Motif ID: HIC1.p2

Z-value: 3.882


Transcription factors associated with HIC1.p2:

Gene SymbolEntrez IDGene Name
HIC1 3090 hypermethylated in cancer 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HIC1chr17_+_19062620.731.3e-03Click!


Activity profile for motif HIC1.p2.

activity profile for motif HIC1.p2


Sorted Z-values histogram for motif HIC1.p2

Sorted Z-values for motif HIC1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_109757442 5.977 NM_001845
COL4A1
collagen, type IV, alpha 1
chr14_+_105012106 5.626 NM_001312
CRIP2
cysteine-rich protein 2
chr9_+_115958051 5.473 NM_032888
COL27A1
collagen, type XXVII, alpha 1
chr13_+_109757593 5.327 NM_001846
COL4A2
collagen, type IV, alpha 2
chr1_+_22909916 5.072 NM_004442
NM_017449
EPHB2

EPH receptor B2

chr19_-_61324456 4.747 NM_001002836
ZNF787
zinc finger protein 787
chr14_+_104402626 4.700 NM_001112726
NM_015005
KIAA0284

KIAA0284

chr5_-_171813960 4.413 SH3PXD2B
SH3 and PX domains 2B
chr11_-_11987414 4.402 DKK3
dickkopf homolog 3 (Xenopus laevis)
chr9_+_123501186 4.393 DAB2IP
DAB2 interacting protein
chr16_-_4106186 4.107 NM_001116
ADCY9
adenylate cyclase 9
chr5_+_92946348 4.099 NR2F1
nuclear receptor subfamily 2, group F, member 1
chr2_+_235525355 4.080 NM_014521
SH3BP4
SH3-domain binding protein 4
chr9_-_139060285 3.921 NPDC1
neural proliferation, differentiation and control, 1
chr11_+_101485946 3.886 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr5_-_171814026 3.864 NM_001017995
SH3PXD2B
SH3 and PX domains 2B
chr11_-_6633427 3.845 NM_003737
DCHS1
dachsous 1 (Drosophila)
chr2_-_235070431 3.623 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr12_+_95112131 3.604 NM_005230
ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr7_-_44331544 3.553 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr10_+_134060681 3.498 NM_001098637
NM_138499
PWWP2B

PWWP domain containing 2B

chr9_-_135847106 3.435 NM_001134398
NM_003371
VAV2

vav 2 guanine nucleotide exchange factor

chr8_+_142207866 3.381 NM_014957
DENND3
DENN/MADD domain containing 3
chr9_-_71476917 3.365 NM_001163
APBA1
amyloid beta (A4) precursor protein-binding, family A, member 1
chr14_+_103621768 3.365 NM_001080464
ASPG
asparaginase homolog (S. cerevisiae)
chr16_-_4106022 3.343 ADCY9
adenylate cyclase 9
chr16_-_79395379 3.195 NM_152342
CDYL2
chromodomain protein, Y-like 2
chr12_-_131415854 3.133 NM_001122636
GALNT9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)
chr12_+_119562737 3.058 NM_001033677
CABP1
calcium binding protein 1
chr13_+_97593711 2.999 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr13_+_26029879 2.937 WASF3
WAS protein family, member 3
chr8_+_32525269 2.929 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr12_-_41269679 2.908 NM_153026
PRICKLE1
prickle homolog 1 (Drosophila)
chr12_+_3056781 2.894 NM_001168320
NM_006675
TSPAN9

tetraspanin 9

chr9_+_136673534 2.888 COL5A1
collagen, type V, alpha 1
chr13_-_109236897 2.883 NM_003749
IRS2
insulin receptor substrate 2
chr13_+_97593469 2.831 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr5_-_2804768 2.825 NM_001134222
NM_033267
IRX2

iroquois homeobox 2

chr9_-_139060377 2.798 NPDC1
neural proliferation, differentiation and control, 1
chr1_+_22762575 2.793 NM_001006943
NM_020526
EPHA8

