Motif ID: GTF2I.p2

Z-value: 2.639


Transcription factors associated with GTF2I.p2:

Gene SymbolEntrez IDGene Name
GTF2I 2969 general transcription factor II, i

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GTF2Ichr7_+_73709991-0.087.7e-01Click!


Activity profile for motif GTF2I.p2.

activity profile for motif GTF2I.p2


Sorted Z-values histogram for motif GTF2I.p2

Sorted Z-values for motif GTF2I.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2I.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_68470585 5.887 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr11_+_12355600 4.225 NM_018222
PARVA
parvin, alpha
chr11_-_27697768 4.167 NM_001143807
BDNF
brain-derived neurotrophic factor
chr1_-_20685314 4.107 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr3_+_77171938 3.749 NM_002942
ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr1_+_202308814 3.673 NM_005686
SOX13
SRY (sex determining region Y)-box 13
chr2_+_100802923 3.524 NM_002518
NPAS2
neuronal PAS domain protein 2
chr1_+_156229934 3.505 KIRREL
kin of IRRE like (Drosophila)
chr22_-_34566210 3.501 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr9_+_108665168 3.481 NM_021224
ZNF462
zinc finger protein 462
chr12_-_113606322 3.355 NM_005996
NM_016569
TBX3

T-box 3

chr22_-_35914200 3.301 NM_031910
NM_182486
C1QTNF6

C1q and tumor necrosis factor related protein 6

chr19_-_36531958 3.230 NM_020856
TSHZ3
teashirt zinc finger homeobox 3
chr14_+_85069217 3.220


chr20_+_13924263 3.211 MACROD2
MACRO domain containing 2
chr19_-_59676153 3.191 NM_145057
CDC42EP5
CDC42 effector protein (Rho GTPase binding) 5
chr2_-_19421852 3.179 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chr19_-_60573552 3.165 NM_000641
IL11
interleukin 11
chr9_+_35528890 3.156 RUSC2
RUN and SH3 domain containing 2
chr22_-_34566276 3.079 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chrX_+_152413540 2.905 NM_001711
BGN
biglycan
chr2_-_218551786 2.887 TNS1
tensin 1
chr9_+_138341752 2.870 NM_001145638
NM_015597
GPSM1

G-protein signaling modulator 1

chr16_-_63713466 2.855 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr3_-_64648703 2.854 ADAMTS9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
chr15_-_86600658 2.849 NM_001007156
NM_001012338
NM_002530
NTRK3


neurotrophic tyrosine kinase, receptor, type 3


chr7_-_78920806 2.827 NM_012301
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr16_-_63713485 2.823 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr9_-_16860719 2.809 NM_017637
BNC2
basonuclin 2
chr5_+_135392482 2.798 NM_000358
TGFBI
transforming growth factor, beta-induced, 68kDa
chr16_-_63713382 2.794 NM_001797
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr1_+_221955876 2.792 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chrX_+_152413646 2.735 BGN
biglycan
chr19_+_60487578 2.651 BRSK1
BR serine/threonine kinase 1
chr20_+_13924014 2.624 NM_080676
MACROD2
MACRO domain containing 2
chr21_-_27139563 2.621 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr12_+_6363482 2.619 NM_002342
LTBR
lymphotoxin beta receptor (TNFR superfamily, member 3)
chr11_-_56846246 2.570 TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr21_-_27139143 2.563 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr4_+_61749540 2.523 LPHN3
latrophilin 3
chr1_-_20684858 2.448 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr10_+_20145350 2.434 NM_032812
PLXDC2
plexin domain containing 2
chr3_+_37878647 2.363 NM_001008392
NM_005808
CTDSPL

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like

chr9_+_8848130 2.345


chr22_+_44277354 2.327 NM_001996
NM_006485
NM_006486
NM_006487
FBLN1



fibulin 1



chr4_-_122213018 2.316 NM_024574
C4orf31
chromosome 4 open reading frame 31
chr13_+_87122778 2.313 NM_015567
SLITRK5
SLIT and NTRK-like family, member 5
chr7_-_32077504 2.304 NM_001191059
NM_005020
PDE1C

phosphodiesterase 1C, calmodulin-dependent 70kDa

chr9_-_16860664 2.295 BNC2
basonuclin 2
chr16_+_56219802 2.255 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr12_+_6800950 2.248 NM_014449
NM_019858
GPR162

