Motif ID: FOXN1.p2

Z-value: 1.358


Transcription factors associated with FOXN1.p2:

Gene SymbolEntrez IDGene Name
FOXN1 8456 forkhead box N1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXN1chr17_+_23875085-0.683.9e-03Click!


Activity profile for motif FOXN1.p2.

activity profile for motif FOXN1.p2


Sorted Z-values histogram for motif FOXN1.p2

Sorted Z-values for motif FOXN1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXN1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_82038669 2.454 NM_012302
LPHN2
latrophilin 2
chr14_+_64086366 2.094 NM_172365
C14orf50
chromosome 14 open reading frame 50
chr21_-_26867138 2.059 NM_052954
CYYR1
cysteine/tyrosine-rich 1
chr7_-_27120015 1.998 HOXA3
homeobox A3
chr17_-_28644118 1.879 NM_183377
ACCN1
amiloride-sensitive cation channel 1, neuronal
chrX_-_83329562 1.839 NM_014496
RPS6KA6
ribosomal protein S6 kinase, 90kDa, polypeptide 6
chr9_-_109290107 1.709 KLF4
Kruppel-like factor 4 (gut)
chr10_+_124211353 1.641 HTRA1
HtrA serine peptidase 1
chr19_-_58449752 1.610 ZNF677
zinc finger protein 677
chr13_-_77390907 1.579 NM_001122659
NM_003991
EDNRB

endothelin receptor type B

chr2_+_71534260 1.475 NM_001130976
NM_001130977
NM_001130978
NM_001130979
NM_001130980
NM_001130981
NM_003494
DYSF






dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)






chr4_+_57066131 1.437 NM_206919
ARL9
ADP-ribosylation factor-like 9
chr5_-_100266769 1.433 NM_175052
NM_005668
ST8SIA4

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

chr13_+_35903966 1.289 NM_001111046
NM_001111047
CCNA1

cyclin A1

chr7_-_131911768 1.284 PLXNA4
plexin A4
chr11_+_65357972 1.267 NM_152760
SNX32
sorting nexin 32
chr6_+_148705646 1.262 SASH1
SAM and SH3 domain containing 1
chr2_-_219614481 1.231 NM_152389
NM_194302
CCDC108

coiled-coil domain containing 108

chr7_-_131911808 1.185 NM_001105543
NM_020911
PLXNA4

plexin A4

chr4_-_156517394 1.168 MAP9
microtubule-associated protein 9
chr14_+_75521806 1.146 NM_001102564
NM_052873
C14orf179

chromosome 14 open reading frame 179

chr2_-_39040981 1.143 LOC375196
hypothetical LOC375196
chr4_-_156517423 1.069 MAP9
microtubule-associated protein 9
chrX_+_15666312 1.042 NM_007220
CA5B
carbonic anhydrase VB, mitochondrial
chr1_+_32992131 1.031


chr3_-_191321367 1.024 LEPREL1
leprecan-like 1
chr4_+_148621567 1.018 EDNRA
endothelin receptor type A
chr11_+_125279481 1.017 NM_013264
DDX25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr4_-_111763655 0.997 NM_000325
PITX2
paired-like homeodomain 2
chr12_+_56406296 0.991 LOC100130776
hypothetical LOC100130776
chr3_-_121944052 0.989 NM_173825
RABL3
RAB, member of RAS oncogene family-like 3
chr8_-_38245694 0.937 NM_001102559
NM_001102560
NM_032483
PPAPDC1B


phosphatidic acid phosphatase type 2 domain containing 1B


chr17_+_4922445 0.931 NM_153018
ZFP3
zinc finger protein 3 homolog (mouse)
chr7_-_84654106 0.929 SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr10_+_103103797 0.917 NM_003939
NM_033637
BTRC

beta-transducin repeat containing

chr3_+_121944247 0.909 NM_005513
GTF2E1
general transcription factor IIE, polypeptide 1, alpha 56kDa
chr14_+_99273751 0.906 EML1
echinoderm microtubule associated protein like 1
chr11_-_133332089 0.904 NM_014987
IGSF9B
immunoglobulin superfamily, member 9B
chr11_-_88864061 0.892 NM_001143836
NM_016931
NOX4

