Motif ID: HES1.p2

Z-value: 0.934


Transcription factors associated with HES1.p2:

Gene SymbolEntrez IDGene Name
HES1 3280 hairy and enhancer of split 1, (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HES1chr3_+_1953366310.116.9e-01Click!


Activity profile for motif HES1.p2.

activity profile for motif HES1.p2


Sorted Z-values histogram for motif HES1.p2

Sorted Z-values for motif HES1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HES1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_225615556 2.021 NM_014689
DOCK10
dedicator of cytokinesis 10
chr2_+_149895274 1.321 NM_194317
LYPD6
LY6/PLAUR domain containing 6
chr14_+_73073570 1.278 NM_001037161
ACOT1
acyl-CoA thioesterase 1
chr6_+_72949092 1.252 RIMS1
regulating synaptic membrane exocytosis 1
chr1_+_199108705 1.040 NM_005298
GPR25
G protein-coupled receptor 25
chr17_-_10042579 1.036 NM_201433
GAS7
growth arrest-specific 7
chr1_-_9111674 1.031 NM_024980
GPR157
G protein-coupled receptor 157
chr8_+_69405510 0.996 NM_001195639
NM_052958
C8orf34

chromosome 8 open reading frame 34

chr18_+_18969724 0.845 NM_001100619
CABLES1
Cdk5 and Abl enzyme substrate 1
chr13_-_77390907 0.837 NM_001122659
NM_003991
EDNRB

endothelin receptor type B

chr17_-_76985538 0.819


chr3_-_189354510 0.809 LOC339929
hypothetical LOC339929
chr21_-_38954433 0.802 ERG
v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr9_+_123501186 0.767 DAB2IP
DAB2 interacting protein
chr19_-_61680510 0.767 NM_022103
ZNF667
zinc finger protein 667
chr14_+_73105618 0.750 ACOT2
acyl-CoA thioesterase 2
chr7_-_15692551 0.738 MEOX2
mesenchyme homeobox 2
chr14_-_87859284 0.736 NM_138317
KCNK10
potassium channel, subfamily K, member 10
chr3_-_185025989 0.730 NM_024871
MAP6D1
MAP6 domain containing 1
chr4_+_19864332 0.723 NM_004787
SLIT2
slit homolog 2 (Drosophila)
chr16_-_28542366 0.721 NM_177536
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr11_-_86061003 0.716 NM_006680
ME3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chrX_+_21302317 0.714 NM_001168647
NM_001168648
NM_001168649
NM_014927
CNKSR2



connector enhancer of kinase suppressor of Ras 2



chr12_+_120840829 0.713 NM_001178003
NM_144668
WDR66

WD repeat domain 66

chr11_-_86060812 0.710 NM_001014811
ME3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr20_-_49818306 0.685 NM_006045
ATP9A
ATPase, class II, type 9A
chr8_+_59069522 0.663 NM_147189
FAM110B
family with sequence similarity 110, member B
chr9_-_112381593 0.659 NM_153366
SVEP1
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
chr3_+_189354167 0.655 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr22_+_34107087 0.646 HMOX1
heme oxygenase (decycling) 1
chr6_-_80713589 0.642 NM_022726
ELOVL4
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
chr22_+_34107051 0.629 NM_002133
HMOX1
heme oxygenase (decycling) 1
chr7_-_100068612 0.627 TFR2
transferrin receptor 2
chr15_+_38485310 0.621 IVD
isovaleryl-CoA dehydrogenase
chr7_-_45927263 0.612 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr11_+_65357972 0.612 NM_152760
SNX32
sorting nexin 32
chr12_-_105057940 0.612 NM_014840
NUAK1
NUAK family, SNF1-like kinase, 1
chr20_-_49818268 0.608 ATP9A
ATPase, class II, type 9A
chr7_+_129918408 0.599 NM_177525
MEST
mesoderm specific transcript homolog (mouse)
chr2_-_96174865 0.599 NM_004418
DUSP2
dual specificity phosphatase 2
chr13_-_43259032 0.596 NM_017993
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr4_+_91267706 0.594 NM_001145065
FAM190A
family with sequence similarity 190, member A
chr17_-_40695216 0.575 NM_152343
C17orf46
chromosome 17 open reading frame 46
chr11_+_131285747 0.573 NM_001144058
NM_001144059
NM_016522
NTM


