Motif ID: E2F1..5.p2

Z-value: 2.344


Transcription factors associated with E2F1..5.p2:

Gene SymbolEntrez IDGene Name
E2F1 1869 E2F transcription factor 1
E2F2 1870 E2F transcription factor 2
E2F3 1871 E2F transcription factor 3
E2F4 1874 E2F transcription factor 4, p107/p130-binding
E2F5 1875 E2F transcription factor 5, p130-binding

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
E2F1chr20_-_31737731-0.811.3e-04Click!
E2F2chr1_-_23730298-0.702.8e-03Click!
E2F5chr8_+_86287161-0.421.0e-01Click!
E2F4chr16_+_65783599-0.361.7e-01Click!
E2F3chr6_+_20510019-0.243.7e-01Click!


Activity profile for motif E2F1..5.p2.

activity profile for motif E2F1..5.p2


Sorted Z-values histogram for motif E2F1..5.p2

Sorted Z-values for motif E2F1..5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F1..5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_146869613 2.790 DPYSL3
dihydropyrimidinase-like 3
chr14_+_85069217 2.684


chr6_+_72949092 2.638 RIMS1
regulating synaptic membrane exocytosis 1
chr9_+_17124974 2.359 NM_001114395
NM_017738
CNTLN

centlein, centrosomal protein

chr5_-_146869811 2.281 NM_001197294
DPYSL3
dihydropyrimidinase-like 3
chr15_+_45263517 2.254 NM_001198999
SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr22_+_18485145 1.954 RANBP1
RAN binding protein 1
chr22_+_18485068 1.911 RANBP1
RAN binding protein 1
chr22_+_18485076 1.805 RANBP1
RAN binding protein 1
chr9_-_25668230 1.759 TUSC1
tumor suppressor candidate 1
chr8_-_124477639 1.751 ATAD2
ATPase family, AAA domain containing 2
chr1_+_115198977 1.742 NM_003176
SYCP1
synaptonemal complex protein 1
chrX_-_99873152 1.693 NM_001174068
NM_080737
SYTL4

synaptotagmin-like 4

chr22_+_18485057 1.656 RANBP1
RAN binding protein 1
chr8_-_121526568 1.651 MRPL13
mitochondrial ribosomal protein L13
chr17_-_43977273 1.629 NM_002145
HOXB2
homeobox B2
chr4_+_30331543 1.614 PCDH7
protocadherin 7
chr3_+_148609841 1.576 NM_003412
ZIC1
Zic family member 1 (odd-paired homolog, Drosophila)
chr22_+_18485095 1.559 RANBP1
RAN binding protein 1
chr8_-_24869945 1.546 NM_006158
NEFL
neurofilament, light polypeptide
chr13_-_25523164 1.515 NM_001007538
SHISA2
shisa homolog 2 (Xenopus laevis)
chr4_+_134289893 1.504 NM_020815
NM_032961
PCDH10

protocadherin 10

chr8_-_124477846 1.495 ATAD2
ATPase family, AAA domain containing 2
chr19_+_15079141 1.488 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr4_-_104860277 1.475 NM_001059
TACR3
tachykinin receptor 3
chr5_-_39110251 1.451 NM_152756
RICTOR
RPTOR independent companion of MTOR, complex 2
chr4_+_134292630 1.436 PCDH10
protocadherin 10
chr8_-_124477850 1.435 ATAD2
ATPase family, AAA domain containing 2
chr5_-_39110235 1.404 RICTOR
RPTOR independent companion of MTOR, complex 2
chr8_-_121526514 1.396 MRPL13
mitochondrial ribosomal protein L13
chr8_-_124477869 1.373 NM_014109
ATAD2
ATPase family, AAA domain containing 2
chr2_+_71534260 1.359 NM_001130976
NM_001130977
NM_001130978
NM_001130979
NM_001130980
NM_001130981
NM_003494
DYSF






dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)