NADPH oxidase 4

chr8_-_11096257 0.878 NM_173683
XKR6
XK, Kell blood group complex subunit-related family, member 6
chr7_-_50828159 0.869 GRB10
growth factor receptor-bound protein 10
chr17_+_4922478 0.859 ZFP3
zinc finger protein 3 homolog (mouse)
chr14_-_88087575 0.844 PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr4_-_66218777 0.832 EPHA5
EPH receptor A5
chr17_-_60208083 0.826 LOC146880
hypothetical LOC146880
chr9_+_8848130 0.810


chr18_+_17076166 0.808 NM_001142966
GREB1L
growth regulation by estrogen in breast cancer-like
chr16_-_3295375 0.789


chr11_+_101423378 0.787 NM_001195005
NM_032930
C11orf70

chromosome 11 open reading frame 70

chr11_-_93774223 0.775 NM_016540
GPR83
G protein-coupled receptor 83
chr3_-_87122936 0.750 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr3_-_121944040 0.749


chr16_+_3295433 0.749 NM_153028
ZNF75A
zinc finger protein 75a
chr4_-_156517544 0.744 NM_001039580
MAP9
microtubule-associated protein 9
chr5_-_115938305 0.743 NM_020796
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chrX_-_106846253 0.743 NM_001015881
TSC22D3
TSC22 domain family, member 3
chr3_+_33293915 0.743 NM_012157
NM_001171713
FBXL2

F-box and leucine-rich repeat protein 2

chr17_-_74432671 0.737 TIMP2
TIMP metallopeptidase inhibitor 2
chr6_+_108593907 0.729 NM_003269
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr7_+_29200850 0.709 CHN2
chimerin (chimaerin) 2
chr3_-_87122958 0.703 VGLL3
vestigial like 3 (Drosophila)
chr1_+_45565126 0.703 NM_032756
HPDL
4-hydroxyphenylpyruvate dioxygenase-like
chr15_+_45796802 0.691 SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr13_-_77391525 0.687


chr1_-_158091760 0.677 NM_001134233
C1orf204
chromosome 1 open reading frame 204
chr1_-_181654027 0.667


chr17_-_72045218 0.664 NM_134268
CYGB
cytoglobin
chr15_+_43209422 0.658 NM_017434
NM_175940
DUOX1

dual oxidase 1

chr2_-_142605010 0.653 LRP1B
low density lipoprotein receptor-related protein 1B
chr12_+_3470685 0.647 NM_019854
PRMT8
protein arginine methyltransferase 8
chr15_-_47235057 0.644 NM_001143887
NM_004236
COPS2

COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)

chr6_+_72949092 0.634 RIMS1
regulating synaptic membrane exocytosis 1
chr5_+_80292213 0.627 RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr5_+_156819782 0.624 NIPAL4
NIPA-like domain containing 4
chr17_+_7883076 0.616 NM_001039130
NM_001039131
NM_001141
ALOX15B


arachidonate 15-lipoxygenase, type B


chr9_+_127550298 0.609 NM_001134778
PBX3
pre-B-cell leukemia homeobox 3
chr13_+_26029879 0.607 WASF3
WAS protein family, member 3
chr1_-_158091296 0.601 C1orf204
chromosome 1 open reading frame 204
chr19_-_45888259 0.597 NM_004756
NUMBL
numb homolog (Drosophila)-like
chr13_+_45524950 0.594


chr22_-_44188116 0.588 NM_148674
SMC1B
structural maintenance of chromosomes 1B
chr12_+_121825021 0.584 NM_032573
NM_201435
CCDC62

coiled-coil domain containing 62

chr15_+_68971835 0.579 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr5_-_140978664 0.576 DIAPH1
diaphanous homolog 1 (Drosophila)
chr8_+_32525269 0.570 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr15_+_81906983 0.568 NM_003027
SH3GL3
SH3-domain GRB2-like 3
chr7_+_100302885 0.568 NM_003302
TRIP6
thyroid hormone receptor interactor 6
chr15_+_47235243 0.567 NM_001001556
GALK2
galactokinase 2
chr13_-_45524846 0.564 NM_015070
ZC3H13
zinc finger CCCH-type containing 13
chr14_+_103675194 0.562 KIF26A
kinesin family member 26A
chr6_-_75972286 0.561 NM_004370
NM_080645
COL12A1

