Motif ID: EGR1..3.p2

Z-value: 2.105


Transcription factors associated with EGR1..3.p2:

Gene SymbolEntrez IDGene Name
EGR1 1958 early growth response 1
EGR2 1959 early growth response 2 (Krox-20 homolog, Drosophila)
EGR3 1960 early growth response 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EGR2chr10_-_64246129-0.476.7e-02Click!
EGR3chr8_-_22606653-0.292.7e-01Click!
EGR1chr5_+_137829077-0.185.0e-01Click!


Activity profile for motif EGR1..3.p2.

activity profile for motif EGR1..3.p2


Sorted Z-values histogram for motif EGR1..3.p2

Sorted Z-values for motif EGR1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EGR1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_152592450 3.413 PNCK
pregnancy up-regulated non-ubiquitously expressed CaM kinase
chr16_+_29725311 3.361 NM_001042539
NM_002383
 MAZ

MYC-associated zinc finger protein (purine-binding transcription factor)

chr16_+_29725597 2.443


chr16_-_53520208 2.340 CRNDE
colorectal neoplasia differentially expressed (non-protein coding)
chr2_+_104838177 2.268 NM_006236
 POU3F3
POU class 3 homeobox 3
chr16_+_1143241 2.072 NM_001005407
NM_021098
 CACNA1H

calcium channel, voltage-dependent, T type, alpha 1H subunit

chr19_+_1704661 2.052 NM_001080488
 ONECUT3
one cut homeobox 3
chr9_-_122679387 2.020 NM_001009936
NM_015651
 PHF19

PHD finger protein 19

chr22_+_38183262 1.964 NM_002409
 MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr7_-_150283794 1.867 NM_172057
 KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr16_+_88305743 1.845 LOC100128881
hypothetical LOC100128881
chrX_-_152591936 1.748 NM_001135740
 PNCK
pregnancy up-regulated non-ubiquitously expressed CaM kinase
chr6_-_13819622 1.683 NM_005493
 RANBP9
RAN binding protein 9
chr1_+_224317062 1.654 H3F3A
LOC440926
H3 histone, family 3A
H3 histone, family 3A pseudogene
chr1_+_224317030 1.636 H3F3A
H3 histone, family 3A
chr6_-_79844618 1.601 PHIP
pleckstrin homology domain interacting protein
chr3_-_24511456 1.585 THRB
thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
chr1_+_224317056 1.577 H3F3A
LOC440926
H3 histone, family 3A
H3 histone, family 3A pseudogene
chr7_+_128257698 1.575 NM_001127487
NM_001458
 FLNC

filamin C, gamma

chr22_-_20551937 1.568 MAPK1
mitogen-activated protein kinase 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 154 entries
enrichment   p-value GO term description
4.42 2.02e-02 GO:0045815 positive regulation of gene expression, epigenetic
2.95 9.94e-03 GO:0070936 protein K48-linked ubiquitination
2.70 5.97e-03 GO:0031047 gene silencing by RNA
2.38 1.99e-03 GO:0016458 gene silencing
2.33 7.79e-04 GO:0000209 protein polyubiquitination
2.26 4.63e-05 GO:0040029 regulation of gene expression, epigenetic
2.23 2.50e-02 GO:0018394 peptidyl-lysine acetylation
2.22 3.90e-02 GO:0016573 histone acetylation
2.19 3.64e-02 GO:0006475 internal protein amino acid acetylation
2.17 5.44e-09 GO:0016570 histone modification
2.16 5.05e-09 GO:0016569 covalent chromatin modification
2.13 7.19e-03 GO:0018205 peptidyl-lysine modification
2.12 4.42e-02 GO:0006473 protein acetylation
2.00 3.43e-14 GO:0016568 chromatin modification
1.97 1.86e-03 GO:0006403 RNA localization
1.92 1.10e-02 GO:0050657 nucleic acid transport
1.92 1.10e-02 GO:0050658 RNA transport
1.92 1.10e-02 GO:0051236 establishment of RNA localization
1.85 8.49e-03 GO:0006184 GTP catabolic process
1.83 9.93e-07 GO:0032446 protein modification by small protein conjugation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 46 entries
enrichment   p-value GO term description
3.82 1.77e-04 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
3.69 4.60e-02 GO:0010494 stress granule
2.53 4.45e-02 GO:0042641 actomyosin
2.46 2.34e-07 GO:0016585 chromatin remodeling complex
2.40 2.88e-02 GO:0008287 protein serine/threonine phosphatase complex
2.32 7.04e-03 GO:0035770 RNA granule
2.23 3.88e-03 GO:0000123 histone acetyltransferase complex
1.99 7.68e-03 GO:0042470 melanosome
1.99 7.68e-03 GO:0048770 pigment granule
1.98 1.97e-02 GO:0000790 nuclear chromatin
1.62 3.37e-02 GO:0031252 cell leading edge
1.52 1.71e-08 GO:0044451 nucleoplasm part
1.49 7.57e-15 GO:0005654 nucleoplasm
1.49 4.75e-03 GO:0048471 perinuclear region of cytoplasm
1.47 7.02e-20 GO:0031981 nuclear lumen
1.43 1.78e-20 GO:0044428 nuclear part
1.39 3.29e-03 GO:0044431 Golgi apparatus part
1.39 1.49e-02 GO:0005730 nucleolus
1.39 2.07e-02 GO:0000139 Golgi membrane
1.36 1.57e-13 GO:0005829 cytosol

Gene overrepresentation in function category:

Showing 1 to 20 of 55 entries
enrichment   p-value GO term description
2.83 3.36e-03 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
2.09 1.67e-02 GO:0042393 histone binding
1.99 3.87e-02 GO:0031625 ubiquitin protein ligase binding
1.98 2.02e-02 GO:0035257 nuclear hormone receptor binding
1.86 8.09e-07 GO:0019787 small conjugating protein ligase activity
1.84 5.85e-05 GO:0003682 chromatin binding
1.79 1.57e-07 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.78 8.47e-08 GO:0016563 transcription activator activity
1.78 1.85e-06 GO:0016881 acid-amino acid ligase activity
1.78 6.67e-03 GO:0003714 transcription corepressor activity
1.77 7.89e-05 GO:0004842 ubiquitin-protein ligase activity
1.74 2.19e-04 GO:0003713 transcription coactivator activity
1.73 2.74e-08 GO:0000988 protein binding transcription factor activity
1.73 2.74e-08 GO:0000989 transcription factor binding transcription factor activity
1.72 4.83e-08 GO:0003712 transcription cofactor activity
1.72 2.54e-06 GO:0016564 transcription repressor activity
1.70 1.28e-03 GO:0003924 GTPase activity
1.70 1.71e-03 GO:0000975 regulatory region DNA binding
1.70 1.71e-03 GO:0001067 regulatory region nucleic acid binding
1.70 1.71e-03 GO:0044212 transcription regulatory region DNA binding