Motif ID: HMGA1,2.p2

Z-value: 2.147


Transcription factors associated with HMGA1,2.p2:

Gene SymbolEntrez IDGene Name
HMGA1 3159 high mobility group AT-hook 1
HMGA2 8091 high mobility group AT-hook 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HMGA1chr6_+_34313347-0.457.9e-02Click!
HMGA2chr12_+_64504835-0.312.5e-01Click!


Activity profile for motif HMGA1,2.p2.

activity profile for motif HMGA1,2.p2


Sorted Z-values histogram for motif HMGA1,2.p2

Sorted Z-values for motif HMGA1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMGA1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_151922350 2.664 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr3_+_115099007 2.185 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr7_-_7724762 2.158 NM_002947
RPA3
replication protein A3, 14kDa
chr18_+_30544193 1.982 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr4_-_88669267 1.963 SPARCL1
SPARC-like 1 (hevin)
chrX_+_118598325 1.864 NM_181777
UBE2A
ubiquitin-conjugating enzyme E2A (RAD6 homolog)
chrX_-_138742050 1.675 NM_001010986
NM_173694
ATP11C

ATPase, class VI, type 11C

chr12_-_25692754 1.666 NM_001145727
IFLTD1
intermediate filament tail domain containing 1
chr1_+_84540921 1.616 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr13_-_48873735 1.607 NM_030925
CAB39L
calcium binding protein 39-like
chr12_-_66905802 1.583 NM_018402
IL26
interleukin 26
chr1_+_194887630 1.564 NM_000186
NM_001014975
CFH

complement factor H

chr2_+_161701711 1.553 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr2_-_175170674 1.507 WIPF1
WAS/WASL interacting protein family, member 1
chr9_+_129893948 1.439 NM_001006642
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr1_+_84539876 1.433 NM_001134663
SAMD13
sterile alpha motif domain containing 13
chr2_+_36777406 1.421 VIT
vitrin
chr1_+_78888064 1.403 NM_006417
IFI44
interferon-induced protein 44
chr2_-_242205556 1.396 NM_001164356
THAP4
THAP domain containing 4
chr8_-_93099040 1.384 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr7_+_116447499 1.384 ST7
suppression of tumorigenicity 7
chr7_+_90176647 1.357 NM_012395
CDK14
cyclin-dependent kinase 14
chr13_+_51933228 1.346 CKAP2
cytoskeleton associated protein 2
chr3_-_152529999 1.343 NM_176894
P2RY13
purinergic receptor P2Y, G-protein coupled, 13
chr7_+_116447527 1.333 ST7
suppression of tumorigenicity 7
chr7_+_838663 1.322 NM_001130965
SUN1
Sad1 and UNC84 domain containing 1
chr7_+_91762227 1.295


chr12_-_15706340 1.281 EPS8
epidermal growth factor receptor pathway substrate 8
chr2_-_158008763 1.278 NM_004288
CYTIP
cytohesin 1 interacting protein
chr15_-_70350609 1.260 NM_020214
PARP6
poly (ADP-ribose) polymerase family, member 6
chr5_+_35892747 1.249 NM_002185
IL7R
interleukin 7 receptor
chr4_-_87500398 1.246 NM_138980
NM_138982
MAPK10

mitogen-activated protein kinase 10

chr2_+_165860528 1.234 NM_001040143
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr1_+_185064654 1.223 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr3_-_114176401 1.223 NM_138806
NM_138939
NM_138940
NM_170780
CD200R1



CD200 receptor 1



chr8_+_107807415 1.196 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr5_+_36642424 1.177 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_-_157892391 1.172 NM_001009959
ERMN
ermin, ERM-like protein
chr7_-_92615593 1.170 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr2_-_227952249 1.164 NM_024795
TM4SF20
transmembrane 4 L six family member 20
chr9_+_74956601 1.134 ANXA1
annexin A1
chr3_-_152585226 1.132 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr11_-_71458739 1.115 NUMA1
nuclear mitotic apparatus protein 1
chr4_-_153523113 1.115 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr7_-_41709191 1.110 NM_002192
INHBA
inhibin, beta A
chr7_-_16471817 1.109 NM_015464
SOSTDC1
sclerostin domain containing 1
chr1_+_157246305 1.077 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr7_+_90177082 1.077 CDK14
cyclin-dependent kinase 14
chr9_+_124835608 1.075 RABGAP1
GPR21
RAB GTPase activating protein 1
G protein-coupled receptor 21
chr4_+_72321113 1.071 SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr1_+_78858675 1.062 NM_006820
IFI44L
interferon-induced protein 44-like
chr7_-_13992351 1.051 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr20_+_56904042 1.042 GNAS
GNAS complex locus
chr4_+_72423633 1.036 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr1_-_203320153 1.029 NM_203376
TMEM81
transmembrane protein 81
chr11_-_5130174 1.012 NM_012375
OR52A1
olfactory receptor, family 52, subfamily A, member 1
chr5_+_96237399 0.998 NM_001130140
NM_022350
ERAP2

