Motif ID: HBP1_HMGB_SSRP1_UBTF.p2

Z-value: 1.668


Transcription factors associated with HBP1_HMGB_SSRP1_UBTF.p2:

Gene SymbolEntrez IDGene Name
HBP1 26959 HMG-box transcription factor 1
HMGB2 3148 high-mobility group box 2
HMGB3 3149 high-mobility group box 3
SSRP1 6749 structure specific recognition protein 1
UBTF 7343 upstream binding transcription factor, RNA polymerase I

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
UBTFchr17_-_396523910.224.0e-01Click!
HMGB2chr4_-_174492029-0.224.0e-01Click!
HBP1chr7_+_1065966410.077.8e-01Click!
HMGB3chrX_+_1499024150.039.2e-01Click!
SSRP1chr11_-_568599000.029.3e-01Click!


Activity profile for motif HBP1_HMGB_SSRP1_UBTF.p2.

activity profile for motif HBP1_HMGB_SSRP1_UBTF.p2


Sorted Z-values histogram for motif HBP1_HMGB_SSRP1_UBTF.p2

Sorted Z-values for motif HBP1_HMGB_SSRP1_UBTF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HBP1_HMGB_SSRP1_UBTF.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_12398514 3.302 NM_001168319
NM_001955
EDN1

endothelin 1

chr7_+_134114912 2.473 CALD1
caldesmon 1
chr7_+_134114957 2.470 CALD1
caldesmon 1
chr6_+_148705421 2.356 NM_015278
SASH1
SAM and SH3 domain containing 1
chr16_+_85169615 2.303 NM_005250
FOXL1
forkhead box L1
chr13_-_73606362 2.077 KLF12
Kruppel-like factor 12
chr2_+_101874809 2.025 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr6_+_114285209 2.021 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr4_+_86918882 1.962 ARHGAP24
Rho GTPase activating protein 24
chr9_+_18464090 1.957 NM_001040272
NM_052866
ADAMTSL1

ADAMTS-like 1

chr3_-_116272911 1.904 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr12_-_16649211 1.902 LMO3
LIM domain only 3 (rhombotin-like 2)
chr13_-_73605914 1.852 NM_007249
KLF12
Kruppel-like factor 12
chr12_+_13240987 1.828 EMP1
epithelial membrane protein 1
chrX_-_99778340 1.802 NM_003270
TSPAN6
tetraspanin 6
chr9_+_18464138 1.798 ADAMTSL1
ADAMTS-like 1
chr5_-_111119846 1.786 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr11_-_85107569 1.774 NM_206929
SYTL2
synaptotagmin-like 2
chr9_+_27099138 1.734 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr1_-_197173159 1.674 LOC100131234
familial acute myelogenous leukemia related factor
chr2_-_39310176 1.621 NM_001009565
CDKL4
cyclin-dependent kinase-like 4
chr2_+_101874765 1.580 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr13_+_23742846 1.555 SPATA13
spermatogenesis associated 13
chr2_-_215953818 1.530 FN1
fibronectin 1
chr11_+_20005704 1.510 NAV2
neuron navigator 2
chr2_-_215967442 1.500 FN1
fibronectin 1
chr15_+_47502666 1.487 NM_002009
FGF7
fibroblast growth factor 7
chr12_-_88270375 1.481 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr13_-_109757442 1.478 NM_001845
COL4A1
collagen, type IV, alpha 1
chr8_+_32623792 1.469 NM_013959
NRG1
neuregulin 1
chr11_+_112337199 1.469 NM_000615
NM_001076682
NM_181351
NCAM1


neural cell adhesion molecule 1


chr1_+_85819004 1.465 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr3_-_188936941 1.460 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr7_-_27186400 1.453 NM_153715
HOXA10
homeobox A10
chr7_+_134226690 1.441 NM_033139
NM_033140
CALD1

