Motif ID: MTF1.p2

Z-value: 3.259


Transcription factors associated with MTF1.p2:

Gene SymbolEntrez IDGene Name
MTF1 4520 metal-regulatory transcription factor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MTF1chr1_-_38097811-0.312.4e-01Click!


Activity profile for motif MTF1.p2.

activity profile for motif MTF1.p2


Sorted Z-values histogram for motif MTF1.p2

Sorted Z-values for motif MTF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MTF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_105012106 4.952 NM_001312
CRIP2
cysteine-rich protein 2
chr9_+_136358145 4.802 RXRA
retinoid X receptor, alpha
chr16_+_1143738 4.243 CACNA1H
calcium channel, voltage-dependent, T type, alpha 1H subunit
chr9_+_136358134 3.918 NM_002957
RXRA
retinoid X receptor, alpha
chr9_+_115958051 3.638 NM_032888
COL27A1
collagen, type XXVII, alpha 1
chr15_-_76890626 3.618 NM_014272
ADAMTS7
ADAM metallopeptidase with thrombospondin type 1 motif, 7
chr1_-_32002222 3.565 NM_001703
BAI2
brain-specific angiogenesis inhibitor 2
chr10_+_124211353 3.246 HTRA1
HtrA serine peptidase 1
chr6_-_170441493 3.124 NM_005618
DLL1
delta-like 1 (Drosophila)
chr20_-_60228665 3.115 NM_007232
HRH3
histamine receptor H3
chr13_-_105985313 3.096 NM_004093
EFNB2
ephrin-B2
chr19_+_38377329 2.998 NM_002333
LRP3
low density lipoprotein receptor-related protein 3
chr11_+_125279481 2.983 NM_013264
DDX25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr17_+_70495318 2.965 NM_014603
CDR2L
cerebellar degeneration-related protein 2-like
chr15_-_23659329 2.857 NM_024490
ATP10A
ATPase, class V, type 10A
chr3_-_135575925 2.851 NM_016201
AMOTL2
angiomotin like 2
chr2_+_100087812 2.804


chr22_-_23318829 2.784 NM_207644
C22orf36
chromosome 22 open reading frame 36
chr2_+_28469172 2.749 FOSL2
FOS-like antigen 2
chr9_+_90796169 2.748 NM_005226
S1PR3
sphingosine-1-phosphate receptor 3
chr2_+_219532590 2.713 NM_003936
CDK5R2
cyclin-dependent kinase 5, regulatory subunit 2 (p39)
chr6_+_35335278 2.663 ZNF76
zinc finger protein 76
chr10_+_124210980 2.614 NM_002775
HTRA1
HtrA serine peptidase 1
chr12_+_6179736 2.587 NM_001769
CD9
CD9 molecule
chr22_-_44751671 2.555 NM_058238
WNT7B
wingless-type MMTV integration site family, member 7B
chr1_+_33494745 2.538 NM_152493
ZNF362
zinc finger protein 362
chr3_-_51976428 2.516 NM_020418
NM_001174100
NM_033008
PCBP4


poly(rC) binding protein 4


chr9_+_90339835 2.487 NM_001161625
NM_145283
NXNL2

nucleoredoxin-like 2

chr19_+_951295 2.472 NM_138690
GRIN3B
glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
chr19_-_36531958 2.459 NM_020856
TSHZ3
teashirt zinc finger homeobox 3
chr2_+_235525355 2.407 NM_014521
SH3BP4
SH3-domain binding protein 4
chr19_-_50963942 2.390


chr13_-_109757442 2.375 NM_001845
COL4A1
collagen, type IV, alpha 1
chr2_+_28469275 2.356 NM_005253
FOSL2
FOS-like antigen 2
chr2_-_128792515 2.352 NM_004807
HS6ST1
heparan sulfate 6-O-sulfotransferase 1
chr12_+_130878870 2.342 NM_016155
MMP17
matrix metallopeptidase 17 (membrane-inserted)
chr16_+_55217180 2.281 MT1E
metallothionein 1E
chr10_-_128884411 2.269 NM_001039762
FAM196A
family with sequence similarity 196, member A
chr3_-_48607596 2.257 NM_000094
COL7A1
collagen, type VII, alpha 1
chr2_-_40532651 2.220 SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr3_-_48445719 2.212 NM_002673
PLXNB1
plexin B1
chr10_+_134060681 2.192 NM_001098637
NM_138499
PWWP2B

