Motif ID: EP300.p2

Z-value: 2.500


Transcription factors associated with EP300.p2:

Gene SymbolEntrez IDGene Name
EP300 2033 E1A binding protein p300

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EP300chr22_+_398177330.449.1e-02Click!


Activity profile for motif EP300.p2.

activity profile for motif EP300.p2


Sorted Z-values histogram for motif EP300.p2

Sorted Z-values for motif EP300.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EP300.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_174084137 2.742 NM_002449
MSX2
msh homeobox 2
chr10_-_126839546 2.594 NM_001083914
CTBP2
C-terminal binding protein 2
chr11_-_72111027 2.588 NM_001135190
NM_015242
ARAP1

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

chr12_-_26169074 2.495 NM_030762
BHLHE41
basic helix-loop-helix family, member e41
chr4_-_122213018 2.442 NM_024574
C4orf31
chromosome 4 open reading frame 31
chr9_+_111442888 2.441 NM_001037293
PALM2
paralemmin 2
chr9_-_116920232 2.285 NM_002160
TNC
tenascin C
chr2_+_130846263 2.138 PTPN18
protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
chr4_+_183302105 2.066 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr9_+_35782405 2.066 NM_003995
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr20_+_60810610 2.062 NM_002531
NTSR1
neurotensin receptor 1 (high affinity)
chr13_-_43259032 2.020 NM_017993
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr8_-_145085616 1.994 NM_201384
PLEC
plectin
chr1_+_156229934 1.958 KIRREL
kin of IRRE like (Drosophila)
chr8_-_122722674 1.930 NM_005328
HAS2
hyaluronan synthase 2
chr1_-_159275357 1.923 NM_001113205
NM_001113206
NM_001113207
TSTD1


F11R
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1


F11 receptor
chr15_-_66511488 1.903 NM_001004439
ITGA11
integrin, alpha 11
chr5_+_96024434 1.883 CAST
calpastatin
chr3_+_48482625 1.824 TREX1
three prime repair exonuclease 1
chr18_-_33399997 1.797 NM_001025087
NM_001025088
NM_001025089
NM_020180
CELF4



CUGBP, Elav-like family member 4



chr10_-_49483002 1.792 NM_021226
ARHGAP22
Rho GTPase activating protein 22
chr15_+_90738108 1.774 NM_006011
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr11_+_131286513 1.738 NTM
neurotrimin
chr1_+_179148935 1.690 NM_020950
KIAA1614
KIAA1614
chr5_-_33927724 1.677 NM_030955
ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr17_-_72045218 1.643 NM_134268
CYGB
cytoglobin
chr6_+_73388291 1.616 NM_001160130
NM_001160132
NM_001160133
NM_001160134
NM_019842
KCNQ5




potassium voltage-gated channel, KQT-like subfamily, member 5




chr10_-_116154504 1.606 NM_001001936
NM_032550
AFAP1L2

actin filament associated protein 1-like 2

chr12_+_6179736 1.597 NM_001769
CD9
CD9 molecule
chr17_-_76985538 1.583


chr11_+_92342436 1.578 NM_005959
MTNR1B
melatonin receptor 1B
chr8_-_57395794 1.560 NM_138969
SDR16C5
short chain dehydrogenase/reductase family 16C, member 5
chr15_+_66658626 1.542 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr17_+_4922478 1.511 ZFP3
zinc finger protein 3 homolog (mouse)
chr10_+_46413551 1.494 NM_014696
GPRIN2
G protein regulated inducer of neurite outgrowth 2
chr14_+_20580224 1.480 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr17_+_4922445 1.471 NM_153018
ZFP3
zinc finger protein 3 homolog (mouse)
chr17_-_24068759 1.462 NM_001144942
NM_031934
RAB34

RAB34, member RAS oncogene family

chr4_-_5761194 1.454 NM_147127
EVC2
Ellis van Creveld syndrome 2
chr19_-_51608665 1.411 NM_032040
CCDC8
coiled-coil domain containing 8
chr2_-_230287442 1.408 NM_139072
DNER
delta/notch-like EGF repeat containing
chr9_+_119506428 1.394 TLR4
toll-like receptor 4
chr1_+_199519202 1.362 NM_000299
NM_001005337
PKP1

plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)

chr1_+_213323182 1.360 NM_001017425
NM_014217
KCNK2

potassium channel, subfamily K, member 2

chr13_-_37341859 1.335 NM_001135955
NM_001135956
NM_001135957
NM_001135958
NM_003306
NM_016179
TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr4_-_122905731 1.333 NM_152399
TMEM155
transmembrane protein 155
chr12_-_47605478 1.324 NM_001143782
NM_016594
FKBP11