EPH receptor A8

chr12_+_95112385 2.774 ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr9_-_21549696 2.773 LOC554202
hypothetical LOC554202
chr15_+_99237527 2.737 NM_000693
ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr4_+_77829743 2.733 SHROOM3
shroom family member 3
chr12_-_123023052 2.729 NM_025140
CCDC92
coiled-coil domain containing 92
chr2_+_241023908 2.718 GPC1
glypican 1
chr16_+_2016807 2.679 NM_001130012
NM_004785
SLC9A3R2

solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2

chr2_-_1727247 2.676 PXDN
peroxidasin homolog (Drosophila)
chr5_+_14196287 2.675 NM_007118
TRIO
triple functional domain (PTPRF interacting)
chr14_-_104515738 2.675 NM_138420
AHNAK2
AHNAK nucleoprotein 2
chr19_+_49943773 2.636 NM_005178
BCL3
B-cell CLL/lymphoma 3
chr16_-_4105703 2.628 ADCY9
adenylate cyclase 9
chr15_+_78774664 2.622 NM_021214
FAM108C1
family with sequence similarity 108, member C1
chr10_-_99521701 2.620 NM_003015
SFRP5
secreted frizzled-related protein 5
chr11_-_11987458 2.606 NM_013253
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr19_-_6230927 2.574 NM_005934
MLLT1
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
chr6_-_170441493 2.524 NM_005618
DLL1
delta-like 1 (Drosophila)
chr9_+_136358145 2.522 RXRA
retinoid X receptor, alpha
chr4_-_177950658 2.514 NM_005429
VEGFC
vascular endothelial growth factor C
chr6_+_72055235 2.491 OGFRL1
opioid growth factor receptor-like 1
chr11_-_525532 2.470 NM_001130442
NM_005343
NM_176795
HRAS


v-Ha-ras Harvey rat sarcoma viral oncogene homolog


chr7_-_27136876 2.450 NM_002141
HOXA4
homeobox A4
chr18_+_74841262 2.432 NM_171999
SALL3
sal-like 3 (Drosophila)
chr3_-_129024665 2.420 NM_001003794
MGLL
monoglyceride lipase
chr14_+_92049396 2.417 NM_024832
RIN3
Ras and Rab interactor 3
chr2_-_127580975 2.413 NM_004305
NM_139343
NM_139344
NM_139345
NM_139346
NM_139347
NM_139348
NM_139349
NM_139350
NM_139351
BIN1









bridging integrator 1









chr8_+_27547379 2.407 NM_016240
NM_182826
SCARA3

scavenger receptor class A, member 3

chr14_+_104226769 2.396 NM_001031714
NM_022489
NM_032714
INF2


inverted formin, FH2 and WH2 domain containing


chr2_-_233501069 2.393 NM_001114090
NGEF
neuronal guanine nucleotide exchange factor
chr2_-_1727292 2.388 NM_012293
PXDN
peroxidasin homolog (Drosophila)
chr18_+_75540786 2.381 NM_004715
NM_048368
CTDP1

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1

chr11_+_75056343 2.376


chr14_-_103251497 2.361 NM_001100118
NM_001100119
NM_005432
XRCC3


X-ray repair complementing defective repair in Chinese hamster cells 3


chrX_+_9943793 2.329 NM_015691
WWC3
WWC family member 3
chr17_-_24940728 2.273 NM_001085454
NM_014030
GIT1

G protein-coupled receptor kinase interacting ArfGAP 1

chr13_-_39075304 2.270 LHFP
lipoma HMGIC fusion partner
chr10_-_128067001 2.249 ADAM12
ADAM metallopeptidase domain 12
chr9_+_115678365 2.235 NM_133374
ZNF618
zinc finger protein 618
chr3_-_50515857 2.234 NM_001005505
NM_001174051
NM_006030
CACNA2D2


calcium channel, voltage-dependent, alpha 2/delta subunit 2


chr10_+_126140330 2.218 NM_001167880
NM_022126
LHPP

phospholysine phosphohistidine inorganic pyrophosphate phosphatase

chr13_+_26029799 2.212 NM_006646
WASF3
WAS protein family, member 3
chr19_+_38377329 2.209 NM_002333
LRP3
low density lipoprotein receptor-related protein 3
chr2_-_175578156 2.181 NM_001025201
NM_001822
CHN1

