Motif ID: PAX4.p2

Z-value: 1.350


Transcription factors associated with PAX4.p2:

Gene SymbolEntrez IDGene Name
PAX4 5078 paired box 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PAX4chr7_-_1270428100.039.2e-01Click!


Activity profile for motif PAX4.p2.

activity profile for motif PAX4.p2


Sorted Z-values histogram for motif PAX4.p2

Sorted Z-values for motif PAX4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_101475149 2.776 S1PR1
sphingosine-1-phosphate receptor 1
chr9_-_20612433 2.280 MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr18_-_51406841 1.804 NM_001083962
NM_003199
TCF4

transcription factor 4

chr1_+_101474892 1.634 NM_001400
S1PR1
sphingosine-1-phosphate receptor 1
chr6_+_32713160 1.608 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr8_-_21827057 1.582 NM_003974
DOK2
docking protein 2, 56kDa
chr5_-_169340321 1.540 NM_001129891
FAM196B
family with sequence similarity 196, member B
chr9_-_88064338 1.533 NM_001010907
C9orf153
chromosome 9 open reading frame 153
chr1_+_12046020 1.461 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr3_+_120781212 1.459 NM_001125
ADPRH
ADP-ribosylarginine hydrolase
chr18_-_59137488 1.348 NM_000633
NM_000657
BCL2

B-cell CLL/lymphoma 2

chr19_+_2928480 1.317 NM_001143986
NM_024760
TLE6

transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)

chr7_+_68702252 1.305 AUTS2
autism susceptibility candidate 2
chr1_-_158948176 1.242 NM_001778
CD48
CD48 molecule
chr7_+_134567270 1.218 NM_182489
STRA8
stimulated by retinoic acid gene 8 homolog (mouse)
chr19_+_59833719 1.175 NM_001081638
NM_001081639
NM_001081637
LILRB1


leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1


chr6_+_32515596 1.147 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr12_-_93568336 1.140 NM_020698
TMCC3
transmembrane and coiled-coil domain family 3
chr1_-_208024491 1.068 NM_152485
C1orf74
chromosome 1 open reading frame 74
chr11_-_58736897 1.038 NM_001039396
MPEG1
macrophage expressed 1
chrX_-_47941142 0.995 NM_021015
NM_175723
SSX5

synovial sarcoma, X breakpoint 5

chr22_-_41447214 0.991 A4GALT
alpha 1,4-galactosyltransferase
chr1_+_205137410 0.988 NM_001185156
NM_001185157
NM_001185158
NM_006850
IL24



interleukin 24



chr9_-_122716670 0.983 NM_001190947
TRAF1
TNF receptor-associated factor 1
chr1_+_20353284 0.980


chr4_+_82171142 0.961 NM_001201
BMP3
bone morphogenetic protein 3
chr16_+_49288550 0.948 NM_022162
NOD2
nucleotide-binding oligomerization domain containing 2
chr3_+_123779122 0.922 NM_001113523
PARP15
poly (ADP-ribose) polymerase family, member 15
chr12_+_120055013 0.917 NM_002562
P2RX7
purinergic receptor P2X, ligand-gated ion channel, 7
chr2_-_136590210 0.912 NM_001008540
CXCR4
chemokine (C-X-C motif) receptor 4
chr18_-_62422195 0.893 NM_021153
CDH19
cadherin 19, type 2
chr2_-_217267742 0.870 IGFBP5
insulin-like growth factor binding protein 5
chr4_+_39874921 0.851 NM_004310
RHOH
ras homolog gene family, member H
chr19_-_59476734 0.844 NM_001080978
NM_005874
LILRB2

leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2

chr3_+_113287864 0.805 NM_001171747
NM_024616
C3orf52

chromosome 3 open reading frame 52

chr10_-_85921703 0.803 LOC642934
hypothetical LOC642934
chr18_-_59138192 0.789 BCL2
B-cell CLL/lymphoma 2
chr2_-_213723298 0.786 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr2_-_64944214 0.773


chr4_+_47181987 0.771 NM_020453
ATP10D
ATPase, class V, type 10D
chr1_+_34098662 0.764 NM_145205
HMGB4
high-mobility group box 4
chr11_+_7463175 0.749 NM_198474
OLFML1
olfactomedin-like 1
chr5_-_35083996 0.747 NM_031900
AGXT2
alanine--glyoxylate aminotransferase 2
chr2_-_217268492 0.735 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr2_+_102345528 0.730 NM_003855
IL18R1
interleukin 18 receptor 1
chr5_+_146594718 0.699 NM_001112724
NM_145001
STK32A

