Motif ID: SOX17.p2

Z-value: 1.280


Transcription factors associated with SOX17.p2:

Gene SymbolEntrez IDGene Name
SOX17 64321 SRY (sex determining region Y)-box 17

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX17chr8_+_555330470.683.6e-03Click!


Activity profile for motif SOX17.p2.

activity profile for motif SOX17.p2


Sorted Z-values histogram for motif SOX17.p2

Sorted Z-values for motif SOX17.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX17.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_139761182 1.464


chr11_+_13646727 1.385 NM_032228
FAR1
fatty acyl CoA reductase 1
chr11_+_13646806 1.161 FAR1
fatty acyl CoA reductase 1
chr11_-_57173823 1.074 NM_145008
YPEL4
yippee-like 4 (Drosophila)
chr18_-_21186107 1.064 NM_015461
ZNF521
zinc finger protein 521
chr8_-_9046460 1.035 PPP1R3B
protein phosphatase 1, regulatory (inhibitor) subunit 3B
chr14_-_22458134 1.025 RBM23
RNA binding motif protein 23
chr8_+_55533047 1.010 NM_022454
SOX17
SRY (sex determining region Y)-box 17
chrX_+_49013243 0.994 NM_001184745
NM_033215
PPP1R3F

protein phosphatase 1, regulatory (inhibitor) subunit 3F

chr2_-_37752272 0.987 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr17_-_35017691 0.972 NM_006160
NEUROD2
neurogenic differentiation 2
chrX_-_83644054 0.934 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr11_+_13646839 0.865 FAR1
fatty acyl CoA reductase 1
chr14_-_22458199 0.844 RBM23
RNA binding motif protein 23
chr19_-_56582997 0.840 NM_001161748
NM_030657
LIM2

lens intrinsic membrane protein 2, 19kDa

chr2_-_188021117 0.835 NM_005795
CALCRL
calcitonin receptor-like
chr6_-_72187168 0.824 C6orf155
chromosome 6 open reading frame 155
chr6_+_25862905 0.818 NM_005495
SLC17A4
solute carrier family 17 (sodium phosphate), member 4
chrX_+_15428820 0.811 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr1_+_175406685 0.802 FAM5B
family with sequence similarity 5, member B
chr5_+_79651545 0.799 NM_032567
SPZ1
spermatogenic leucine zipper 1
chr14_-_87529600 0.785 NM_000153
NM_001037525
GALC

galactosylceramidase

chr19_-_6230927 0.768 NM_005934
MLLT1
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
chr14_-_99842519 0.750 NM_001039355
SLC25A29
solute carrier family 25, member 29
chr1_-_151910080 0.747 ILF2
interleukin enhancer binding factor 2, 45kDa
chr4_-_2233504 0.744 NM_006454
MXD4
MAX dimerization protein 4
chr7_+_50314801 0.728 NM_006060
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr1_-_26105477 0.723 NM_001145454
NM_005563
STMN1

stathmin 1

chr15_-_70277163 0.719 NM_001012642
GRAMD2
GRAM domain containing 2
chr7_-_122627235 0.702 NM_022444
SLC13A1
solute carrier family 13 (sodium/sulfate symporters), member 1
chr11_-_66877519 0.701 NM_021173
POLD4
polymerase (DNA-directed), delta 4
chr9_-_126945536 0.691 NM_001144877
NM_173690
SCAI

suppressor of cancer cell invasion

chr3_+_51397756 0.688 MANF
mesencephalic astrocyte-derived neurotrophic factor
chr15_-_73719546 0.670 NM_018285
IMP3
IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr15_+_38437703 0.659 NM_033510
DISP2
dispatched homolog 2 (Drosophila)
chr14_-_22458220 0.648 NM_001077351
NM_001077352
NM_018107
RBM23


