Motif ID: FOXD3.p2

Z-value: 1.281


Transcription factors associated with FOXD3.p2:

Gene SymbolEntrez IDGene Name
FOXD3 27022 forkhead box D3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXD3chr1_+_635616320.495.2e-02Click!


Activity profile for motif FOXD3.p2.

activity profile for motif FOXD3.p2


Sorted Z-values histogram for motif FOXD3.p2

Sorted Z-values for motif FOXD3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXD3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_19863716 2.976 RIN2
Ras and Rab interactor 2
chr18_+_59405513 2.502 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr2_-_218739891 2.423 NM_000634
CXCR1
chemokine (C-X-C motif) receptor 1
chr22_+_36008511 2.314 CYTH4
cytohesin 4
chr22_+_36008465 2.076 CYTH4
cytohesin 4
chr19_+_6415259 2.010 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr22_+_36008369 1.845 NM_013385
CYTH4
cytohesin 4
chr4_+_75393053 1.759 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr4_-_38710376 1.645 NM_024943
TMEM156
transmembrane protein 156
chr1_-_158948176 1.546 NM_001778
CD48
CD48 molecule
chr3_+_123385219 1.524 NM_000388
CASR
calcium-sensing receptor
chr5_-_24680841 1.496 NM_006727
CDH10
cadherin 10, type 2 (T2-cadherin)
chr1_-_27825178 1.459 NM_001042747
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr2_+_37282516 1.457 LOC100505876
hypothetical LOC100505876
chr11_-_128399218 1.453 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr19_+_12995782 1.410 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr19_-_51319769 1.394 NM_207393
IGFL3
IGF-like family member 3
chr10_+_118177371 1.394 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr1_-_159275334 1.384 TSTD1
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
chr12_+_47584159 1.372 NM_033124
CCDC65
coiled-coil domain containing 65
chr18_+_27281729 1.370 NM_001944
DSG3
desmoglein 3
chr13_-_98708549 1.365 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr12_+_53178834 1.339 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr9_-_116608113 1.259 NM_005118
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr3_+_123256902 1.255 NM_175862
CD86
CD86 molecule
chr3_+_190990142 1.241 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr13_-_83354474 1.228 NM_052910
SLITRK1
SLIT and NTRK-like family, member 1
chr21_+_38550739 1.221 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr3_+_138159396 1.208 NM_144717
IL20RB
interleukin 20 receptor beta
chr3_-_12561962 1.194 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr5_-_22889487 1.189 NM_004061
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr15_+_56217686 1.174 NM_020980
AQP9
aquaporin 9
chr10_-_98021144 1.158 NM_001114094
NM_013314
BLNK

B-cell linker

chr2_+_61225710 1.129 NM_001143960
C2orf74
chromosome 2 open reading frame 74
chr1_-_159275357 1.068 NM_001113205
NM_001113206
NM_001113207
TSTD1


F11R
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1


F11 receptor
chr19_+_41177882 1.062 NM_001042631
SDHAF1
succinate dehydrogenase complex assembly factor 1
chr13_-_83354425 1.022 SLITRK1
SLIT and NTRK-like family, member 1
chr12_-_120219941 1.019 CAMKK2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr8_-_42742729 1.006 NM_004198
CHRNA6
cholinergic receptor, nicotinic, alpha 6
chr16_+_67235651 1.005 NM_001793
CDH3
cadherin 3, type 1, P-cadherin (placental)
chr22_+_43527101 0.998 NM_001017526
NM_001198726
NM_181335
ARHGAP8


Rho GTPase activating protein 8


chr2_-_215711313 0.995 NM_173076
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr17_-_53847937 0.991 RNF43
ring finger protein 43
chr16_+_80370400 0.976 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr12_+_91620749 0.975 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr18_+_59726183 0.927 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr18_-_65766068 0.926 CD226
CD226 molecule
chr3_+_133798770 0.919 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr5_-_114543632 0.916 NM_001017397
NM_001017398
NM_018700
TRIM36


tripartite motif containing 36


chr1_-_158759606 0.913 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr4_+_100957003 0.896 NM_014395
DAPP1
dual adaptor of phosphotyrosine and 3-phosphoinositides
chr6_-_32892705 0.895 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr13_-_85271329 0.889 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr19_+_57564981 0.886 NM_001145434
ZNF880
zinc finger protein 880
chr1_+_179719338 0.878 NM_000721
CACNA1E
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr3_+_11242666 0.877 NM_001098211
HRH1
histamine receptor H1
chr19_-_4289750 0.874 NM_001013841
NM_017720
STAP2