chr15_+_30694982 1.358 NM_014783
NM_199357
ARHGAP11A

Rho GTPase activating protein 11A

chr15_-_81743198 1.339 BNC1
basonuclin 1
chr5_+_126654354 1.336 NM_032446
MEGF10
multiple EGF-like-domains 10
chr10_-_131652007 1.330 NM_001005463
EBF3
early B-cell factor 3
chr9_+_35782405 1.326 NM_003995
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr2_+_188865634 1.324 NM_016315
GULP1
GULP, engulfment adaptor PTB domain containing 1
chr9_-_78710698 1.316 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr5_+_170221584 1.305 NM_022897
RANBP17
RAN binding protein 17
chr2_+_188865796 1.285 GULP1
GULP, engulfment adaptor PTB domain containing 1
chr1_+_238321794 1.283 NM_020066
FMN2
formin 2
chr18_-_68361742 1.276 CBLN2
cerebellin 2 precursor
chr19_-_57082907 1.260 NM_001135590
NM_032679
ZNF577

zinc finger protein 577

chr8_-_121526806 1.260 NM_014078
MRPL13
mitochondrial ribosomal protein L13
chr6_+_88356503 1.258 NM_001197259
NM_012381
NM_181837
ORC3


origin recognition complex, subunit 3


chr15_+_42507123 1.251 CTDSPL2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr5_-_95793618 1.240 NM_001177875
PCSK1
proprotein convertase subtilisin/kexin type 1
chr10_+_62208256 1.231 CDK1
cyclin-dependent kinase 1
chr4_+_30331289 1.227 PCDH7
protocadherin 7
chr9_-_23811808 1.224 ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr6_-_88356445 1.210 NM_020320
RARS2
arginyl-tRNA synthetase 2, mitochondrial
chr11_-_117252541 1.189 FXYD6
FXYD domain containing ion transport regulator 6
chr8_+_31616809 1.177 NM_013962
NRG1
neuregulin 1
chr1_-_226712140 1.171 NM_033445
HIST3H2A
histone cluster 3, H2a
chr10_+_75580914 1.166 NM_006721
ADK
adenosine kinase
chr15_+_28705656 1.164 ARHGAP11B
Rho GTPase activating protein 11B
chr11_-_118739838 1.156 USP2
ubiquitin specific peptidase 2
chr7_+_120378052 1.145 NM_019071
NM_198267
ING3

inhibitor of growth family, member 3

chr6_-_88356411 1.142 RARS2
arginyl-tRNA synthetase 2, mitochondrial
chr18_-_5620629 1.116 EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr2_-_164300758 1.116 NM_018086
FIGN
fidgetin
chr11_-_19219000 1.114 NM_024680
E2F8
E2F transcription factor 8
chr8_+_121526823 1.099 NM_022045
MTBP
Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa
chr13_+_33290254 1.094 RFC3
replication factor C (activator 1) 3, 38kDa
chr12_+_5411534 1.089 NM_001102654
NTF3
neurotrophin 3
chr8_-_95634845 1.078 NM_015496
NM_183009
KIAA1429

KIAA1429

chr9_-_23811842 1.066 NM_001171195
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr22_+_49293520 1.055 NCAPH2
non-SMC condensin II complex, subunit H2
chr4_+_30330963 1.049 NM_001173523
NM_002589
NM_032456
NM_032457
PCDH7



protocadherin 7



chr7_-_44854092 1.045 H2AFV
H2A histone family, member V
chr11_+_12987455 1.040 NM_001080521
RASSF10
Ras association (RalGDS/AF-6) domain family (N-terminal) member 10
chr2_+_219141761 1.030 NM_005444
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr9_-_103289154 1.030 NM_032342
C9orf125
chromosome 9 open reading frame 125
chr3_-_62334229 1.025 NM_018008
FEZF2
FEZ family zinc finger 2
chr1_-_26105230 1.024 NM_203401
STMN1
stathmin 1
chr1_-_68470585 1.014 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr10_+_96295511 1.012 NM_018063
HELLS
helicase, lymphoid-specific
chr9_-_121171400 1.010 NM_014618
DBC1
deleted in bladder cancer 1
chrX_-_99873728 0.993 NM_001129896
SYTL4
synaptotagmin-like 4
chrX_-_103386215 0.990 NM_153448
ESX1
ESX homeobox 1
chr4_-_170915602 0.990 NM_017867
C4orf27
chromosome 4 open reading frame 27
chr1_+_226712430 0.989 NM_175055
HIST3H2BB
histone cluster 3, H2bb
chr3_+_64645819 0.980 LOC100507098
hypothetical LOC100507098
chr7_-_27153892 0.932 NM_024014
HOXA6
homeobox A6
chr19_-_58449752 0.925 ZNF677
zinc finger protein 677
chr5_+_79986222 0.920 MSH3
mutS homolog 3 (E. coli)
chr11_-_63195371 0.915 ATL3
atlastin GTPase 3
chr5_+_79986227 0.902 MSH3
mutS homolog 3 (E. coli)
chr2_-_136350404 0.895 MCM6
minichromosome maintenance complex component 6
chr15_+_42507057 0.882 CTDSPL2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr5_-_79986063 0.879 DHFR
dihydrofolate reductase
chr5_+_170221441 0.874 RANBP17
RAN binding protein 17
chr22_+_49293493 0.865 NM_001185011
NM_014551
NM_152299
NCAPH2