G protein-coupled receptor 162

chr2_-_164300758 2.230 NM_018086
FIGN
fidgetin
chr5_+_135392624 2.230 TGFBI
transforming growth factor, beta-induced, 68kDa
chr11_+_129823667 2.204 NM_139055
ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr4_-_16509126 2.165 LDB2
LIM domain binding 2
chr9_+_35528628 2.143 NM_001135999
RUSC2
RUN and SH3 domain containing 2
chr7_-_27136876 2.122 NM_002141
HOXA4
homeobox A4
chr7_-_27120015 2.100 HOXA3
homeobox A3
chr19_-_242168 2.097 NM_177543
PPAP2C
phosphatidic acid phosphatase type 2C
chr14_-_26136799 2.092 NM_002515
NM_006489
NM_006491
NOVA1


neuro-oncological ventral antigen 1


chr8_-_93184629 2.082 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chrX_+_144707022 2.074 NM_001144003
NM_001144004
NM_001144005
NM_032539
SLITRK2



SLIT and NTRK-like family, member 2



chr15_+_45796802 2.072 SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr3_+_185580554 2.048 NM_003741
CHRD
chordin
chr13_+_57103789 2.043 NM_001040429
PCDH17
protocadherin 17
chr7_+_29200636 2.027 NM_004067
CHN2
chimerin (chimaerin) 2
chr8_-_122722674 2.022 NM_005328
HAS2
hyaluronan synthase 2
chr6_+_1335067 2.021 NM_001452
FOXF2
forkhead box F2
chr19_+_59061422 2.019 NM_001020820
MYADM
myeloid-associated differentiation marker
chr8_-_89408832 2.014 NM_005941
MMP16
matrix metallopeptidase 16 (membrane-inserted)
chr4_-_16509446 2.013 NM_001130834
NM_001290
LDB2

LIM domain binding 2

chr1_+_156229686 2.010 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr13_+_57103944 1.982 PCDH17
protocadherin 17
chr1_-_194844299 1.969 KCNT2
potassium channel, subfamily T, member 2
chr4_-_158111995 1.956 NM_016205
PDGFC
platelet derived growth factor C
chr16_+_66244314 1.946 RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr19_+_60691733 1.945 SSC5D
scavenger receptor cysteine rich domain containing (5 domains)
chr19_-_242335 1.918 NM_003712
NM_177526
PPAP2C

phosphatidic acid phosphatase type 2C

chr22_-_34566367 1.918 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr4_+_30331289 1.886 PCDH7
protocadherin 7
chr12_-_47468985 1.885 NM_020983
ADCY6
adenylate cyclase 6
chr15_+_41597097 1.884 NM_002373
MAP1A
microtubule-associated protein 1A
chr19_-_54557450 1.874 NM_003598
TEAD2
TEA domain family member 2
chr8_+_27547379 1.870 NM_016240
NM_182826
SCARA3

scavenger receptor class A, member 3

chr2_-_165186232 1.866 GRB14
growth factor receptor-bound protein 14
chr4_-_16509354 1.859 LDB2
LIM domain binding 2
chr1_+_168898898 1.842 PRRX1
paired related homeobox 1
chr19_+_60487345 1.834 NM_032430
BRSK1
BR serine/threonine kinase 1
chr19_+_43572679 1.830 NM_001039616
NM_001042522
SPRED3

sprouty-related, EVH1 domain containing 3

chr19_-_55914837 1.799


chr1_-_212791188 1.798 PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr2_-_165186064 1.781 GRB14
growth factor receptor-bound protein 14
chr2_-_198248828 1.777 NM_144629
RFTN2
raftlin family member 2
chr1_+_162795538 1.777 PBX1
pre-B-cell leukemia homeobox 1
chr7_+_78920846 1.763 LOC100505881
hypothetical LOC100505881
chr14_-_104507862 1.750 AHNAK2
AHNAK nucleoprotein 2
chr12_-_56418295 1.720 NM_001122772
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr3_-_193609531 1.715 NM_021032
FGF12
fibroblast growth factor 12
chr8_-_22044463 1.710 NM_005144
NM_018411
HR