chimerin (chimaerin) 1

chr9_-_139060416 2.178 NM_015392
NPDC1
neural proliferation, differentiation and control, 1
chr8_+_26491317 2.178 NM_001386
DPYSL2
dihydropyrimidinase-like 2
chr9_+_115957537 2.174 COL27A1
collagen, type XXVII, alpha 1
chr15_+_90198031 2.164 SLCO3A1
solute carrier organic anion transporter family, member 3A1
chr3_-_130807865 2.161 NM_015103
PLXND1
plexin D1
chr22_+_36286350 2.148 NM_152243
CDC42EP1
CDC42 effector protein (Rho GTPase binding) 1
chr11_-_11987198 2.130 NM_015881
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr9_+_131974506 2.129 NM_014286
NCS1
neuronal calcium sensor 1
chr22_-_41446740 2.127 NM_017436
A4GALT
alpha 1,4-galactosyltransferase
chr8_+_27547303 2.111 SCARA3
scavenger receptor class A, member 3
chr1_+_33494745 2.100 NM_152493
ZNF362
zinc finger protein 362
chr9_+_136358134 2.090 NM_002957
RXRA
retinoid X receptor, alpha
chr3_+_50167424 2.087 SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr19_+_1892157 2.085 NM_001319
CSNK1G2
casein kinase 1, gamma 2
chr1_-_6480058 2.081 NM_001042663
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr6_+_1335067 2.070 NM_001452
FOXF2
forkhead box F2
chr16_+_85158357 2.066 NM_005251
FOXC2
forkhead box C2 (MFH-1, mesenchyme forkhead 1)
chr3_-_126257425 2.062 NM_020733
HEG1
HEG homolog 1 (zebrafish)
chr7_+_2525922 2.057 NM_001040167
NM_001040168
LFNG

LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

chr14_+_51188289 2.043 NM_152330
FRMD6
FERM domain containing 6
chr14_+_85069217 2.040


chr19_+_60803412 2.029 NM_153219
ZNF524
zinc finger protein 524
chr4_-_52599181 2.021 NM_000232
SGCB
sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
chr3_+_50167851 2.020 NM_004186
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr19_+_50004134 2.009 NM_001013257
NM_005581
BCAM

basal cell adhesion molecule (Lutheran blood group)

chr11_-_11987115 2.004 DKK3
dickkopf homolog 3 (Xenopus laevis)
chr8_-_41286088 1.996 NM_003012
SFRP1
secreted frizzled-related protein 1
chr8_-_143855438 1.995 NM_177476
NM_177477
LYNX1

Ly6/neurotoxin 1

chr5_-_146869811 1.992 NM_001197294
DPYSL3
dihydropyrimidinase-like 3
chr9_+_136673464 1.979 NM_000093
COL5A1
collagen, type V, alpha 1
chr1_-_22136263 1.967 NM_005529
HSPG2
heparan sulfate proteoglycan 2
chr11_+_832821 1.962 NM_001025238
NM_001025239
NM_003271
NM_001025235
NM_001025236
TSPAN4




tetraspanin 4




chr3_+_128874458 1.950 NM_172027
ABTB1
ankyrin repeat and BTB (POZ) domain containing 1
chr1_+_19843261 1.948 NM_005380
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr2_+_10969513 1.944 NM_002236
KCNF1
potassium voltage-gated channel, subfamily F, member 1
chr10_+_124124196 1.939 PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr1_+_31659246 1.939 NM_001199039
NM_018565
SERINC2

serine incorporator 2

chr4_-_24523605 1.938 NM_001130726
CCDC149
coiled-coil domain containing 149
chr17_+_5914364 1.935 NM_015253
WSCD1
WSC domain containing 1
chr4_+_151218862 1.935 NM_001040260
NM_001040261
DCLK2

doublecortin-like kinase 2

chr22_-_32646325 1.930 NM_004737
NM_133642
LARGE

like-glycosyltransferase

chr7_+_55054416 1.922 EGFR
epidermal growth factor receptor
chr15_-_81744469 1.919 NM_001717
BNC1
basonuclin 1
chr3_+_30623376 1.906 TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr19_-_2259155 1.882 NM_001101391
LINGO3
leucine rich repeat and Ig domain containing 3
chr20_-_49073023 1.875 NM_002237
KCNG1
potassium voltage-gated channel, subfamily G, member 1
chr18_-_68361742 1.874 CBLN2
cerebellin 2 precursor
chr7_-_131911808 1.870 NM_001105543
NM_020911
PLXNA4

plexin A4

chr13_-_94162249 1.866 NM_007084
SOX21
SRY (sex determining region Y)-box 21
chr2_-_96174865 1.865 NM_004418
DUSP2
dual specificity phosphatase 2
chr12_+_26003218 1.844 NM_001164748
NM_007211
RASSF8