serine/threonine kinase 32A

chr11_+_108798047 0.697 NM_207645
C11orf87
chromosome 11 open reading frame 87
chr9_-_86173232 0.693 NM_022127
SLC28A3
solute carrier family 28 (sodium-coupled nucleoside transporter), member 3
chr22_-_16060485 0.690 NM_177405
CECR1
cat eye syndrome chromosome region, candidate 1
chr9_+_78305368 0.680 NM_001097636
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr19_+_59796858 0.664 NM_006863
LILRA1
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
chr9_-_20612476 0.656 NM_004529
MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr11_+_1830763 0.642 NM_002339
LSP1
lymphocyte-specific protein 1
chr13_+_99027366 0.641


chr3_+_51870684 0.632 NM_203424
IQCF2
IQ motif containing F2
chr17_-_44154878 0.629 NM_032391
PRAC
prostate cancer susceptibility candidate
chr18_-_51406359 0.626 TCF4
transcription factor 4
chr7_-_38279757 0.617 NM_001003799
NM_001003806
TARP

TRGV9
TCR gamma alternate reading frame protein

T cell receptor gamma variable 9
chr6_-_149847718 0.606 ZC3H12D
zinc finger CCCH-type containing 12D
chr12_-_18134319 0.589 NM_024730
RERGL
RERG/RAS-like
chr2_-_232087293 0.588 C2orf52
chromosome 2 open reading frame 52
chr6_+_31661934 0.577 NM_205838
NM_205839
LST1

leukocyte specific transcript 1

chr19_-_6284561 0.574 NM_133492
ACER1
alkaline ceramidase 1
chr6_-_32665409 0.565 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr11_+_118561375 0.561 NM_001168468
NM_024791
PDZD3

PDZ domain containing 3

chr13_-_46368968 0.557 NM_000621
NM_001165947
HTR2A

5-hydroxytryptamine (serotonin) receptor 2A

chr2_-_215711313 0.545 NM_173076
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr1_-_25164061 0.545 NM_001031680
RUNX3
runt-related transcription factor 3
chr4_-_40211324 0.540 RBM47
RNA binding motif protein 47
chrX_+_134895300 0.539 SLC9A6
solute carrier family 9 (sodium/hydrogen exchanger), member 6
chr4_-_40212670 0.535 NM_019027
RBM47
RNA binding motif protein 47
chr6_+_30002084 0.522


chr1_-_42738535 0.518 TMSB4XP1
thymosin beta 4, X-linked pseudogene 1
chr1_+_149298774 0.514 NM_006818
MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr22_-_16080265 0.510 CECR1
cat eye syndrome chromosome region, candidate 1
chrX_+_134895239 0.508 NM_001177651
NM_001042537
NM_006359
SLC9A6


solute carrier family 9 (sodium/hydrogen exchanger), member 6


chr4_-_85638410 0.507 NM_006168
NKX6-1
NK6 homeobox 1
chr19_-_59516155 0.502 NM_181879
NM_181985
NM_181986
NM_021250
LILRA5



leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5



chr7_+_26158257 0.500 NM_004289
NFE2L3
nuclear factor (erythroid-derived 2)-like 3
chr19_-_54314090 0.497 NM_018111
C19orf73
chromosome 19 open reading frame 73
chr6_-_90119329 0.496 NM_016021
UBE2J1
ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)
chr16_+_31273969 0.490 NM_000887
ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr6_-_2580296 0.485 NM_152554
C6orf195
chromosome 6 open reading frame 195
chr6_-_137536412 0.484 NM_052962
NM_181309
NM_181310
IL22RA2


interleukin 22 receptor, alpha 2


chr22_-_41095123 0.483


chr10_+_124204168 0.478 NM_001099667
ARMS2
age-related maculopathy susceptibility 2
chr19_+_14405216 0.478 PKN1
protein kinase N1
chr15_-_38188333 0.477 NM_001003940
BMF
Bcl2 modifying factor
chr12_+_25096755 0.473 LRMP
lymphoid-restricted membrane protein
chr1_-_109420091 0.469 NM_005645
TAF13
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
chr7_+_5609416 0.463 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chrX_+_154880439 0.462 NM_002186
IL9R
interleukin 9 receptor
chr1_-_72520735 0.457 NM_173808
NEGR1
neuronal growth regulator 1
chr4_-_113426332 0.453 NM_052864
TIFA
TRAF-interacting protein with forkhead-associated domain
chr18_-_22696532 0.450 NM_004028
AQP4
aquaporin 4
chr10_+_91142301 0.448 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr2_+_218833982 0.446 NM_001077191
NM_001077194
NM_170699
GPBAR1