non-SMC condensin II complex, subunit H2


chr3_+_14195231 0.865 NM_014463
LSM3
LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr14_+_37748345 0.864 SSTR1
somatostatin receptor 1
chr3_+_14195333 0.863 LSM3
LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr8_+_55533047 0.847 NM_022454
SOX17
SRY (sex determining region Y)-box 17
chr2_+_15998090 0.847 NM_005378
MYCN
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr7_+_88226617 0.838 NM_181646
ZNF804B
zinc finger protein 804B
chrX_+_101792949 0.832 NM_001099410
NM_001099411
NM_014710
NM_001184727
GPRASP1



G protein-coupled receptor associated sorting protein 1



chr1_+_52642826 0.831 PRPF38A
PRP38 pre-mRNA processing factor 38 (yeast) domain containing A
chr5_-_79986104 0.827 DHFR
dihydrofolate reductase
chr5_-_178704934 0.824 ADAMTS2
ADAM metallopeptidase with thrombospondin type 1 motif, 2
chr1_+_52642802 0.821 NM_032864
PRPF38A
PRP38 pre-mRNA processing factor 38 (yeast) domain containing A
chr5_+_72897323 0.818 NM_032175
UTP15
UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae)
chr3_+_5139032 0.812 ARL8B
ADP-ribosylation factor-like 8B
chr7_-_95063738 0.811 NM_002612
PDK4
pyruvate dehydrogenase kinase, isozyme 4
chr1_-_203985701 0.810 NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr5_+_79986254 0.809 MSH3
mutS homolog 3 (E. coli)
chr19_-_58449919 0.807 NM_182609
ZNF677
zinc finger protein 677
chr5_+_65476418 0.802 NM_139168
SREK1
splicing regulatory glutamine/lysine-rich protein 1
chr8_+_69027277 0.795 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr1_-_24179326 0.792 SRSF10
serine/arginine-rich splicing factor 10
chr1_-_210275402 0.783 NM_015434
INTS7
integrator complex subunit 7
chr1_-_29380850 0.782 SRSF4
serine/arginine-rich splicing factor 4
chr7_-_44854145 0.781 H2AFV
H2A histone family, member V
chr7_+_26207854 0.779 CBX3
chromobox homolog 3
chr5_+_79986049 0.775 NM_002439
MSH3
mutS homolog 3 (E. coli)
chr5_+_36912656 0.773 NIPBL
Nipped-B homolog (Drosophila)
chr12_+_97511805 0.770 SLC25A3
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
chr7_-_44854183 0.769 H2AFV
H2A histone family, member V
chr9_-_23816062 0.766 NM_004432
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr21_-_27139143 0.761 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr10_+_8136639 0.755 NM_001002295
NM_002051
GATA3

GATA binding protein 3

chr9_+_85785456 0.754 NM_024945
RMI1
RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)
chr5_-_178705036 0.753 NM_014244
NM_021599
ADAMTS2