RNA binding motif protein 23


chr13_+_94052022 0.647 NM_180989
GPR180
G protein-coupled receptor 180
chr21_-_14840506 0.639 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr14_+_62740878 0.634 NM_020663
RHOJ
ras homolog gene family, member J
chr17_-_59817722 0.631 NM_000442
PECAM1
platelet/endothelial cell adhesion molecule
chr3_+_44665220 0.630 NM_003420
ZNF35
zinc finger protein 35
chr1_-_241485105 0.629 CEP170
centrosomal protein 170kDa
chr10_+_17311282 0.628 VIM
vimentin
chr12_+_119418294 0.626 DYNLL1
dynein, light chain, LC8-type 1
chr2_-_37752731 0.621 NM_006449
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr8_-_60194099 0.620 NM_014729
TOX
thymocyte selection-associated high mobility group box
chr1_-_157772420 0.610 NM_001004469
OR10J5
olfactory receptor, family 10, subfamily J, member 5
chr4_+_55218663 0.609 NM_000222
NM_001093772
KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr10_+_70748581 0.602 NM_000188
HK1
hexokinase 1
chr11_-_550706 0.601 NM_173573
C11orf35
chromosome 11 open reading frame 35
chr6_+_100161370 0.601 NM_021620
PRDM13
PR domain containing 13
chr3_-_87122936 0.595 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr7_-_8268666 0.584 NM_004968
ICA1
islet cell autoantigen 1, 69kDa
chr11_-_6633427 0.582 NM_003737
DCHS1
dachsous 1 (Drosophila)
chr19_-_58462729 0.572 NM_173857
VN1R4
vomeronasal 1 receptor 4
chr12_-_102413875 0.572 NM_198521
NM_001099336
C12orf42

chromosome 12 open reading frame 42

chr5_-_169340321 0.571 NM_001129891
FAM196B
family with sequence similarity 196, member B
chr6_-_91063301 0.568 NM_001170794
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr12_-_6103945 0.564 NM_000552
VWF
von Willebrand factor
chr3_+_45902999 0.563 NM_006641
NM_031200
CCR9

chemokine (C-C motif) receptor 9

chr5_+_148717762 0.563 NM_024028
PCYOX1L
prenylcysteine oxidase 1 like
chr6_+_27222839 0.562 NM_080596
HIST1H2AH
histone cluster 1, H2ah
chr1_-_26105230 0.555 NM_203401
STMN1
stathmin 1
chr17_-_64649608 0.549 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr2_-_9688450 0.542 YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
chr6_-_91063181 0.538 NM_021813
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr4_-_2233606 0.529 MXD4
MAX dimerization protein 4
chr19_+_50086362 0.528 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr5_-_139760838 0.525


chr1_-_40140126 0.520 NM_001033081
NM_001033082
NM_005376
MYCL1


v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)


chr17_-_59817456 0.519 PECAM1
platelet/endothelial cell adhesion molecule
chr5_+_148717806 0.518 PCYOX1L
prenylcysteine oxidase 1 like
chr8_+_69027143 0.517 NM_024870
NM_025170
PREX2

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

chr8_-_120033240 0.517 NM_002546
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr1_+_24158898 0.516 PNRC2
proline-rich nuclear receptor coactivator 2
chr10_+_12431477 0.513 NM_020397
NM_153498
CAMK1D

calcium/calmodulin-dependent protein kinase ID

chr11_+_33520348 0.512 NM_012194
C11orf41
chromosome 11 open reading frame 41
chr11_+_13646822 0.509 FAR1
fatty acyl CoA reductase 1
chr11_+_36274300 0.507 NM_001160167
PRR5L
proline rich 5 like
chr1_-_204179169 0.504 NM_052934
NM_134325
SLC26A9