caldesmon 1

chr11_+_19328846 1.436 NM_001111018
NAV2
neuron navigator 2
chr6_+_148705817 1.413 SASH1
SAM and SH3 domain containing 1
chr11_+_112337299 1.397 NCAM1
neural cell adhesion molecule 1
chr2_-_215955206 1.390 FN1
fibronectin 1
chr6_+_148705646 1.389 SASH1
SAM and SH3 domain containing 1
chr5_+_15553288 1.381 NM_012304
FBXL7
F-box and leucine-rich repeat protein 7
chr9_+_102380156 1.368 NM_001018116
MURC
muscle-related coiled-coil protein
chr2_+_69093641 1.324 NM_018153
NM_032208
NM_053034
ANTXR1


anthrax toxin receptor 1


chr7_-_47588160 1.310 TNS3
tensin 3
chr2_-_175578156 1.296 NM_001025201
NM_001822
CHN1

chimerin (chimaerin) 1

chr11_+_101488380 1.288 NM_001195045
YAP1
Yes-associated protein 1
chr6_-_128883125 1.267 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr9_-_16717887 1.260 BNC2
basonuclin 2
chr7_-_41709191 1.255 NM_002192
INHBA
inhibin, beta A
chr4_+_3264509 1.243 RGS12
regulator of G-protein signaling 12
chr14_+_85066265 1.240 FLRT2
fibronectin leucine rich transmembrane protein 2
chr4_-_138673078 1.224 NM_019035
PCDH18
protocadherin 18
chr9_-_14304036 1.217 NM_001190737
NM_005596
NFIB

nuclear factor I/B

chr15_+_45797977 1.213 NM_020858
NM_024966
NM_153616
NM_153617
NM_153618
NM_153619
SEMA6D





sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D





chr9_-_14303899 1.195 NFIB
nuclear factor I/B
chr1_+_242283906 1.193


chr8_-_18710575 1.181 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr3_+_189425886 1.179 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chrX_+_77889861 1.169 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chr2_+_108571336 1.164 NM_001193488
LIMS1
LIM and senescent cell antigen-like domains 1
chr3_-_71376919 1.141 FOXP1
forkhead box P1
chr4_-_184480572 1.140 NM_001185149
CLDN24
claudin 24
chr17_-_10393664 1.136 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr9_-_14303509 1.133 NFIB
nuclear factor I/B
chr15_+_37330176 1.128 NM_207445
C15orf54
chromosome 15 open reading frame 54
chr10_+_70517823 1.125 NM_002727
SRGN
serglycin
chr1_+_161305188 1.120 NM_005613
RGS4
regulator of G-protein signaling 4
chr3_-_113841967 1.106 CCDC80
coiled-coil domain containing 80
chr3_-_113842133 1.097 CCDC80
coiled-coil domain containing 80
chr5_-_16989371 1.089 NM_012334
MYO10
myosin X
chr7_+_134226727 1.085 CALD1
caldesmon 1
chr21_+_34112456 1.084 ITSN1
intersectin 1 (SH3 domain protein)
chr3_-_115825742 1.083 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr12_+_13240868 1.083 NM_001423
EMP1
epithelial membrane protein 1
chr2_+_85834111 1.072 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr3_-_113842255 1.070 CCDC80
coiled-coil domain containing 80
chr4_+_86918870 1.068 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr6_-_11340886 1.059 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr1_+_242283129 1.059 NM_006352
ZNF238
zinc finger protein 238
chr10_+_114699953 1.057 NM_001146274
NM_001146283
NM_001146284
NM_001146285
NM_001146286
NM_001198525
NM_001198526
NM_001198527
NM_001198528
NM_001198529
NM_001198530
NM_001198531
NM_030756
TCF7L2












transcription factor 7-like 2 (T-cell specific, HMG-box)












chr2_+_101680594 1.051 NM_004834
NM_145686
NM_145687
MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chr11_-_121492010 1.050 NM_001001786
BLID
BH3-like motif containing, cell death inducer
chr6_-_11340887 1.048 NM_006403
NM_182966
NEDD9