PWWP domain containing 2B

chr14_-_104515738 2.157 NM_138420
AHNAK2
AHNAK nucleoprotein 2
chr7_-_42243142 2.146 NM_000168
GLI3
GLI family zinc finger 3
chr10_-_725522 2.133 NM_014974
DIP2C
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr14_+_101097440 2.123 NM_001362
DIO3
deiodinase, iodothyronine, type III
chr11_+_47386707 2.122 SLC39A13
solute carrier family 39 (zinc transporter), member 13
chr13_+_26029799 2.111 NM_006646
WASF3
WAS protein family, member 3
chr2_+_85834111 2.102 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr1_+_208472817 2.092 NM_019605
SERTAD4
SERTA domain containing 4
chr15_-_99276933 2.048


chr16_-_4106186 2.046 NM_001116
ADCY9
adenylate cyclase 9
chr18_+_42168180 2.035 NM_152470
C18orf23
RNF165
chromosome 18 open reading frame 23
ring finger protein 165
chr2_+_176702667 1.988 NM_019558
HOXD8
homeobox D8
chr9_-_83494198 1.972 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr17_+_78630793 1.964 NM_001004431
METRNL
meteorin, glial cell differentiation regulator-like
chr13_+_97593469 1.962 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr17_+_32368611 1.956 NM_005568
LHX1
LIM homeobox 1
chr10_+_133850325 1.939 NM_006426
DPYSL4
dihydropyrimidinase-like 4
chr7_-_27136876 1.920 NM_002141
HOXA4
homeobox A4
chr9_-_139042416 1.913 ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr22_-_32646325 1.908 NM_004737
NM_133642
LARGE

like-glycosyltransferase

chr2_+_28469199 1.903 FOSL2
FOS-like antigen 2
chr22_+_49459935 1.902 NM_001080420
SHANK3
SH3 and multiple ankyrin repeat domains 3
chr4_-_22126437 1.891 NM_145290
GPR125
G protein-coupled receptor 125
chr17_-_34015631 1.886 NM_025248
SRCIN1
SRC kinase signaling inhibitor 1
chr9_-_109291130 1.872 KLF4
Kruppel-like factor 4 (gut)
chr7_+_2525922 1.866 NM_001040167
NM_001040168
LFNG

LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

chr14_+_104852225 1.865 PACS2
phosphofurin acidic cluster sorting protein 2
chr15_+_99276982 1.859 NM_024652
LRRK1
leucine-rich repeat kinase 1
chr7_+_3307445 1.849 NM_152744
SDK1
sidekick homolog 1, cell adhesion molecule (chicken)
chr9_-_112840064 1.848 NM_001401
NM_057159
LPAR1

lysophosphatidic acid receptor 1

chr12_-_105056577 1.841 NUAK1
NUAK family, SNF1-like kinase, 1
chr15_-_68933481 1.839 NM_018357
NM_197958
LARP6

La ribonucleoprotein domain family, member 6

chr16_+_27232745 1.824 NM_000418
NM_001008699
IL4R

interleukin 4 receptor

chr2_-_204108151 1.814 NM_203365
NM_213589
RAPH1

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

chr16_+_85169615 1.814 NM_005250
FOXL1
forkhead box L1
chr18_+_74841262 1.814 NM_171999
SALL3
sal-like 3 (Drosophila)
chr8_-_121893468 1.805 NM_021021
SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr2_+_220015016 1.800 SPEG
SPEG complex locus
chr16_+_55273879 1.799 NM_005952
MT1X
metallothionein 1X
chr11_+_35596310 1.793 NM_014344
FJX1
four jointed box 1 (Drosophila)
chr11_+_47386621 1.778 NM_001128225
NM_152264
SLC39A13

solute carrier family 39 (zinc transporter), member 13

chr3_-_187025501 1.753 NM_001007225
NM_006548
IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr5_+_72452131 1.751 NM_001161342
NM_173490
TMEM171

transmembrane protein 171

chr16_+_1143241 1.751 NM_001005407
NM_021098
CACNA1H

calcium channel, voltage-dependent, T type, alpha 1H subunit

chr9_-_139042526 1.751 NM_001606
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr7_+_2638156 1.748 TTYH3
tweety homolog 3 (Drosophila)
chr7_+_288051 1.746 NM_020223
FAM20C
family with sequence similarity 20, member C
chr8_+_1699418 1.745 CLN8
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
chr8_-_26427304 1.743 NM_007257
PNMA2
paraneoplastic antigen MA2
chr3_+_160964574 1.734 SCHIP1
schwannomin interacting protein 1
chr22_-_45311730 1.726 NM_014246
CELSR1
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
chr20_-_3714905 1.723 NM_001810
CENPB
centromere protein B, 80kDa
chr3_+_191714533 1.717 NM_001167928
NM_001167929
NM_001167930
NM_001167931
NM_002182
NM_134470
IL1RAP