ADAM metallopeptidase with thrombospondin type 1 motif, 2

chr11_-_118740069 0.749 NM_171997
USP2
ubiquitin specific peptidase 2
chr7_-_151763857 0.740 MLL3
myeloid/lymphoid or mixed-lineage leukemia 3
chr11_-_33847507 0.734 LMO2
LIM domain only 2 (rhombotin-like 1)
chr1_-_147665783 0.725 HIST2H2BF
histone cluster 2, H2bf
chr7_-_94123308 0.724 SGCE
sarcoglycan, epsilon
chr7_-_44854188 0.716 H2AFV
H2A histone family, member V
chr7_-_44854222 0.715 NM_012412
NM_138635
NM_201436
NM_201516
NM_201517
H2AFV




H2A histone family, member V




chr1_-_36008009 0.715 NM_001190481
NM_022111
CLSPN

claspin

chr3_-_14195075 0.710 NM_001145769
NM_004628
XPC

xeroderma pigmentosum, complementation group C

chr13_+_102047286 0.710 NM_003291
TPP2
tripeptidyl peptidase II
chr9_-_97119677 0.709 NM_000136
FANCC
Fanconi anemia, complementation group C
chr1_-_42573210 0.702 NM_001198851
FOXJ3
forkhead box J3
chr17_+_28279283 0.701 TMEM98
transmembrane protein 98
chr1_-_203985752 0.700 NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr10_+_62208094 0.699 NM_001170406
NM_001170407
NM_001786
NM_033379
CDK1



cyclin-dependent kinase 1



chr7_+_26207897 0.699 CBX3
chromobox homolog 3
chr1_+_52642871 0.694 PRPF38A
PRP38 pre-mRNA processing factor 38 (yeast) domain containing A
chr13_+_33290205 0.693 NM_002915
NM_181558
RFC3

replication factor C (activator 1) 3, 38kDa

chr15_-_63871492 0.691 DENND4A
DENN/MADD domain containing 4A
chr1_-_203985780 0.688 NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr5_-_72897132 0.688 NM_023039
ANKRA2
ankyrin repeat, family A (RFXANK-like), 2
chr1_+_220952518 0.685 NM_144695
BROX
BRO1 domain and CAAX motif containing
chr1_-_91259601 0.684 NM_016620
ZNF644
zinc finger protein 644
chr6_-_27949266 0.684 NM_003546
HIST1H4L
histone cluster 1, H4l
chr1_+_220952681 0.681 BROX
BRO1 domain and CAAX motif containing
chr8_-_124322764 0.680 NM_032847
C8orf76
chromosome 8 open reading frame 76
chr1_+_149309703 0.680 NM_144618
GABPB2
GA binding protein transcription factor, beta subunit 2
chrX_+_101887562 0.679 NM_001142529
NM_001142530
BHLHB9

basic helix-loop-helix domain containing, class B, 9

chr7_+_98084531 0.674 NM_002523
NPTX2
neuronal pentraxin II
chr3_-_52694554 0.669 NM_018313
PBRM1
polybromo 1
chr11_-_117252828 0.664 NM_001164832
NM_001164836
NM_001164837
NM_022003
FXYD6



FXYD domain containing ion transport regulator 6



chr5_+_56505412 0.664 NM_022913
GPBP1
GC-rich promoter binding protein 1
chr1_+_43386180 0.662 NM_001101376
FAM183A
family with sequence similarity 183, member A
chr5_-_139761182 0.660


chr7_+_121300394 0.659 NM_002851
PTPRZ1
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
chr5_+_130627669 0.652 CDC42SE2
CDC42 small effector 2
chr11_-_64302440 0.650 SF1
splicing factor 1
chr1_+_176329578 0.649 RASAL2
RAS protein activator like 2
chr3_+_44778284 0.646 KIF15
kinesin family member 15
chr10_+_8136778 0.643 GATA3
GATA binding protein 3
chr1_+_210275541 0.642 NM_016448
DTL
denticleless homolog (Drosophila)
chr11_-_95162333 0.641 FAM76B
family with sequence similarity 76, member B
chr3_-_140148671 0.639 NM_023067
FOXL2
forkhead box L2
chr1_+_62675323 0.638 USP1
ubiquitin specific peptidase 1
chr7_-_94123362 0.630 SGCE
sarcoglycan, epsilon
chr8_+_17824790 0.629 PCM1
pericentriolar material 1
chr3_+_14195347 0.629 LSM3
LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr7_-_19123765 0.626 TWIST1
twist homolog 1 (Drosophila)
chr6_-_91353492 0.624 NM_003188
NM_145332
NM_145333
MAP3K7


mitogen-activated protein kinase kinase kinase 7


chrX_+_122923279 0.624 STAG2
stromal antigen 2
chr13_-_72254071 0.623 NM_001128226
NM_014953
DIS3

