Motif ID: ESRRA.p2

Z-value: 2.426


Transcription factors associated with ESRRA.p2:

Gene SymbolEntrez IDGene Name
ESRRA 2101 estrogen-related receptor alpha

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ESRRAchr11_+_63829616-0.351.8e-01Click!


Activity profile for motif ESRRA.p2.

activity profile for motif ESRRA.p2


Sorted Z-values histogram for motif ESRRA.p2

Sorted Z-values for motif ESRRA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESRRA.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_143706265 7.542 PDE4DIP
phosphodiesterase 4D interacting protein
chr1_-_143706196 5.707 PDE4DIP
phosphodiesterase 4D interacting protein
chr19_-_44518465 4.909 GMFG
glia maturation factor, gamma
chr19_-_44518516 4.633 NM_004877
GMFG
glia maturation factor, gamma
chr19_-_4486202 4.164 NM_001013706
PLIN5
perilipin 5
chr19_+_17923110 3.545 NM_002248
KCNN1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
chr6_+_44076281 3.341 NM_001171992
NM_153246
C6orf223

chromosome 6 open reading frame 223

chr4_-_40212670 3.091 NM_019027
RBM47
RNA binding motif protein 47
chr10_+_44726635 2.983 NM_001123376
TMEM72
transmembrane protein 72
chr20_+_36867708 2.730 NM_001172735
NM_015568
PPP1R16B

protein phosphatase 1, regulatory (inhibitor) subunit 16B

chr11_-_64268841 2.646 NM_001098670
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr19_+_62434188 2.561 NM_001015879
NM_003160
NM_001015878
AURKC


aurora kinase C


chr1_+_32489426 2.403 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr11_-_64268126 2.377 NM_001098671
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr14_+_87560646 2.336 LOC283587
hypothetical protein LOC283587
chr20_+_41621119 2.244 SGK2
serum/glucocorticoid regulated kinase 2
chr1_-_172153087 2.141 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr20_+_41621079 2.074 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr12_-_107257205 2.047 NM_001142343
NM_001142344
NM_004072
CMKLR1


chemokine-like receptor 1


chrX_+_65152004 2.027


chr6_+_37081387 2.009 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr6_-_108252200 1.949 NM_198081
SCML4
sex comb on midleg-like 4 (Drosophila)
chr17_-_34014390 1.941 SRCIN1
SRC kinase signaling inhibitor 1
chr5_+_271355 1.924 NM_004168
SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr1_-_143706300 1.922 NM_001002812
NM_014644
NM_001002810
NM_001198834
NM_001195261
PDE4DIP




phosphodiesterase 4D interacting protein




chr1_-_172153024 1.863 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr22_+_18485076 1.854 RANBP1
RAN binding protein 1
chr11_-_780103 1.851 NM_016564
CEND1
cell cycle exit and neuronal differentiation 1
chr19_-_62759536 1.831 NM_001039654
ZNF550
zinc finger protein 550
chr6_+_31662454 1.824 NM_205837
LST1
leukocyte specific transcript 1
chr11_-_64284762 1.808 NM_001164716
NM_005609
PYGM

phosphorylase, glycogen, muscle

chr7_-_38355949 1.797


chr12_-_52980984 1.790 NM_001136023
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr22_+_18485145 1.784 RANBP1
RAN binding protein 1
chr1_-_152431175 1.781 NM_152263
TPM3
tropomyosin 3
chr22_+_18485068 1.773 RANBP1
RAN binding protein 1
chr7_-_38356100 1.738 TRGV5
T cell receptor gamma variable 5
chr19_-_3013191 1.731 NM_001130
NM_198970
AES

amino-terminal enhancer of split

chr22_+_35586950 1.717 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr22_+_18485095 1.697 RANBP1
RAN binding protein 1
chr7_+_128795280 1.670 AHCYL2
adenosylhomocysteinase-like 2
chr19_-_3013441 1.662 AES
amino-terminal enhancer of split
chr19_-_3013768 1.657 AES
amino-terminal enhancer of split
chr5_+_143171918 1.633 NM_021182
HMHB1
histocompatibility (minor) HB-1
chr19_-_3013880 1.631 NM_198969
AES
amino-terminal enhancer of split
chr5_+_271428 1.618 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr19_+_1358531 1.607 NM_018959
NM_170711
DAZAP1