interleukin 1 receptor accessory protein





chr14_+_95575319 1.716 C14orf132
chromosome 14 open reading frame 132
chr16_+_12902955 1.701 NM_001145204
NM_001145205
SHISA9

shisa homolog 9 (Xenopus laevis)

chr16_+_5023672 1.677 LOC100507589
hypothetical LOC100507589
chr12_-_41269679 1.668 NM_153026
PRICKLE1
prickle homolog 1 (Drosophila)
chr7_-_97719372 1.667 NM_015395
TECPR1
tectonin beta-propeller repeat containing 1
chr9_+_115265827 1.663 NM_017790
RGS3
regulator of G-protein signaling 3
chr20_-_10602139 1.656 JAG1
jagged 1
chr20_+_6696744 1.650 NM_001200
BMP2
bone morphogenetic protein 2
chr1_-_199742871 1.650 NM_001193570
NM_004078
CSRP1

cysteine and glycine-rich protein 1

chr8_-_120033240 1.645 NM_002546
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr17_+_24944605 1.632 NM_152345
ANKRD13B
ankyrin repeat domain 13B
chr14_+_69415880 1.629 NM_001034852
NM_022137
SMOC1

SPARC related modular calcium binding 1

chr5_-_146869811 1.625 NM_001197294
DPYSL3
dihydropyrimidinase-like 3
chr3_+_50167424 1.618 SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr16_+_27232770 1.605 IL4R
interleukin 4 receptor
chr11_+_128751044 1.599 NM_003658
BARX2
BARX homeobox 2
chr2_+_238060602 1.596 NM_001042467
NM_024101
MLPH

melanophilin

chr16_-_63713466 1.592 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr13_-_76358433 1.590 NM_138444
KCTD12
potassium channel tetramerisation domain containing 12
chr10_-_79067476 1.582 KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr12_+_95112131 1.576 NM_005230
ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr9_+_115678365 1.569 NM_133374
ZNF618
zinc finger protein 618
chr8_-_121893449 1.566 SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr14_-_20636568 1.552 NM_016423
ZNF219
zinc finger protein 219
chr11_+_76455574 1.547 NM_004055
CAPN5
calpain 5
chr14_+_104851948 1.539 NM_001100913
NM_015197
PACS2

phosphofurin acidic cluster sorting protein 2

chr1_+_22762575 1.534 NM_001006943
NM_020526
EPHA8

EPH receptor A8

chr10_-_131652364 1.532 EBF3
early B-cell factor 3
chr6_+_35335212 1.529 ZNF76
zinc finger protein 76
chr1_-_3437834 1.527 MEGF6
multiple EGF-like-domains 6
chr8_+_136538739 1.523 NM_006558
KHDRBS3
KH domain containing, RNA binding, signal transduction associated 3
chr1_+_22909916 1.513 NM_004442
NM_017449
EPHB2

EPH receptor B2

chr22_-_18635614 1.513 NM_023004
RTN4R
reticulon 4 receptor
chr11_-_11986704 1.511 NM_001018057
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr15_+_71763674 1.503 NM_001024736
NM_025240
CD276

CD276 molecule

chr10_+_128583984 1.498 NM_001380
DOCK1
dedicator of cytokinesis 1
chr19_-_61324456 1.490 NM_001002836
ZNF787
zinc finger protein 787
chr2_-_207739815 1.484 KLF7
Kruppel-like factor 7 (ubiquitous)
chr7_-_150495799 1.483 NM_001098834
GBX1
gastrulation brain homeobox 1
chr7_+_27102508 1.478


chr11_+_696103 1.451 NM_022772
EPS8L2
EPS8-like 2
chr18_-_72336133 1.448 NM_014643
ZNF516
zinc finger protein 516
chr7_+_150442652 1.429 AGAP3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr2_+_242146791 1.421 NM_032515
BOK
BCL2-related ovarian killer
chr19_-_5291700 1.417 NM_002850
NM_130853
NM_130854
NM_130855
PTPRS