Ras association (RalGDS/AF-6) domain family (N-terminal) member 8

chr17_-_24940521 1.837 GIT1
G protein-coupled receptor kinase interacting ArfGAP 1
chr10_+_128583984 1.832 NM_001380
DOCK1
dedicator of cytokinesis 1
chr18_+_75540831 1.830 CTDP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
chr13_-_100866839 1.829 NALCN
sodium leak channel, non-selective
chr12_-_108802561 1.823 NM_016433
GLTP
glycolipid transfer protein
chr14_+_64240996 1.823 PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr11_+_19691397 1.821 NM_145117
NM_182964
NAV2

neuron navigator 2

chr3_+_71885890 1.821 NM_018971
GPR27
G protein-coupled receptor 27
chr14_+_64240902 1.801 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr14_+_104852225 1.785 PACS2
phosphofurin acidic cluster sorting protein 2
chr19_+_40213431 1.783 NM_001037
NM_199037
SCN1B

sodium channel, voltage-gated, type I, beta

chr16_+_85101605 1.782 NM_001451
FOXF1
forkhead box F1
chr19_-_15204194 1.780 NM_024794
EPHX3
epoxide hydrolase 3
chr12_-_107775462 1.773 NM_001161330
NM_018984
SSH1

slingshot homolog 1 (Drosophila)

chr22_+_31527678 1.766 TIMP3
TIMP metallopeptidase inhibitor 3
chr9_-_13269562 1.757 MPDZ
multiple PDZ domain protein
chr20_+_8997660 1.753 NM_001172646
PLCB4
phospholipase C, beta 4
chr2_+_109112428 1.752 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr17_+_24944605 1.749 NM_152345
ANKRD13B
ankyrin repeat domain 13B
chr7_-_27162688 1.748 NM_006896
HOXA7
homeobox A7
chr19_-_11234117 1.734 NM_020812
DOCK6
dedicator of cytokinesis 6
chr3_-_129023850 1.733 NM_007283
MGLL
monoglyceride lipase
chr9_-_138454071 1.732 NM_019892
INPP5E
inositol polyphosphate-5-phosphatase, 72 kDa
chr17_-_77602938 1.727 NM_002917
RFNG
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr7_+_3307445 1.722 NM_152744
SDK1
sidekick homolog 1, cell adhesion molecule (chicken)
chr20_-_55718351 1.722 NM_020182
PMEPA1
prostate transmembrane protein, androgen induced 1
chr12_+_107047594 1.718 NM_014653
WSCD2
WSC domain containing 2
chr17_+_75689955 1.715 GAA
glucosidase, alpha; acid
chr13_-_39075355 1.715 NM_005780
LHFP
lipoma HMGIC fusion partner
chr15_+_94674849 1.710 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr19_+_15079141 1.709 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr6_+_72055197 1.707 NM_024576
OGFRL1
opioid growth factor receptor-like 1
chr17_+_58058774 1.703 MRC2
mannose receptor, C type 2
chr17_-_74433048 1.703 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr3_-_162305319 1.701 NM_033169
NM_001038628
NM_003781
NM_033167
NM_033168
B3GALNT1




beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)




chr2_-_241408296 1.695 NM_004321
KIF1A
kinesin family member 1A
chr17_-_77422463 1.690 ARHGDIA
Rho GDP dissociation inhibitor (GDI) alpha
chr5_-_146869613 1.686 DPYSL3
dihydropyrimidinase-like 3
chr7_+_2565238 1.676 IQCE
IQ motif containing E
chr1_-_56817717 1.673 PPAP2B
phosphatidic acid phosphatase type 2B
chr19_-_1188840 1.671 NM_152769
C19orf26
chromosome 19 open reading frame 26
chr22_-_19122047 1.671 SCARF2
scavenger receptor class F, member 2
chr5_+_76150588 1.671 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr19_+_748452 1.671 PTBP1
polypyrimidine tract binding protein 1
chr2_+_29191711 1.670 NM_024692
CLIP4
CAP-GLY domain containing linker protein family, member 4
chr14_+_101097440 1.661 NM_001362
DIO3
deiodinase, iodothyronine, type III
chr19_+_748390 1.657 NM_002819
NM_031990
NM_031991
NM_175847
PTBP1



polypyrimidine tract binding protein 1



chr7_-_81910956 1.657 NM_000722
CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr9_-_15297148 1.654 TTC39B
tetratricopeptide repeat domain 39B
chr8_+_37672427 1.650 NM_025069
ZNF703
zinc finger protein 703
chr11_-_112851051 1.648 NM_000795
NM_016574
DRD2