G protein-coupled bile acid receptor 1


chr1_-_158759606 0.445 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr17_+_69781980 0.445 NM_001172810
NM_023036
DNAI2

dynein, axonemal, intermediate chain 2

chr2_-_222145240 0.442 NM_004438
EPHA4
EPH receptor A4
chr4_+_40953698 0.442 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr11_-_87548199 0.437 NM_022337
RAB38
RAB38, member RAS oncogene family
chr2_-_176656935 0.437 NM_001080458
EVX2
even-skipped homeobox 2
chr9_+_70161634 0.430 NM_021965
PGM5
phosphoglucomutase 5
chr1_+_151147646 0.429 NM_005547
IVL
involucrin
chr1_-_202730135 0.428 PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr18_+_28023984 0.427 NM_005925
MEP1B
meprin A, beta
chr12_+_10973100 0.425 NM_005042
NM_001110213
PRH2

proline-rich protein HaeIII subfamily 2

chr19_-_19245177 0.423


chr3_+_190831909 0.417 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr2_-_169596078 0.413 NM_003742
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr19_+_15024014 0.410 NM_012114
CASP14
caspase 14, apoptosis-related cysteine peptidase
chr1_-_84099261 0.410


chr12_+_15955549 0.409 DERA
deoxyribose-phosphate aldolase (putative)
chr12_+_103677388 0.408 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr4_+_3434830 0.406 NM_001164673
NM_173660
DOK7

docking protein 7

chr7_-_96489884 0.400


chr18_-_72857665 0.393 MBP
myelin basic protein
chr6_-_105734535 0.393 NM_022361
POPDC3
popeye domain containing 3
chr13_+_77213295 0.388 NM_144595
SLAIN1
SLAIN motif family, member 1
chr14_+_103464504 0.382 NM_153046
TDRD9
tudor domain containing 9
chrX_-_151057615 0.370 NM_001011543
NM_021048
MAGEA10

melanoma antigen family A, 10

chr16_+_29739215 0.369 NM_005115
NM_017458
MVP

major vault protein

chr4_-_174557191 0.368 NM_007281
SCRG1
stimulator of chondrogenesis 1
chr12_+_56284867 0.364 NM_178502
DTX3
deltex homolog 3 (Drosophila)
chr7_-_16811131 0.361 NM_006408
AGR2
anterior gradient homolog 2 (Xenopus laevis)
chr12_-_49897743 0.357 POU6F1
POU class 6 homeobox 1
chr19_+_10820105 0.356 NM_001136482
C19orf38
chromosome 19 open reading frame 38
chr8_-_109165012 0.356 NM_178565
RSPO2
R-spondin 2 homolog (Xenopus laevis)
chr12_+_47162552 0.355 NM_152319
C12orf54
chromosome 12 open reading frame 54
chr14_+_87541220 0.352 NM_003608
GPR65
G protein-coupled receptor 65
chr18_-_59137948 0.349 BCL2
B-cell CLL/lymphoma 2
chr11_-_73787065 0.349 NM_173582
PGM2L1
phosphoglucomutase 2-like 1
chr9_-_69468634 0.347 NM_001126334
FOXD4L5
forkhead box D4-like 5
chr6_+_31662454 0.347 NM_205837
LST1
leukocyte specific transcript 1
chr1_+_229443541 0.347 NM_014236
GNPAT
glyceronephosphate O-acyltransferase
chr14_-_49629110 0.346 NM_001014830
C14orf183
chromosome 14 open reading frame 183
chr4_-_121207338 0.345 NM_002358
MAD2L1
MAD2 mitotic arrest deficient-like 1 (yeast)
chr3_-_133236447 0.343 NM_130808
CPNE4
copine IV
chr2_+_122124034 0.340 LOC254128
hypothetical LOC254128
chr6_-_90119169 0.338 UBE2J1
ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)
chr18_+_59405513 0.338 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr7_+_150013716 0.336 NM_015660
GIMAP2
GTPase, IMAP family member 2
chr17_+_73054614 0.333


chr18_+_59726183 0.332 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr19_+_14405100 0.331 NM_002741
PKN1
protein kinase N1
chr5_-_142763418 0.331 NM_000176
NM_001020825
NM_001024094
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr13_-_28190961 0.330 NM_001135919
NM_181785
SLC46A3

solute carrier family 46, member 3

chr2_+_45732416 0.330 NM_005400
PRKCE
protein kinase C, epsilon
chr9_+_831689 0.329 NM_021951
DMRT1
doublesex and mab-3 related transcription factor 1
chr1_-_158815850 0.328 CD84
CD84 molecule
chr20_-_2437544 0.325 ZNF343
zinc finger protein 343
chr14_-_104142125 0.320 NM_207379
TMEM179
transmembrane protein 179
chr6_+_33151703 0.319 NM_002121
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chrX_+_128942435 0.318