hairless homolog (mouse)

chr11_-_122571046 1.691 CLMP
CXADR-like membrane protein
chr11_-_122571198 1.679 NM_024769
CLMP
CXADR-like membrane protein
chr4_-_158111916 1.671 PDGFC
platelet derived growth factor C
chr2_+_39746525 1.668 NM_152390
TMEM178
transmembrane protein 178
chrX_-_54538591 1.629 FGD1
FYVE, RhoGEF and PH domain containing 1
chr5_+_140326473 1.625 NM_031883
PCDHAC2
protocadherin alpha subfamily C, 2
chr3_-_162572441 1.607 NM_001040100
C3orf57
chromosome 3 open reading frame 57
chr7_+_29200850 1.606 CHN2
chimerin (chimaerin) 2
chr7_+_121300394 1.602 NM_002851
PTPRZ1
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
chr19_-_56178882 1.577 NM_139277
NM_005046
KLK7

kallikrein-related peptidase 7

chr12_+_51729239 1.560 TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr12_-_6354650 1.556 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr3_-_197103848 1.550 TNK2
tyrosine kinase, non-receptor, 2
chr12_-_6354818 1.537 SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr1_-_72520735 1.531 NM_173808
NEGR1
neuronal growth regulator 1
chr5_-_168660293 1.530 NM_003062
SLIT3
slit homolog 3 (Drosophila)
chr7_+_27191534 1.523 HOXA11-AS1
HOXA11 antisense RNA 1 (non-protein coding)
chr8_-_97242119 1.520 NM_001001557
GDF6
growth differentiation factor 6
chr13_-_35603513 1.516 NM_004734
DCLK1
doublecortin-like kinase 1
chr12_-_105057940 1.516 NM_014840
NUAK1
NUAK family, SNF1-like kinase, 1
chr16_-_30929217 1.498 NM_052874
STX1B
syntaxin 1B
chr9_-_112381593 1.491 NM_153366
SVEP1
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
chr5_-_59100194 1.488 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr2_+_188864975 1.487 GULP1
GULP, engulfment adaptor PTB domain containing 1
chr7_+_73506172 1.474 GTF2IRD1
GTF2I repeat domain containing 1
chr2_+_220033777 1.471 NM_001173476
SPEG
SPEG complex locus
chr5_-_59100091 1.462 PDE4D
phosphodiesterase 4D, cAMP-specific
chr19_+_60691671 1.449 NM_001144950
NM_001195267
SSC5D

scavenger receptor cysteine rich domain containing (5 domains)

chr13_-_35603432 1.447 DCLK1
doublecortin-like kinase 1
chr3_+_189354167 1.446 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr18_-_33399997 1.442 NM_001025087
NM_001025088
NM_001025089
NM_020180
CELF4



CUGBP, Elav-like family member 4



chr6_-_152999678 1.442 NM_033071
SYNE1
spectrin repeat containing, nuclear envelope 1
chr7_+_18093068 1.435 HDAC9
histone deacetylase 9
chr2_-_166940710 1.426 NM_002977
SCN9A
sodium channel, voltage-gated, type IX, alpha subunit
chr5_+_140325930 1.419 NM_018899
PCDHAC2
protocadherin alpha subfamily C, 2
chr8_+_26427378 1.412 NM_001197293
DPYSL2
dihydropyrimidinase-like 2
chr15_+_90738108 1.407 NM_006011
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr1_-_212791597 1.407 NM_005401
PTPN14
protein tyrosine phosphatase, non-receptor type 14
chrX_-_150893752 1.405 NM_004961
GABRE
gamma-aminobutyric acid (GABA) A receptor, epsilon
chr1_+_208472817 1.401 NM_019605
SERTAD4
SERTA domain containing 4
chr13_-_35603466 1.401 DCLK1
doublecortin-like kinase 1
chr8_+_97575317 1.399 SDC2
syndecan 2
chr4_-_158111504 1.398 PDGFC
platelet derived growth factor C
chr7_+_33911636 1.397 NM_133468
BMPER
BMP binding endothelial regulator
chr4_-_177950658 1.396 NM_005429
VEGFC
vascular endothelial growth factor C
chr6_-_153494076 1.391 NM_012419
RGS17
regulator of G-protein signaling 17
chr1_+_2975590 1.391 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr19_+_46416975 1.381 AXL
AXL receptor tyrosine kinase
chr1_+_201711505 1.376 NM_002725
NM_201348
PRELP