neural precursor cell expressed, developmentally down-regulated 9

chr3_-_115960807 1.047 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr6_-_11340869 1.043 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr1_-_85703198 1.042 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr8_-_38445272 1.033 FGFR1
fibroblast growth factor receptor 1
chr2_-_56266408 1.027 LOC100129434
hypothetical LOC100129434
chr17_-_59817654 1.020 PECAM1
platelet/endothelial cell adhesion molecule
chr9_+_108665168 1.011 NM_021224
ZNF462
zinc finger protein 462
chr6_-_134540666 1.001 NM_001143677
SGK1
serum/glucocorticoid regulated kinase 1
chr5_-_38631263 0.998 NM_002310
LIFR
leukemia inhibitory factor receptor alpha
chr5_+_15553736 0.996 FBXL7
F-box and leucine-rich repeat protein 7
chr14_+_20226762 0.996 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr4_-_184478920 0.996 NM_001111319
CLDN22
claudin 22
chr5_+_98132898 0.996 NM_001012761
RGMB
RGM domain family, member B
chr4_-_186814852 0.995 SORBS2
sorbin and SH3 domain containing 2
chr2_-_164300758 0.994 NM_018086
FIGN
fidgetin
chr14_-_30927931 0.990 NM_015473
HEATR5A
HEAT repeat containing 5A
chr5_+_15553539 0.973 FBXL7
F-box and leucine-rich repeat protein 7
chr13_-_32678142 0.972 NM_052851
STARD13
StAR-related lipid transfer (START) domain containing 13
chr10_+_123913094 0.959 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chrX_+_86659370 0.958 NM_019117
NM_057162
KLHL4

kelch-like 4 (Drosophila)

chr7_-_47588266 0.954 TNS3
tensin 3
chr1_-_85816520 0.954 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr8_-_93099040 0.952 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr1_-_95165089 0.951 NM_001839
CNN3
calponin 3, acidic
chr5_-_121441910 0.947 NM_002317
LOX
lysyl oxidase
chr7_-_27149750 0.947 NM_019102
HOXA5
homeobox A5
chr15_+_97009194 0.946 IGF1R
insulin-like growth factor 1 receptor
chr19_+_12995782 0.931 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr2_+_189547377 0.930 COL3A1
collagen, type III, alpha 1
chr17_-_1359745 0.923 INPP5K
inositol polyphosphate-5-phosphatase K
chr1_+_162795538 0.922 PBX1
pre-B-cell leukemia homeobox 1
chr8_-_124622434 0.916 NM_058229
FBXO32
F-box protein 32
chr11_+_120478584 0.916 NM_005422
TECTA
tectorin alpha
chr8_-_38444982 0.915 FGFR1
fibroblast growth factor receptor 1
chr7_-_27171673 0.912 NM_152739
HOXA9
homeobox A9
chr12_+_50592379 0.906 NM_001077401
ACVRL1
activin A receptor type II-like 1
chr4_-_40631397 0.904 APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr6_-_56824672 0.898 DST
dystonin
chr2_-_207738858 0.896 NM_003709
KLF7
Kruppel-like factor 7 (ubiquitous)
chr12_-_6103945 0.896 NM_000552
VWF
von Willebrand factor
chr3_-_113842237 0.894 CCDC80
coiled-coil domain containing 80
chr4_-_111777651 0.893 PITX2
paired-like homeodomain 2
chr3_-_158704056 0.890 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr13_-_98428244 0.888 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr5_-_16795336 0.887 MYO10
myosin X
chr13_+_96592051 0.883 MBNL2
muscleblind-like 2 (Drosophila)
chr5_-_39461054 0.883 NM_001343
DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr2_-_188021117 0.882 NM_005795
CALCRL
calcitonin receptor-like
chr4_-_141293572 0.880 MAML3
mastermind-like 3 (Drosophila)
chr5_-_39460687 0.874 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr18_-_21184824 0.874