DIS3 mitotic control homolog (S. cerevisiae)

chr8_+_38208322 0.620 NM_001164232
DDHD2
DDHD domain containing 2
chrX_-_70390704 0.619 NM_201599
ZMYM3
zinc finger, MYM-type 3
chr15_+_39412183 0.619 NM_001129897
NM_016359
NM_018454
NUSAP1


nucleolar and spindle associated protein 1


chr4_-_130233855 0.619 NM_144643
SCLT1
sodium channel and clathrin linker 1
chr22_+_33983444 0.618 NM_001003681
HMGXB4
HMG box domain containing 4
chr7_+_121300446 0.617 PTPRZ1
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
chr8_+_69405510 0.616 NM_001195639
NM_052958
C8orf34

chromosome 8 open reading frame 34

chr11_-_62379788 0.615 SNHG1
small nucleolar RNA host gene 1 (non-protein coding)
chr13_+_109757593 0.615 NM_001846
COL4A2
collagen, type IV, alpha 2
chr8_-_132122016 0.611 NM_001115
ADCY8
adenylate cyclase 8 (brain)
chr13_-_109236897 0.610 NM_003749
IRS2
insulin receptor substrate 2
chr6_-_91353322 0.607 NM_145331
MAP3K7
mitogen-activated protein kinase kinase kinase 7
chr19_-_41237138 0.607 THAP8
THAP domain containing 8
chr7_+_138695241 0.604 LUC7L2
LUC7-like 2 (S. cerevisiae)
chr11_-_64302509 0.603 NM_001178030
SF1
splicing factor 1
chr5_+_50714714 0.603 NM_002202
ISL1
ISL LIM homeobox 1
chr4_+_154485224 0.603 NM_032117
MND1
meiotic nuclear divisions 1 homolog (S. cerevisiae)
chr6_-_88356385 0.603 RARS2
arginyl-tRNA synthetase 2, mitochondrial
chr5_-_72896964 0.602 ANKRA2
ankyrin repeat, family A (RFXANK-like), 2
chr19_-_12706480 0.600 C19orf43
chromosome 19 open reading frame 43
chrX_-_135677022 0.599 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr7_-_77163475 0.599