proline/arginine-rich end leucine-rich repeat protein

chr15_-_91417312 1.375 RGMA
RGM domain family, member A
chr8_-_26427304 1.367 NM_007257
PNMA2
paraneoplastic antigen MA2
chr17_-_44047299 1.366 NM_024016
HOXB8
homeobox B8
chr15_+_87147667 1.366 NM_001135
NM_013227
ACAN

aggrecan

chr14_-_37134191 1.366 NM_004496
FOXA1
forkhead box A1
chr17_-_72045218 1.362 NM_134268
CYGB
cytoglobin
chr10_-_126839546 1.349 NM_001083914
CTBP2
C-terminal binding protein 2
chrX_+_12066505 1.349 NM_014728
FRMPD4
FERM and PDZ domain containing 4
chr19_+_59077241 1.346 NM_002739
PRKCG
protein kinase C, gamma
chr12_+_51728999 1.339 NM_015319
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr3_-_115825742 1.332 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr10_-_33663777 1.332 NM_001024628
NM_001024629
NM_003873
NRP1


neuropilin 1


chr3_+_148610516 1.327 ZIC1
Zic family member 1 (odd-paired homolog, Drosophila)
chr1_-_57661373 1.320 DAB1
disabled homolog 1 (Drosophila)
chr7_-_100262971 1.313 NM_004444
EPHB4
EPH receptor B4
chr1_+_226404037 1.311 NM_020435
GJC2
gap junction protein, gamma 2, 47kDa
chr20_+_8997791 1.309 PLCB4
phospholipase C, beta 4
chr8_+_27547303 1.308 SCARA3
scavenger receptor class A, member 3
chr14_-_53491019 1.305 NM_130851
BMP4
bone morphogenetic protein 4
chr11_-_129803515 1.305 ADAMTS8
ADAM metallopeptidase with thrombospondin type 1 motif, 8
chrX_+_73557809 1.289 NM_006517
SLC16A2
solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
chr2_-_200030412 1.285 SATB2
SATB homeobox 2
chr1_+_162795328 1.283 NM_002585
PBX1
pre-B-cell leukemia homeobox 1
chr9_+_35782405 1.283 NM_003995
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr1_+_15957832 1.281 NM_017556
FBLIM1
filamin binding LIM protein 1
chr2_+_188864640 1.267 GULP1
GULP, engulfment adaptor PTB domain containing 1
chr7_+_73506333 1.262 NM_005685
GTF2IRD1
GTF2I repeat domain containing 1
chr1_-_240754620 1.254 NM_152666
PLD5
phospholipase D family, member 5
chr17_-_7061641 1.252 NM_001128827
DLG4
discs, large homolog 4 (Drosophila)
chr15_+_45797977 1.251 NM_020858
NM_024966
NM_153616
NM_153617
NM_153618
NM_153619
SEMA6D





sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D





chr1_-_166172901 1.250 NM_001143674
BRP44
brain protein 44
chr3_-_69674412 1.246 FRMD4B
FERM domain containing 4B
chr1_-_212791467 1.245 PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr4_+_30330963 1.240 NM_001173523
NM_002589
NM_032456
NM_032457
PCDH7



protocadherin 7



chr2_-_72228427 1.240 NM_019885
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr18_+_17076166 1.239 NM_001142966
GREB1L
growth regulation by estrogen in breast cancer-like
chr1_-_103346482 1.238 COL11A1
collagen, type XI, alpha 1
chr1_-_24307514 1.238 MYOM3
myomesin family, member 3
chr1_-_103346639 1.228 NM_001190709
NM_001854
NM_080629
NM_080630
COL11A1