collagen, type XII, alpha 1

chr13_-_72253970 0.558 DIS3
DIS3 mitotic control homolog (S. cerevisiae)
chrX_-_21586337 0.557 NM_153270
KLHL34
kelch-like 34 (Drosophila)
chr11_+_7997366 0.549 TUB
tubby homolog (mouse)
chr15_-_43209348 0.543 NM_144565
DUOXA1
dual oxidase maturation factor 1
chr19_-_58449919 0.543 NM_182609
ZNF677
zinc finger protein 677
chr13_+_72254180 0.538 NM_006346
PIBF1
progesterone immunomodulatory binding factor 1
chr7_+_113513828 0.535 FOXP2
forkhead box P2
chr5_+_99899133 0.533 FAM174A
family with sequence similarity 174, member A
chrX_-_108754906 0.532 NM_012282
KCNE1L
KCNE1-like
chr12_+_77782579 0.526 NM_005639
SYT1
synaptotagmin I
chr17_-_46553083 0.525 NM_001130528
NM_003971
SPAG9

sperm associated antigen 9

chr12_+_70344257 0.523 THAP2
THAP domain containing, apoptosis associated protein 2
chr12_+_103133631 0.520 NM_001093771
TXNRD1
thioredoxin reductase 1
chr17_+_6856697 0.520 RNASEK-C17ORF49
RNASEK-C17orf49 read-through transcript
chr17_+_4743645 0.516 NM_001145536
C17orf107
chromosome 17 open reading frame 107
chrX_-_99778340 0.515 NM_003270
TSPAN6
tetraspanin 6
chr14_+_73128162 0.514 NM_152331
ACOT4
acyl-CoA thioesterase 4
chr6_+_148705817 0.512 SASH1
SAM and SH3 domain containing 1
chr17_+_6856676 0.508 RNASEK-C17ORF49
RNASEK
RNASEK-C17orf49 read-through transcript
ribonuclease, RNase K
chr15_-_57452345 0.508 MYO1E
myosin IE
chr2_-_38683119 0.504 HNRPLL
heterogeneous nuclear ribonucleoprotein L-like
chr8_-_98359248 0.503 TSPYL5
TSPY-like 5
chrX_-_17789276 0.501 NM_001172732
NM_001172739
NM_001172743
NM_021785
RAI2



retinoic acid induced 2



chr17_+_6856521 0.496 NM_001004333
RNASEK-C17ORF49
RNASEK
RNASEK-C17orf49 read-through transcript
ribonuclease, RNase K
chr10_-_120091795 0.489 NM_001134672
NM_022063
C10orf84

chromosome 10 open reading frame 84

chr12_+_87060176 0.486 NM_181783
TMTC3
transmembrane and tetratricopeptide repeat containing 3
chr14_+_64077171 0.486 HSPA2
heat shock 70kDa protein 2
chr4_-_170770111 0.484 NM_012224
NEK1
NIMA (never in mitosis gene a)-related kinase 1
chr15_-_57452361 0.482 NM_004998
MYO1E
myosin IE
chr14_-_52487022 0.482 FERMT2
fermitin family member 2
chr5_+_80292313 0.480 NM_006909
RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr14_+_36196523 0.480 NM_006194
PAX9
paired box 9
chr13_-_37341859 0.479 NM_001135955
NM_001135956
NM_001135957
NM_001135958
NM_003306
NM_016179
TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr1_+_221633337 0.478 NM_152610
C1orf65
chromosome 1 open reading frame 65
chr5_+_174084137 0.477 NM_002449
MSX2
msh homeobox 2
chr1_-_32479785 0.473 MTMR9LP
myotubularin related protein 9-like, pseudogene
chr15_-_57452357 0.471 MYO1E
myosin IE
chr9_+_96176638 0.470 NM_032558
HIATL1
hippocampus abundant transcript-like 1
chr22_+_44188205 0.463 NM_015653
RIBC2
RIB43A domain with coiled-coils 2
chr1_-_181654124 0.461 NM_015039
NMNAT2
nicotinamide nucleotide adenylyltransferase 2
chr15_+_97609059 0.459 NM_144598
LRRC28
leucine rich repeat containing 28
chr2_-_165406098 0.458 COBLL1
COBL-like 1
chr4_-_122521562 0.458 NM_198179
QRFPR
pyroglutamylated RFamide peptide receptor
chr19_-_54188378 0.457 NM_001161587
NM_002103
GYS1

glycogen synthase 1 (muscle)

chr13_+_48448950 0.455 FNDC3A
fibronectin type III domain containing 3A
chr13_+_26029799 0.454 NM_006646
WASF3
WAS protein family, member 3
chr13_-_72254059 0.452 DIS3
DIS3 mitotic control homolog (S. cerevisiae)
chr22_+_40195058 0.451 NM_001098
ACO2
aconitase 2, mitochondrial
chr12_-_67012303 0.450 NM_017440
NM_020128
MDM1