solute carrier family 26, member 9

chr7_+_128802719 0.504 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr18_-_21185968 0.503 ZNF521
zinc finger protein 521
chrX_+_99726445 0.503 NM_022144
TNMD
tenomodulin
chr14_-_87529222 0.500 GALC
galactosylceramidase
chr11_-_6418705 0.500 NM_000613
HPX
hemopexin
chr13_-_98428244 0.499 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr1_+_207668787 0.498 NM_001104548
LOC642587
NPC-A-5
chr14_-_50631407 0.497 TRIM9
tripartite motif containing 9
chr12_+_47658502 0.495 NM_005430
WNT1
wingless-type MMTV integration site family, member 1
chr3_+_51397731 0.495 NM_006010
MANF
mesencephalic astrocyte-derived neurotrophic factor
chr11_+_18676913 0.492 NM_153347
TMEM86A
transmembrane protein 86A
chr2_-_9688552 0.492 NM_006826
YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
chr7_-_13995811 0.489 ETV1
ets variant 1
chr14_-_87529212 0.489 GALC
galactosylceramidase
chr1_+_234372454 0.488 NM_003272
GPR137B
G protein-coupled receptor 137B
chr1_+_149299504 0.488 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr6_-_46246543 0.485 NM_021572
ENPP5
ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)
chr1_-_194844061 0.483 NM_198503
KCNT2
potassium channel, subfamily T, member 2
chr7_+_123083096 0.481 NM_207163
LMOD2
leiomodin 2 (cardiac)
chr19_+_1401208 0.479 APC2
adenomatosis polyposis coli 2
chr9_-_35804997 0.479 HINT2
histidine triad nucleotide binding protein 2
chrX_+_136475979 0.475 NM_003413
ZIC3
Zic family member 3 (odd-paired homolog, Drosophila)
chr19_+_13767207 0.474 NM_023072
ZSWIM4
zinc finger, SWIM-type containing 4
chr10_+_17311962 0.474 VIM
vimentin
chr11_-_4585947 0.473 NM_018073
TRIM68
tripartite motif containing 68
chr8_-_22606653 0.472 NM_004430
EGR3
early growth response 3
chr1_-_234096793 0.471


chr15_-_39973566 0.469 NM_016642
SPTBN5
spectrin, beta, non-erythrocytic 5
chr12_+_8557402 0.468 NM_080387
CLEC4D
C-type lectin domain family 4, member D
chr18_+_29412538 0.466 NM_030632
ASXL3
additional sex combs like 3 (Drosophila)
chr2_-_144991386 0.466 ZEB2
zinc finger E-box binding homeobox 2
chr17_-_71747867 0.465 NM_052916
RNF157
ring finger protein 157
chr22_-_30981317 0.462 NM_014227
SLC5A4
solute carrier family 5 (low affinity glucose cotransporter), member 4
chr6_-_20320607 0.460 NM_001080480
MBOAT1
membrane bound O-acyltransferase domain containing 1
chr1_+_43539239 0.460 NM_005424
TIE1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr1_+_199975674 0.457 NAV1
neuron navigator 1
chr11_+_128068982 0.452 NM_002017
FLI1
Friend leukemia virus integration 1
chr3_-_170347019 0.451 NM_001105078
MECOM
MDS1 and EVI1 complex locus
chr3_-_59010797 0.450 C3orf67
chromosome 3 open reading frame 67
chr1_+_149299530 0.443 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_149299490 0.442 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr19_+_50086357 0.441 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chrX_+_82649924 0.438 NM_000307
POU3F4
POU class 3 homeobox 4
chr5_+_40715778 0.435 NM_000958
PTGER4
prostaglandin E receptor 4 (subtype EP4)
chr20_-_55718982 0.433 NM_199169
NM_199170
PMEPA1

prostate transmembrane protein, androgen induced 1

chr5_-_41107161 0.431 NM_173489
HEATR7B2
HEAT repeat family member 7B2
chr14_+_85066207 0.431 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr5_-_157011949 0.431 NM_007017
NM_178424
SOX30