collagen, type XI, alpha 1



chr14_-_60185659 1.227 NM_005982
SIX1
SIX homeobox 1
chr2_+_210344972 1.223 UNC80
unc-80 homolog (C. elegans)
chr12_+_84198015 1.212 NM_006982
ALX1
ALX homeobox 1
chr3_+_185538998 1.206 FAM131A
family with sequence similarity 131, member A
chr1_-_72521079 1.202


chr5_+_38882017 1.201 OSMR
oncostatin M receptor
chr13_-_37341859 1.186 NM_001135955
NM_001135956
NM_001135957
NM_001135958
NM_003306
NM_016179
TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr2_+_210344945 1.185 NM_032504
NM_182587
UNC80

unc-80 homolog (C. elegans)

chr14_-_36058648 1.183 NM_003317
NKX2-1
NK2 homeobox 1
chr4_+_145786622 1.183 NM_022475
HHIP
hedgehog interacting protein
chr7_-_15692551 1.180 MEOX2
mesenchyme homeobox 2
chr2_+_188864898 1.169 GULP1
GULP, engulfment adaptor PTB domain containing 1
chr10_-_105604942 1.169 NM_014631
SH3PXD2A
SH3 and PX domains 2A

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.16 8.44e-24 GO:0050794 regulation of cellular process
1.30 1.00e-22 GO:0048731 system development
1.15 3.47e-21 GO:0050789 regulation of biological process
1.14 3.89e-21 GO:0065007 biological regulation
1.41 9.81e-21 GO:0007399 nervous system development
1.26 4.84e-20 GO:0048856 anatomical structure development
1.25 7.69e-20 GO:0007275 multicellular organismal development
1.39 2.59e-18 GO:0009653 anatomical structure morphogenesis
1.22 8.11e-18 GO:0032502 developmental process
1.48 2.60e-16 GO:0022008 neurogenesis
1.08 3.32e-16 GO:0009987 cellular process
1.49 5.06e-16 GO:0048699 generation of neurons
1.26 1.42e-15 GO:0048518 positive regulation of biological process
1.27 4.35e-15 GO:0048522 positive regulation of cellular process
1.20 2.86e-14 GO:0023052 signaling
1.28 1.40e-13 GO:0048523 negative regulation of cellular process
1.25 9.08e-13 GO:0048519 negative regulation of biological process
1.57 1.12e-11 GO:0031175 neuron projection development
1.48 1.22e-11 GO:0030182 neuron differentiation
1.20 2.53e-11 GO:0016043 cellular component organization
1.49 4.09e-11 GO:0030030 cell projection organization
1.50 5.13e-11 GO:0000902 cell morphogenesis
1.19 8.54e-11 GO:0007165 signal transduction
1.29 8.96e-11 GO:0023051 regulation of signaling
1.51 9.33e-11 GO:0048666 neuron development
1.54 1.08e-10 GO:0000904 cell morphogenesis involved in differentiation
1.57 1.45e-10 GO:0048812 neuron projection morphogenesis
1.19 1.58e-10 GO:0071840 cellular component organization or biogenesis
1.53 2.50e-10 GO:0032990 cell part morphogenesis
1.47 2.88e-10 GO:0032989 cellular component morphogenesis
1.53 3.43e-10 GO:0048858 cell projection morphogenesis
1.37 3.69e-10 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.22 4.06e-10 GO:0071842 cellular component organization at cellular level
1.24 1.44e-09 GO:0048869 cellular developmental process
1.24 1.44e-09 GO:0030154 cell differentiation
1.16 1.60e-09 GO:0051716 cellular response to stimulus
1.30 1.66e-09 GO:0009966 regulation of signal transduction
1.55 1.71e-09 GO:0048667 cell morphogenesis involved in neuron differentiation
1.56 2.42e-09 GO:0007409 axonogenesis
1.43 6.94e-09 GO:0009719 response to endogenous stimulus
1.20 1.03e-08 GO:0071841 cellular component organization or biogenesis at cellular level
1.25 1.10e-08 GO:0048583 regulation of response to stimulus
1.32 1.28e-08 GO:0010604 positive regulation of macromolecule metabolic process
1.36 1.72e-08 GO:0048468 cell development
1.31 2.13e-08 GO:0031325 positive regulation of cellular metabolic process
