Motif ID: ATF4.p2

Z-value: 1.245


Transcription factors associated with ATF4.p2:

Gene SymbolEntrez IDGene Name
ATF4 468 activating transcription factor 4 (tax-responsive enhancer element B67)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ATF4chr22_+_382465090.224.2e-01Click!


Activity profile for motif ATF4.p2.

activity profile for motif ATF4.p2


Sorted Z-values histogram for motif ATF4.p2

Sorted Z-values for motif ATF4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_586997 1.805 NM_014410
CLUL1
clusterin-like 1 (retinal)
chr12_-_121946635 1.243 NM_024667
VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr11_+_117362272 1.237 NM_001558
IL10RA
interleukin 10 receptor, alpha
chr7_-_140270749 1.079 NM_004333
BRAF
v-raf murine sarcoma viral oncogene homolog B1
chr12_-_121946581 1.052 VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr7_-_158314963 1.044 NM_020728
ESYT2
extended synaptotagmin-like protein 2
chr7_-_158314945 1.016 ESYT2
extended synaptotagmin-like protein 2
chr19_+_16048306 0.890 TPM4
tropomyosin 4
chr19_+_55671600 0.876 C19orf63
chromosome 19 open reading frame 63
chr19_-_55671273 0.833 FAM71E1
family with sequence similarity 71, member E1
chr19_+_16048266 0.792 TPM4
tropomyosin 4
chr19_+_55671594 0.789 C19orf63
chromosome 19 open reading frame 63
chr10_+_22674379 0.779 NM_012443
NM_172242
SPAG6

sperm associated antigen 6

chr19_+_55671468 0.771 NM_175063
NM_206538
C19orf63

chromosome 19 open reading frame 63

chr7_-_44992729 0.753 C7orf40
chromosome 7 open reading frame 40
chr7_-_129379947 0.748 NM_003344
NM_182697
UBE2H

ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)

chr1_-_153098811 0.743 NM_170782
KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr19_+_55671584 0.731 C19orf63
chromosome 19 open reading frame 63
chr19_+_10388448 0.727 PDE4A
phosphodiesterase 4A, cAMP-specific
chr6_-_90119329 0.716 NM_016021
UBE2J1
ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)
chr5_+_60663842 0.705 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chr5_-_172130766 0.688 NM_004417
DUSP1
dual specificity phosphatase 1
chr12_-_121946561 0.679


chr7_-_8268206 0.672 NM_022307
ICA1
islet cell autoantigen 1, 69kDa
chr1_-_156923111 0.671 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr7_-_8268292 0.623 NM_001136020
ICA1
islet cell autoantigen 1, 69kDa
chr5_-_1547872 0.618 LPCAT1
lysophosphatidylcholine acyltransferase 1
chr4_-_1980756 0.598 NM_005663
WHSC2
Wolf-Hirschhorn syndrome candidate 2
chr16_+_55523526 0.598 HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chrX_+_12903145 0.595 NM_021109
NM_183049
TMSB4X
TMSL3
thymosin beta 4, X-linked
thymosin-like 3
chr1_-_201162938 0.592 KLHL12
kelch-like 12 (Drosophila)
chr2_+_219453487 0.581 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr1_+_109090789 0.568 NM_007269
STXBP3
syntaxin binding protein 3
chr7_-_137337354 0.553 NM_194071
CREB3L2
cAMP responsive element binding protein 3-like 2
chr20_+_19863716 0.544 RIN2
Ras and Rab interactor 2
chr5_-_133589644 0.541 PPP2CA
protein phosphatase 2, catalytic subunit, alpha isozyme
chr15_+_74416129 0.541 ISL2
ISL LIM homeobox 2
chrX_+_151975421 0.530 NM_013364
PNMA3
paraneoplastic antigen MA3
chr7_-_137337352 0.528 CREB3L2
cAMP responsive element binding protein 3-like 2
chr7_-_137337318 0.523 CREB3L2
cAMP responsive element binding protein 3-like 2
chr1_+_51855343 0.514 OSBPL9
oxysterol binding protein-like 9
chr6_-_53321658 0.511 ELOVL5
ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)
chr16_+_54782802 0.505 GNAO1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
chr1_-_1274618 0.503 DVL1
dishevelled, dsh homolog 1 (Drosophila)
chr7_-_23537968 0.496 NM_013293
TRA2A
transformer 2 alpha homolog (Drosophila)
chr15_+_74416156 0.492 NM_145805
ISL2
ISL LIM homeobox 2
chr19_-_9556166 0.484 NM_001008727
ZNF121
zinc finger protein 121
chr19_+_2240996 0.484