DAZ associated protein 1

chr10_-_101831579 1.607 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr1_+_55237193 1.598 NM_057176
BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr11_-_780065 1.597 CEND1
cell cycle exit and neuronal differentiation 1
chr12_-_52980914 1.557 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr10_-_91394881 1.556 PANK1
pantothenate kinase 1
chr22_+_18484810 1.546 NM_002882
RANBP1
RAN binding protein 1
chr7_+_128795178 1.502 NM_001130723
AHCYL2
adenosylhomocysteinase-like 2
chr11_+_82545784 1.500 NM_015885
PCF11
PCF11, cleavage and polyadenylation factor subunit, homolog (S. cerevisiae)
chr17_-_77386156 1.475 DYSFIP1
dysferlin interacting protein 1
chr8_-_131097856 1.471 FAM49B
family with sequence similarity 49, member B
chr19_+_59796858 1.457 NM_006863
LILRA1
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
chr1_-_29381223 1.443 NM_005626
SRSF4
serine/arginine-rich splicing factor 4
chr5_-_1647617 1.439 SDHAP3
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 3
chr19_+_540849 1.432 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr16_+_31274020 1.422 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr1_-_203985932 1.412


chr9_+_130005487 1.408 DNM1
dynamin 1
chr1_+_181028016 1.405 NM_030769
NPL
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chr9_+_130005429 1.398 NM_001005336
NM_004408
DNM1

dynamin 1

chr4_+_24406283 1.396 SOD3
superoxide dismutase 3, extracellular
chr1_-_199259447 1.395 NM_017596
KIF21B
kinesin family member 21B
chr10_+_80777248 1.393 PPIF
peptidylprolyl isomerase F
chr1_-_27689129 1.385 WASF2
WAS protein family, member 2
chr11_-_60379998 1.370 NM_004778
GPR44
G protein-coupled receptor 44
chr1_-_202726068 1.370 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr4_+_24406238 1.365 SOD3
superoxide dismutase 3, extracellular
chr22_+_18485057 1.350 RANBP1
RAN binding protein 1
chr19_-_60360768 1.345 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr1_-_1679940 1.332 NM_001198995
NADK
NAD kinase
chr1_-_27689254 1.332 NM_006990
WASF2
WAS protein family, member 2
chr19_+_1358750 1.329 DAZAP1
DAZ associated protein 1
chr4_+_24406301 1.328 SOD3
superoxide dismutase 3, extracellular
chr9_+_130005489 1.319 DNM1
dynamin 1
chr3_-_49701085 1.315 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr19_+_1358604 1.311 DAZAP1
DAZ associated protein 1
chr17_-_77386212 1.309 NM_001007533
DYSFIP1
dysferlin interacting protein 1
chr4_-_38460983 1.309 NM_001017388
NM_001195106
NM_001195107
NM_001195108
NM_030956
TLR10




toll-like receptor 10




chr4_+_24406336 1.308 SOD3
superoxide dismutase 3, extracellular
chr5_+_138920893 1.298 NM_003339
NM_181838
UBE2D2

ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)

chr12_-_55325912 1.287 ATP5B
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr19_+_1199548 1.284 NM_177401
MIDN
midnolin
chr11_-_64459910 1.280 NM_130769
GPHA2
glycoprotein hormone alpha 2
chr16_+_31274030 1.259 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr5_+_271447 1.243 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr19_+_1358664 1.242 DAZAP1
DAZ associated protein 1
chr6_-_21631992 1.239


chr1_-_201194322 1.224 NM_001127687
ADIPOR1
adiponectin receptor 1
chr17_-_39500512 1.224 NM_152344
LSM12
LSM12 homolog (S. cerevisiae)
chr7_+_150413814 1.223 AGAP3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr9_-_130006309 1.211 NM_001131015
NM_012127
CIZ1