neurotrimin


chr5_+_63497408 0.569 NM_001113561
NM_178532
RNF180

ring finger protein 180

chr2_-_96174502 0.563 DUSP2
dual specificity phosphatase 2
chr17_+_45940911 0.556 MYCBPAP
MYCBP associated protein
chr8_+_26427378 0.546 NM_001197293
DPYSL2
dihydropyrimidinase-like 2
chr11_+_124438407 0.544 SLC37A2
solute carrier family 37 (glycerol-3-phosphate transporter), member 2
chr7_-_27136876 0.542 NM_002141
HOXA4
homeobox A4
chr17_-_7968121 0.532 NM_001165967
NM_032580
HES7

hairy and enhancer of split 7 (Drosophila)

chr18_-_490583 0.529 NM_130386
COLEC12
collectin sub-family member 12
chr20_-_4752067 0.525 NM_014737
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr4_-_83938920 0.524 NM_001037582
NM_024906
SCD5

stearoyl-CoA desaturase 5

chr4_+_109072120 0.520 NM_183075
CYP2U1
cytochrome P450, family 2, subfamily U, polypeptide 1
chr15_+_78858763 0.514 NM_018689
KIAA1199
KIAA1199
chr1_-_58815753 0.513 NM_002353
TACSTD2
tumor-associated calcium signal transducer 2
chr17_+_45940743 0.508 NM_032133
MYCBPAP
MYCBP associated protein
chr1_-_233879617 0.507 NM_001098722
GNG4
guanine nucleotide binding protein (G protein), gamma 4
chr20_+_41978195 0.493 NM_001098796
NM_032883
TOX2

TOX high mobility group box family member 2

chr9_-_21549696 0.491 LOC554202
hypothetical LOC554202
chr13_+_42046182 0.490 NM_003701
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chr11_-_110087982 0.487 ARHGAP20
Rho GTPase activating protein 20
chr12_-_98902562 0.484 NM_152788
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr20_+_6696744 0.483 NM_001200
BMP2
bone morphogenetic protein 2
chr10_-_88720908 0.482 LOC100133190
hypothetical LOC100133190
chr14_-_88953059 0.481 NM_005197
FOXN3
forkhead box N3
chr16_-_84342129 0.480 NM_206967
C16orf74
chromosome 16 open reading frame 74
chr8_-_93184629 0.478 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr22_-_42539399 0.478 NM_022785
NM_198856
EFCAB6

EF-hand calcium binding domain 6

chr11_-_133332089 0.476 NM_014987
IGSF9B
immunoglobulin superfamily, member 9B
chr7_+_44110527 0.475 AEBP1
AE binding protein 1
chr2_+_29191711 0.474 NM_024692
CLIP4
CAP-GLY domain containing linker protein family, member 4
chr12_-_105165805 0.470 NM_006825
CKAP4
cytoskeleton-associated protein 4
chr7_+_116099648 0.470 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr3_-_159932965 0.468 NM_002888
NM_206963
RARRES1

retinoic acid receptor responder (tazarotene induced) 1

chr14_-_73106243 0.464


chr16_+_65754788 0.461 NM_001040667
NM_001538
HSF4

heat shock transcription factor 4

chr1_+_156229934 0.459 KIRREL
kin of IRRE like (Drosophila)
chr10_+_105334704 0.459 NEURL
neuralized homolog (Drosophila)
chr3_-_127558747 0.458 NM_014079
KLF15
Kruppel-like factor 15
chr3_-_159932899 0.457 RARRES1
retinoic acid receptor responder (tazarotene induced) 1
chr15_+_38485292 0.455 IVD
isovaleryl-CoA dehydrogenase
chr22_-_27405708 0.454 NM_001145418
TTC28
tetratricopeptide repeat domain 28
chr2_+_177210683 0.453