signal transducing adaptor family member 2

chr1_+_13784553 0.861 NM_001006624
NM_001006625
PDPN

podoplanin

chr2_-_108972048 0.859 EDAR
ectodysplasin A receptor
chr3_+_123779122 0.842 NM_001113523
PARP15
poly (ADP-ribose) polymerase family, member 15
chr5_-_43432969 0.839 CCL28
chemokine (C-C motif) ligand 28
chr17_-_26665144 0.837 EVI2B
ecotropic viral integration site 2B
chr13_-_35327798 0.834 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr19_-_55539769 0.833 NAPSB
napsin B aspartic peptidase pseudogene
chr2_-_85490997 0.823 NM_001747
CAPG
capping protein (actin filament), gelsolin-like
chr2_-_108972100 0.819 NM_022336
EDAR
ectodysplasin A receptor
chr19_-_11550765 0.819 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr14_-_60818263 0.806 NM_001017970
TMEM30B
transmembrane protein 30B
chr11_-_26550243 0.795 NM_001135091
NM_001135092
NM_145650
MUC15


mucin 15, cell surface associated


chr1_-_56817568 0.789 PPAP2B
phosphatidic acid phosphatase type 2B
chr19_-_41191423 0.788 NM_001039876
C19orf46
chromosome 19 open reading frame 46
chr10_-_11614279 0.779 NM_001080491
USP6NL
USP6 N-terminal like
chr2_-_160765008 0.774 ITGB6
integrin, beta 6
chr19_-_14853166 0.773 NM_030901
OR7A17
olfactory receptor, family 7, subfamily A, member 17
chr17_-_26665213 0.771 EVI2B
ecotropic viral integration site 2B
chr20_-_33658823 0.768 FER1L4
fer-1-like 4 (C. elegans) pseudogene
chr6_+_150304813 0.767 NM_025217
ULBP2
UL16 binding protein 2
chr17_-_26665194 0.765 EVI2B
ecotropic viral integration site 2B
chr20_+_51023159 0.756 TSHZ2
teashirt zinc finger homeobox 2
chr5_-_22889192 0.752 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr15_-_72445551 0.750 NM_001099773
CYP11A1
cytochrome P450, family 11, subfamily A, polypeptide 1
chr14_-_98807307 0.748 BCL11B
B-cell CLL/lymphoma 11B (zinc finger protein)
chr3_-_184756101 0.747 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr16_-_3567354 0.746 NM_178844
NLRC3
NLR family, CARD domain containing 3
chr9_+_92629525 0.745 NM_001174167
SYK
spleen tyrosine kinase
chr6_-_159386007 0.741 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr18_-_21184824 0.737


chr1_-_221920023 0.735 NM_001143962
CAPN8
calpain 8
chr6_-_137536412 0.717 NM_052962
NM_181309
NM_181310
IL22RA2


interleukin 22 receptor, alpha 2


chr2_+_237143118 0.716 NM_020311
CXCR7
chemokine (C-X-C motif) receptor 7
chr17_+_7883076 0.715 NM_001039130
NM_001039131
NM_001141
ALOX15B


arachidonate 15-lipoxygenase, type B


chr19_+_48772791 0.714 NM_001193621
LOC390940
hypothetical protein LOC390940
chr1_-_221919982 0.712 CAPN8
calpain 8
chr14_-_60817946 0.700


chr4_+_167013859 0.700 NM_012464
TLL1
tolloid-like 1
chr6_+_29963328 0.697 HLA-H
major histocompatibility complex, class I, H (pseudogene)
chr8_+_54926920 0.685 NM_170587
RGS20
regulator of G-protein signaling 20
chr10_-_116241572 0.685


chr9_-_205892 0.683 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr17_-_26665220 0.680 NM_006495
EVI2B
ecotropic viral integration site 2B
chr19_+_59820413 0.671 NM_006669
LILRB1
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
chr9_+_66197108 0.668


chr5_+_147562531 0.668 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr19_-_61876057 0.668 NM_001005850
ZNF835
zinc finger protein 835
chr15_+_97990705 0.661 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr12_+_9871343 0.652 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr3_+_108578877 0.650 NM_032600
CCDC54
coiled-coil domain containing 54
chr1_+_13782838 0.648 NM_006474
NM_198389
PDPN

podoplanin

chr19_-_16111695 0.639


chr9_+_676640 0.636


chr1_-_25164061 0.636 NM_001031680
RUNX3
runt-related transcription factor 3
chr8_-_110724594 0.635 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr19_+_45973139 0.634 NM_006533
MIA
melanoma inhibitory activity
chr1_-_155788775 0.631 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr12_-_28016182 0.629 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr1_+_154389945 0.624 NM_001193300
NM_022367
NM_001193302
SEMA4A