dopamine receptor D2

chr3_-_51976428 1.640 NM_020418
NM_001174100
NM_033008
PCBP4


poly(rC) binding protein 4


chr18_+_54489597 1.635 NM_006785
NM_173844
MALT1

mucosa associated lymphoid tissue lymphoma translocation gene 1

chr11_-_124137260 1.627 NM_138961
ESAM
endothelial cell adhesion molecule
chr8_-_119192985 1.624 NM_000127
EXT1
exostosin 1
chr2_-_242274862 1.622 DTYMK
deoxythymidylate kinase (thymidylate kinase)
chr20_+_4077466 1.621 SMOX
spermine oxidase
chr17_-_75624048 1.620 NM_019020
TBC1D16
TBC1 domain family, member 16
chr22_+_36632242 1.620 NM_033386
MICALL1
MICAL-like 1
chr19_+_748448 1.616 PTBP1
polypyrimidine tract binding protein 1
chr15_+_90197884 1.615 NM_001145044
NM_013272
SLCO3A1

solute carrier organic anion transporter family, member 3A1

chr5_+_76150637 1.612 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr11_+_1367665 1.605 NM_003957
BRSK2
BR serine/threonine kinase 2
chr11_-_44928803 1.604 NM_001076787
NM_006034
TP53I11

tumor protein p53 inducible protein 11

chr8_-_48813236 1.602 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr16_+_4361775 1.602 NM_138440
VASN
vasorin