chr8_-_29262240 0.453 NM_057158
DUSP4
dual specificity phosphatase 4
chr9_-_83493415 0.452 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr6_-_42218692 0.451 NM_001164446
C6orf132
chromosome 6 open reading frame 132
chr8_-_125809559 0.451 MTSS1
metastasis suppressor 1
chr15_+_38485269 0.450 IVD
isovaleryl-CoA dehydrogenase
chr2_-_45090025 0.449 NM_016932
SIX2
SIX homeobox 2
chr17_+_26322168 0.446 RNF135
ring finger protein 135
chr14_+_95575319 0.445 C14orf132
chromosome 14 open reading frame 132
chr16_+_15397120 0.445 MPV17L
MPV17 mitochondrial membrane protein-like
chr10_-_71575953 0.443 TYSND1
trypsin domain containing 1
chr20_+_56701224 0.441 NM_024663
NPEPL1
aminopeptidase-like 1
chr17_+_26322081 0.441 NM_001184992
NM_032322
NM_197939
RNF135


ring finger protein 135


chr2_-_222145240 0.440 NM_004438
EPHA4
EPH receptor A4
chr3_-_181237210 0.440 NM_016559
PEX5L
peroxisomal biogenesis factor 5-like
chr17_-_45562112 0.439 NM_174920
SAMD14
sterile alpha motif domain containing 14
chr8_+_104582151 0.437 NM_001100117
RIMS2
regulating synaptic membrane exocytosis 2
chr1_+_92268072 0.436 NM_173567
EPHX4
epoxide hydrolase 4
chr3_-_129023850 0.435 NM_007283
MGLL
monoglyceride lipase
chr1_-_45444812 0.434 NM_020883
ZSWIM5
zinc finger, SWIM-type containing 5
chr13_+_20175481 0.431 NM_138284
IL17D
interleukin 17D
chr18_-_75894902 0.431


chr11_+_19691397 0.426 NM_145117
NM_182964
NAV2

neuron navigator 2

chr4_+_2789686 0.425 NM_001145856
SH3BP2
SH3-domain binding protein 2
chr2_-_177210904 0.424 LOC375295
hypothetical LOC375295
chr5_+_175725050 0.424 NM_173664
ARL10
ADP-ribosylation factor-like 10
chr11_+_124438217 0.419 NM_001145290
NM_198277
SLC37A2

solute carrier family 37 (glycerol-3-phosphate transporter), member 2

chr17_-_959007 0.418 NM_001092
ABR
active BCR-related gene
chr18_-_72336133 0.417 NM_014643
ZNF516
zinc finger protein 516
chr6_+_19945578 0.415 NM_001546
ID4
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
chr2_-_127580975 0.415 NM_004305
NM_139343
NM_139344
NM_139345
NM_139346
NM_139347
NM_139348
NM_139349
NM_139350
NM_139351
BIN1









bridging integrator 1









chr11_-_110088097 0.415 ARHGAP20
Rho GTPase activating protein 20
chr19_-_19599973 0.411 NM_004720
LPAR2
lysophosphatidic acid receptor 2
chr16_-_85099941 0.411 LOC400550
hypothetical LOC400550
chr6_-_112682038 0.407 LAMA4
laminin, alpha 4
chr7_-_47588160 0.405 TNS3
tensin 3
chr16_+_15397087 0.404 NM_001128423
NM_173803
MPV17L

MPV17 mitochondrial membrane protein-like

chr7_+_129919134 0.404 MEST
mesoderm specific transcript homolog (mouse)
chr14_+_75114692 0.404 NM_017791
FLVCR2
feline leukemia virus subgroup C cellular receptor family, member 2
chr6_-_150431864 0.402 NM_024518
ULBP3
UL16 binding protein 3
chr8_+_120955080 0.401 NM_022783
DEPTOR
DEP domain containing MTOR-interacting protein
chr11_-_60819110 0.401 VWCE
von Willebrand factor C and EGF domains
chr1_+_234372454 0.400 NM_003272
GPR137B
G protein-coupled receptor 137B
chr18_+_54682261 0.397 ZNF532
zinc finger protein 532
chr13_+_30378311 0.393 NM_032849
C13orf33
chromosome 13 open reading frame 33
chr17_-_829655 0.393 NM_022463
NXN
nucleoredoxin
chr8_-_26427304 0.393 NM_007257
PNMA2
paraneoplastic antigen MA2
chr3_+_106568334 0.392 NM_001627
ALCAM
activated leukocyte cell adhesion molecule
chr2_-_175255717 0.391 NM_001077269
WIPF1
WAS/WASL interacting protein family, member 1
chr12_-_15833383 0.390 EPS8
epidermal growth factor receptor pathway substrate 8
chr7_-_47588266 0.389 TNS3
tensin 3
chr12_+_15366712 0.387 NM_002848
NM_030667
PTPRO