1.24 2.15e-08 GO:0048513 organ development
1.13 3.11e-08 GO:0043170 macromolecule metabolic process
1.38 6.37e-08 GO:0051173 positive regulation of nitrogen compound metabolic process
1.29 6.39e-08 GO:0009893 positive regulation of metabolic process
1.14 1.01e-07 GO:0044260 cellular macromolecule metabolic process
1.41 1.77e-07 GO:0007167 enzyme linked receptor protein signaling pathway
1.42 2.07e-07 GO:0009725 response to hormone stimulus
1.31 3.02e-07 GO:0010646 regulation of cell communication
1.48 3.26e-07 GO:0072358 cardiovascular system development
1.48 3.26e-07 GO:0072359 circulatory system development
1.37 3.63e-07 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.16 4.12e-07 GO:0031323 regulation of cellular metabolic process
1.58 4.59e-07 GO:0060284 regulation of cell development
1.58 6.31e-07 GO:0022603 regulation of anatomical structure morphogenesis
1.39 6.56e-07 GO:0051254 positive regulation of RNA metabolic process
1.40 1.00e-06 GO:0045893 positive regulation of transcription, DNA-dependent
1.34 1.06e-06 GO:0008219 cell death
1.55 1.12e-06 GO:0007411 axon guidance
1.34 1.17e-06 GO:0031328 positive regulation of cellular biosynthetic process
1.15 1.34e-06 GO:0080090 regulation of primary metabolic process
1.33 1.51e-06 GO:0050793 regulation of developmental process
1.34 1.54e-06 GO:0051128 regulation of cellular component organization
1.16 1.85e-06 GO:0060255 regulation of macromolecule metabolic process
1.14 2.06e-06 GO:0019222 regulation of metabolic process
1.33 2.12e-06 GO:0016265 death
1.36 2.15e-06 GO:2000026 regulation of multicellular organismal development
1.38 2.19e-06 GO:0010628 positive regulation of gene expression
1.43 3.28e-06 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.35 3.89e-06 GO:0010557 positive regulation of macromolecule biosynthetic process
1.37 4.23e-06 GO:0009790 embryo development
1.33 4.31e-06 GO:0009891 positive regulation of biosynthetic process
1.44 1.10e-05 GO:0048646 anatomical structure formation involved in morphogenesis
1.30 1.15e-05 GO:0032879 regulation of localization
1.26 1.17e-05 GO:0051239 regulation of multicellular organismal process
1.51 2.01e-05 GO:0071495 cellular response to endogenous stimulus
1.31 3.01e-05 GO:0040011 locomotion
1.54 3.41e-05 GO:0001944 vasculature development
1.40 3.62e-05 GO:0007417 central nervous system development
1.28 3.94e-05 GO:0009605 response to external stimulus
1.30 4.55e-05 GO:0006351 transcription, DNA-dependent
1.53 9.87e-05 GO:0035295 tube development
1.54 1.04e-04 GO:0001568 blood vessel development
2.03 1.48e-04 GO:2000027 regulation of organ morphogenesis
1.33 1.56e-04 GO:0045595 regulation of cell differentiation
1.27 2.00e-04 GO:0032774 RNA biosynthetic process
1.17 2.66e-04 GO:0042221 response to chemical stimulus
1.49 2.80e-04 GO:0032870 cellular response to hormone stimulus
1.32 2.81e-04 GO:0006915 apoptosis
1.35 3.33e-04 GO:0010629 negative regulation of gene expression
1.60 3.35e-04 GO:0045664 regulation of neuron differentiation
1.49 3.41e-04 GO:0051130 positive regulation of cellular component organization
1.37 3.61e-04 GO:0006935 chemotaxis
1.37 3.61e-04 GO:0042330 taxis
1.31 3.67e-04 GO:0012501 programmed cell death
1.55 3.84e-04 GO:0051129 negative regulation of cellular component organization
1.09 4.15e-04 GO:0044238 primary metabolic process
1.19 4.22e-04 GO:0006464 protein modification process
1.53 6.56e-04 GO:0050767 regulation of neurogenesis