chr6_+_47553399 0.481 NM_012120
CD2AP
CD2-associated protein
chr11_-_3775547 0.479 NM_005387
NM_016320
NM_139131
NM_139132
NUP98



nucleoporin 98kDa



chr5_-_95323353 0.476 NM_012081
ELL2
elongation factor, RNA polymerase II, 2
chr16_+_54782751 0.474 NM_020988
NM_138736
GNAO1

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O

chr3_+_171558215 0.473 SKIL
SKI-like oncogene
chr22_+_19601619 0.469 NM_005207
CRKL
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
chr3_+_195688974 0.468 FLJ34208
hypothetical LOC401106
chr5_-_133589450 0.467 PPP2CA
protein phosphatase 2, catalytic subunit, alpha isozyme
chr5_+_177473071 0.465 NM_015111
N4BP3
NEDD4 binding protein 3
chr7_-_150847698 0.464 RHEB
Ras homolog enriched in brain
chr11_+_65945050 0.463 NM_178864
NPAS4
neuronal PAS domain protein 4
chr19_+_16048315 0.461 TPM4
tropomyosin 4
chr3_+_171558188 0.460 SKIL
SKI-like oncogene
chr19_-_6453224 0.455 NM_006087
TUBB4
tubulin, beta 4
chr19_-_6432765 0.448 NM_024898
DENND1C
DENN/MADD domain containing 1C
chr22_+_19601721 0.447 CRKL
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
chr5_-_32210142 0.447 GOLPH3
golgi phosphoprotein 3 (coat-protein)
chr5_-_177986678 0.445 CLK4
CDC-like kinase 4
chr19_-_47413642 0.443 NM_133328
DEDD2
death effector domain containing 2
chr5_-_177986695 0.441 CLK4
CDC-like kinase 4
chr11_+_3775529 0.436 NM_001145438
PGAP2
post-GPI attachment to proteins 2
chr7_+_100302885 0.436 NM_003302
TRIP6
thyroid hormone receptor interactor 6
chr5_-_177986607 0.435 NM_020666
CLK4
CDC-like kinase 4
chr8_+_56177567 0.434 NM_052898
XKR4
XK, Kell blood group complex subunit-related family, member 4
chr19_+_54067491 0.430 PPP1R15A
protein phosphatase 1, regulatory (inhibitor) subunit 15A
chrX_-_47364173 0.430 NM_006950
NM_133499
SYN1

synapsin I

chrX_-_151996613 0.424 NM_032882
PNMA6A
paraneoplastic antigen like 6A
chr18_+_52965290 0.418 BOD1P
biorientation of chromosomes in cell division 1 pseudogene
chr5_+_112877251 0.414 NM_022828
YTHDC2
YTH domain containing 2
chr10_+_121401076 0.414 BAG3
BCL2-associated athanogene 3
chr1_-_17318452 0.409 NM_007365
PADI2
peptidyl arginine deiminase, type II
chr6_+_43319199 0.409 NM_032538
TTBK1
tau tubulin kinase 1
chr15_-_70399301 0.409 NM_001172684
CELF6
CUGBP, Elav-like family member 6
chr22_-_17546276 0.409 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr9_+_130684189 0.409 NM_001127245
NM_019594
LRRC8A

leucine rich repeat containing 8 family, member A

chr15_-_70399181 0.407 CELF6
CUGBP, Elav-like family member 6
chr19_+_1892157 0.406 NM_001319
CSNK1G2
casein kinase 1, gamma 2
chr8_+_126511739 0.405 NM_025195
TRIB1
tribbles homolog 1 (Drosophila)
chr19_+_17527457 0.404 GLT25D1
glycosyltransferase 25 domain containing 1
chr11_+_67107852 0.403 GSTP1
glutathione S-transferase pi 1
chr1_+_166414706 0.399 NM_001031800
NM_152902
TIPRL