protein tyrosine phosphatase, receptor type, O

chr2_-_135193011 0.384 NM_030923
TMEM163
transmembrane protein 163
chr13_-_27967215 0.384 NM_001159920
NM_001160030
NM_001160031
NM_002019
FLT1



fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)



chr17_-_25112393 0.382 SSH2
slingshot homolog 2 (Drosophila)
chr6_-_72187168 0.379 C6orf155
chromosome 6 open reading frame 155
chr3_-_129024665 0.378 NM_001003794
MGLL
monoglyceride lipase
chr13_-_100866839 0.377 NALCN
sodium leak channel, non-selective
chr17_-_53920699 0.375 NM_001080439
HSF5
heat shock transcription factor family member 5
chrX_+_105856531 0.375 NM_194463
RNF128
ring finger protein 128
chr12_-_37585602 0.372 NM_153634
CPNE8
copine VIII
chr6_-_137407504 0.371 IL20RA
interleukin 20 receptor, alpha
chr3_-_49370755 0.370 NM_000581
NM_201397
GPX1

glutathione peroxidase 1

chr1_-_223907283 0.369 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr5_+_118719591 0.368 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr18_-_42590989 0.368 NM_013305
ST8SIA5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr12_-_15833617 0.367 NM_004447
EPS8
epidermal growth factor receptor pathway substrate 8
chr3_+_9826643 0.364 NM_001025930
TTLL3
tubulin tyrosine ligase-like family, member 3
chr2_-_73350103 0.363 NM_001080410
FBXO41
F-box protein 41
chr1_+_2975590 0.362 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr7_+_129919157 0.360 NM_002402
MEST
mesoderm specific transcript homolog (mouse)
chr11_-_122571046 0.357 CLMP
CXADR-like membrane protein
chr11_-_62233600 0.356 NM_001130702
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr12_+_121825021 0.356 NM_032573
NM_201435
CCDC62

coiled-coil domain containing 62

chr9_+_17124974 0.356 NM_001114395
NM_017738
CNTLN

centlein, centrosomal protein

chr7_-_15692798 0.356 NM_005924
MEOX2
mesenchyme homeobox 2
chr18_-_53621277 0.355 NM_005603
ATP8B1
ATPase, aminophospholipid transporter, class I, type 8B, member 1
chr3_+_44571600 0.354 NM_018651
NM_025169
ZNF167

zinc finger protein 167

chr4_+_2790338 0.351 NM_003023
SH3BP2
SH3-domain binding protein 2
chrX_-_140098959 0.350 NM_012317
LDOC1
leucine zipper, down-regulated in cancer 1
chr2_+_207016525 0.349 NM_003812
ADAM23
ADAM metallopeptidase domain 23
chr11_-_86061301 0.349 NM_001161586
ME3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr3_+_112273464 0.348 NM_015480
PVRL3
poliovirus receptor-related 3
chr11_-_122571198 0.348 NM_024769
CLMP
CXADR-like membrane protein
chr5_+_80292213 0.347 RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr16_-_265868 0.347 NM_003834
NM_183337
RGS11

regulator of G-protein signaling 11

chr6_+_89912464 0.346 NM_001010853
PM20D2
peptidase M20 domain containing 2
chr3_+_54131731 0.346 NM_018398
CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr18_+_54681657 0.345 ZNF532
zinc finger protein 532
chr11_-_62233552 0.344 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr11_+_104986620 0.338 NM_001112812
GRIA4
glutamate receptor, ionotrophic, AMPA 4
chr4_-_171247757 0.338 NM_016228
AADAT
aminoadipate aminotransferase
chr15_+_82113813 0.338 NM_207517
ADAMTSL3
ADAMTS-like 3
chr15_-_43457916 0.338 GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr11_-_88864061 0.337 NM_001143836
NM_016931
NOX4