Mdm1 nuclear protein homolog (mouse)

chrX_+_105856531 0.450 NM_194463
RNF128
ring finger protein 128
chr11_-_132318741 0.449 OPCML
opioid binding protein/cell adhesion molecule-like
chr12_-_79855580 0.448 LIN7A
lin-7 homolog A (C. elegans)
chr13_+_51484517 0.443 NM_001004127
ALG11
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
chr4_-_21559471 0.442 NM_147182
KCNIP4
Kv channel interacting protein 4
chr19_+_41980248 0.442 LOC284408
hypothetical LOC284408
chr19_+_61711008 0.442 NM_020813
ZNF471
zinc finger protein 471
chr11_+_24475091 0.442 NM_001009909
LUZP2
leucine zipper protein 2
chr3_-_192063158 0.441 NM_001146686
GEMC1
geminin coiled-coil domain-containing protein 1
chr4_+_48038095 0.440 SLAIN2
SLAIN motif family, member 2
chr3_-_191321601 0.437 NM_018192
LEPREL1
leprecan-like 1
chr3_-_49370755 0.435 NM_000581
NM_201397
GPX1

glutathione peroxidase 1

chr10_+_124210980 0.433 NM_002775
HTRA1
HtrA serine peptidase 1
chr4_+_113777568 0.431 NM_016648
LARP7
La ribonucleoprotein domain family, member 7
chr10_+_94342940 0.431 KIF11
kinesin family member 11
chr3_+_113534710 0.429 CD200
CD200 molecule
chr14_-_51605695 0.428 NM_007361
NID2
nidogen 2 (osteonidogen)
chr2_-_27966715 0.428 NM_022128
RBKS
ribokinase
chr9_+_129226535 0.427 ZNF79
zinc finger protein 79
chr5_-_148911194 0.425 NM_001025105
NM_001892
CSNK1A1

casein kinase 1, alpha 1

chr15_-_68971665 0.425 NM_020147
THAP10
THAP domain containing 10
chr2_+_188864848 0.424 GULP1
GULP, engulfment adaptor PTB domain containing 1
chr20_+_773283 0.420 NM_031424
FAM110A
family with sequence similarity 110, member A
chrX_-_106846684 0.419 TSC22D3
TSC22 domain family, member 3
chr19_+_22608964 0.419 NM_020855
ZNF492
zinc finger protein 492
chr3_-_52418933 0.416 NM_004656
BAP1
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
chr4_+_110574420 0.408 SEC24B
SEC24 family, member B (S. cerevisiae)
chr1_+_219026661 0.406 NM_022746
MOSC1
MOCO sulphurase C-terminal domain containing 1
chr17_+_9420668 0.405 NM_001080556
NM_145054
WDR16

WD repeat domain 16

chr1_+_101134276 0.405 SLC30A7
solute carrier family 30 (zinc transporter), member 7
chr1_+_69805398 0.405


chr3_+_143925904 0.404 NM_003304
TRPC1
transient receptor potential cation channel, subfamily C, member 1
chr8_-_17148637 0.403 NM_013354
NM_054026
CNOT7

CCR4-NOT transcription complex, subunit 7

chr4_+_148621694 0.401 EDNRA
endothelin receptor type A
chr15_+_91248706 0.399 CHD2
chromodomain helicase DNA binding protein 2
chr19_-_54188376 0.399 GYS1
glycogen synthase 1 (muscle)
chrX_-_132376660 0.397 NM_001448
GPC4
glypican 4
chr19_-_54188332 0.397 GYS1
glycogen synthase 1 (muscle)
chr17_+_7328497 0.396 POLR2A
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
chr3_-_49370682 0.396 GPX1
glutathione peroxidase 1
chr6_-_25019173 0.396 NM_014722
FAM65B
family with sequence similarity 65, member B
chr6_+_29799095 0.395 NM_001098478
NM_001098479
NM_018950
HLA-F


major histocompatibility complex, class I, F


chr4_+_41687249 0.395 NM_006345
SLC30A9
solute carrier family 30 (zinc transporter), member 9
chr3_-_47180417 0.394 NM_014159
SETD2
SET domain containing 2
chr4_-_113777470 0.393 C4orf21
chromosome 4 open reading frame 21
chr8_-_98359366 0.390 TSPYL5
TSPY-like 5
chr7_-_82629735 0.388 PCLO
piccolo (presynaptic cytomatrix protein)
chr12_+_77782648 0.388 SYT1
synaptotagmin I
chr13_-_95094920 0.387 NM_014934
NM_198968
DZIP1