protein tyrosine phosphatase, receptor type, S



chr14_-_20636909 1.414 NM_001101672
ZNF219
zinc finger protein 219
chr7_+_288195 1.411 FAM20C
family with sequence similarity 20, member C
chr9_-_138560058 1.408 NM_017617
NOTCH1
notch 1
chr8_+_26427378 1.408 NM_001197293
DPYSL2
dihydropyrimidinase-like 2
chr14_-_88090641 1.405 NM_007039
PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr19_-_50964336 1.403 NM_175875
SIX5
SIX homeobox 5
chr10_-_116517945 1.403 ABLIM1
actin binding LIM protein 1
chr19_+_43830154 1.396 NM_004924
ACTN4
actinin, alpha 4
chr16_-_63713485 1.395 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr15_+_78774664 1.394 NM_021214
FAM108C1
family with sequence similarity 108, member C1
chr22_+_31527678 1.394 TIMP3
TIMP metallopeptidase inhibitor 3
chr20_-_3166834 1.392 NM_001174090
SLC4A11
solute carrier family 4, sodium borate transporter, member 11
chr5_-_2804768 1.392 NM_001134222
NM_033267
IRX2

iroquois homeobox 2

chr4_+_148872902 1.374 NM_024605
ARHGAP10
Rho GTPase activating protein 10
chr13_+_111769913 1.371 NM_005986
SOX1
SRY (sex determining region Y)-box 1
chr9_+_494661 1.370 NM_015158
KANK1
KN motif and ankyrin repeat domains 1
chr9_+_96806235 1.368 C9orf3
chromosome 9 open reading frame 3
chr16_-_63713382 1.353 NM_001797
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr10_+_99463468 1.350 MARVELD1
MARVEL domain containing 1
chr13_+_26029879 1.348 WASF3
WAS protein family, member 3
chr8_-_82186832 1.343 NM_018440
PAG1
phosphoprotein associated with glycosphingolipid microdomains 1
chr14_+_73073570 1.340 NM_001037161
ACOT1
acyl-CoA thioesterase 1
chr22_+_41836697 1.336 NM_001197
BIK
BCL2-interacting killer (apoptosis-inducing)
chr4_+_151218862 1.334 NM_001040260
NM_001040261
DCLK2

doublecortin-like kinase 2

chr2_+_120820140 1.324 NM_002193
INHBB
inhibin, beta B
chr13_+_109757593 1.319 NM_001846
COL4A2
collagen, type IV, alpha 2
chr14_+_20608179 1.319 NM_018071
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chr15_+_29406335 1.312 NM_015995
KLF13
Kruppel-like factor 13
chr16_+_1763185 1.308 NM_001010865
EME2
essential meiotic endonuclease 1 homolog 2 (S. pombe)
chr2_+_20510312 1.284 NM_004040
RHOB
ras homolog gene family, member B
chr3_+_61522219 1.284 NM_002841
PTPRG
protein tyrosine phosphatase, receptor type, G
chr14_+_85069217 1.270


chr16_-_30929217 1.270 NM_052874
STX1B
syntaxin 1B
chr1_+_1250115 1.268 GLTPD1
glycolipid transfer protein domain containing 1
chr3_-_64648370 1.265 NM_182920
ADAMTS9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
chr3_-_48446405 1.265 NM_001130082
PLXNB1
plexin B1
chr8_-_121892877 1.262 SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr9_+_35479989 1.259 NM_014806
RUSC2
RUN and SH3 domain containing 2
chr16_+_55199978 1.258 NM_005953
MT2A
metallothionein 2A
chr5_-_146869613 1.255 DPYSL3
dihydropyrimidinase-like 3
chr19_+_38376980 1.255 LRP3
low density lipoprotein receptor-related protein 3
chr12_-_123023312 1.248 CCDC92
coiled-coil domain containing 92
chr1_-_50661716 1.247 NM_032110
DMRTA2
DMRT-like family A2
chr9_+_138497767 1.247 NM_152571
C9orf163
chromosome 9 open reading frame 163
chr17_-_40263124 1.244 NM_005497
GJC1
gap junction protein, gamma 1, 45kDa
chr13_-_76358370 1.241 KCTD12
potassium channel tetramerisation domain containing 12
chr11_+_17697685 1.241 NM_002478
MYOD1
myogenic differentiation 1
chr15_+_88345612 1.233 NM_198526
ZNF710
zinc finger protein 710
chr1_+_156229934 1.231 KIRREL
kin of IRRE like (Drosophila)
chr13_+_97593411 1.230 NM_001001715
NM_005766
FARP1