SRY (sex determining region Y)-box 30

chr19_+_17281374 0.430 DDA1
DET1 and DDB1 associated 1
chr5_-_146813343 0.430 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr2_-_71307705 0.428 NM_020459
PAIP2B
poly(A) binding protein interacting protein 2B
chr11_-_94603857 0.428 NM_144665
SESN3
sestrin 3
chr5_-_64813459 0.425 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr14_+_51525942 0.425 NM_016039
C14orf166
chromosome 14 open reading frame 166
chr4_+_183482130 0.425 NM_001080477
ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr22_+_42900168 0.424 NM_001137605
PARVG
parvin, gamma
chr1_-_153109349 0.423 NM_002249
KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr13_-_78075683 0.423 NM_006237
POU4F1
POU class 4 homeobox 1
chr1_-_68470585 0.422 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr18_+_18003401 0.420 NM_005257
GATA6
GATA binding protein 6
chr11_+_55319607 0.418 NM_001004735
OR5D14
olfactory receptor, family 5, subfamily D, member 14
chr5_+_76047536 0.417 NM_001992
F2R
coagulation factor II (thrombin) receptor
chr4_+_151218862 0.415 NM_001040260
NM_001040261
DCLK2

doublecortin-like kinase 2

chr7_-_27171648 0.415 HOXA9
homeobox A9
chr7_-_27206249 0.410 NM_000522
HOXA13
homeobox A13
chr1_+_84539876 0.409 NM_001134663
SAMD13
sterile alpha motif domain containing 13
chr6_+_21701942 0.408 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr7_+_123036312 0.407 NM_080928
ASB15
ankyrin repeat and SOCS box containing 15
chr3_-_186752952 0.407 NM_139248
LIPH
lipase, member H
chr15_-_56829069 0.406 ADAM10
ADAM metallopeptidase domain 10
chr2_-_159021201 0.405 NM_001171637
NM_138803
CCDC148

coiled-coil domain containing 148

chr4_-_149582948 0.405 NM_000901
NM_001166104
NR3C2

nuclear receptor subfamily 3, group C, member 2

chr7_-_27171673 0.404 NM_152739
HOXA9
homeobox A9
chr19_-_6061561 0.404 NM_000635
NM_134433
RFX2

regulatory factor X, 2 (influences HLA class II expression)

chr3_+_158637273 0.404 NM_002852
PTX3
pentraxin 3, long
chr1_+_149299307 0.403 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr7_-_27102049 0.403 NM_005522
NM_153620
HOXA1

homeobox A1

chr7_-_117300702 0.402 CTTNBP2
cortactin binding protein 2
chr10_+_22645370 0.399 COMMD3
COMM domain containing 3
chr14_+_51526071 0.398 C14orf166
chromosome 14 open reading frame 166
chr7_+_149895390 0.397 NM_018326
GIMAP4
GTPase, IMAP family member 4
chr19_+_50086350 0.397 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr11_+_6998275 0.397 NM_176822
NLRP14
NLR family, pyrin domain containing 14
chr11_-_123353607 0.396 NM_001004474
OR10S1
olfactory receptor, family 10, subfamily S, member 1
chr1_-_166149867 0.395 NM_001167749
NM_018417
ADCY10

adenylate cyclase 10 (soluble)

chr17_-_34607257 0.395 NM_000723
NM_199247
NM_199248
CACNB1


calcium channel, voltage-dependent, beta 1 subunit


chr10_-_127361583 0.394 NM_001128202
C10orf122
chromosome 10 open reading frame 122
chr1_-_148124738 0.392 NM_003528
HIST2H2BE
histone cluster 2, H2be
chr14_-_52689680 0.391 DDHD1
DDHD domain containing 1
chr8_-_124622434 0.389 NM_058229
FBXO32
F-box protein 32
chr18_-_18002926 0.389 LOC100128893
hypothetical LOC100128893
chr12_+_27511009 0.388 NM_001145010
C12orf70
chromosome 12 open reading frame 70
chr20_+_6696744 0.386 NM_001200
BMP2
bone morphogenetic protein 2
chrX_+_77889861 0.385 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chr10_+_17311242 0.385 VIM
vimentin
chr19_-_45888259 0.382 NM_004756
NUMBL
numb homolog (Drosophila)-like
chr12_-_21702021 0.382 LDHB
lactate dehydrogenase B
chr13_-_45654327 0.382 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr5_-_168660293 0.381 NM_003062
SLIT3
slit homolog 3 (Drosophila)
chr5_-_139402989 0.380 NM_001184935
NM_004883
NM_013981
NM_013982
NM_013983
NRG2




neuregulin 2




chrX_-_47815944 0.379 NM_001190255
ZNF630
zinc finger protein 630
chr6_+_74462226 0.378 NM_001159587
NM_001159588
NM_133493
CD109