CDKN1A interacting zinc finger protein 1

chr7_+_116238309 1.207 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr16_+_31273969 1.201 NM_000887
ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr15_+_41597097 1.196 NM_002373
MAP1A
microtubule-associated protein 1A
chr12_-_116021473 1.192 NM_001168325
NM_017899
TESC

tescalcin

chr8_-_131097828 1.192 FAM49B
family with sequence similarity 49, member B
chr12_-_119038941 1.190 RAB35
RAB35, member RAS oncogene family
chr3_-_122862391 1.178 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr4_+_24406182 1.176 NM_003102
SOD3
superoxide dismutase 3, extracellular
chr1_-_200396354 1.169 NM_002832
PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr1_-_45224784 1.161 EIF2B3
eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
chrX_-_47374187 1.159 NM_001145252
CFP
complement factor properdin
chr12_-_24628348 1.149 C12orf67
chromosome 12 open reading frame 67
chr11_-_64582568 1.139 NM_005468
NAALADL1
N-acetylated alpha-linked acidic dipeptidase-like 1
chr14_-_95250155 1.134 NM_001098725
NM_021966
TCL1A

T-cell leukemia/lymphoma 1A

chr10_-_97190885 1.118 NM_001034954
NM_001034955
NM_001034956
NM_001034957
NM_006434
SORBS1




sorbin and SH3 domain containing 1




chr22_-_48865907 1.090 NM_139202
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr22_-_48865980 1.089 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr12_-_3732478 1.077 EFCAB4B
EF-hand calcium binding domain 4B
chr1_-_203985963 1.075 NM_022731
NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr2_-_32344192 1.075 NM_021209
NLRC4
NLR family, CARD domain containing 4
chr5_+_138921041 1.058 UBE2D2
ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)
chr14_-_105245959 1.054 IGHA1
immunoglobulin heavy constant alpha 1
chr3_+_187917791 1.050 NM_000893
NM_001102416
NM_001166451
KNG1


kininogen 1


chr2_+_119905812 1.043 NM_183240
TMEM37
transmembrane protein 37
chr10_-_81955256 1.042 ANXA11
annexin A11
chr10_+_75427853 1.041 NM_003373
NM_014000
VCL

vinculin

chr12_-_55326052 1.036 NM_001686
ATP5B
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr3_+_46423682 1.026 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr8_-_131098015 0.994 FAM49B
family with sequence similarity 49, member B
chr3_-_14141293 0.994 CHCHD4
coiled-coil-helix-coiled-coil-helix domain containing 4
chr22_-_48865864 0.992 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr16_-_79597940 0.987 NM_020188
C16orf61
chromosome 16 open reading frame 61
chr7_-_86942910 0.984 NM_000443
NM_018849
NM_018850
ABCB4


ATP-binding cassette, sub-family B (MDR/TAP), member 4


chr8_+_11225904 0.978 NM_054028
AMAC1L2
acyl-malonyl condensing enzyme 1-like 2
chr12_-_55326043 0.976 ATP5B
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr22_-_48866484 0.975 NM_015166
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr17_-_31332568 0.969 NM_004590
CCL16
chemokine (C-C motif) ligand 16
chr19_+_12941431 0.967 NM_152654
DAND5
DAN domain family, member 5
chr6_-_31789824 0.958


chr7_-_150408824 0.958 NM_006712
NM_033015
FASTK

Fas-activated serine/threonine kinase

chr11_-_47427263 0.951 NM_005055
NM_032645
RAPSN

receptor-associated protein of the synapse

chr10_-_81955268 0.950 ANXA11
annexin A11
chr15_+_97009194 0.948 IGF1R
insulin-like growth factor 1 receptor
chr19_+_7734034 0.947 NM_001144904
NM_001144905
NM_001144906
NM_001144907
NM_001144908
NM_001144909
NM_001144910
NM_001144911
NM_014257
CLEC4M