endoplasmic reticulum aminopeptidase 2

chr22_-_34564611 0.997 RPL41P5
ribosomal protein L41 pseudogene 5
chr9_+_74956614 0.992 ANXA1
annexin A1
chr10_-_113933457 0.987 NM_020918
GPAM
glycerol-3-phosphate acyltransferase, mitochondrial
chr12_+_97513644 0.972 SLC25A3
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
chr2_-_77602843 0.960 NM_001134745
NM_024993
LRRTM4

leucine rich repeat transmembrane neuronal 4

chr1_+_242283129 0.958 NM_006352
ZNF238
zinc finger protein 238
chr5_-_77880731 0.954 LHFPL2
lipoma HMGIC fusion partner-like 2
chr2_+_36777336 0.947 NM_001177969
NM_001177970
NM_001177971
NM_001177972
NM_053276
VIT




vitrin




chr10_+_70517863 0.947 SRGN
serglycin
chr12_-_51887266 0.943 NM_000889
ITGB7
integrin, beta 7
chr4_+_160408447 0.940 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr5_+_36642213 0.937 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr11_-_127962662 0.926 NM_001143820
ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr1_-_177378801 0.915 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr1_+_200698493 0.914 NM_032103
NM_032104
PPP1R12B

protein phosphatase 1, regulatory (inhibitor) subunit 12B

chr10_-_11614279 0.914 NM_001080491
USP6NL
USP6 N-terminal like
chr1_-_150353179 0.905 NM_007113
TCHH
trichohyalin
chr12_-_51887318 0.895 ITGB7
integrin, beta 7
chr7_-_104696678 0.893 NM_182691
SRPK2
SRSF protein kinase 2
chr11_+_113671744 0.892 NM_006169
NNMT
nicotinamide N-methyltransferase
chr7_+_18515440 0.892 HDAC9
histone deacetylase 9
chr2_+_228064531 0.892 AGFG1
ArfGAP with FG repeats 1
chr3_-_46224791 0.890 NM_001295
CCR1
chemokine (C-C motif) receptor 1
chr8_+_24297742 0.887 NM_001145271
NM_001145272
NM_014479
ADAMDEC1


ADAM-like, decysin 1


chr8_-_120720200 0.884 NM_001040092
NM_001130863
NM_006209
ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr12_+_46799279 0.882 NM_000289
PFKM
phosphofructokinase, muscle
chr4_+_71806538 0.882 NM_001037442
NM_014961
RUFY3

RUN and FYVE domain containing 3

chr11_-_102156531 0.881 NM_002425
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr15_+_65217412 0.869 NM_001145103
SMAD3
SMAD family member 3
chr12_-_101396459 0.863 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr16_+_83349816 0.850 USP10
ubiquitin specific peptidase 10
chr4_-_88669625 0.845 NM_001128310
NM_004684
SPARCL1

SPARC-like 1 (hevin)

chrX_+_73080887 0.841 NCRNA00183
non-protein coding RNA 183
chr12_-_9913724 0.838 NM_005127
CLEC2B
C-type lectin domain family 2, member B
chr14_-_63076155 0.834 PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr22_-_41685827 0.834 NM_001184971
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr10_+_70517823 0.828 NM_002727
SRGN
serglycin
chr1_-_143708467 0.828 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr1_-_158948176 0.827 NM_001778
CD48
CD48 molecule
chr12_+_63090008 0.826 XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr3_+_143824955 0.821 NM_002670
PLS1
plastin 1
chr10_+_89257569 0.815 NM_001178118
MINPP1
multiple inositol-polyphosphate phosphatase 1
chr10_+_5976354 0.814 NM_032807
FBXO18
F-box protein, helicase, 18
chr11_-_85103438 0.814 NM_032379
SYTL2
synaptotagmin-like 2
chr8_-_19504285 0.813 NM_001130518
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr4_+_170817787 0.796 CLCN3
chloride channel 3
chr17_-_64568641 0.796 NM_080283
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr2_+_157822355 0.795 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr8_-_93181091 0.792 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr14_+_77939845 0.789 NM_004796
NRXN3
neurexin 3
chr2_-_65447267 0.788 SPRED2
sprouty-related, EVH1 domain containing 2
chr8_-_82557956 0.787 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr12_+_18305740 0.780 NM_004570
PIK3C2G
phosphoinositide-3-kinase, class 2, gamma polypeptide
chr1_+_146827470 0.756 NM_173638
NBPF15
neuroblastoma breakpoint family, member 15
chr4_-_152366970 0.756 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr11_-_71424614 0.753