NADPH oxidase 4

chr6_+_86216457 0.337 NT5E
5'-nucleotidase, ecto (CD73)
chr9_-_112840064 0.337 NM_001401
NM_057159
LPAR1

lysophosphatidic acid receptor 1

chr5_+_118719448 0.336 NM_014350
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr7_-_139987044 0.336 DENND2A
DENN/MADD domain containing 2A
chr8_+_28407613 0.335 NM_017412
FZD3
frizzled homolog 3 (Drosophila)
chr11_+_43920385 0.331 NM_001145033
C11orf96
chromosome 11 open reading frame 96
chr1_+_226937732 0.330 RHOU
ras homolog gene family, member U
chr18_+_2836979 0.329 NM_032048
EMILIN2
elastin microfibril interfacer 2
chr10_+_129595289 0.329 NM_006504
PTPRE
protein tyrosine phosphatase, receptor type, E
chr5_-_57791544 0.328 NM_006622
PLK2
polo-like kinase 2
chr13_-_76358433 0.328 NM_138444
KCTD12
potassium channel tetramerisation domain containing 12
chr2_+_9532087 0.328 NM_001039613
IAH1
isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae)
chrX_-_13866565 0.327 NM_001001994
GPM6B
glycoprotein M6B
chr3_+_54131613 0.326 CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr5_+_74197473 0.322 LOC441086
hypothetical LOC441086
chr5_+_110587546 0.322 NM_001744
CAMK4
calcium/calmodulin-dependent protein kinase IV
chr2_-_175060001 0.322 NM_001033045
NM_152529
GPR155