FK506 binding protein 11, 19 kDa

chr7_-_32076985 1.323 NM_001191056
NM_001191057
PDE1C

phosphodiesterase 1C, calmodulin-dependent 70kDa

chr7_-_117300763 1.318 NM_033427
CTTNBP2
cortactin binding protein 2
chr9_-_25668230 1.313 TUSC1
tumor suppressor candidate 1
chr7_-_45927263 1.304 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chrX_-_3274680 1.298 NM_015419
MXRA5
matrix-remodelling associated 5
chr4_+_61749540 1.295 LPHN3
latrophilin 3
chr11_-_122571198 1.288 NM_024769
CLMP
CXADR-like membrane protein
chr16_+_639278 1.282 NM_145294
WDR90
WD repeat domain 90
chr18_-_45630154 1.257 MYO5B
myosin VB
chr13_+_36146048 1.242 NM_203451
C13orf36
chromosome 13 open reading frame 36
chr9_+_71848555 1.241 MAMDC2
MAM domain containing 2
chr8_-_57395254 1.241 SDR16C5
short chain dehydrogenase/reductase family 16C, member 5
chr6_+_73388713 1.238 KCNQ5
potassium voltage-gated channel, KQT-like subfamily, member 5
chr14_+_78815406 1.238 NM_001105250
NM_138970
NRXN3

neurexin 3

chr3_-_38046034 1.235 NM_006225
PLCD1
phospholipase C, delta 1
chr7_-_32077504 1.226 NM_001191059
NM_005020
PDE1C

phosphodiesterase 1C, calmodulin-dependent 70kDa

chr10_+_88720477 1.223 NM_133447
AGAP11
ankyrin repeat and GTPase domain Arf GTPase activating protein 11
chr2_-_56266408 1.175 LOC100129434
hypothetical LOC100129434
chr13_-_32822759 1.161 STARD13
StAR-related lipid transfer (START) domain containing 13
chr2_+_182030173 1.158 ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr19_-_60573552 1.152 NM_000641
IL11
interleukin 11
chr15_-_81743198 1.142 BNC1
basonuclin 1
chr11_+_129823667 1.138 NM_139055
ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr10_-_21502993 1.135 NEBL
nebulette
chr9_+_108665168 1.129 NM_021224
ZNF462
zinc finger protein 462
chr12_+_52806103 1.125 LOC400043
hypothetical LOC400043
chr22_+_40800193 1.123 NM_001002034
FAM109B
family with sequence similarity 109, member B
chrX_-_99551926 1.122 NM_001105243
NM_001184880
NM_020766
PCDH19


protocadherin 19


chr20_+_10147455 1.122 NM_003081
NM_130811
SNAP25

synaptosomal-associated protein, 25kDa

chr2_+_109729176 1.111 NM_023016
ANKRD57
ankyrin repeat domain 57
chr6_-_72187168 1.105 C6orf155
chromosome 6 open reading frame 155
chr9_+_119506446 1.104 TLR4
toll-like receptor 4
chr9_+_86473273 1.102 NM_001018064
NM_006180
NTRK2

neurotrophic tyrosine kinase, receptor, type 2

chr3_+_160964574 1.102 SCHIP1
schwannomin interacting protein 1
chr11_+_104986620 1.090 NM_001112812
GRIA4
glutamate receptor, ionotrophic, AMPA 4
chr22_+_40800213 1.088 FAM109B
family with sequence similarity 109, member B
chr4_-_142273881 1.087 NM_020724
RNF150
ring finger protein 150
chr3_+_156280539 1.072 MME
membrane metallo-endopeptidase
chr2_-_40532651 1.066 SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr2_+_182029863 1.063 NM_000885
ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr12_-_47468985 1.062 NM_020983
ADCY6
adenylate cyclase 6
chr11_+_24475091 1.052 NM_001009909
LUZP2
leucine zipper protein 2
chr11_+_46679140 1.046 NM_001184751
ZNF408
zinc finger protein 408
chr4_-_122063118 1.042 NM_018699
PRDM5
PR domain containing 5
chr2_-_160627366 1.042 NM_001007267
NM_001195641
NM_007366
PLA2R1


phospholipase A2 receptor 1, 180kDa


chr10_+_52504239 1.040 NM_006258
PRKG1
protein kinase, cGMP-dependent, type I
chr2_-_160627181 1.036 PLA2R1
phospholipase A2 receptor 1, 180kDa
chr6_-_47117951 1.034 NM_025048
NM_153840
GPR110