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)

chr17_-_21395483 1.224 NM_001113434
C17orf51
chromosome 17 open reading frame 51
chr11_+_124240491 1.224 NM_022370
ROBO3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr1_+_29011240 1.221 NM_000911
OPRD1
opioid receptor, delta 1
chr12_+_55896844 1.220 NM_007224
NXPH4
neurexophilin 4
chr9_-_83493415 1.216 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr12_-_46439127 1.214 NM_001098531
RAPGEF3
Rap guanine nucleotide exchange factor (GEF) 3
chr12_-_119187871 1.214 PXN
paxillin
chr11_+_129689536 1.209 FLJ34521
hypothetical protein LOC646383
chr15_+_78483624 1.205 NM_014862
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr17_+_56831951 1.200 NM_005994
TBX2
T-box 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.64 8.54e-30 GO:0007399 nervous system development
1.78 3.44e-26 GO:0022008 neurogenesis
1.80 9.53e-26 GO:0048699 generation of neurons
1.39 6.72e-24 GO:0048731 system development
1.35 9.56e-24 GO:0007275 multicellular organismal development
1.32 3.90e-23 GO:0032502 developmental process
1.36 1.29e-22 GO:0048856 anatomical structure development
1.82 3.25e-21 GO:0030182 neuron differentiation
1.45 4.49e-21 GO:0030154 cell differentiation
1.52 4.56e-20 GO:0009653 anatomical structure morphogenesis
1.43 5.36e-20 GO:0048869 cellular developmental process
1.29 2.50e-18 GO:0023052 signaling
1.47 1.97e-17 GO:0023051 regulation of signaling
1.89 4.05e-17 GO:0000904 cell morphogenesis involved in differentiation
1.49 1.16e-16 GO:0009966 regulation of signal transduction
1.93 1.54e-16 GO:0048667 cell morphogenesis involved in neuron differentiation
1.92 1.82e-16 GO:0048812 neuron projection morphogenesis
1.62 2.65e-16 GO:0048468 cell development
1.94 2.92e-16 GO:0007409 axonogenesis
1.86 1.05e-15 GO:0031175 neuron projection development
1.68 1.38e-15 GO:2000026 regulation of multicellular organismal development
1.60 3.82e-15 GO:0050793 regulation of developmental process
1.77 7.16e-15 GO:0048666 neuron development
1.70 1.14e-14 GO:0045595 regulation of cell differentiation
1.15 3.74e-14 GO:0065007 biological regulation
1.48 1.11e-13 GO:0051239 regulation of multicellular organismal process
1.16 1.20e-13 GO:0050794 regulation of cellular process
1.27 2.64e-13 GO:0007165 signal transduction
1.78 3.98e-13 GO:0048858 cell projection morphogenesis
1.68 4.32e-13 GO:0030030 cell projection organization
1.15 4.72e-13 GO:0050789 regulation of biological process
1.70 1.02e-12 GO:0000902 cell morphogenesis
1.76 1.08e-12 GO:0032990 cell part morphogenesis
1.67 3.41e-12 GO:0032989 cellular component morphogenesis
1.91 1.21e-11 GO:0007411 axon guidance
1.48 3.94e-11 GO:0010646 regulation of cell communication
1.89 2.14e-10 GO:0060284 regulation of cell development
1.95 2.50e-10 GO:0051960 regulation of nervous system development
1.08 9.30e-10 GO:0009987 cellular process
1.33 1.07e-09 GO:0048583 regulation of response to stimulus
1.21 1.09e-09 GO:0051716 cellular response to stimulus
1.98 1.69e-09 GO:0050767 regulation of neurogenesis
1.71 3.17e-09 GO:0051094 positive regulation of developmental process
1.82 4.17e-09 GO:0045597 positive regulation of cell differentiation
2.05 6.17e-09 GO:0045664 regulation of neuron differentiation
1.49 6.18e-09 GO:0040011 locomotion
1.65 7.46e-09 GO:0007417 central nervous system development
1.87 9.51e-09 GO:0001944 vasculature development
1.59 9.73e-09 GO:0009887 organ morphogenesis
2.80 1.22e-08 GO:0050770 regulation of axonogenesis
1.32 2.19e-08 GO:0007166 cell surface receptor linked signaling pathway
1.16 2.59e-08 GO:0032501 multicellular organismal process
1.82 2.67e-08 GO:0022603 regulation of anatomical structure morphogenesis
1.27 2.81e-08 GO:0048522 positive regulation of cellular process
1.31 3.03e-08 GO:0048513 organ development
1.25 3.71e-08 GO:0048518 positive regulation of biological process
1.55 4.57e-08 GO:0007167 enzyme linked receptor protein signaling pathway
