Motif ID: GTF2I.p2

Z-value: 2.639


Transcription factors associated with GTF2I.p2:

Gene SymbolEntrez IDGene Name
GTF2I 2969 general transcription factor II, i

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GTF2Ichr7_+_73709991-0.087.7e-01Click!


Activity profile for motif GTF2I.p2.

activity profile for motif GTF2I.p2


Sorted Z-values histogram for motif GTF2I.p2

Sorted Z-values for motif GTF2I.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2I.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_68470585 5.887 NM_001002292
NM_001193334
NM_024911
 WLS


wntless homolog (Drosophila)


chr11_+_12355600 4.225 NM_018222
 PARVA
parvin, alpha
chr11_-_27697768 4.167 NM_001143807
 BDNF
brain-derived neurotrophic factor
chr1_-_20685314 4.107 NM_018584
 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr3_+_77171938 3.749 NM_002942
 ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr1_+_202308814 3.673 NM_005686
 SOX13
SRY (sex determining region Y)-box 13
chr2_+_100802923 3.524 NM_002518
 NPAS2
neuronal PAS domain protein 2
chr1_+_156229934 3.505 KIRREL
kin of IRRE like (Drosophila)
chr22_-_34566210 3.501 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr9_+_108665168 3.481 NM_021224
 ZNF462
zinc finger protein 462
chr12_-_113606322 3.355 NM_005996
NM_016569
 TBX3

T-box 3

chr22_-_35914200 3.301 NM_031910
NM_182486
 C1QTNF6

C1q and tumor necrosis factor related protein 6

chr19_-_36531958 3.230 NM_020856
 TSHZ3
teashirt zinc finger homeobox 3
chr14_+_85069217 3.220


chr20_+_13924263 3.211 MACROD2
MACRO domain containing 2
chr19_-_59676153 3.191 NM_145057
 CDC42EP5
CDC42 effector protein (Rho GTPase binding) 5
chr2_-_19421852 3.179 NM_145260
 OSR1
odd-skipped related 1 (Drosophila)
chr19_-_60573552 3.165 NM_000641
 IL11
interleukin 11
chr9_+_35528890 3.156 RUSC2
RUN and SH3 domain containing 2
chr22_-_34566276 3.079 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 183 entries
enrichment   p-value GO term description
2.40 1.37e-02 GO:0060688 regulation of morphogenesis of a branching structure
2.27 3.58e-02 GO:0050673 epithelial cell proliferation
2.03 1.48e-04 GO:2000027 regulation of organ morphogenesis
1.95 9.89e-04 GO:0022612 gland morphogenesis
1.88 3.49e-02 GO:0030518 steroid hormone receptor signaling pathway
1.76 1.34e-03 GO:0035023 regulation of Rho protein signal transduction
1.76 5.82e-03 GO:0030323 respiratory tube development
1.75 1.20e-02 GO:0030278 regulation of ossification
1.75 1.20e-02 GO:0030324 lung development
1.70 8.05e-03 GO:0060541 respiratory system development
1.68 4.40e-02 GO:0035107 appendage morphogenesis
1.68 4.40e-02 GO:0035108 limb morphogenesis
1.67 3.22e-02 GO:0048736 appendage development
1.67 3.22e-02 GO:0060173 limb development
1.62 7.55e-03 GO:0001655 urogenital system development
1.61 4.38e-02 GO:0022604 regulation of cell morphogenesis
1.60 3.35e-04 GO:0045664 regulation of neuron differentiation
1.58 4.59e-07 GO:0060284 regulation of cell development
1.58 6.31e-07 GO:0022603 regulation of anatomical structure morphogenesis
1.57 1.12e-11 GO:0031175 neuron projection development

Gene overrepresentation in compartment category:

Showing 1 to 20 of 28 entries
enrichment   p-value GO term description
1.70 3.46e-02 GO:0014069 postsynaptic density
1.60 1.29e-03 GO:0045211 postsynaptic membrane
1.59 1.96e-04 GO:0030424 axon
1.56 3.59e-04 GO:0030425 dendrite
1.53 3.08e-03 GO:0043025 neuronal cell body
1.51 6.08e-03 GO:0044297 cell body
1.50 3.48e-02 GO:0005912 adherens junction
1.49 1.64e-07 GO:0043005 neuron projection
1.48 3.53e-07 GO:0045202 synapse
1.42 1.01e-04 GO:0031012 extracellular matrix
1.38 8.36e-07 GO:0030054 cell junction
1.38 1.11e-02 GO:0044456 synapse part
1.36 1.55e-02 GO:0005578 proteinaceous extracellular matrix
1.32 4.55e-07 GO:0042995 cell projection
1.18 8.85e-03 GO:0005654 nucleoplasm
1.17 5.64e-03 GO:0005856 cytoskeleton
1.15 5.58e-04 GO:0044459 plasma membrane part
1.14 9.68e-03 GO:0005829 cytosol
1.14 4.18e-02 GO:0031981 nuclear lumen
1.12 1.85e-03 GO:0043234 protein complex

Gene overrepresentation in function category:

Showing 1 to 16 of 16 entries
enrichment   p-value GO term description
2.77 2.07e-02 GO:0051721 protein phosphatase 2A binding
1.84 4.74e-03 GO:0005089 Rho guanyl-nucleotide exchange factor activity
1.47 4.48e-05 GO:0016563 transcription activator activity
1.41 2.19e-04 GO:0000988 protein binding transcription factor activity
1.41 2.19e-04 GO:0000989 transcription factor binding transcription factor activity
1.41 3.13e-04 GO:0003712 transcription cofactor activity
1.37 3.10e-02 GO:0008134 transcription factor binding
1.36 1.60e-06 GO:0043565 sequence-specific DNA binding
1.32 1.08e-02 GO:0019904 protein domain specific binding
1.31 1.63e-07 GO:0030528 transcription regulator activity
1.28 4.35e-06 GO:0001071 nucleic acid binding transcription factor activity
1.28 4.35e-06 GO:0003700 sequence-specific DNA binding transcription factor activity
1.27 1.30e-03 GO:0019899 enzyme binding
1.27 3.27e-02 GO:0008092 cytoskeletal protein binding
1.15 3.15e-24 GO:0005515 protein binding
1.07 8.18e-17 GO:0005488 binding