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.50 1.68e-23 GO:0007399 nervous system development
1.48 2.51e-23 GO:0023051 regulation of signaling
1.49 1.89e-22 GO:0009653 anatomical structure morphogenesis
1.64 5.39e-22 GO:0022008 neurogenesis
1.49 3.05e-21 GO:0009966 regulation of signal transduction
1.64 7.51e-21 GO:0048699 generation of neurons
1.29 2.03e-20 GO:0007275 multicellular organismal development
1.39 2.96e-20 GO:0048869 cellular developmental process
1.32 5.15e-20 GO:0048731 system development
1.39 6.20e-20 GO:0030154 cell differentiation
1.83 1.74e-19 GO:0000904 cell morphogenesis involved in differentiation
1.17 2.01e-19 GO:0050794 regulation of cellular process
1.29 4.00e-19 GO:0048856 anatomical structure development
1.26 4.66e-19 GO:0032502 developmental process
1.59 1.04e-18 GO:0048468 cell development
1.71 2.54e-17 GO:0000902 cell morphogenesis
1.85 4.33e-17 GO:0007409 axonogenesis
1.84 4.47e-17 GO:0048667 cell morphogenesis involved in neuron differentiation
1.65 5.17e-17 GO:0030182 neuron differentiation
1.82 7.28e-17 GO:0048812 neuron projection morphogenesis
1.67 3.74e-16 GO:0032989 cellular component morphogenesis
1.15 7.50e-16 GO:0050789 regulation of biological process
1.74 1.58e-15 GO:0032990 cell part morphogenesis
1.75 2.42e-15 GO:0031175 neuron projection development
1.74 2.70e-15 GO:0048858 cell projection morphogenesis
1.14 6.43e-15 GO:0065007 biological regulation
1.64 7.08e-15 GO:0030030 cell projection organization
1.67 1.76e-14 GO:0048666 neuron development
1.09 1.84e-13 GO:0009987 cellular process
1.22 1.82e-12 GO:0023052 signaling
1.29 4.23e-12 GO:0048519 negative regulation of biological process
1.30 5.16e-12 GO:0048523 negative regulation of cellular process
1.82 5.44e-12 GO:0007411 axon guidance
1.32 1.05e-11 GO:0048583 regulation of response to stimulus
1.43 2.35e-11 GO:0010646 regulation of cell communication
1.66 2.98e-11 GO:0072358 cardiovascular system development
1.66 2.98e-11 GO:0072359 circulatory system development
1.22 1.44e-10 GO:0007165 signal transduction
1.82 2.68e-10 GO:0001944 vasculature development
1.43 2.92e-10 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.78 3.31e-10 GO:0060284 regulation of cell development
1.54 3.55e-10 GO:0007167 enzyme linked receptor protein signaling pathway
1.55 4.19e-10 GO:0045893 positive regulation of transcription, DNA-dependent
1.52 9.29e-10 GO:0051254 positive regulation of RNA metabolic process
1.51 1.68e-09 GO:0010628 positive regulation of gene expression
1.51 2.00e-09 GO:0045595 regulation of cell differentiation
1.25 5.27e-09 GO:0048522 positive regulation of cellular process
1.42 7.05e-09 GO:0050793 regulation of developmental process
1.23 1.17e-08 GO:0071842 cellular component organization at cellular level
1.46 1.43e-08 GO:2000026 regulation of multicellular organismal development
1.79 1.46e-08 GO:0001568 blood vessel development
1.28 2.19e-08 GO:0048513 organ development
1.56 2.24e-08 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.59 2.72e-08 GO:0048646 anatomical structure formation involved in morphogenesis
1.58 3.33e-08 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.19 8.42e-08 GO:0016043 cellular component organization
1.50 9.07e-08 GO:0009887 organ morphogenesis
1.17 1.15e-07 GO:0051716 cellular response to stimulus
1.70 1.34e-07 GO:0022603 regulation of anatomical structure morphogenesis
1.22 1.54e-07 GO:0048518 positive regulation of biological process
1.41 1.55e-07 GO:0040011 locomotion
1.63 2.17e-07 GO:0051056 regulation of small GTPase mediated signal transduction
1.53 2.18e-07 GO:0007417 central nervous system development
2.06 2.74e-07 GO:0030111 regulation of Wnt receptor signaling pathway
1.60 4.45e-07 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
2.06 4.72e-07 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.31 4.98e-07 GO:0035556 intracellular signal transduction
1.42 6.03e-07 GO:0051173 positive regulation of nitrogen compound metabolic process
1.26 6.80e-07 GO:0007166 cell surface receptor linked signaling pathway
1.58 6.95e-07 GO:0009968 negative regulation of signal transduction
1.21 7.01e-07 GO:0071841 cellular component organization or biogenesis at cellular level
2.05 7.49e-07 GO:0022604 regulation of cell morphogenesis
1.71 7.58e-07 GO:0051960 regulation of nervous system development
2.41 9.31e-07 GO:0050770 regulation of axonogenesis
1.78 9.87e-07 GO:0048011 nerve growth factor receptor signaling pathway
1.31 1.23e-06 GO:0051239 regulation of multicellular organismal process
1.50 1.25e-06 GO:0045892 negative regulation of transcription, DNA-dependent
1.74 1.35e-06 GO:0046578 regulation of Ras protein signal transduction