CD109 molecule


chr12_+_105500814 0.378 RFX4
regulatory factor X, 4 (influences HLA class II expression)
chr5_-_137099602 0.377 NM_017415
KLHL3
kelch-like 3 (Drosophila)
chr12_-_21702046 0.376 NM_002300
LDHB
lactate dehydrogenase B
chr7_-_112513379 0.376 NM_001146266
NM_001146267
GPR85

G protein-coupled receptor 85

chr12_-_89976261 0.376 NM_007035
KERA
keratocan
chr6_-_85529884 0.375 TBX18
T-box 18
chr12_-_21702036 0.374 LDHB
lactate dehydrogenase B
chr17_+_8154280 0.374 NM_173728
ARHGEF15
Rho guanine nucleotide exchange factor (GEF) 15
chr10_+_11087280 0.373 CELF2
CUGBP, Elav-like family member 2
chr12_-_21702000 0.371 LDHB
lactate dehydrogenase B
chr9_-_35101534 0.369 KIAA1539
KIAA1539
chr3_+_174598937 0.369 NM_014932
NLGN1
neuroligin 1
chr7_+_150321771 0.369 NM_001160109
NM_001160110
NM_001160111
NOS3


nitric oxide synthase 3 (endothelial cell)


chr4_-_81213333 0.369 NM_001145794
NM_058172
ANTXR2

anthrax toxin receptor 2

chr6_+_74161296 0.367 DDX43
DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
chr2_-_2313894 0.367 NM_015025
MYT1L
myelin transcription factor 1-like
chr3_+_151171755 0.366 LOC646903
hypothetical LOC646903
chr10_+_70881221 0.366 NM_012339
TSPAN15
tetraspanin 15

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.22 3.40e-07 GO:0032501 multicellular organismal process
1.24 2.14e-04 GO:0007275 multicellular organismal development
1.38 4.61e-04 GO:0007399 nervous system development
1.21 9.60e-04 GO:0032502 developmental process
1.67 2.13e-03 GO:0007606 sensory perception of chemical stimulus
1.29 4.07e-03 GO:0030154 cell differentiation
1.68 6.86e-03 GO:0007608 sensory perception of smell
2.50 8.40e-03 GO:0006334 nucleosome assembly
1.47 1.02e-02 GO:0051128 regulation of cellular component organization
1.27 1.13e-02 GO:0048869 cellular developmental process
1.46 1.28e-02 GO:0007600 sensory perception
2.12 1.44e-02 GO:0071103 DNA conformation change
1.48 1.64e-02 GO:0010557 positive regulation of macromolecule biosynthetic process
1.30 1.93e-02 GO:0003008 system process
1.22 1.98e-02 GO:0048731 system development
1.58 2.28e-02 GO:0007417 central nervous system development
2.37 2.58e-02 GO:0031497 chromatin assembly
1.36 3.16e-02 GO:0010604 positive regulation of macromolecule metabolic process
1.20 4.55e-02 GO:0048856 anatomical structure development
2.14 4.69e-02 GO:0006323 DNA packaging
1.34 4.80e-02 GO:0009893 positive regulation of metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.95 6.81e-04 GO:0000786 nucleosome
1.13 1.02e-02 GO:0005634 nucleus

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.45 3.19e-04 GO:0001071 nucleic acid binding transcription factor activity
1.45 3.19e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.71 8.80e-04 GO:0004984 olfactory receptor activity
1.40 2.60e-03 GO:0030528 transcription regulator activity
1.45 1.91e-02 GO:0043565 sequence-specific DNA binding
1.21 4.72e-02 GO:0003677 DNA binding