1.27 5.54e-08 GO:0048519 negative regulation of biological process
1.28 6.28e-08 GO:0048523 negative regulation of cellular process
1.60 1.67e-07 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.62 3.24e-07 GO:0072358 cardiovascular system development
1.62 3.24e-07 GO:0072359 circulatory system development
1.67 3.73e-07 GO:0009968 negative regulation of signal transduction
1.62 4.53e-07 GO:0048646 anatomical structure formation involved in morphogenesis
2.22 5.26e-07 GO:0010975 regulation of neuron projection development
1.63 5.32e-07 GO:0010648 negative regulation of cell communication
1.63 8.85e-07 GO:0023057 negative regulation of signaling
2.18 1.20e-06 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.49 1.49e-06 GO:0009790 embryo development
2.17 1.79e-06 GO:0022604 regulation of cell morphogenesis
1.77 2.48e-06 GO:0035295 tube development
1.79 2.56e-06 GO:0001568 blood vessel development
1.48 3.06e-06 GO:0019220 regulation of phosphate metabolic process
1.48 3.06e-06 GO:0051174 regulation of phosphorus metabolic process
1.48 3.45e-06 GO:0042325 regulation of phosphorylation
1.66 4.40e-06 GO:0007420 brain development
2.11 5.69e-06 GO:0030111 regulation of Wnt receptor signaling pathway
1.49 1.01e-05 GO:0001932 regulation of protein phosphorylation
1.55 1.01e-05 GO:0048585 negative regulation of response to stimulus
2.41 1.17e-05 GO:0050769 positive regulation of neurogenesis
1.61 1.25e-05 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.66 1.76e-05 GO:0007389 pattern specification process
1.38 2.05e-05 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.31 2.50e-05 GO:0035556 intracellular signal transduction
1.98 3.98e-05 GO:0031344 regulation of cell projection organization
1.36 6.02e-05 GO:0007154 cell communication
1.39 6.29e-05 GO:0009888 tissue development
1.57 6.91e-05 GO:0040008 regulation of growth
1.52 7.67e-05 GO:0019226 transmission of nerve impulse
1.52 7.67e-05 GO:0035637 multicellular organismal signaling
2.39 9.35e-05 GO:0010721 negative regulation of cell development
1.50 1.13e-04 GO:0006935 chemotaxis
1.50 1.13e-04 GO:0042330 taxis
1.78 1.33e-04 GO:0048514 blood vessel morphogenesis
2.14 1.34e-04 GO:0010720 positive regulation of cell development
1.85 1.35e-04 GO:0035239 tube morphogenesis
3.02 1.36e-04 GO:0050772 positive regulation of axonogenesis
2.53 1.40e-04 GO:0050768 negative regulation of neurogenesis
1.43 1.71e-04 GO:0009719 response to endogenous stimulus
1.48 2.02e-04 GO:0045892 negative regulation of transcription, DNA-dependent
1.81 2.54e-04 GO:0032582 negative regulation of gene-specific transcription
1.72 2.71e-04 GO:0001558 regulation of cell growth
1.69 2.85e-04 GO:0045596 negative regulation of cell differentiation
1.47 2.93e-04 GO:0051253 negative regulation of RNA metabolic process
1.62 3.24e-04 GO:0001501 skeletal system development
1.52 4.03e-04 GO:0007268 synaptic transmission
1.37 4.14e-04 GO:0051128 regulation of cellular component organization
1.48 4.31e-04 GO:0009967 positive regulation of signal transduction
1.44 4.53e-04 GO:0009725 response to hormone stimulus
1.56 5.39e-04 GO:0043009 chordate embryonic development
1.56 5.73e-04 GO:0009792 embryo development ending in birth or egg hatching
1.46 6.17e-04 GO:0023056 positive regulation of signaling
1.72 6.45e-04 GO:0002009 morphogenesis of an epithelium
1.84 7.26e-04 GO:0001525 angiogenesis
1.21 7.27e-04 GO:0042221 response to chemical stimulus
1.16 7.45e-04 GO:0080090 regulation of primary metabolic process
1.70 8.23e-04 GO:0003002 regionalization
1.33 1.05e-03 GO:0009605 response to external stimulus
1.16 1.06e-03 GO:0016043 cellular component organization
1.37 1.09e-03 GO:0031399 regulation of protein modification process
2.52 1.16e-03 GO:0032412 regulation of ion transmembrane transporter activity
1.45 1.19e-03 GO:0010647 positive regulation of cell communication