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A


chr19_-_16111594 0.618


chr2_-_238164042 0.615 RAB17
RAB17, member RAS oncogene family
chr14_+_87541220 0.611 NM_003608
GPR65
G protein-coupled receptor 65
chr4_-_164754106 0.611 NM_017923
MARCH1
membrane-associated ring finger (C3HC4) 1
chr20_+_35583020 0.608 NM_005386
NM_181689
NNAT

neuronatin

chr4_-_90978469 0.604 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr12_+_45896318 0.603 NM_138371
FAM113B
family with sequence similarity 113, member B
chr2_+_165858586 0.598 NM_021007
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr5_+_159546951 0.596 NM_001130958
FABP6
fatty acid binding protein 6, ileal
chr6_+_49626071 0.582 NM_001145652
C6orf141
chromosome 6 open reading frame 141
chrX_-_32340291 0.576 NM_004011
NM_004012
DMD

dystrophin

chr9_+_126094067 0.571 NM_001166170
NM_001166171
NEK6

NIMA (never in mitosis gene a)-related kinase 6

chr6_+_71192862 0.569 NM_001162529
FAM135A
family with sequence similarity 135, member A
chr1_-_56817717 0.566 PPAP2B
phosphatidic acid phosphatase type 2B
chr1_+_181421796 0.560 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr18_-_59480082 0.557 NM_006919
SERPINB3
SERPINB4
serpin peptidase inhibitor, clade B (ovalbumin), member 3
serpin peptidase inhibitor, clade B (ovalbumin), member 4
chr16_-_28542366 0.550 NM_177536
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr1_-_56817823 0.550 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr12_-_10173947 0.550 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr3_+_137224266 0.548 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chrX_-_76823813 0.544


chr9_-_87904844 0.543 NM_177937
GOLM1
golgi membrane protein 1
chr3_+_120799411 0.541 NM_015900
PLA1A
phospholipase A1 member A
chr1_+_34993234 0.538 NM_005268
GJB5
gap junction protein, beta 5, 31.1kDa
chrX_-_15593074 0.535 NM_020665
TMEM27
transmembrane protein 27
chr13_+_48968097 0.533 PHF11
PHD finger protein 11
chr10_+_71231693 0.533 COL13A1
collagen, type XIII, alpha 1
chr10_-_116276560 0.532 ABLIM1
actin binding LIM protein 1
chr9_+_204816 0.532 DOCK8
dedicator of cytokinesis 8
chr3_+_123526700 0.530 NM_005213
CSTA
cystatin A (stefin A)
chr16_-_73365975 0.524 FA2H
fatty acid 2-hydroxylase
chr2_+_143603439 0.524 ARHGAP15
Rho GTPase activating protein 15
chr12_-_52868855 0.521 NM_014311
SMUG1
single-strand-selective monofunctional uracil-DNA glycosylase 1
chr19_-_55560686 0.520 NM_004851
NAPSA
napsin A aspartic peptidase
chr13_-_73605914 0.520 NM_007249
KLF12
Kruppel-like factor 12
chr1_+_32512298 0.519 NM_001042771
LCK
lymphocyte-specific protein tyrosine kinase
chr10_+_101078784 0.519 NM_020348
CNNM1
cyclin M1
chr1_-_150564302 0.510 NM_002016
FLG
filaggrin
chr7_+_28441758 0.509 NM_004904
CREB5
cAMP responsive element binding protein 5
chr1_-_56817802 0.508 PPAP2B
phosphatidic acid phosphatase type 2B
chr1_-_24112345 0.502 NM_001841
CNR2
cannabinoid receptor 2 (macrophage)
chr1_+_158975662 0.501 NM_021181
SLAMF7
SLAM family member 7
chr10_+_47216925 0.500 NM_001630
ANXA8L2
ANXA8
annexin A8-like 2
annexin A8
chr8_+_85258056 0.499 NM_173848
RALYL
RALY RNA binding protein-like
chr2_-_72228427 0.498 NM_019885
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr19_+_14913298 0.497 NM_012377
OR7C2
olfactory receptor, family 7, subfamily C, member 2
chr3_-_191321601 0.497 NM_018192
LEPREL1
leprecan-like 1
chr12_-_15005761 0.497 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr4_+_69465107 0.493 NM_014058
TMPRSS11E
transmembrane protease, serine 11E
chr16_+_22432344 0.489 NM_001135865
LOC100132247
NPIPL3
nuclear pore complex interacting protein related gene
nuclear pore complex interacting protein-like 3
chr10_+_47875229 0.488 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr5_-_115938305 0.486 NM_020796
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chrX_+_123062143 0.485 STAG2
stromal antigen 2
chr6_+_52159143 0.484 NM_002190
IL17A
interleukin 17A
chr14_+_20319049 0.484 NM_005615
RNASE6
ribonuclease, RNase A family, k6
chr4_-_123596921 0.478 NM_000586
IL2
interleukin 2
chr1_+_154390939 0.478 SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr17_-_36719030 0.478 NM_001146182
KRTAP16-1
keratin associated protein 16-1
chr22_+_23753940 0.478 NM_001145206
KIAA1671
KIAA1671
chr3_-_114176401 0.474 NM_138806
NM_138939
NM_138940
NM_170780
CD200R1