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.74 1.33e-24 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.83 1.53e-23 GO:0090304 nucleic acid metabolic process
2.22 3.20e-20 GO:0007049 cell cycle
1.47 2.57e-19 GO:0044260 cellular macromolecule metabolic process
1.59 9.53e-19 GO:0034641 cellular nitrogen compound metabolic process
1.55 3.38e-17 GO:0006807 nitrogen compound metabolic process
2.26 1.76e-16 GO:0022402 cell cycle process
2.32 5.78e-15 GO:0022403 cell cycle phase
1.38 1.01e-14 GO:0043170 macromolecule metabolic process
1.75 3.47e-14 GO:0016070 RNA metabolic process
2.44 2.78e-13 GO:0016071 mRNA metabolic process
1.30 4.02e-13 GO:0044237 cellular metabolic process
1.52 1.00e-11 GO:0071841 cellular component organization or biogenesis at cellular level
1.28 1.97e-11 GO:0044238 primary metabolic process
2.27 2.42e-11 GO:0000278 mitotic cell cycle
1.15 3.44e-11 GO:0009987 cellular process
1.52 4.51e-11 GO:0071842 cellular component organization at cellular level
1.44 5.68e-11 GO:0016043 cellular component organization
1.43 6.50e-11 GO:0071840 cellular component organization or biogenesis
2.20 6.68e-11 GO:0051276 chromosome organization
1.63 9.70e-11 GO:0010467 gene expression
1.68 1.31e-10 GO:0006996 organelle organization
3.94 3.21e-09 GO:0065004 protein-DNA complex assembly
3.84 3.48e-09 GO:0071824 protein-DNA complex subunit organization
2.24 5.62e-09 GO:0034621 cellular macromolecular complex subunit organization
2.42 5.96e-09 GO:0006397 mRNA processing
2.07 8.49e-09 GO:0006396 RNA processing
1.22 1.15e-08 GO:0008152 metabolic process
2.58 1.46e-08 GO:0051325 interphase
1.74 1.61e-08 GO:0044085 cellular component biogenesis
2.40 4.10e-08 GO:0034622 cellular macromolecular complex assembly
3.24 6.39e-08 GO:0071103 DNA conformation change
2.26 7.13e-08 GO:0000279 M phase
1.86 1.21e-07 GO:0043933 macromolecular complex subunit organization
3.73 1.52e-07 GO:0034728 nucleosome organization
3.39 1.79e-07 GO:0006323 DNA packaging
3.79 1.93e-07 GO:0031497 chromatin assembly
2.50 2.02e-07 GO:0051329 interphase of mitotic cell cycle
2.03 2.23e-07 GO:0006259 DNA metabolic process
1.74 2.29e-07 GO:0022607 cellular component assembly
3.86 2.42e-07 GO:0006334 nucleosome assembly
1.99 3.61e-07 GO:0051726 regulation of cell cycle
2.08 6.19e-07 GO:0006974 response to DNA damage stimulus
1.87 6.35e-07 GO:0071844 cellular component assembly at cellular level
1.90 7.54e-07 GO:0065003 macromolecular complex assembly
2.41 1.75e-06 GO:0008380 RNA splicing
3.08 5.49e-06 GO:0006333 chromatin assembly or disassembly
1.51 1.32e-05 GO:0034645 cellular macromolecule biosynthetic process
2.87 2.21e-05 GO:0000226 microtubule cytoskeleton organization
1.49 3.27e-05 GO:0009059 macromolecule biosynthetic process
2.00 3.51e-05 GO:0006325 chromatin organization
2.66 4.84e-05 GO:0006260 DNA replication
2.25 1.02e-04 GO:0000280 nuclear division
2.25 1.02e-04 GO:0007067 mitosis
2.85 1.13e-04 GO:0000082 G1/S transition of mitotic cell cycle
2.15 1.14e-04 GO:0006281 DNA repair
2.52 1.55e-04 GO:0000375 RNA splicing, via transesterification reactions
2.11 2.20e-04 GO:0010564 regulation of cell cycle process
1.37 2.25e-04 GO:0044249 cellular biosynthetic process
2.52 2.26e-04 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.52 2.26e-04 GO:0000398 nuclear mRNA splicing, via spliceosome
2.19 2.61e-04 GO:0000087 M phase of mitotic cell cycle
2.18 2.92e-04 GO:0048285 organelle fission
3.04 3.14e-04 GO:0051320 S phase
1.67 4.67e-04 GO:0033554 cellular response to stress
2.98 8.09e-04 GO:0000084 S phase of mitotic cell cycle
1.33 1.63e-03 GO:0009058 biosynthetic process
4.05 1.98e-03 GO:0007051 spindle organization
1.97 4.71e-03 GO:0051301 cell division
1.25 7.03e-03 GO:0031323 regulation of cellular metabolic process