chr8_+_26491507 0.870 DPYSL2
dihydropyrimidinase-like 2
chr12_-_16652202 0.869 NM_001001395
LMO3
LIM domain only 3 (rhombotin-like 2)
chr8_-_33544184 0.860 NM_024787
RNF122
ring finger protein 122
chr3_-_71625318 0.859 FOXP1
forkhead box P1
chr10_+_63331018 0.857 NM_032199
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr11_+_20001130 0.855 NM_001111019
NAV2
neuron navigator 2
chr7_+_134114701 0.853 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr8_+_70567634 0.853 SULF1
sulfatase 1
chr5_-_83715947 0.851 EDIL3
EGF-like repeats and discoidin I-like domains 3
chr12_-_88270128 0.849 DUSP6
dual specificity phosphatase 6
chr9_+_123501186 0.847 DAB2IP
DAB2 interacting protein
chr8_-_38444675 0.836 FGFR1
fibroblast growth factor receptor 1
chr7_-_47588652 0.831 TNS3
tensin 3
chr6_-_134680888 0.831 NM_001143676
SGK1
serum/glucocorticoid regulated kinase 1
chr2_-_162808123 0.827 NM_004460
FAP
fibroblast activation protein, alpha
chr12_-_88270369 0.826 DUSP6
dual specificity phosphatase 6
chr4_-_159313167 0.826 NM_016613
FAM198B
family with sequence similarity 198, member B
chr14_+_22375753 0.825 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr4_-_159312973 0.825 FAM198B
family with sequence similarity 198, member B
chr17_+_3047559 0.823 NM_012352
OR1A2
olfactory receptor, family 1, subfamily A, member 2
chr8_+_70567581 0.820 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr5_-_83716346 0.819 NM_005711
EDIL3
EGF-like repeats and discoidin I-like domains 3
chr6_+_136214495 0.819 NM_018945
PDE7B
phosphodiesterase 7B
chr6_+_155579788 0.811 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chrX_+_51944658 0.811 NM_001098800
NM_030801
NM_177535
NM_177537
MAGED4
MAGED4B


melanoma antigen family D, 4
melanoma antigen family D, 4B


chr1_-_177106702 0.803 NM_004673
ANGPTL1
angiopoietin-like 1
chr3_-_55496607 0.802 WNT5A
wingless-type MMTV integration site family, member 5A
chr18_+_71051713 0.797 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr1_-_56817823 0.797 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr14_+_76298693 0.796 VASH1
vasohibin 1
chr7_-_47545717 0.794 NM_022748
TNS3
tensin 3
chr14_+_22375747 0.789 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr19_+_40824486 0.788 NM_014209
ETV2
ets variant 2
chr13_+_75232797 0.785 NM_015842
LMO7
LIM domain 7
chr15_-_68781662 0.784 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr12_+_32546243 0.784 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr5_-_64813459 0.780 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr4_-_186969041 0.779 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr12_+_50633430 0.778 NM_020327
ACVR1B
activin A receptor, type IB
chr20_+_11846536 0.778 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr3_-_150903749 0.775 NM_001168278
WWTR1
WW domain containing transcription regulator 1
chr2_-_1727220 0.771 PXDN
peroxidasin homolog (Drosophila)
chr16_-_71639670 0.769 NM_006885
ZFHX3
zinc finger homeobox 3
chr17_+_30472710 0.768 NM_017559
FNDC8
fibronectin type III domain containing 8
chr7_+_93388951 0.762 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr4_-_83566802 0.761 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr2_-_128138435 0.760 NM_017980
LIMS2
LIM and senescent cell antigen-like domains 2
chr5_-_146813343 0.755 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr17_+_16886491 0.754 NM_015134
NM_201274
MPRIP

myosin phosphatase Rho interacting protein

chr9_+_36026900 0.754 NM_021111
RECK
reversion-inducing-cysteine-rich protein with kazal motifs
chr1_-_199742871 0.753 NM_001193570
NM_004078
CSRP1

cysteine and glycine-rich protein 1

chr8_+_60194328 0.749


chr4_-_5941043 0.748 CRMP1
collapsin response mediator protein 1
chr15_+_22751162 0.748 NM_003097
NM_022804
NM_005678
SNRPN
SNURF

small nuclear ribonucleoprotein polypeptide N
SNRPN upstream reading frame

chr16_+_54072969 0.747 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr5_-_121441866 0.740 LOX
lysyl oxidase
chr13_+_110653407 0.740 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr18_-_21186107 0.737 NM_015461
ZNF521
zinc finger protein 521
chr4_+_87070449 0.732 NM_031305
ARHGAP24
Rho GTPase activating protein 24
chr2_-_192420168 0.732 NM_004657
SDPR
serum deprivation response
chr1_-_230717850 0.730 NM_020808
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr16_+_88517187 0.728 NM_006086
TUBB3
tubulin, beta 3
chr14_+_62740878 0.727 NM_020663
RHOJ
ras homolog gene family, member J
chr20_-_2589476 0.724 IDH3B
isocitrate dehydrogenase 3 (NAD+) beta
chr15_-_75259714 0.723 PEAK1
NKF3 kinase family member
chr6_-_53034547 0.723 NM_014920
NM_016513
ICK