TIP41, TOR signaling pathway regulator-like (S. cerevisiae)

chr22_+_22566586 0.398 MIF
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
chr6_+_56927882 0.393 BEND6
BEN domain containing 6
chr5_-_32480586 0.392 NM_016107
ZFR
zinc finger RNA binding protein
chr2_+_28469275 0.392 NM_005253
FOSL2
FOS-like antigen 2
chr11_+_18372687 0.391 LDHA
lactate dehydrogenase A
chr1_+_109090817 0.391 STXBP3
syntaxin binding protein 3
chr19_+_54067489 0.390 PPP1R15A
protein phosphatase 1, regulatory (inhibitor) subunit 15A
chrX_+_151975518 0.389 PNMA3
paraneoplastic antigen MA3
chr19_-_47413733 0.387 DEDD2
death effector domain containing 2
chr22_-_17546234 0.386 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr3_-_16281287 0.382 NM_001047434
NM_206831
DPH3

DPH3, KTI11 homolog (S. cerevisiae)

chr19_+_54067450 0.381 NM_014330
PPP1R15A
protein phosphatase 1, regulatory (inhibitor) subunit 15A
chr19_+_1892184 0.380 CSNK1G2
casein kinase 1, gamma 2
chr7_+_116447499 0.380 ST7
suppression of tumorigenicity 7
chr1_+_87567164 0.379 LMO4
LIM domain only 4
chr11_+_18372682 0.379 LDHA
lactate dehydrogenase A
chr22_-_17546296 0.378 NM_005984
SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chrX_-_7855400 0.378 NM_004650
PNPLA4
patatin-like phospholipase domain containing 4
chr6_-_42821815 0.378 NM_003192
TBCC
tubulin folding cofactor C
chr5_-_95323180 0.378 ELL2
elongation factor, RNA polymerase II, 2
chr19_-_60587414 0.377 NM_001190764
LOC388564
hypothetical protein LOC388564
chr11_-_61341011 0.376 NM_013402
FADS1
fatty acid desaturase 1
chr11_+_18372708 0.376 LDHA
lactate dehydrogenase A
chr17_-_7106497 0.375 CLDN7
claudin 7
chr6_-_53321706 0.375 NM_021814
ELOVL5
ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)
chr11_+_117362333 0.375 IL10RA
interleukin 10 receptor, alpha
chr5_-_133589670 0.374 PPP2CA
protein phosphatase 2, catalytic subunit, alpha isozyme
chr3_-_151963577 0.373 SIAH2
seven in absentia homolog 2 (Drosophila)
chrX_-_7855764 0.370 NM_001142389
NM_001172672
PNPLA4

patatin-like phospholipase domain containing 4

chr4_-_1980500 0.370 WHSC2
Wolf-Hirschhorn syndrome candidate 2
chr16_-_3870686 0.368 CREBBP
CREB binding protein
chr2_-_96899326 0.368 SEMA4C
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr16_+_87300385 0.367 NM_001012759
NM_001012762
CTU2

cytosolic thiouridylase subunit 2 homolog (S. pombe)

chr19_+_17527381 0.366 GLT25D1
glycosyltransferase 25 domain containing 1
chr10_+_121401032 0.365 BAG3
BCL2-associated athanogene 3
chr5_-_32210154 0.365 NM_022130
GOLPH3
golgi phosphoprotein 3 (coat-protein)
chr7_-_150847884 0.365 NM_005614
RHEB
Ras homolog enriched in brain
chr19_+_16048047 0.362 NM_003290
TPM4
tropomyosin 4
chr11_+_63498590 0.362 NM_004074
COX8A
cytochrome c oxidase subunit VIIIA (ubiquitous)
chr3_+_188222337 0.361 NM_003032
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr15_-_70399551 0.358 NM_052840
CELF6
CUGBP, Elav-like family member 6
chr4_-_120595218 0.358