G protein-coupled receptor 155

chr4_+_79197747 0.321 NM_001166133
NM_025074
FRAS1

Fraser syndrome 1

chr7_-_27149750 0.320 NM_019102
HOXA5
homeobox A5
chr4_+_169789327 0.318 NM_001166109
PALLD
palladin, cytoskeletal associated protein
chr9_+_71848555 0.316 MAMDC2
MAM domain containing 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.50 1.62e-09 GO:0009966 regulation of signal transduction
1.46 1.73e-09 GO:0023051 regulation of signaling
1.16 1.30e-07 GO:0050794 regulation of cellular process
1.67 6.74e-07 GO:0007167 enzyme linked receptor protein signaling pathway
1.42 7.29e-07 GO:0009653 anatomical structure morphogenesis
1.27 9.11e-07 GO:0048856 anatomical structure development
1.15 1.16e-06 GO:0050789 regulation of biological process
1.42 1.44e-06 GO:0007399 nervous system development
1.51 2.04e-06 GO:0006793 phosphorus metabolic process
1.51 2.04e-06 GO:0006796 phosphate metabolic process
1.24 2.14e-06 GO:0032502 developmental process
1.25 2.67e-06 GO:0007275 multicellular organismal development
1.77 3.21e-06 GO:0072358 cardiovascular system development
1.77 3.21e-06 GO:0072359 circulatory system development
1.60 3.33e-06 GO:0006468 protein phosphorylation
1.28 5.92e-06 GO:0048731 system development
1.13 2.21e-05 GO:0065007 biological regulation
1.50 3.42e-05 GO:0022008 neurogenesis
1.33 3.70e-05 GO:0048583 regulation of response to stimulus
1.51 4.90e-05 GO:0048699 generation of neurons
1.48 3.35e-04 GO:0016310 phosphorylation
1.31 4.27e-04 GO:0006464 protein modification process
1.92 6.31e-04 GO:0007507 heart development
1.61 6.54e-04 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.20 9.16e-04 GO:0023052 signaling
1.44 9.51e-04 GO:0048468 cell development
1.56 1.00e-03 GO:0009887 organ morphogenesis
1.49 1.18e-03 GO:2000026 regulation of multicellular organismal development
1.44 1.28e-03 GO:0050793 regulation of developmental process
1.29 1.50e-03 GO:0043412 macromolecule modification
1.27 1.56e-03 GO:0048869 cellular developmental process
1.60 1.57e-03 GO:0000904 cell morphogenesis involved in differentiation
1.76 1.80e-03 GO:0001501 skeletal system development
1.42 1.82e-03 GO:0042127 regulation of cell proliferation
1.28 1.92e-03 GO:0030154 cell differentiation
1.50 2.16e-03 GO:0030182 neuron differentiation
1.52 2.28e-03 GO:0030030 cell projection organization
1.54 2.54e-03 GO:0000902 cell morphogenesis
1.50 2.84e-03 GO:0045595 regulation of cell differentiation
1.29 3.02e-03 GO:0007166 cell surface receptor linked signaling pathway
1.20 3.52e-03 GO:0007165 signal transduction
1.50 5.33e-03 GO:0032989 cellular component morphogenesis
2.51 5.87e-03 GO:0030336 negative regulation of cell migration
2.51 5.87e-03 GO:2000146 negative regulation of cell motility
1.59 6.35e-03 GO:0048646 anatomical structure formation involved in morphogenesis
2.38 6.39e-03 GO:0040013 negative regulation of locomotion
1.75 6.52e-03 GO:0001944 vasculature development
1.25 6.53e-03 GO:0048523 negative regulation of cellular process
2.42 9.84e-03 GO:0051271 negative regulation of cellular component movement
1.69 1.31e-02 GO:0060284 regulation of cell development
1.07 1.52e-02 GO:0009987 cellular process
1.74 1.62e-02 GO:0035295 tube development
2.88 1.63e-02 GO:0003205 cardiac chamber development
1.54 1.74e-02 GO:0031175 neuron projection development
1.37 1.95e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.83 1.95e-02 GO:0048514 blood vessel morphogenesis
1.40 2.26e-02 GO:0009888 tissue development
2.55 2.37e-02 GO:0035282 segmentation
1.69 2.53e-02 GO:0048729 tissue morphogenesis
1.74 2.72e-02 GO:0030334 regulation of cell migration
1.61 2.84e-02 GO:0051056 regulation of small GTPase mediated signal transduction
1.46 2.98e-02 GO:0001932 regulation of protein phosphorylation
1.18 3.05e-02 GO:0016043 cellular component organization
1.71 3.29e-02 GO:0051960 regulation of nervous system development
1.72 3.49e-02 GO:0001568 blood vessel development
1.54 3.80e-02 GO:0045859 regulation of protein kinase activity
1.72 4.12e-02 GO:2000145 regulation of cell motility
1.48 4.22e-02 GO:0048666 neuron development
2.90 4.52e-02 GO:0003206 cardiac chamber morphogenesis
1.22 5.00e-02 GO:0048519 negative regulation of biological process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.08 1.72e-05 GO:0005622 intracellular
1.07 1.56e-04 GO:0044424 intracellular part
1.10 4.81e-04 GO:0005737 cytoplasm
2.04 8.91e-04 GO:0005912 adherens junction
2.18 2.79e-03 GO:0030055 cell-substrate junction
2.24 2.81e-03 GO:0005925 focal adhesion
1.93 2.95e-03 GO:0070161 anchoring junction
2.19 3.16e-03 GO:0005924 cell-substrate adherens junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.54 1.89e-05 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.53 2.91e-04 GO:0004672 protein kinase activity
1.47 2.98e-04 GO:0016301 kinase activity
1.57 1.57e-03 GO:0030695 GTPase regulator activity
1.55 3.10e-03 GO:0060589 nucleoside-triphosphatase regulator activity
1.39 3.50e-03 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.98 2.98e-02 GO:0005267 potassium channel activity
2.12 3.20e-02 GO:0005249 voltage-gated potassium channel activity
1.90 3.81e-02 GO:0022843 voltage-gated cation channel activity
2.22 4.25e-02 GO:0019199 transmembrane receptor protein kinase activity
1.05 4.35e-02 GO:0005488 binding
1.50 4.35e-02 GO:0004674 protein serine/threonine kinase activity
1.49 4.93e-02 GO:0019904 protein domain specific binding