CD200 receptor 1



chr22_+_44828338 0.469


chr3_+_195336625 0.467 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr4_-_77176163 0.466 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr4_+_71713324 0.466 NM_031889
ENAM
enamelin
chr11_+_112763722 0.465 NM_178510
ANKK1
ankyrin repeat and kinase domain containing 1
chr13_-_74799898 0.465 TBC1D4
TBC1 domain family, member 4
chr19_-_23248804 0.464 LOC100132815
hypothetical LOC100132815
chr11_+_20005704 0.462 NAV2
neuron navigator 2
chr2_+_17861266 0.459 NM_001105569
MSGN1
mesogenin 1
chr19_-_59258846 0.458 NM_198481
VSTM1
V-set and transmembrane domain containing 1
chr6_-_136889302 0.457 MAP7
microtubule-associated protein 7
chr9_+_27514311 0.457 NM_020124
IFNK
interferon, kappa
chr19_+_3087026 0.455 NM_002068
GNA15
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
chr9_+_86474393 0.455 NM_001018065
NM_001018066
NTRK2

neurotrophic tyrosine kinase, receptor, type 2

chr8_+_144711619 0.452 NM_024736
GSDMD
gasdermin D
chr4_-_84254873 0.452 PLAC8
placenta-specific 8
chr2_-_121759237 0.449 NM_014553
TFCP2L1
transcription factor CP2-like 1
chr10_+_49279647 0.449 NM_002750
NM_139046
NM_139047
NM_139049
MAPK8



mitogen-activated protein kinase 8



chr3_-_191321367 0.448 LEPREL1
leprecan-like 1
chr1_+_107485071 0.447 NTNG1
netrin G1
chr12_+_29193399 0.446 FAR2
fatty acyl CoA reductase 2
chr7_+_26298136 0.445 SNX10
sorting nexin 10
chr18_-_59462469 0.443 NM_002974
SERPINB4
serpin peptidase inhibitor, clade B (ovalbumin), member 4
chr4_+_106693225 0.441 NM_017700
ARHGEF38
Rho guanine nucleotide exchange factor (GEF) 38

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.01 1.52e-10 GO:0007608 sensory perception of smell
1.91 1.39e-09 GO:0007606 sensory perception of chemical stimulus
1.50 1.08e-04 GO:0007600 sensory perception
1.36 1.29e-03 GO:0002376 immune system process
1.13 2.06e-03 GO:0050896 response to stimulus
2.57 3.15e-03 GO:0034754 cellular hormone metabolic process
1.14 1.02e-02 GO:0032501 multicellular organismal process
1.43 1.42e-02 GO:0006955 immune response
1.86 2.31e-02 GO:0046649 lymphocyte activation
4.76 4.18e-02 GO:0008210 estrogen metabolic process
1.42 4.18e-02 GO:0002682 regulation of immune system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.25 2.15e-10 GO:0005886 plasma membrane
1.24 5.85e-10 GO:0071944 cell periphery
1.11 3.82e-03 GO:0044425 membrane part
1.09 5.21e-03 GO:0016020 membrane
1.12 8.02e-03 GO:0031224 intrinsic to membrane
1.22 1.06e-02 GO:0005576 extracellular region
1.11 2.31e-02 GO:0016021 integral to membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.07 6.76e-12 GO:0004984 olfactory receptor activity
1.44 3.66e-10 GO:0004872 receptor activity
1.37 2.23e-09 GO:0004871 signal transducer activity
1.37 2.23e-09 GO:0060089 molecular transducer activity
1.47 3.20e-08 GO:0004888 transmembrane receptor activity
1.56 1.70e-07 GO:0004930 G-protein coupled receptor activity
2.92 1.49e-02 GO:0003823 antigen binding