1.53 1.27e-03 GO:0007264 small GTPase mediated signal transduction
1.33 1.28e-03 GO:0042127 regulation of cell proliferation
1.54 1.43e-03 GO:0051056 regulation of small GTPase mediated signal transduction
1.60 1.53e-03 GO:0048729 tissue morphogenesis
1.44 1.60e-03 GO:0006928 cellular component movement
1.51 1.70e-03 GO:0016477 cell migration
1.26 1.80e-03 GO:0065009 regulation of molecular function
2.30 1.90e-03 GO:0042326 negative regulation of phosphorylation
1.39 1.92e-03 GO:0009890 negative regulation of biosynthetic process
2.18 2.12e-03 GO:0030178 negative regulation of Wnt receptor signaling pathway
1.61 2.46e-03 GO:0061061 muscle structure development
1.61 2.67e-03 GO:0007423 sensory organ development
1.41 2.89e-03 GO:0010629 negative regulation of gene expression
1.15 2.97e-03 GO:0051179 localization
2.23 3.05e-03 GO:0010563 negative regulation of phosphorus metabolic process
2.23 3.05e-03 GO:0045936 negative regulation of phosphate metabolic process
2.23 3.05e-03 GO:0048638 regulation of developmental growth
1.56 3.13e-03 GO:0051093 negative regulation of developmental process
2.43 3.34e-03 GO:0022898 regulation of transmembrane transporter activity
2.38 3.68e-03 GO:0034765 regulation of ion transmembrane transport
1.47 3.79e-03 GO:0048870 cell motility
1.47 3.79e-03 GO:0051674 localization of cell
1.14 3.86e-03 GO:0019222 regulation of metabolic process
1.31 3.86e-03 GO:0032879 regulation of localization
1.44 3.95e-03 GO:0051338 regulation of transferase activity
1.46 4.04e-03 GO:0045859 regulation of protein kinase activity
1.38 4.16e-03 GO:0031327 negative regulation of cellular biosynthetic process
1.40 4.28e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.50 4.94e-03 GO:0010627 regulation of intracellular protein kinase cascade
1.15 5.11e-03 GO:0031323 regulation of cellular metabolic process
1.38 5.48e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.44 6.00e-03 GO:0043549 regulation of kinase activity
1.81 6.64e-03 GO:0045165 cell fate commitment
1.62 6.67e-03 GO:0046578 regulation of Ras protein signal transduction
1.65 7.02e-03 GO:0048011 nerve growth factor receptor signaling pathway
1.37 7.31e-03 GO:0010628 positive regulation of gene expression
1.57 8.11e-03 GO:0051270 regulation of cellular component movement
3.38 9.11e-03 GO:0003279 cardiac septum development
1.78 9.22e-03 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
1.38 1.01e-02 GO:0051172 negative regulation of nitrogen compound metabolic process
1.34 1.03e-02 GO:0007267 cell-cell signaling
1.49 1.14e-02 GO:0048598 embryonic morphogenesis
1.90 1.14e-02 GO:0060541 respiratory system development
3.89 1.18e-02 GO:0060411 cardiac septum morphogenesis
1.29 1.19e-02 GO:0006793 phosphorus metabolic process
1.29 1.19e-02 GO:0006796 phosphate metabolic process
1.56 1.30e-02 GO:0040012 regulation of locomotion
1.77 1.43e-02 GO:0043062 extracellular structure organization
2.22 1.51e-02 GO:0032409 regulation of transporter activity
1.84 1.60e-02 GO:0001763 morphogenesis of a branching structure
1.37 1.61e-02 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.34 1.71e-02 GO:0006468 protein phosphorylation
1.85 1.74e-02 GO:0010959 regulation of metal ion transport
1.85 1.74e-02 GO:0033673 negative regulation of kinase activity
1.14 1.76e-02 GO:0071840 cellular component organization or biogenesis
1.51 1.89e-02 GO:0032535 regulation of cellular component size
1.82 1.92e-02 GO:0051348 negative regulation of transferase activity
2.02 1.96e-02 GO:0060828 regulation of canonical Wnt receptor signaling pathway
2.89 2.14e-02 GO:0050771 negative regulation of axonogenesis
1.14 2.23e-02 GO:0060255 regulation of macromolecule metabolic process
1.58 2.24e-02 GO:0030334 regulation of cell migration
1.44 2.42e-02 GO:0032583 regulation of gene-specific transcription
1.19 2.51e-02 GO:0065008 regulation of biological quality
1.47 2.72e-02 GO:0090066 regulation of anatomical structure size