chr17_+_4743645 0.358 NM_001145536
C17orf107
chromosome 17 open reading frame 107
chr7_-_91601972 0.357 NM_001146152
CYP51A1
cytochrome P450, family 51, subfamily A, polypeptide 1
chr15_-_70399523 0.357 CELF6
CUGBP, Elav-like family member 6
chrX_+_151991474 0.357 NM_001170944
NM_032882
LOC100287428
PNMA6A
paraneoplastic antigen-like protein 6A related gene
paraneoplastic antigen like 6A
chr11_+_18372689 0.357 LDHA
lactate dehydrogenase A
chr10_+_121401061 0.357 BAG3
BCL2-associated athanogene 3
chr20_+_44070946 0.356 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr19_+_1018536 0.354 HMHA1
histocompatibility (minor) HA-1
chr9_-_130683997 0.354 NM_001122671
NM_001122672
NM_004059
CCBL1


cysteine conjugate-beta lyase, cytoplasmic


chr19_-_50779924 0.353 NM_001017989
NM_025136
OPA3

optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)

chr1_-_184611424 0.353 TPR
translocated promoter region (to activated MET oncogene)
chr22_-_48437081 0.349 C22orf34
chromosome 22 open reading frame 34
chr10_-_23043449 0.348 NM_005028
PIP4K2A
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
chr3_+_171558143 0.348 NM_001145098
NM_005414
SKIL

SKI-like oncogene

chr3_-_151963607 0.345 SIAH2
seven in absentia homolog 2 (Drosophila)
chr6_-_42821800 0.343 TBCC
tubulin folding cofactor C
chr22_+_22566569 0.342 MIF
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
chr7_-_8268666 0.340 NM_004968
ICA1
islet cell autoantigen 1, 69kDa
chr20_+_32610161 0.339 NM_032514
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr5_-_132976121 0.339 NM_015082
FSTL4
follistatin-like 4
chr11_+_62405736 0.338 SLC3A2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr8_-_41641881 0.334 NM_001142445
NM_020478
NM_020480
ANK1


ankyrin 1, erythrocytic


chr8_+_23442331 0.334 SLC25A37
solute carrier family 25, member 37
chr2_-_87906400 0.334 NM_001078170
RGPD2
RANBP2-like and GRIP domain containing 2
chr3_+_151609395 0.334 NM_014779
TSC22D2
TSC22 domain family, member 2
chr14_+_23710924 0.332 REC8
REC8 homolog (yeast)
chr1_+_9522107 0.329 NM_032315
SLC25A33
solute carrier family 25, member 33
chr1_-_23367934 0.328 NM_001142546
NM_033631
LUZP1

leucine zipper protein 1

chr4_-_1980473 0.328 WHSC2
Wolf-Hirschhorn syndrome candidate 2
chr8_+_38763878 0.327 NM_001122824
NM_006283
TACC1

transforming, acidic coiled-coil containing protein 1

chr22_+_22566575 0.326


chr2_+_107809819 0.326 NM_182588
RGPD4
RANBP2-like and GRIP domain containing 4
chr17_-_20886680 0.325 NM_015276
USP22
ubiquitin specific peptidase 22
chr3_-_33734544 0.325 CLASP2
cytoplasmic linker associated protein 2
chr6_-_53321545 0.325 ELOVL5
ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)
chr19_-_9510257 0.325 NM_024106
ZNF426
zinc finger protein 426
chr9_+_130684248 0.324 LRRC8A
leucine rich repeat containing 8 family, member A
chr5_-_32210112 0.322 GOLPH3
golgi phosphoprotein 3 (coat-protein)
chr1_+_210848763 0.322 ATF3
activating transcription factor 3
chr1_-_23367918 0.322 LUZP1
leucine zipper protein 1
chr1_-_23367871 0.322 LUZP1
leucine zipper protein 1
chr15_-_75259714 0.322 PEAK1
NKF3 kinase family member
chr2_+_24003648 0.321 UBXN2A
UBX domain protein 2A
chr7_+_38184393 0.321 STARD3NL
STARD3 N-terminal like
chr22_+_22566579 0.318 MIF
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
chr17_+_26446067 0.317 NM_000267
NM_001042492
NM_001128147
NF1