C-type lectin domain family 4, member M








chr10_+_80777265 0.941 PPIF
peptidylprolyl isomerase F
chr5_+_271441 0.935 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr17_-_40339919 0.927 GFAP
glial fibrillary acidic protein
chrX_-_47374647 0.926 NM_002621
CFP
complement factor properdin
chr10_-_81955271 0.923 ANXA11
annexin A11
chr6_+_31662954 0.915 NM_001166538
NM_007161
NM_205840
LST1


leukocyte specific transcript 1


chr1_-_209818675 0.905 NM_021194
SLC30A1
solute carrier family 30 (zinc transporter), member 1
chrX_+_135407336 0.902 NM_014500
HTATSF1
HIV-1 Tat specific factor 1
chr19_-_13074973 0.901 NM_005583
LYL1
lymphoblastic leukemia derived sequence 1
chr7_-_100630912 0.899 NM_178176
MOGAT3
monoacylglycerol O-acyltransferase 3
chr14_-_74400288 0.897 NM_001080408
PROX2
prospero homeobox 2
chr12_-_16652202 0.893 NM_001001395
LMO3
LIM domain only 3 (rhombotin-like 2)
chr16_+_21872155 0.889 UQCRC2
ubiquinol-cytochrome c reductase core protein II
chrX_-_153397566 0.888 NM_001171132
NM_001171133
NM_001171134
NM_021806
FAM3A



family with sequence similarity 3, member A



chr16_+_21872178 0.885 UQCRC2
ubiquinol-cytochrome c reductase core protein II
chr1_-_29380945 0.879 SRSF4
serine/arginine-rich splicing factor 4
chr3_-_122862447 0.879 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr6_+_43257883 0.877 NM_015089
CUL9
cullin 9
chr17_+_35471971 0.876 NM_001190919
THRA
thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
chr10_+_80777234 0.873 PPIF
peptidylprolyl isomerase F
chr1_+_46413335 0.872 NM_005727
TSPAN1
tetraspanin 1
chrX_+_65299157 0.871 NM_138737
HEPH
hephaestin
chr3_-_14141371 0.870 NM_001098502
NM_144636
CHCHD4

coiled-coil-helix-coiled-coil-helix domain containing 4

chr1_+_157441133 0.869 NM_002036
DARC
Duffy blood group, chemokine receptor
chr11_-_18704294 0.867 NM_173588
IGSF22
immunoglobulin superfamily, member 22
chr5_-_142795269 0.857 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr16_+_79598016 0.855 CENPN
centromere protein N
chrX_+_153310313 0.852 ATP6AP1
ATPase, H+ transporting, lysosomal accessory protein 1
chr19_+_59866217 0.842 LILRB4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
chr17_-_40839082 0.841 NM_001159330
ARHGAP27
Rho GTPase activating protein 27
chr1_-_200396328 0.832 PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr12_+_103677388 0.832 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr6_-_37061902 0.830 MTCH1
mitochondrial carrier homolog 1 (C. elegans)
chr1_-_29380850 0.830 SRSF4
serine/arginine-rich splicing factor 4
chr21_-_42659671 0.825 NM_003225
TFF1
trefoil factor 1
chr17_-_70430839 0.825 NM_173477
USH1G
Usher syndrome 1G (autosomal recessive)
chr16_+_21872201 0.818 UQCRC2
ubiquinol-cytochrome c reductase core protein II
chr16_+_21872109 0.812 NM_003366
UQCRC2
ubiquinol-cytochrome c reductase core protein II
chr1_-_29380969 0.805 SRSF4
serine/arginine-rich splicing factor 4
chr3_-_14141247 0.801 CHCHD4
coiled-coil-helix-coiled-coil-helix domain containing 4
chr11_-_65550425 0.795 NM_053054
CATSPER1
cation channel, sperm associated 1
chr7_-_150408785 0.794 FASTK
Fas-activated serine/threonine kinase
chr10_+_80777199 0.792 NM_005729
PPIF
peptidylprolyl isomerase F
chr20_-_581808 0.791 SRXN1
sulfiredoxin 1
chr1_+_47572034 0.787 NM_001136140
NM_016308
CMPK1

