Motif ID: E2F1..5.p2

Z-value: 2.344


Transcription factors associated with E2F1..5.p2:

Gene SymbolEntrez IDGene Name
E2F1 1869 E2F transcription factor 1
E2F2 1870 E2F transcription factor 2
E2F3 1871 E2F transcription factor 3
E2F4 1874 E2F transcription factor 4, p107/p130-binding
E2F5 1875 E2F transcription factor 5, p130-binding

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
E2F1chr20_-_31737731-0.811.3e-04Click!
E2F2chr1_-_23730298-0.702.8e-03Click!
E2F5chr8_+_86287161-0.421.0e-01Click!
E2F4chr16_+_65783599-0.361.7e-01Click!
E2F3chr6_+_20510019-0.243.7e-01Click!


Activity profile for motif E2F1..5.p2.

activity profile for motif E2F1..5.p2


Sorted Z-values histogram for motif E2F1..5.p2

Sorted Z-values for motif E2F1..5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F1..5.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_146869613 2.790 DPYSL3
dihydropyrimidinase-like 3
chr14_+_85069217 2.684


chr6_+_72949092 2.638 RIMS1
regulating synaptic membrane exocytosis 1
chr9_+_17124974 2.359 NM_001114395
NM_017738
 CNTLN

centlein, centrosomal protein

chr5_-_146869811 2.281 NM_001197294
 DPYSL3
dihydropyrimidinase-like 3
chr15_+_45263517 2.254 NM_001198999
 SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr22_+_18485145 1.954 RANBP1
RAN binding protein 1
chr22_+_18485068 1.911 RANBP1
RAN binding protein 1
chr22_+_18485076 1.805 RANBP1
RAN binding protein 1
chr9_-_25668230 1.759 TUSC1
tumor suppressor candidate 1
chr8_-_124477639 1.751 ATAD2
ATPase family, AAA domain containing 2
chr1_+_115198977 1.742 NM_003176
 SYCP1
synaptonemal complex protein 1
chrX_-_99873152 1.693 NM_001174068
NM_080737
 SYTL4

synaptotagmin-like 4

chr22_+_18485057 1.656 RANBP1
RAN binding protein 1
chr8_-_121526568 1.651 MRPL13
mitochondrial ribosomal protein L13
chr17_-_43977273 1.629 NM_002145
 HOXB2
homeobox B2
chr4_+_30331543 1.614 PCDH7
protocadherin 7
chr3_+_148609841 1.576 NM_003412
 ZIC1
Zic family member 1 (odd-paired homolog, Drosophila)
chr22_+_18485095 1.559 RANBP1
RAN binding protein 1
chr8_-_24869945 1.546 NM_006158
 NEFL
neurofilament, light polypeptide

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 87 entries
enrichment   p-value GO term description
7.23 3.17e-02 GO:0071897 DNA biosynthetic process
5.16 2.02e-02 GO:0031055 chromatin remodeling at centromere
4.96 3.13e-02 GO:0043486 histone exchange
4.87 1.40e-02 GO:0043044 ATP-dependent chromatin remodeling
4.05 1.98e-03 GO:0007051 spindle organization
3.94 3.21e-09 GO:0065004 protein-DNA complex assembly
3.86 2.42e-07 GO:0006334 nucleosome assembly
3.84 3.48e-09 GO:0071824 protein-DNA complex subunit organization
3.79 1.93e-07 GO:0031497 chromatin assembly
3.73 1.52e-07 GO:0034728 nucleosome organization
3.39 1.79e-07 GO:0006323 DNA packaging
3.24 6.39e-08 GO:0071103 DNA conformation change
3.19 1.95e-02 GO:0006261 DNA-dependent DNA replication
3.08 5.49e-06 GO:0006333 chromatin assembly or disassembly
3.06 2.11e-02 GO:0000956 nuclear-transcribed mRNA catabolic process
3.04 3.14e-04 GO:0051320 S phase
2.99 1.81e-02 GO:0006402 mRNA catabolic process
2.98 8.09e-04 GO:0000084 S phase of mitotic cell cycle
2.87 2.21e-05 GO:0000226 microtubule cytoskeleton organization
2.85 1.13e-04 GO:0000082 G1/S transition of mitotic cell cycle

Gene overrepresentation in compartment category:

Showing 1 to 20 of 44 entries
enrichment   p-value GO term description
9.64 3.07e-04 GO:0035098 ESC/E(Z) complex
5.87 2.77e-03 GO:0031519 PcG protein complex
4.02 8.92e-03 GO:0005657 replication fork
3.60 4.95e-04 GO:0000786 nucleosome
3.58 6.35e-07 GO:0032993 protein-DNA complex
3.21 3.09e-02 GO:0034708 methyltransferase complex
3.21 3.09e-02 GO:0035097 histone methyltransferase complex
2.82 1.26e-09 GO:0000785 chromatin
2.70 8.67e-06 GO:0044454 nuclear chromosome part
2.66 4.39e-07 GO:0000228 nuclear chromosome
2.65 2.08e-07 GO:0016604 nuclear body
2.56 7.77e-18 GO:0005694 chromosome
2.52 5.59e-14 GO:0044427 chromosomal part
2.52 2.84e-03 GO:0005681 spliceosomal complex
2.34 4.52e-02 GO:0016607 nuclear speck
2.30 2.14e-02 GO:0000793 condensed chromosome
2.12 2.17e-02 GO:0005819 spindle
2.11 2.41e-12 GO:0044451 nucleoplasm part
2.10 2.46e-08 GO:0030529 ribonucleoprotein complex
1.98 3.17e-19 GO:0005654 nucleoplasm

Gene overrepresentation in function category:

Showing 1 to 17 of 17 entries
enrichment   p-value GO term description
3.06 5.11e-03 GO:0003729 mRNA binding
2.39 1.57e-02 GO:0003690 double-stranded DNA binding
2.14 1.91e-02 GO:0043566 structure-specific DNA binding
1.90 1.70e-09 GO:0003723 RNA binding
1.53 7.57e-18 GO:0003676 nucleic acid binding
1.49 2.44e-09 GO:0003677 DNA binding
1.43 4.24e-02 GO:0030528 transcription regulator activity
1.42 8.87e-07 GO:0000166 nucleotide binding
1.35 3.27e-02 GO:0032559 adenyl ribonucleotide binding
1.34 4.33e-02 GO:0030554 adenyl nucleotide binding
1.34 4.73e-02 GO:0005524 ATP binding
1.30 3.50e-02 GO:0017076 purine nucleotide binding
1.30 3.62e-02 GO:0032553 ribonucleotide binding
1.30 3.62e-02 GO:0032555 purine ribonucleotide binding
1.30 4.12e-02 GO:0035639 purine ribonucleoside triphosphate binding
1.27 2.33e-15 GO:0005515 protein binding
1.14 5.67e-13 GO:0005488 binding