intestinal cell (MAK-like) kinase


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.38 8.78e-12 GO:0048731 system development
1.34 1.02e-11 GO:0007275 multicellular organismal development
1.32 1.13e-11 GO:0032502 developmental process
1.36 1.32e-11 GO:0048856 anatomical structure development
1.40 6.04e-10 GO:0048519 negative regulation of biological process
1.41 1.21e-09 GO:0048523 negative regulation of cellular process
1.51 1.32e-09 GO:0009653 anatomical structure morphogenesis
1.50 3.05e-09 GO:0007399 nervous system development
1.18 6.61e-09 GO:0050794 regulation of cellular process
1.74 7.33e-08 GO:0007167 enzyme linked receptor protein signaling pathway
1.68 8.14e-08 GO:2000026 regulation of multicellular organismal development
1.16 1.48e-07 GO:0050789 regulation of biological process
1.34 3.55e-07 GO:0048522 positive regulation of cellular process
1.46 3.78e-07 GO:0009966 regulation of signal transduction
1.15 5.78e-07 GO:0065007 biological regulation
1.36 1.39e-06 GO:0030154 cell differentiation
1.30 2.10e-06 GO:0048518 positive regulation of biological process
1.35 2.16e-06 GO:0048869 cellular developmental process
1.81 2.37e-06 GO:0072358 cardiovascular system development
1.81 2.37e-06 GO:0072359 circulatory system development
2.08 3.15e-06 GO:0001568 blood vessel development
1.59 3.83e-06 GO:0051128 regulation of cellular component organization
1.26 4.34e-06 GO:0016043 cellular component organization
2.02 6.36e-06 GO:0001944 vasculature development
1.54 8.32e-06 GO:0022008 neurogenesis
1.54 9.14e-06 GO:0050793 regulation of developmental process
1.65 1.69e-05 GO:0032989 cellular component morphogenesis
1.39 1.84e-05 GO:0023051 regulation of signaling
1.19 2.22e-05 GO:0032501 multicellular organismal process
1.62 2.51e-05 GO:0045595 regulation of cell differentiation
1.97 2.60e-05 GO:0030029 actin filament-based process
1.54 2.75e-05 GO:0048699 generation of neurons
1.66 2.78e-05 GO:0000902 cell morphogenesis
1.24 2.92e-05 GO:0071840 cellular component organization or biogenesis
1.72 3.01e-05 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
2.86 3.84e-05 GO:0051271 negative regulation of cellular component movement
1.89 8.43e-05 GO:0060284 regulation of cell development
1.70 8.49e-05 GO:0000904 cell morphogenesis involved in differentiation
1.93 1.04e-04 GO:0051270 regulation of cellular component movement
1.62 1.54e-04 GO:0010629 negative regulation of gene expression
1.96 2.11e-04 GO:0030334 regulation of cell migration
1.86 2.20e-04 GO:0001501 skeletal system development
1.72 2.61e-04 GO:0048812 neuron projection morphogenesis
1.22 2.67e-04 GO:0023052 signaling
2.37 2.85e-04 GO:0048705 skeletal system morphogenesis
1.73 3.10e-04 GO:0007409 axonogenesis
1.97 3.13e-04 GO:0030036 actin cytoskeleton organization
2.79 3.38e-04 GO:0030336 negative regulation of cell migration
2.79 3.38e-04 GO:2000146 negative regulation of cell motility
1.94 3.45e-04 GO:2000145 regulation of cell motility
2.04 3.59e-04 GO:0048514 blood vessel morphogenesis
1.53 4.64e-04 GO:0007155 cell adhesion
1.53 4.64e-04 GO:0022610 biological adhesion
1.22 4.67e-04 GO:0007165 signal transduction
2.00 5.03e-04 GO:0048011 nerve growth factor receptor signaling pathway
1.66 5.10e-04 GO:0048858 cell projection morphogenesis
1.85 5.40e-04 GO:0022603 regulation of anatomical structure morphogenesis
1.66 5.53e-04 GO:0007010 cytoskeleton organization
1.64 7.95e-04 GO:0032990 cell part morphogenesis
1.21 8.32e-04 GO:0031323 regulation of cellular metabolic process
1.69 8.65e-04 GO:0048667 cell morphogenesis involved in neuron differentiation
1.57 9.73e-04 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.08 1.00e-03 GO:0009987 cellular process
1.48 1.03e-03 GO:0040011 locomotion
1.55 1.22e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.25 1.28e-03 GO:0071842 cellular component organization at cellular level
2.55 1.29e-03 GO:0040013 negative regulation of locomotion
1.61 1.31e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.31 1.34e-03 GO:0048583 regulation of response to stimulus
1.46 1.53e-03 GO:0006351 transcription, DNA-dependent
1.45 1.95e-03 GO:0048468 cell development
1.21 1.95e-03 GO:0060255 regulation of macromolecule metabolic process
1.78 2.07e-03 GO:0051093 negative regulation of developmental process
1.21 2.30e-03 GO:0080090 regulation of primary metabolic process
1.45 2.34e-03 GO:0010605 negative regulation of macromolecule metabolic process
1.65 2.74e-03 GO:0051094 positive regulation of developmental process