2.78 8.81e-03 GO:0006401 RNA catabolic process
4.87 1.40e-02 GO:0043044 ATP-dependent chromatin remodeling
1.24 1.40e-02 GO:0080090 regulation of primary metabolic process
2.16 1.57e-02 GO:0071156 regulation of cell cycle arrest
2.19 1.62e-02 GO:0000075 cell cycle checkpoint
1.25 1.80e-02 GO:0060255 regulation of macromolecule metabolic process
2.99 1.81e-02 GO:0006402 mRNA catabolic process
3.19 1.95e-02 GO:0006261 DNA-dependent DNA replication
5.16 2.02e-02 GO:0031055 chromatin remodeling at centromere
1.51 2.03e-02 GO:0032774 RNA biosynthetic process
3.06 2.11e-02 GO:0000956 nuclear-transcribed mRNA catabolic process
1.22 3.06e-02 GO:0019222 regulation of metabolic process
4.96 3.13e-02 GO:0043486 histone exchange
7.23 3.17e-02 GO:0071897 DNA biosynthetic process
2.64 3.49e-02 GO:0051028 mRNA transport
1.99 4.04e-02 GO:0007017 microtubule-based process
1.27 4.79e-02 GO:0051171 regulation of nitrogen compound metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.31 9.85e-39 GO:0043226 organelle
1.31 4.20e-38 GO:0043229 intracellular organelle
1.53 1.05e-37 GO:0005634 nucleus
1.33 1.66e-34 GO:0043227 membrane-bounded organelle
1.33 4.31e-34 GO:0043231 intracellular membrane-bounded organelle
1.23 2.83e-33 GO:0044424 intracellular part
1.21 2.59e-30 GO:0005622 intracellular
1.88 8.63e-28 GO:0044428 nuclear part
1.81 6.89e-25 GO:0070013 intracellular organelle lumen
1.43 1.44e-24 GO:0044446 intracellular organelle part
1.42 3.93e-24 GO:0044422 organelle part
1.78 7.60e-24 GO:0031974 membrane-enclosed lumen
1.90 8.25e-24 GO:0031981 nuclear lumen
1.78 1.02e-23 GO:0043233 organelle lumen
1.98 3.17e-19 GO:0005654 nucleoplasm
2.56 7.77e-18 GO:0005694 chromosome
1.50 2.28e-17 GO:0032991 macromolecular complex
1.56 1.44e-15 GO:0043228 non-membrane-bounded organelle
1.56 1.44e-15 GO:0043232 intracellular non-membrane-bounded organelle
2.52 5.59e-14 GO:0044427 chromosomal part
2.11 2.41e-12 GO:0044451 nucleoplasm part
2.82 1.26e-09 GO:0000785 chromatin
2.10 2.46e-08 GO:0030529 ribonucleoprotein complex
2.65 2.08e-07 GO:0016604 nuclear body
1.37 4.14e-07 GO:0043234 protein complex
2.66 4.39e-07 GO:0000228 nuclear chromosome
3.58 6.35e-07 GO:0032993 protein-DNA complex
1.05 2.05e-06 GO:0044464 cell part
1.05 2.12e-06 GO:0005623 cell
2.70 8.67e-06 GO:0044454 nuclear chromosome part
1.14 1.45e-04 GO:0005737 cytoplasm
9.64 3.07e-04 GO:0035098 ESC/E(Z) complex
3.60 4.95e-04 GO:0000786 nucleosome
5.87 2.77e-03 GO:0031519 PcG protein complex
2.52 2.84e-03 GO:0005681 spliceosomal complex
1.71 5.09e-03 GO:0005730 nucleolus
4.02 8.92e-03 GO:0005657 replication fork
1.57 1.05e-02 GO:0015630 microtubule cytoskeleton
2.30 2.14e-02 GO:0000793 condensed chromosome
2.12 2.17e-02 GO:0005819 spindle
3.21 3.09e-02 GO:0034708 methyltransferase complex
3.21 3.09e-02 GO:0035097 histone methyltransferase complex
1.78 3.51e-02 GO:0005815 microtubule organizing center
2.34 4.52e-02 GO:0016607 nuclear speck

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.53 7.57e-18 GO:0003676 nucleic acid binding
1.27 2.33e-15 GO:0005515 protein binding
1.14 5.67e-13 GO:0005488 binding
1.90 1.70e-09 GO:0003723 RNA binding
1.49 2.44e-09 GO:0003677 DNA binding
1.42 8.87e-07 GO:0000166 nucleotide binding
3.06 5.11e-03 GO:0003729 mRNA binding
2.39 1.57e-02 GO:0003690 double-stranded DNA binding
2.14 1.91e-02 GO:0043566 structure-specific DNA binding
1.35 3.27e-02 GO:0032559 adenyl ribonucleotide binding
1.30 3.50e-02 GO:0017076 purine nucleotide binding
1.30 3.62e-02 GO:0032553 ribonucleotide binding
1.30 3.62e-02 GO:0032555 purine ribonucleotide binding
1.30 4.12e-02 GO:0035639 purine ribonucleoside triphosphate binding
1.43 4.24e-02 GO:0030528 transcription regulator activity
1.34 4.33e-02 GO:0030554 adenyl nucleotide binding
1.34 4.73e-02 GO:0005524 ATP binding