cytidine monophosphate (UMP-CMP) kinase 1, cytosolic

chrX_+_103297721 0.785 FAM199X
family with sequence similarity 199, X-linked
chr1_+_109090817 0.785 STXBP3
syntaxin binding protein 3
chr22_+_19651446 0.784 NM_001146288
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr18_+_53967544 0.784 NM_001144965
NM_001144968
NM_001144969
NM_001144971
NEDD4L



neural precursor cell expressed, developmentally down-regulated 4-like



chr6_-_43592481 0.779 YIPF3
Yip1 domain family, member 3
chr10_-_81955307 0.779 NM_001157
NM_145868
NM_145869
ANXA11


annexin A11


chr20_+_30019465 0.772 NM_001011718
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr6_-_30236667 0.770 NM_006778
NM_052828
TRIM10

tripartite motif containing 10

chr10_-_81955093 0.768 ANXA11
annexin A11
chr11_+_22652957 0.767 GAS2
growth arrest-specific 2
chr7_+_97679501 0.764 NM_177455
BHLHA15
basic helix-loop-helix family, member a15
chr5_+_38481392 0.760 NM_182801
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr16_-_56886380 0.756 NM_001080492
PRSS54
protease, serine, 54
chr9_-_99994704 0.751 NM_052820
CORO2A
coronin, actin binding protein, 2A

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.47 2.31e-07 GO:0006810 transport
1.45 1.02e-06 GO:0051234 establishment of localization
1.38 1.37e-05 GO:0051179 localization
3.53 2.96e-05 GO:0045333 cellular respiration
3.96 4.21e-05 GO:0022904 respiratory electron transport chain
3.24 3.42e-04 GO:0022900 electron transport chain
2.15 1.24e-03 GO:0006091 generation of precursor metabolites and energy
1.71 1.63e-03 GO:0055114 oxidation-reduction process
1.37 4.12e-02 GO:0065008 regulation of biological quality

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.42 1.20e-15 GO:0005743 mitochondrial inner membrane
3.24 6.11e-15 GO:0019866 organelle inner membrane
2.88 1.97e-14 GO:0031966 mitochondrial membrane
2.80 6.76e-14 GO:0005740 mitochondrial envelope
2.44 1.18e-13 GO:0044429 mitochondrial part
1.94 3.85e-13 GO:0005739 mitochondrion
2.14 1.49e-09 GO:0031975 envelope
2.13 3.46e-09 GO:0031967 organelle envelope
3.67 1.08e-06 GO:0044455 mitochondrial membrane part
1.25 3.05e-06 GO:0044444 cytoplasmic part
1.18 4.94e-06 GO:0005737 cytoplasm
1.36 1.09e-02 GO:0005829 cytosol
3.51 1.15e-02 GO:0070469 respiratory chain
3.53 2.08e-02 GO:0005746 mitochondrial respiratory chain

Gene overrepresentation in function category:

enrichment   p-value GO term description
5.38 2.04e-04 GO:0003823 antigen binding
1.76 1.02e-03 GO:0016491 oxidoreductase activity
2.40 1.12e-03 GO:0022890 inorganic cation transmembrane transporter activity
1.16 3.44e-03 GO:0005515 protein binding
1.64 1.78e-02 GO:0015075 ion transmembrane transporter activity
2.34 2.67e-02 GO:0015077 monovalent inorganic cation transmembrane transporter activity
2.84 4.95e-02 GO:0015078 hydrogen ion transmembrane transporter activity