G protein-coupled receptor 110

chr20_+_58064360 1.032 NM_173644
C20orf197
chromosome 20 open reading frame 197
chr11_-_27700180 1.031 NM_170731
BDNF
brain-derived neurotrophic factor
chr1_-_68288899 1.019 NM_004675
DIRAS3
DIRAS family, GTP-binding RAS-like 3
chr11_+_128266460 1.015 NM_000890
KCNJ5
potassium inwardly-rectifying channel, subfamily J, member 5
chrX_-_140098941 1.010 LDOC1
leucine zipper, down-regulated in cancer 1
chr1_-_68470585 1.001 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr9_+_33740463 0.998 NM_001197097
NM_007343
NM_001197098
PRSS3


protease, serine, 3


chr9_+_119506274 0.994 NM_138554
TLR4
toll-like receptor 4
chr8_+_22513043 0.991 NM_001013842
NM_001198827
NM_173686
C8orf58


chromosome 8 open reading frame 58


chr11_-_63014986 0.984 NM_001146728
NM_001146729
NM_054108
HRASLS5


HRAS-like suppressor family, member 5


chr6_-_40663089 0.969 NM_020737
LRFN2
leucine rich repeat and fibronectin type III domain containing 2
chr3_+_156280497 0.968 MME
membrane metallo-endopeptidase
chr10_-_21503025 0.967 NM_001173484
NM_213569
NEBL

nebulette

chr1_-_99242765 0.964 NM_001010861
NM_001037317
LPPR5

lipid phosphate phosphatase-related protein type 5

chr5_-_139992621 0.959 NM_000591
CD14
CD14 molecule
chr2_-_139254273 0.951 NM_007226
NXPH2
neurexophilin 2
chr19_+_42517337 0.946 NM_181786
HKR1
HKR1, GLI-Kruppel zinc finger family member
chr2_+_109112428 0.944 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr12_+_52653176 0.941 NM_014212
HOXC11
homeobox C11
chr4_+_167013859 0.940 NM_012464
TLL1
tolloid-like 1
chr7_-_107883929 0.926 NM_001193582
NM_001193583
NM_001193584
NM_005010
NRCAM



neuronal cell adhesion molecule



chr15_-_80123935 0.921 MEX3B
mex-3 homolog B (C. elegans)
chr12_-_118725672 0.921 CIT
citron (rho-interacting, serine/threonine kinase 21)
chr11_+_15093059 0.919 NM_001042536
INSC
inscuteable homolog (Drosophila)
chr3_-_69674412 0.919 FRMD4B
FERM domain containing 4B
chr16_-_85099941 0.917 LOC400550
hypothetical LOC400550
chr4_-_114901672 0.916 CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr15_-_86600658 0.915 NM_001007156
NM_001012338
NM_002530
NTRK3


neurotrophic tyrosine kinase, receptor, type 3


chr1_+_156229686 0.912 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr9_-_20612433 0.898 MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr8_+_31616809 0.898 NM_013962
NRG1
neuregulin 1
chr7_-_142293382 0.894 NM_018646
TRPV6
transient receptor potential cation channel, subfamily V, member 6
chr4_+_156900053 0.893 GUCY1B3
guanylate cyclase 1, soluble, beta 3
chrX_-_140098871 0.891 LDOC1
leucine zipper, down-regulated in cancer 1
chr11_+_696607 0.891 EPS8L2
EPS8-like 2
chr11_+_124539814 0.890 PKNOX2
PBX/knotted 1 homeobox 2
chr12_-_6354650 0.884 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr10_-_116154212 0.883 AFAP1L2
actin filament associated protein 1-like 2
chr5_+_65927895 0.881 NM_001164664
NM_198828
MAST4