DAZ interacting protein 1

chr13_+_48448912 0.386 FNDC3A
fibronectin type III domain containing 3A
chr5_-_140978747 0.386 DIAPH1
diaphanous homolog 1 (Drosophila)
chr8_+_87424074 0.382 NM_007013
WWP1
WW domain containing E3 ubiquitin protein ligase 1
chr8_-_98359347 0.380 NM_033512
TSPYL5
TSPY-like 5
chr5_-_140978751 0.379 NM_001079812
NM_005219
DIAPH1

diaphanous homolog 1 (Drosophila)

chr15_-_32875040 0.379 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr13_-_72254071 0.379 NM_001128226
NM_014953
DIS3

DIS3 mitotic control homolog (S. cerevisiae)

chr9_-_114135607 0.379 ROD1
ROD1 regulator of differentiation 1 (S. pombe)
chr9_+_129226473 0.379 NM_007135
ZNF79
zinc finger protein 79
chr14_-_76856776 0.378 NM_013382
POMT2
protein-O-mannosyltransferase 2
chr4_+_41687302 0.377 SLC30A9
solute carrier family 30 (zinc transporter), member 9

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.34 4.64e-08 GO:0044260 cellular macromolecule metabolic process
1.23 1.02e-05 GO:0044237 cellular metabolic process
1.12 2.83e-05 GO:0009987 cellular process
1.27 2.94e-05 GO:0043170 macromolecule metabolic process
1.39 2.42e-04 GO:0044267 cellular protein metabolic process
1.20 2.66e-04 GO:0044238 primary metabolic process
1.18 7.10e-04 GO:0008152 metabolic process
1.43 1.43e-03 GO:0006464 protein modification process
1.41 2.02e-03 GO:0043412 macromolecule modification
2.02 1.29e-02 GO:0019941 modification-dependent protein catabolic process
1.31 1.48e-02 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.01 1.54e-02 GO:0043632 modification-dependent macromolecule catabolic process
2.02 1.73e-02 GO:0006511 ubiquitin-dependent protein catabolic process
1.97 2.59e-02 GO:0051603 proteolysis involved in cellular protein catabolic process
1.26 2.70e-02 GO:0071840 cellular component organization or biogenesis
1.28 3.29e-02 GO:0019538 protein metabolic process
1.26 3.54e-02 GO:0016043 cellular component organization
1.93 4.26e-02 GO:0044257 cellular protein catabolic process
1.73 4.31e-02 GO:0044265 cellular macromolecule catabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.17 3.57e-15 GO:0005622 intracellular
1.17 6.08e-15 GO:0044424 intracellular part
1.32 1.21e-11 GO:0005634 nucleus
1.21 4.95e-11 GO:0043231 intracellular membrane-bounded organelle
1.21 6.63e-11 GO:0043227 membrane-bounded organelle
1.17 1.52e-09 GO:0043229 intracellular organelle
1.17 2.46e-09 GO:0043226 organelle
1.20 1.15e-08 GO:0005737 cytoplasm
1.06 2.66e-04 GO:0044464 cell part
1.06 2.74e-04 GO:0005623 cell
1.19 7.95e-04 GO:0044444 cytoplasmic part
1.39 1.40e-03 GO:0031981 nuclear lumen
1.35 1.72e-03 GO:0044428 nuclear part
1.19 2.43e-03 GO:0044446 intracellular organelle part
1.18 7.01e-03 GO:0044422 organelle part
1.31 1.27e-02 GO:0070013 intracellular organelle lumen
1.41 1.86e-02 GO:0005654 nucleoplasm
1.58 1.95e-02 GO:0015630 microtubule cytoskeleton
1.29 2.89e-02 GO:0031974 membrane-enclosed lumen
1.29 2.98e-02 GO:0043233 organelle lumen

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 1.80e-05 GO:0005488 binding
1.17 1.59e-04 GO:0005515 protein binding
1.86 1.32e-03 GO:0016874 ligase activity
2.22 1.86e-03 GO:0019787 small conjugating protein ligase activity
2.10 3.13e-03 GO:0016881 acid-amino acid ligase activity
2.17 7.74e-03 GO:0004842 ubiquitin-protein ligase activity
1.94 1.82e-02 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.29 4.32e-02 GO:0000166 nucleotide binding