neurofibromin 1


chr1_-_154665807 0.315 NM_006365
C1orf61
chromosome 1 open reading frame 61
chr12_+_54838408 0.315 MYL6
myosin, light chain 6, alkali, smooth muscle and non-muscle
chr1_+_9522133 0.315 SLC25A33
solute carrier family 25, member 33
chr6_-_144371035 0.314 NM_001080952
NM_001080953
NM_001080954
NM_001080956
NM_002656
NM_006718
PLAGL1





HYMAI
pleiomorphic adenoma gene-like 1





hydatidiform mole associated and imprinted (non-protein coding)
chrX_-_102452461 0.312 NM_001168399
NM_001168400
NM_001168401
NM_032621
BEX2



brain expressed X-linked 2



chr19_+_17527502 0.312 NM_024656
GLT25D1
glycosyltransferase 25 domain containing 1
chr8_+_38763911 0.310 TACC1
transforming, acidic coiled-coil containing protein 1
chr5_-_32210084 0.310 GOLPH3
golgi phosphoprotein 3 (coat-protein)
chr10_-_113933457 0.309 NM_020918
GPAM
glycerol-3-phosphate acyltransferase, mitochondrial
chr12_+_54838361 0.307 NM_021019
NM_079423
MYL6

myosin, light chain 6, alkali, smooth muscle and non-muscle

chr1_-_201162991 0.306 NM_021633
KLHL12
kelch-like 12 (Drosophila)
chr22_-_18484695 0.306 TRMT2A
TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)
chr22_+_22566556 0.306 NM_002415
MIF
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
chr2_+_170149348 0.306 PPIG
peptidylprolyl isomerase G (cyclophilin G)
chr6_-_3102690 0.305 NM_001069
TUBB2A
tubulin, beta 2A
chr3_-_33734747 0.305 NM_015097
CLASP2
cytoplasmic linker associated protein 2
chr19_+_54682661 0.305 RPL13A
ribosomal protein L13a
chr1_+_109090876 0.303