microtubule associated serine/threonine kinase family member 4

chr11_-_128279670 0.881 C11orf45
chromosome 11 open reading frame 45
chr18_-_20231709 0.880 OSBPL1A
oxysterol binding protein-like 1A
chr5_-_111782637 0.878 NM_022140
EPB41L4A
erythrocyte membrane protein band 4.1 like 4A
chr2_-_225615556 0.873 NM_014689
DOCK10
dedicator of cytokinesis 10
chr9_-_131555111 0.871 NM_004878
PTGES
prostaglandin E synthase
chr12_-_6313219 0.870 TNFRSF1A
tumor necrosis factor receptor superfamily, member 1A
chr17_+_76988134 0.869 NM_001080519
BAHCC1
BAH domain and coiled-coil containing 1
chr2_+_182030510 0.869 ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr22_-_43987010 0.868 NM_015264
KIAA0930
KIAA0930
chr9_-_121171400 0.863 NM_014618
DBC1
deleted in bladder cancer 1
chrX_+_122145776 0.860 NM_000828
NM_007325
GRIA3

glutamate receptor, ionotrophic, AMPA 3

chr10_+_88718167 0.852 NM_006829
C10orf116
chromosome 10 open reading frame 116
chr16_+_85158357 0.851 NM_005251
FOXC2
forkhead box C2 (MFH-1, mesenchyme forkhead 1)
chr2_-_229844198 0.847 NM_001100818
NM_017933
PID1

phosphotyrosine interaction domain containing 1

chr1_+_203064397 0.841 NM_001005388
NM_001005389
NM_001160332
NM_001160333
NM_015090
NFASC




neurofascin




chr11_+_46678892 0.838 NM_024741
ZNF408
zinc finger protein 408
chr8_+_106400322 0.837 NM_012082
ZFPM2
zinc finger protein, multitype 2
chr12_+_52665196 0.833 NM_017409
HOXC10
homeobox C10
chr18_-_20231783 0.832 NM_080597
OSBPL1A
oxysterol binding protein-like 1A
chr11_-_64641700 0.825 NM_014205
ZNHIT2
zinc finger, HIT-type containing 2
chr4_-_114902010 0.823 CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr5_-_41546384 0.821 NM_001005473
PLCXD3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr14_+_51397059 0.820 GNG2
guanine nucleotide binding protein (G protein), gamma 2
chr10_+_71232281 0.819 COL13A1
collagen, type XIII, alpha 1
chr6_+_10663934 0.817 NM_001491
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr6_+_101948102 0.817


chr2_-_189752575 0.816 NM_000393
COL5A2
collagen, type V, alpha 2
chr9_-_25668855 0.814 NM_001004125
TUSC1
tumor suppressor candidate 1
chr22_-_43986896 0.813 KIAA0930
KIAA0930
chr14_+_92049396 0.812 NM_024832
RIN3
Ras and Rab interactor 3
chr12_+_3470685 0.811 NM_019854
PRMT8
protein arginine methyltransferase 8
chr9_+_115396020 0.811 NM_144489
RGS3
regulator of G-protein signaling 3
chrX_-_140098959 0.808 NM_012317
LDOC1
leucine zipper, down-regulated in cancer 1
chr11_-_27677755 0.806 NM_170734
BDNF
brain-derived neurotrophic factor
chr21_-_30234100 0.806 NM_000830
NM_175611
GRIK1

glutamate receptor, ionotropic, kainate 1

chr1_+_202308814 0.803 NM_005686
SOX13
SRY (sex determining region Y)-box 13
chr3_+_44729138 0.802 NM_001134440
NM_001134441
NM_001134442
NM_033210
ZNF502



