1.65 1.17e-04 GO:0050778 positive regulation of immune response
2.11 1.26e-04 GO:0002429 immune response-activating cell surface receptor signaling pathway
2.08 2.68e-04 GO:0050670 regulation of lymphocyte proliferation
1.92 3.25e-04 GO:0050870 positive regulation of T cell activation
1.28 3.47e-04 GO:0035556 intracellular signal transduction
1.82 3.57e-04 GO:0050863 regulation of T cell activation
2.06 3.93e-04 GO:0032944 regulation of mononuclear cell proliferation
2.05 3.95e-04 GO:0070663 regulation of leukocyte proliferation
2.70 6.15e-04 GO:0050871 positive regulation of B cell activation
1.57 9.35e-04 GO:0031347 regulation of defense response
2.19 1.46e-03 GO:0050852 T cell receptor signaling pathway
3.01 1.79e-03 GO:0030890 positive regulation of B cell proliferation
1.50 2.38e-03 GO:0007264 small GTPase mediated signal transduction
1.64 2.85e-03 GO:0030168 platelet activation
2.29 3.58e-03 GO:0050864 regulation of B cell activation
1.70 3.72e-03 GO:0046649 lymphocyte activation
1.50 4.15e-03 GO:0045087 innate immune response
1.64 4.61e-03 GO:0002253 activation of immune response
1.42 5.26e-03 GO:0080134 regulation of response to stress
2.12 7.09e-03 GO:0050671 positive regulation of lymphocyte proliferation
2.10 1.05e-02 GO:0032946 positive regulation of mononuclear cell proliferation
2.07 1.55e-02 GO:0070665 positive regulation of leukocyte proliferation
1.44 1.56e-02 GO:0007608 sensory perception of smell
1.87 1.63e-02 GO:0035023 regulation of Rho protein signal transduction
1.29 1.96e-02 GO:0009611 response to wounding
1.17 2.11e-02 GO:0006950 response to stress
2.14 3.06e-02 GO:0031294 lymphocyte costimulation
2.14 3.06e-02 GO:0031295 T cell costimulation
2.79 3.45e-02 GO:0050690 regulation of defense response to virus by virus
1.45 4.40e-02 GO:0051056 regulation of small GTPase mediated signal transduction
1.51 4.52e-02 GO:0006954 inflammatory response
1.22 4.71e-02 GO:0009966 regulation of signal transduction

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.19 3.21e-10 GO:0071944 cell periphery
1.19 5.18e-10 GO:0005886 plasma membrane
1.10 2.63e-07 GO:0016020 membrane
1.11 1.07e-05 GO:0044425 membrane part
1.11 7.77e-04 GO:0016021 integral to membrane
1.10 9.02e-04 GO:0031224 intrinsic to membrane
1.73 5.34e-03 GO:0009897 external side of plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.33 1.08e-12 GO:0004871 signal transducer activity
1.33 1.08e-12 GO:0060089 molecular transducer activity
1.34 3.99e-11 GO:0004872 receptor activity
1.35 4.59e-08 GO:0004888 transmembrane receptor activity
1.40 2.32e-06 GO:0004930 G-protein coupled receptor activity
1.47 1.32e-03 GO:0004984 olfactory receptor activity
2.44 9.18e-03 GO:0003823 antigen binding
1.94 4.67e-02 GO:0005089 Rho guanyl-nucleotide exchange factor activity
1.36 4.72e-02 GO:0030695 GTPase regulator activity