1.41 1.36e-06 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.73 1.76e-06 GO:0050767 regulation of neurogenesis
1.49 2.58e-06 GO:0051253 negative regulation of RNA metabolic process
1.41 2.72e-06 GO:0010557 positive regulation of macromolecule biosynthetic process
1.42 3.59e-06 GO:0009890 negative regulation of biosynthetic process
1.53 3.67e-06 GO:0023057 negative regulation of signaling
1.38 3.94e-06 GO:0009888 tissue development
2.11 4.38e-06 GO:0010720 positive regulation of cell development
1.53 4.54e-06 GO:0010648 negative regulation of cell communication
1.17 5.48e-06 GO:0071840 cellular component organization or biogenesis
1.64 5.48e-06 GO:0048729 tissue morphogenesis
2.21 5.85e-06 GO:0060828 regulation of canonical Wnt receptor signaling pathway
1.49 6.78e-06 GO:0048585 negative regulation of response to stimulus
1.17 1.03e-05 GO:0080090 regulation of primary metabolic process
1.42 1.04e-05 GO:0031327 negative regulation of cellular biosynthetic process
1.42 1.21e-05 GO:0010558 negative regulation of macromolecule biosynthetic process
1.16 1.37e-05 GO:0031323 regulation of cellular metabolic process
1.73 2.32e-05 GO:0048514 blood vessel morphogenesis
1.43 2.56e-05 GO:0010629 negative regulation of gene expression
1.47 2.98e-05 GO:0006935 chemotaxis
1.47 2.98e-05 GO:0042330 taxis
1.55 4.06e-05 GO:0048598 embryonic morphogenesis
1.92 5.09e-05 GO:0048705 skeletal system morphogenesis
1.41 5.92e-05 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.94 5.95e-05 GO:0010975 regulation of neuron projection development
1.35 6.66e-05 GO:0031328 positive regulation of cellular biosynthetic process
1.41 8.17e-05 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.52 8.69e-05 GO:0007264 small GTPase mediated signal transduction
1.41 8.86e-05 GO:0051172 negative regulation of nitrogen compound metabolic process
1.56 9.58e-05 GO:0045597 positive regulation of cell differentiation
1.34 1.00e-04 GO:0009891 positive regulation of biosynthetic process
1.83 1.28e-04 GO:0031344 regulation of cell projection organization
1.71 1.47e-04 GO:0045664 regulation of neuron differentiation
1.28 1.59e-04 GO:0031325 positive regulation of cellular metabolic process
1.56 1.61e-04 GO:0001501 skeletal system development
1.14 1.67e-04 GO:0019222 regulation of metabolic process
1.58 2.25e-04 GO:0051270 regulation of cellular component movement
1.52 2.44e-04 GO:0007420 brain development
1.37 2.48e-04 GO:0009790 embryo development
1.34 3.24e-04 GO:0051128 regulation of cellular component organization
1.46 3.97e-04 GO:0051094 positive regulation of developmental process
1.51 4.50e-04 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.92 4.65e-04 GO:0035023 regulation of Rho protein signal transduction
1.17 4.70e-04 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.19 5.06e-04 GO:0006355 regulation of transcription, DNA-dependent
2.16 5.24e-04 GO:0048638 regulation of developmental growth
1.31 5.35e-04 GO:0010605 negative regulation of macromolecule metabolic process
2.09 6.32e-04 GO:0030178 negative regulation of Wnt receptor signaling pathway
1.57 7.54e-04 GO:0035295 tube development
1.31 8.24e-04 GO:0031324 negative regulation of cellular metabolic process
1.17 8.27e-04 GO:0051171 regulation of nitrogen compound metabolic process
1.31 8.55e-04 GO:0006351 transcription, DNA-dependent
1.27 1.03e-03 GO:0010604 positive regulation of macromolecule metabolic process
1.29 1.07e-03 GO:0009892 negative regulation of metabolic process
1.26 1.10e-03 GO:0009893 positive regulation of metabolic process
1.18 1.24e-03 GO:0051252 regulation of RNA metabolic process
1.73 1.35e-03 GO:0001525 angiogenesis
1.41 1.87e-03 GO:0019226 transmission of nerve impulse
1.41 1.87e-03 GO:0035637 multicellular organismal signaling
2.04 2.11e-03 GO:0050769 positive regulation of neurogenesis
1.40 2.28e-03 GO:0009967 positive regulation of signal transduction
1.14 2.71e-03 GO:0060255 regulation of macromolecule metabolic process
1.28 3.23e-03 GO:0007154 cell communication
1.43 3.47e-03 GO:0032583 regulation of gene-specific transcription
2.38 3.49e-03 GO:0001704 formation of primary germ layer
1.28 4.49e-03 GO:0009605 response to external stimulus
1.73 4.75e-03 GO:0034330 cell junction organization
1.16 5.09e-03 GO:0009889 regulation of biosynthetic process
1.38 5.21e-03 GO:0023056 positive regulation of signaling
1.45 5.79e-03 GO:0043009 chordate embryonic development
1.63 6.02e-03 GO:0032582 negative regulation of gene-specific transcription
1.45 6.68e-03 GO:0009792 embryo development ending in birth or egg hatching
1.58 7.32e-03 GO:0002009 morphogenesis of an epithelium
2.02 7.55e-03 GO:0007173 epidermal growth factor receptor signaling pathway
2.73 7.70e-03 GO:0050771 negative regulation of axonogenesis