zinc finger protein 502



chr3_+_156280129 0.799 NM_000902
MME
membrane metallo-endopeptidase
chr10_+_102782156 0.799 SFXN3
sideroflexin 3
chr1_-_151852128 0.798 NM_080388
S100A16
S100 calcium binding protein A16
chr22_-_43040063 0.797 NM_001099294
KIAA1644
KIAA1644
chr14_+_103674812 0.797 NM_015656
KIF26A
kinesin family member 26A
chr5_-_146869613 0.794 DPYSL3
dihydropyrimidinase-like 3
chr4_-_84250019 0.794 NM_001130716
PLAC8
placenta-specific 8
chr5_+_128823904 0.794 NM_133638
ADAMTS19
ADAM metallopeptidase with thrombospondin type 1 motif, 19
chr19_+_10900502 0.792 C19orf52
chromosome 19 open reading frame 52
chr8_+_120497732 0.789 NM_002514
NOV
nephroblastoma overexpressed gene
chr8_+_123863224 0.788 ZHX2
zinc fingers and homeoboxes 2
chr19_-_61680510 0.786 NM_022103
ZNF667
zinc finger protein 667
chr3_+_135996990 0.785 EPHB1
EPH receptor B1
chr4_-_114901789 0.783 CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr22_-_42619139 0.781 NM_001177675
NM_138814
PNPLA5

patatin-like phospholipase domain containing 5

chr5_+_139155569 0.778 NM_032289
PSD2
pleckstrin and Sec7 domain containing 2
chr8_-_26427304 0.775 NM_007257
PNMA2
paraneoplastic antigen MA2
chr1_+_221955876 0.774 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr12_-_51173238 0.771 NM_005554
KRT6A
keratin 6A
chr1_+_61980679 0.763 NM_176877
INADL
InaD-like (Drosophila)
chr6_-_152999678 0.763 NM_033071
SYNE1
spectrin repeat containing, nuclear envelope 1
chr3_-_135852514 0.761 NM_178554
KY
kyphoscoliosis peptidase
chr2_+_149895274 0.759 NM_194317
LYPD6
LY6/PLAUR domain containing 6
chr19_-_54005916 0.755 NM_001164773
NM_001190
BCAT2

branched chain amino-acid transaminase 2, mitochondrial

chr19_-_40938046 0.749 HSPB6
heat shock protein, alpha-crystallin-related, B6
chr7_+_21549357 0.742 NM_003777
DNAH11
dynein, axonemal, heavy chain 11
chr8_-_111056099 0.737 NM_014379
KCNV1
potassium channel, subfamily V, member 1
chr4_+_156899575 0.736 NM_000857
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr5_+_82803248 0.735 NM_001126336
NM_001164097
NM_001164098
NM_004385
VCAN



versican




Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.12 1.21e-04 GO:0050794 regulation of cellular process
1.26 2.58e-04 GO:0030154 cell differentiation
1.25 5.44e-04 GO:0048869 cellular developmental process
1.21 1.11e-03 GO:0048731 system development
1.21 1.40e-03 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.20 1.90e-03 GO:0051171 regulation of nitrogen compound metabolic process
1.29 2.78e-03 GO:0007399 nervous system development
1.10 3.44e-03 GO:0065007 biological regulation
1.66 3.68e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.10 6.05e-03 GO:0050789 regulation of biological process
1.20 7.24e-03 GO:0048518 positive regulation of biological process
1.48 7.73e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.47 8.45e-03 GO:0051253 negative regulation of RNA metabolic process
1.21 1.09e-02 GO:0051252 regulation of RNA metabolic process
1.19 1.24e-02 GO:0031326 regulation of cellular biosynthetic process
1.54 1.24e-02 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.17 1.90e-02 GO:0048856 anatomical structure development
1.15 1.92e-02 GO:0032502 developmental process
1.19 2.18e-02 GO:0009889 regulation of biosynthetic process
1.43 2.24e-02 GO:0010629 negative regulation of gene expression
1.25 2.88e-02 GO:0023051 regulation of signaling
1.21 3.53e-02 GO:0006355 regulation of transcription, DNA-dependent
1.41 3.56e-02 GO:0051172 negative regulation of nitrogen compound metabolic process
1.34 3.65e-02 GO:0048699 generation of neurons
1.16 3.88e-02 GO:0007275 multicellular organismal development
1.41 4.53e-02 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.33 4.73e-02 GO:0022008 neurogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.38 1.48e-02 GO:0030054 cell junction
1.44 4.70e-02 GO:0045202 synapse

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.41 3.53e-03 GO:0004714 transmembrane receptor protein tyrosine kinase activity
1.30 1.91e-02 GO:0001071 nucleic acid binding transcription factor activity
1.30 1.91e-02 GO:0003700 sequence-specific DNA binding transcription factor activity