1.63 2.74e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.69 2.91e-03 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.51 3.07e-03 GO:0030182 neuron differentiation
1.54 3.32e-03 GO:0045893 positive regulation of transcription, DNA-dependent
1.71 3.50e-03 GO:0051056 regulation of small GTPase mediated signal transduction
1.58 3.66e-03 GO:0051253 negative regulation of RNA metabolic process
2.30 4.26e-03 GO:0006469 negative regulation of protein kinase activity
1.61 4.38e-03 GO:0031175 neuron projection development
1.80 4.87e-03 GO:0040012 regulation of locomotion
1.41 5.43e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.62 6.02e-03 GO:0048646 anatomical structure formation involved in morphogenesis
1.95 6.61e-03 GO:0045664 regulation of neuron differentiation
1.94 7.79e-03 GO:0044087 regulation of cellular component biogenesis
1.54 8.11e-03 GO:0048666 neuron development
1.40 8.32e-03 GO:0009892 negative regulation of metabolic process
1.82 8.74e-03 GO:0045596 negative regulation of cell differentiation
1.50 8.86e-03 GO:0051254 positive regulation of RNA metabolic process
1.23 1.02e-02 GO:0071841 cellular component organization or biogenesis at cellular level
1.50 1.27e-02 GO:0030030 cell projection organization
1.48 1.33e-02 GO:0009790 embryo development
1.18 1.45e-02 GO:0019222 regulation of metabolic process
2.18 1.59e-02 GO:0033673 negative regulation of kinase activity
1.41 1.77e-02 GO:0031324 negative regulation of cellular metabolic process
1.48 1.89e-02 GO:0031327 negative regulation of cellular biosynthetic process
1.62 1.92e-02 GO:0009968 negative regulation of signal transduction
1.56 1.93e-02 GO:0048585 negative regulation of response to stimulus
1.69 2.05e-02 GO:0007411 axon guidance
1.23 2.06e-02 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.73 2.07e-02 GO:0016337 cell-cell adhesion
1.73 2.07e-02 GO:0051130 positive regulation of cellular component organization
2.09 2.44e-02 GO:0007156 homophilic cell adhesion
1.22 2.45e-02 GO:0010468 regulation of gene expression
1.16 2.62e-02 GO:0044260 cellular macromolecule metabolic process
1.17 2.66e-02 GO:0051716 cellular response to stimulus
1.75 2.76e-02 GO:0061061 muscle structure development
2.44 2.85e-02 GO:0048706 embryonic skeletal system development
2.13 2.93e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.46 3.28e-02 GO:0009890 negative regulation of biosynthetic process
2.11 3.57e-02 GO:0022604 regulation of cell morphogenesis
1.67 3.99e-02 GO:0032535 regulation of cellular component size
1.59 4.05e-02 GO:0008285 negative regulation of cell proliferation
2.18 4.18e-02 GO:0035023 regulation of Rho protein signal transduction
1.43 4.27e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
5.39 4.31e-02 GO:0001953 negative regulation of cell-matrix adhesion
1.43 4.40e-02 GO:0010557 positive regulation of macromolecule biosynthetic process
1.66 4.47e-02 GO:0045597 positive regulation of cell differentiation
1.77 4.74e-02 GO:0050767 regulation of neurogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.23 3.78e-12 GO:0005634 nucleus
1.10 2.04e-09 GO:0044424 intracellular part
1.10 5.82e-09 GO:0005622 intracellular
3.18 1.92e-08 GO:0030027 lamellipodium
1.38 1.64e-07 GO:0031981 nuclear lumen
2.32 2.94e-07 GO:0031252 cell leading edge
2.75 3.42e-07 GO:0030055 cell-substrate junction
2.77 1.10e-06 GO:0005925 focal adhesion
2.39 1.67e-06 GO:0005912 adherens junction
2.29 2.69e-06 GO:0070161 anchoring junction
1.10 4.49e-06 GO:0043229 intracellular organelle
1.10 4.66e-06 GO:0043226 organelle
2.64 5.25e-06 GO:0005924 cell-substrate adherens junction
1.37 1.51e-05 GO:0005856 cytoskeleton
1.40 2.21e-05 GO:0005654 nucleoplasm
1.30 2.42e-05 GO:0044428 nuclear part
1.51 1.61e-04 GO:0044451 nucleoplasm part
1.82 1.92e-04 GO:0015629 actin cytoskeleton
1.26 2.47e-04 GO:0043233 organelle lumen
1.24 2.84e-04 GO:0043228 non-membrane-bounded organelle
1.24 2.84e-04 GO:0043232 intracellular non-membrane-bounded organelle
1.26 3.67e-04 GO:0031974 membrane-enclosed lumen
1.54 4.74e-04 GO:0030054 cell junction
1.25 1.51e-03 GO:0070013 intracellular organelle lumen
1.09 2.89e-03 GO:0043231 intracellular membrane-bounded organelle
1.09 3.71e-03 GO:0043227 membrane-bounded organelle
3.37 4.09e-03 GO:0042641 actomyosin
1.25 4.36e-03 GO:0005829 cytosol
2.17 4.94e-03 GO:0044420 extracellular matrix part
1.78 5.88e-03 GO:0016323 basolateral plasma membrane
1.09 8.57e-03 GO:0005737 cytoplasm
2.10 1.33e-02 GO:0044449 contractile fiber part
1.63 1.63e-02 GO:0005578 proteinaceous extracellular matrix
2.05 2.34e-02 GO:0030016 myofibril
1.72 3.24e-02 GO:0016604 nuclear body
1.99 3.28e-02 GO:0043292 contractile fiber