chr3_+_149930656 0.317 NM_032049
AGTR1
angiotensin II receptor, type 1
chr5_+_140181405 0.317 NM_018908
NM_031501
PCDHA5

protocadherin alpha 5

chr11_+_63754517 0.316 DNAJC4
DnaJ (Hsp40) homolog, subfamily C, member 4
chr19_+_9222605 0.316 NM_001079935
OR7E24
olfactory receptor, family 7, subfamily E, member 24
chr7_+_123352521 0.311 NM_001174044
NM_003117
NM_153189
SPAM1


sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)


chr5_-_137099361 0.309 KLHL3
kelch-like 3 (Drosophila)
chr14_+_61653827 0.309 FLJ43390
hypothetical LOC646113
chr13_-_38462857 0.308 NM_001144033
NM_145286
STOML3

stomatin (EPB72)-like 3

chr1_+_157246305 0.306 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr2_-_231498184 0.302 NM_005683
GPR55
G protein-coupled receptor 55
chr9_+_91409746 0.295 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr13_-_113916159 0.295 RASA3
RAS p21 protein activator 3
chr7_-_149960218 0.294 GIMAP6
GTPase, IMAP family member 6
chr9_+_19039424 0.294 RRAGA
Ras-related GTP binding A
chr6_+_29963328 0.293 HLA-H
major histocompatibility complex, class I, H (pseudogene)
chr7_-_47954561 0.293 NM_138295
PKD1L1
polycystic kidney disease 1 like 1
chr19_-_59452869 0.289 NM_001081442
NM_001081443
NM_006840
LILRB5


leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5


chr3_+_9950474 0.289 CRELD1
cysteine-rich with EGF-like domains 1
chr3_+_112743615 0.288 NM_005816
NM_198196
CD96

CD96 molecule

chr17_+_40655060 0.288 NM_005892
FMNL1
formin-like 1
chr1_-_150328153 0.288 NM_001008536
TCHHL1
trichohyalin-like 1
chr2_+_231569082 0.287 NM_139073
SPATA3
spermatogenesis associated 3
chr12_+_103375116 0.286 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr19_-_41083288 0.286 NM_139239
NFKBID
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
chr2_+_157000197 0.284 NM_001083112
GPD2
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
chr8_+_118602134 0.283 NM_080651
MED30
mediator complex subunit 30
chr1_+_149299307 0.283 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr4_-_109308893 0.283 NM_001130713
NM_001130714
NM_016269
LEF1


lymphoid enhancer-binding factor 1


chrX_+_151653874 0.274 NM_001102576
NM_153478
CSAG1

chondrosarcoma associated gene 1

chrX_+_30143595 0.274 NM_002364
MAGEB2
melanoma antigen family B, 2
chr14_-_49122813 0.273 NM_001030001
NM_001032
RPS29

ribosomal protein S29

chr5_-_95184121 0.273 GLRX
glutaredoxin (thioltransferase)
chr11_-_102081654 0.273 NM_022122
MMP27
matrix metallopeptidase 27
chr12_+_32003648 0.272 C12orf35
chromosome 12 open reading frame 35
chr1_+_246718487 0.268 NM_001004697
OR2T5
olfactory receptor, family 2, subfamily T, member 5
chr11_-_18566758 0.267 NM_001040697
NM_018314
UEVLD

UEV and lactate/malate dehyrogenase domains

chr7_-_141293185 0.267 NM_013252
CLEC5A
C-type lectin domain family 5, member A
chr11_+_108798084 0.266 C11orf87
chromosome 11 open reading frame 87
chr1_+_149299490 0.264 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr12_+_64982542 0.264 NM_033647
HELB
helicase (DNA) B
chrX_-_83644054 0.264 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr11_+_5573906 0.262 NM_058166
TRIM6
tripartite motif containing 6
chr7_+_68702516 0.262 AUTS2
autism susceptibility candidate 2
chr1_-_148473649 0.261 NM_001136479
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr18_+_27925923 0.261 RNF138
ring finger protein 138

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
9.94 4.65e-03 GO:0048485 sympathetic nervous system development
13.32 2.30e-02 GO:0060678 dichotomous subdivision of terminal units involved in ureteric bud branching
11.84 4.97e-02 GO:0048880 sensory system development
11.84 4.97e-02 GO:0048892 lateral line nerve development
11.84 4.97e-02 GO:0048895 lateral line nerve glial cell differentiation
11.84 4.97e-02 GO:0048925 lateral line system development
11.84 4.97e-02 GO:0048937 lateral line nerve glial cell development
11.84 4.97e-02 GO:0050935 iridophore differentiation

Nothing significant found in compartment category.

Nothing significant found in function category.