1.10 6.62e-04 GO:0032501 multicellular organismal process
1.39 6.80e-04 GO:0051094 positive regulation of developmental process
1.15 7.06e-04 GO:0031326 regulation of cellular biosynthetic process
1.43 7.08e-04 GO:0009792 embryo development ending in birth or egg hatching
1.27 7.26e-04 GO:0010605 negative regulation of macromolecule metabolic process
1.45 7.68e-04 GO:0043434 response to peptide hormone stimulus
1.26 9.03e-04 GO:0009892 negative regulation of metabolic process
1.15 9.66e-04 GO:0051171 regulation of nitrogen compound metabolic process
1.30 9.74e-04 GO:0051049 regulation of transport
1.25 9.76e-04 GO:0032268 regulation of cellular protein metabolic process
1.95 9.89e-04 GO:0022612 gland morphogenesis
1.33 9.95e-04 GO:0009887 organ morphogenesis
1.24 1.07e-03 GO:0051246 regulation of protein metabolic process
1.55 1.15e-03 GO:0048514 blood vessel morphogenesis
1.43 1.18e-03 GO:0007420 brain development
1.76 1.34e-03 GO:0035023 regulation of Rho protein signal transduction
1.14 1.41e-03 GO:0019538 protein metabolic process
1.40 1.44e-03 GO:0009968 negative regulation of signal transduction
1.37 1.51e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.41 1.70e-03 GO:0043009 chordate embryonic development
1.15 1.76e-03 GO:0044267 cellular protein metabolic process
1.16 1.77e-03 GO:0065008 regulation of biological quality
1.34 1.78e-03 GO:0051253 negative regulation of RNA metabolic process
1.14 1.86e-03 GO:0009889 regulation of biosynthetic process
1.34 2.12e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.38 2.16e-03 GO:0023057 negative regulation of signaling
1.14 2.38e-03 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.15 2.64e-03 GO:0010468 regulation of gene expression
1.35 2.73e-03 GO:0048585 negative regulation of response to stimulus
1.32 2.83e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.47 3.01e-03 GO:0051960 regulation of nervous system development
1.24 3.15e-03 GO:0010941 regulation of cell death
1.26 3.27e-03 GO:0009888 tissue development
1.21 3.42e-03 GO:0010033 response to organic substance
1.31 3.57e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
1.28 4.14e-03 GO:0007267 cell-cell signaling
1.36 4.42e-03 GO:0010648 negative regulation of cell communication
1.30 4.66e-03 GO:0071310 cellular response to organic substance
1.76 5.82e-03 GO:0030323 respiratory tube development
1.27 6.03e-03 GO:0031399 regulation of protein modification process
1.36 6.65e-03 GO:0032583 regulation of gene-specific transcription
1.19 6.74e-03 GO:0065009 regulation of molecular function
1.16 6.87e-03 GO:0043412 macromolecule modification
1.62 7.55e-03 GO:0001655 urogenital system development
1.70 8.05e-03 GO:0060541 respiratory system development
1.23 8.27e-03 GO:0043067 regulation of programmed cell death
1.28 8.36e-03 GO:0019220 regulation of phosphate metabolic process
1.28 8.36e-03 GO:0051174 regulation of phosphorus metabolic process
1.14 8.86e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.49 1.18e-02 GO:0032868 response to insulin stimulus
1.75 1.20e-02 GO:0030278 regulation of ossification
1.75 1.20e-02 GO:0030324 lung development
1.24 1.22e-02 GO:0031324 negative regulation of cellular metabolic process
2.40 1.37e-02 GO:0060688 regulation of morphogenesis of a branching structure
1.17 1.37e-02 GO:0007166 cell surface receptor linked signaling pathway
1.08 1.37e-02 GO:0044237 cellular metabolic process
1.41 1.48e-02 GO:0001501 skeletal system development