chr19_-_50779914 0.302 OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr1_+_210848726 0.302 ATF3
activating transcription factor 3
chr12_+_131194967 0.301 NOC4L
nucleolar complex associated 4 homolog (S. cerevisiae)
chr5_-_132976094 0.300 FSTL4
follistatin-like 4
chr15_-_80125514 0.300 MEX3B
mex-3 homolog B (C. elegans)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.37 2.24e-14 GO:0044237 cellular metabolic process
1.46 9.21e-13 GO:0044260 cellular macromolecule metabolic process
1.32 4.23e-11 GO:0044238 primary metabolic process
1.38 4.72e-10 GO:0043170 macromolecule metabolic process
1.27 4.40e-09 GO:0008152 metabolic process
1.54 3.84e-08 GO:0044267 cellular protein metabolic process
1.51 7.23e-08 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.46 1.01e-07 GO:0034641 cellular nitrogen compound metabolic process
1.44 1.75e-07 GO:0006807 nitrogen compound metabolic process
1.77 2.39e-06 GO:0044248 cellular catabolic process
1.49 2.37e-05 GO:0090304 nucleic acid metabolic process
1.41 2.86e-05 GO:0019538 protein metabolic process
1.61 8.56e-05 GO:0009056 catabolic process
1.12 1.37e-04 GO:0009987 cellular process
1.46 2.32e-03 GO:0010467 gene expression
2.37 5.40e-03 GO:0072523 purine-containing compound catabolic process
1.45 5.57e-03 GO:0006464 protein modification process
1.43 6.86e-03 GO:0043412 macromolecule modification
1.46 7.22e-03 GO:0016070 RNA metabolic process
2.36 8.21e-03 GO:0006195 purine nucleotide catabolic process
1.99 9.92e-03 GO:0072521 purine-containing compound metabolic process
2.40 1.16e-02 GO:0009154 purine ribonucleotide catabolic process
2.38 1.42e-02 GO:0009261 ribonucleotide catabolic process
2.26 1.52e-02 GO:0009166 nucleotide catabolic process
1.86 1.52e-02 GO:0044265 cellular macromolecule catabolic process
2.12 1.66e-02 GO:0019941 modification-dependent protein catabolic process
2.11 1.95e-02 GO:0043632 modification-dependent macromolecule catabolic process
2.08 2.09e-02 GO:0044257 cellular protein catabolic process
1.28 2.40e-02 GO:0071840 cellular component organization or biogenesis
2.11 2.47e-02 GO:0006511 ubiquitin-dependent protein catabolic process
2.17 2.86e-02 GO:0034655 nucleobase, nucleoside, nucleotide and nucleic acid catabolic process
2.17 2.86e-02 GO:0034656 nucleobase, nucleoside and nucleotide catabolic process
2.06 3.10e-02 GO:0051603 proteolysis involved in cellular protein catabolic process
2.07 3.64e-02 GO:0009150 purine ribonucleotide metabolic process
1.43 3.74e-02 GO:0006996 organelle organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.21 1.03e-18 GO:0044424 intracellular part
1.29 3.54e-18 GO:0043231 intracellular membrane-bounded organelle
1.19 4.92e-18 GO:0005622 intracellular
1.28 4.92e-18 GO:0043227 membrane-bounded organelle
1.24 4.29e-16 GO:0043229 intracellular organelle
1.24 7.45e-16 GO:0043226 organelle
1.36 6.25e-12 GO:0005634 nucleus
1.35 1.23e-11 GO:0044446 intracellular organelle part
1.34 8.89e-11 GO:0044422 organelle part
1.23 3.13e-10 GO:0005737 cytoplasm
1.56 1.76e-08 GO:0070013 intracellular organelle lumen
1.54 2.67e-08 GO:0031974 membrane-enclosed lumen
1.62 2.89e-08 GO:0031981 nuclear lumen
1.54 3.34e-08 GO:0043233 organelle lumen
1.56 3.73e-08 GO:0044428 nuclear part
1.26 5.37e-07 GO:0044444 cytoplasmic part
1.49 8.04e-06 GO:0005829 cytosol
1.57 1.87e-04 GO:0005654 nucleoplasm
1.90 1.10e-03 GO:0005730 nucleolus
1.32 3.23e-03 GO:0043228 non-membrane-bounded organelle
1.32 3.23e-03 GO:0043232 intracellular non-membrane-bounded organelle
4.36 9.88e-03 GO:0008287 protein serine/threonine phosphatase complex
1.25 1.34e-02 GO:0032991 macromolecular complex
1.72 1.89e-02 GO:0005694 chromosome
1.80 1.94e-02 GO:0044427 chromosomal part
2.92 3.62e-02 GO:0042470 melanosome
2.92 3.62e-02 GO:0048770 pigment granule

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.26 2.20e-09 GO:0005515 protein binding
1.53 9.92e-08 GO:0000166 nucleotide binding
1.58 3.36e-07 GO:0035639 purine ribonucleoside triphosphate binding
1.56 5.77e-07 GO:0017076 purine nucleotide binding
1.56 6.64e-07 GO:0032553 ribonucleotide binding
1.56 6.64e-07 GO:0032555 purine ribonucleotide binding
1.62 1.49e-06 GO:0030554 adenyl nucleotide binding
1.62 1.87e-06 GO:0032559 adenyl ribonucleotide binding
1.62 2.24e-06 GO:0005524 ATP binding
1.12 3.87e-06 GO:0005488 binding
1.20 8.15e-03 GO:0003824 catalytic activity
10.15 2.18e-02 GO:0016944 RNA polymerase II transcription elongation factor activity