1.53 7.78e-03 GO:0045596 negative regulation of cell differentiation
1.54 7.94e-03 GO:0030334 regulation of cell migration
1.27 8.71e-03 GO:0032879 regulation of localization
1.37 8.83e-03 GO:0010647 positive regulation of cell communication
1.15 9.40e-03 GO:0031326 regulation of cellular biosynthetic process
1.16 9.88e-03 GO:0010468 regulation of gene expression
1.50 9.98e-03 GO:0040012 regulation of locomotion
1.54 1.04e-02 GO:0030036 actin cytoskeleton organization
1.10 1.12e-02 GO:0032501 multicellular organismal process
1.38 1.12e-02 GO:0007010 cytoskeleton organization
1.46 1.12e-02 GO:0007389 pattern specification process
1.68 1.19e-02 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
1.43 1.19e-02 GO:0010627 regulation of intracellular protein kinase cascade
2.54 1.27e-02 GO:0030516 regulation of axon extension
1.50 1.28e-02 GO:0007423 sensory organ development
1.21 1.40e-02 GO:0065009 regulation of molecular function
1.52 1.49e-02 GO:2000145 regulation of cell motility
1.16 1.71e-02 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.16 1.78e-02 GO:0042221 response to chemical stimulus
1.65 2.07e-02 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
2.44 2.12e-02 GO:0050772 positive regulation of axonogenesis
1.60 2.69e-02 GO:0035239 tube morphogenesis
1.53 2.76e-02 GO:0048568 embryonic organ development
1.96 3.10e-02 GO:0010721 negative regulation of cell development
2.07 3.33e-02 GO:0050768 negative regulation of neurogenesis
1.66 3.34e-02 GO:0045165 cell fate commitment
1.45 3.49e-02 GO:0051093 negative regulation of developmental process
1.38 3.92e-02 GO:0007268 synaptic transmission
1.15 4.30e-02 GO:0010556 regulation of macromolecule biosynthetic process
2.08 4.39e-02 GO:0042058 regulation of epidermal growth factor receptor signaling pathway
1.89 4.39e-02 GO:0060485 mesenchyme development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.07 5.62e-10 GO:0005622 intracellular
1.07 7.13e-09 GO:0044424 intracellular part
1.48 1.74e-08 GO:0030054 cell junction
1.09 4.87e-08 GO:0005737 cytoplasm
1.95 8.56e-08 GO:0005912 adherens junction
1.85 6.01e-07 GO:0070161 anchoring junction
1.03 9.45e-06 GO:0044464 cell part
1.03 1.02e-05 GO:0005623 cell
2.00 2.80e-05 GO:0005925 focal adhesion
1.69 1.27e-04 GO:0031252 cell leading edge
1.28 2.13e-04 GO:0005794 Golgi apparatus
1.90 2.13e-04 GO:0005924 cell-substrate adherens junction
1.06 2.52e-04 GO:0043226 organelle
1.06 2.95e-04 GO:0043229 intracellular organelle
1.87 3.40e-04 GO:0030055 cell-substrate junction
1.18 5.42e-04 GO:0044459 plasma membrane part
1.41 1.59e-03 GO:0045202 synapse
1.06 1.75e-03 GO:0043231 intracellular membrane-bounded organelle
1.06 1.84e-03 GO:0043227 membrane-bounded organelle
1.09 2.34e-03 GO:0044444 cytoplasmic part
1.26 3.88e-03 GO:0042995 cell projection
1.50 3.90e-03 GO:0005667 transcription factor complex
1.40 7.51e-03 GO:0031012 extracellular matrix
1.34 1.24e-02 GO:0000139 Golgi membrane
1.18 1.94e-02 GO:0012505 endomembrane system
1.42 2.03e-02 GO:0015629 actin cytoskeleton
1.35 3.17e-02 GO:0043005 neuron projection
1.29 3.65e-02 GO:0044431 Golgi apparatus part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.41 3.17e-10 GO:0001071 nucleic acid binding transcription factor activity
1.41 3.17e-10 GO:0003700 sequence-specific DNA binding transcription factor activity
1.39 3.23e-09 GO:0030528 transcription regulator activity
1.11 4.76e-09 GO:0005515 protein binding
1.64 1.18e-07 GO:0003779 actin binding
1.06 1.65e-07 GO:0005488 binding
1.53 2.41e-07 GO:0030695 GTPase regulator activity
1.43 2.85e-07 GO:0043565 sequence-specific DNA binding
1.48 5.27e-07 GO:0008092 cytoskeletal protein binding
1.50 1.46e-06 GO:0060589 nucleoside-triphosphatase regulator activity
1.58 3.49e-05 GO:0005083 small GTPase regulator activity
1.70 5.25e-05 GO:0010843 promoter binding
1.46 7.32e-05 GO:0019904 protein domain specific binding
1.67 9.50e-05 GO:0000975 regulatory region DNA binding
1.67 9.50e-05 GO:0001067 regulatory region nucleic acid binding
1.67 9.50e-05 GO:0044212 transcription regulatory region DNA binding
1.53 3.26e-04 GO:0008134 transcription factor binding
2.07 6.02e-04 GO:0005089 Rho guanyl-nucleotide exchange factor activity
1.71 6.35e-04 GO:0005085 guanyl-nucleotide exchange factor activity
1.82 1.09e-03 GO:0051020 GTPase binding
1.92 1.47e-03 GO:0005088 Ras guanyl-nucleotide exchange factor activity
1.76 8.68e-03 GO:0017124 SH3 domain binding
2.28 1.56e-02 GO:0017048 Rho GTPase binding
1.43 1.59e-02 GO:0016564 transcription repressor activity
1.76 1.87e-02 GO:0031267 small GTPase binding
1.36 2.06e-02 GO:0004674 protein serine/threonine kinase activity
1.79 2.91e-02 GO:0017016 Ras GTPase binding