1.29 1.58e-02 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.23 1.64e-02 GO:0042127 regulation of cell proliferation
1.22 1.75e-02 GO:0042981 regulation of apoptosis
1.16 1.82e-02 GO:0010467 gene expression
1.35 1.97e-02 GO:0060341 regulation of cellular localization
1.37 2.06e-02 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.46 2.39e-02 GO:0007507 heart development
1.27 2.41e-02 GO:0042325 regulation of phosphorylation
1.22 2.51e-02 GO:0007154 cell communication
1.19 2.64e-02 GO:0035556 intracellular signal transduction
1.37 2.64e-02 GO:0048598 embryonic morphogenesis
1.47 3.10e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.47 3.10e-02 GO:0071375 cellular response to peptide hormone stimulus
1.67 3.22e-02 GO:0048736 appendage development
1.67 3.22e-02 GO:0060173 limb development
1.88 3.49e-02 GO:0030518 steroid hormone receptor signaling pathway
2.27 3.58e-02 GO:0050673 epithelial cell proliferation
1.13 3.65e-02 GO:0010556 regulation of macromolecule biosynthetic process
1.27 3.91e-02 GO:0010558 negative regulation of macromolecule biosynthetic process
1.38 3.99e-02 GO:0007389 pattern specification process
1.61 4.38e-02 GO:0022604 regulation of cell morphogenesis
1.68 4.40e-02 GO:0035107 appendage morphogenesis
1.68 4.40e-02 GO:0035108 limb morphogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.06 5.01e-09 GO:0044424 intracellular part
1.06 5.95e-09 GO:0005622 intracellular
1.08 5.88e-08 GO:0005737 cytoplasm
1.49 1.64e-07 GO:0043005 neuron projection
1.48 3.53e-07 GO:0045202 synapse
1.32 4.55e-07 GO:0042995 cell projection
1.38 8.36e-07 GO:0030054 cell junction
1.42 1.01e-04 GO:0031012 extracellular matrix
1.59 1.96e-04 GO:0030424 axon
1.09 2.56e-04 GO:0005634 nucleus
1.06 3.16e-04 GO:0043226 organelle
1.56 3.59e-04 GO:0030425 dendrite
1.15 5.58e-04 GO:0044459 plasma membrane part
1.05 7.32e-04 GO:0043229 intracellular organelle
1.60 1.29e-03 GO:0045211 postsynaptic membrane
1.12 1.85e-03 GO:0043234 protein complex
1.53 3.08e-03 GO:0043025 neuronal cell body
1.17 5.64e-03 GO:0005856 cytoskeleton
1.05 5.86e-03 GO:0043227 membrane-bounded organelle
1.51 6.08e-03 GO:0044297 cell body
1.05 6.97e-03 GO:0043231 intracellular membrane-bounded organelle
1.18 8.85e-03 GO:0005654 nucleoplasm
1.14 9.68e-03 GO:0005829 cytosol
1.38 1.11e-02 GO:0044456 synapse part
1.36 1.55e-02 GO:0005578 proteinaceous extracellular matrix
1.70 3.46e-02 GO:0014069 postsynaptic density
1.50 3.48e-02 GO:0005912 adherens junction
1.14 4.18e-02 GO:0031981 nuclear lumen

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.15 3.15e-24 GO:0005515 protein binding
1.07 8.18e-17 GO:0005488 binding
1.31 1.63e-07 GO:0030528 transcription regulator activity
1.36 1.60e-06 GO:0043565 sequence-specific DNA binding
1.28 4.35e-06 GO:0001071 nucleic acid binding transcription factor activity
1.28 4.35e-06 GO:0003700 sequence-specific DNA binding transcription factor activity
1.47 4.48e-05 GO:0016563 transcription activator activity
1.41 2.19e-04 GO:0000988 protein binding transcription factor activity
1.41 2.19e-04 GO:0000989 transcription factor binding transcription factor activity
1.41 3.13e-04 GO:0003712 transcription cofactor activity
1.27 1.30e-03 GO:0019899 enzyme binding
1.84 4.74e-03 GO:0005089 Rho guanyl-nucleotide exchange factor activity
1.32 1.08e-02 GO:0019904 protein domain specific binding
2.77 2.07e-02 GO:0051721 protein phosphatase 2A binding
1.37 3.10e-02 GO:0008134 transcription factor binding
1.27 3.27e-02 GO:0008092 cytoskeletal protein binding