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.24 2.11e-20 GO:0005515 protein binding
1.11 1.83e-13 GO:0005488 binding
1.97 1.26e-12 GO:0008092 cytoskeletal protein binding
2.14 5.12e-10 GO:0003779 actin binding
1.47 2.54e-05 GO:0001071 nucleic acid binding transcription factor activity
1.47 2.54e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.53 6.41e-05 GO:0019899 enzyme binding
1.44 1.05e-04 GO:0030528 transcription regulator activity
1.22 1.46e-04 GO:0003676 nucleic acid binding
3.30 3.42e-04 GO:0008013 beta-catenin binding
1.51 5.08e-04 GO:0043565 sequence-specific DNA binding
1.25 1.20e-03 GO:0003677 DNA binding
2.44 1.36e-03 GO:0005088 Ras guanyl-nucleotide exchange factor activity
2.54 4.53e-03 GO:0005089 Rho guanyl-nucleotide exchange factor activity
1.72 5.19e-03 GO:0005083 small GTPase regulator activity
1.55 7.25e-03 GO:0030695 GTPase regulator activity
1.55 7.34e-03 GO:0060589 nucleoside-triphosphatase regulator activity
1.36 1.70e-02 GO:0030234 enzyme regulator activity
2.15 1.80e-02 GO:0019838 growth factor binding
1.23 2.24e-02 GO:0008270 zinc ion binding
1.42 3.43e-02 GO:0005509 calcium ion binding