1.70 2.81e-02 GO:0030900 forebrain development
1.36 2.83e-02 GO:0045893 positive regulation of transcription, DNA-dependent
1.16 3.15e-02 GO:0071842 cellular component organization at cellular level
1.93 3.17e-02 GO:0030198 extracellular matrix organization
1.58 3.28e-02 GO:0040007 growth
1.50 3.39e-02 GO:0071495 cellular response to endogenous stimulus
1.56 3.59e-02 GO:0008361 regulation of cell size
1.57 3.76e-02 GO:0030036 actin cytoskeleton organization
1.56 3.82e-02 GO:2000145 regulation of cell motility
1.28 4.00e-02 GO:0009892 negative regulation of metabolic process
1.90 4.00e-02 GO:0021700 developmental maturation
1.29 4.03e-02 GO:0031324 negative regulation of cellular metabolic process
1.59 4.10e-02 GO:0048568 embryonic organ development
1.51 4.17e-02 GO:0032870 cellular response to hormone stimulus
1.85 4.21e-02 GO:0035023 regulation of Rho protein signal transduction
1.25 4.22e-02 GO:0031325 positive regulation of cellular metabolic process
1.91 4.29e-02 GO:0030323 respiratory tube development
2.03 4.42e-02 GO:0021953 central nervous system neuron differentiation
1.24 4.59e-02 GO:0009893 positive regulation of metabolic process
1.73 4.60e-02 GO:0060562 epithelial tube morphogenesis
1.93 4.60e-02 GO:0030324 lung development
1.46 4.86e-02 GO:0060429 epithelium development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.31 1.78e-11 GO:0044459 plasma membrane part
1.58 4.41e-06 GO:0045202 synapse
1.46 8.26e-06 GO:0030054 cell junction
1.15 1.31e-05 GO:0005886 plasma membrane
1.15 1.61e-05 GO:0071944 cell periphery
1.09 4.12e-05 GO:0005737 cytoplasm
1.35 9.08e-05 GO:0042995 cell projection
1.52 1.15e-04 GO:0043005 neuron projection
1.09 1.67e-04 GO:0016020 membrane
1.51 3.36e-04 GO:0031012 extracellular matrix
1.73 1.76e-03 GO:0070161 anchoring junction
1.69 1.83e-03 GO:0031252 cell leading edge
1.52 1.88e-03 GO:0005578 proteinaceous extracellular matrix
1.76 2.29e-03 GO:0005912 adherens junction
1.05 3.63e-03 GO:0005622 intracellular
1.21 6.08e-03 GO:0012505 endomembrane system
1.05 8.99e-03 GO:0044424 intracellular part
1.23 9.57e-03 GO:0031226 intrinsic to plasma membrane
2.25 1.00e-02 GO:0005905 coated pit
1.47 2.11e-02 GO:0044456 synapse part
1.22 2.17e-02 GO:0005887 integral to plasma membrane
1.70 2.40e-02 GO:0034703 cation channel complex
1.03 3.78e-02 GO:0044464 cell part
1.03 3.97e-02 GO:0005623 cell
1.88 4.04e-02 GO:0030139 endocytic vesicle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.12 6.99e-09 GO:0005515 protein binding
1.06 1.32e-06 GO:0005488 binding
1.41 1.88e-05 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.39 3.72e-05 GO:0016301 kinase activity
1.41 6.12e-05 GO:0043565 sequence-specific DNA binding
1.34 6.39e-05 GO:0001071 nucleic acid binding transcription factor activity
1.34 6.39e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
2.21 1.64e-04 GO:0019199 transmembrane receptor protein kinase activity
1.30 1.26e-03 GO:0030528 transcription regulator activity
1.38 2.43e-03 GO:0004672 protein kinase activity
2.45 4.23e-03 GO:0008013 beta-catenin binding
1.29 5.14e-03 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.50 9.35e-03 GO:0016564 transcription repressor activity
1.51 9.57e-03 GO:0008134 transcription factor binding
2.79 1.12e-02 GO:0005158 insulin receptor binding
1.89 1.49e-02 GO:0016566 specific transcriptional repressor activity
1.85 1.55e-02 GO:0019838 growth factor binding
2.11 1.90e-02 GO:0004714 transmembrane receptor protein tyrosine kinase activity
1.36 2.01e-02 GO:0008092 cytoskeletal protein binding
1.59 2.07e-02 GO:0000975 regulatory region DNA binding
1.59 2.07e-02 GO:0001067 regulatory region nucleic acid binding
1.59 2.07e-02 GO:0044212 transcription regulatory region DNA binding
1.30 3.18e-02 GO:0019899 enzyme binding
1.45 3.32e-02 GO:0003779 actin binding
1.39 3.41e-02 GO:0004674 protein serine/threonine kinase activity
1.59 3.50e-02 GO:0010843 promoter binding