chr1_+_151015471 0.753 NM_178354
LCE1F
late cornified envelope 1F
chr11_-_104421240 0.751 NM_001017534
NM_052889
CARD16

CASP1
caspase recruitment domain family, member 16

caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr18_-_27594696 0.748 NM_001034172
MCART2
mitochondrial carrier triple repeat 2
chr4_+_14950657 0.747 NM_001135170
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr14_-_72523404 0.746 NM_178441
ZFYVE1
zinc finger, FYVE domain containing 1
chr4_+_159350850 0.744 NM_018342
TMEM144
transmembrane protein 144
chr1_-_191422346 0.744 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr2_+_165858586 0.743 NM_021007
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr9_-_111253484 0.741 NM_001145369
NM_001145370
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr2_-_45648608 0.740 SRBD1
S1 RNA binding domain 1
chr9_-_36266930 0.736 NM_001128227
NM_001190388
GNE

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

chr20_-_33783409 0.732 RBM39
RNA binding motif protein 39
chr1_+_148511806 0.731 NM_024579
C1orf54
chromosome 1 open reading frame 54
chr14_-_19867372 0.728 NM_182852
NM_182851
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr3_-_120761092 0.728 NM_005191
CD80
CD80 molecule
chr5_+_36644187 0.720 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_-_191580567 0.717 STAT1
signal transducer and activator of transcription 1, 91kDa
chr7_-_107930170 0.710 PNPLA8
patatin-like phospholipase domain containing 8
chr13_-_37070862 0.704 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr2_-_65447370 0.703 NM_001128210
SPRED2
sprouty-related, EVH1 domain containing 2
chr2_-_55090759 0.696 NM_007008
RTN4
reticulon 4
chr9_+_74956494 0.684 NM_000700
ANXA1
annexin A1
chr1_-_158759606 0.683 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr3_-_56784634 0.680 NM_001128616
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr11_+_4859624 0.678 NM_001004759
OR51T1
olfactory receptor, family 51, subfamily T, member 1
chr11_+_67107852 0.678 GSTP1
glutathione S-transferase pi 1
chr15_-_97607108 0.678 NM_001040655
NM_001040656
NM_001040657
NM_001040658
NM_001040659
NM_001040660
NM_022905
TTC23






tetratricopeptide repeat domain 23






chr5_+_67558217 0.675 NM_181523
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr6_+_31081707 0.675 NM_001198815
PBMUCL1
panbronchiolitis related mucin-like 1
chr13_-_85271329 0.674 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr14_-_94677807 0.674 NM_030621
DICER1
dicer 1, ribonuclease type III
chr9_-_112139908 0.668 NM_001003936
TXNDC8
thioredoxin domain containing 8 (spermatozoa)
chr3_+_142587973 0.667


chr15_-_91078307 0.659 FAM174B
family with sequence similarity 174, member B
chr12_+_74071145 0.657 NM_152436
GLIPR1L2
GLI pathogenesis-related 1 like 2
chr1_+_208008517 0.656 TRAF3IP3
TRAF3 interacting protein 3
chr3_+_44665220 0.654 NM_003420
ZNF35
zinc finger protein 35
chr12_+_74071116 0.652 GLIPR1L2
GLI pathogenesis-related 1 like 2
chr6_+_134800533 0.651 LOC154092
hypothetical LOC154092
chrX_-_70243362 0.649 NM_001025265
CXorf65
chromosome X open reading frame 65
chr12_+_8167494 0.645 NM_016184
NM_194447
NM_194448
NM_194450
CLEC4A



C-type lectin domain family 4, member A



chrX_-_78509662 0.641 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr21_+_37496616 0.631 TTC3
tetratricopeptide repeat domain 3
chr14_+_59934178 0.630


chr5_+_140460240 0.628 NM_018937
PCDHB3
protocadherin beta 3
chr9_+_99807257 0.626


chr11_-_76676110 0.623 NM_182833
GDPD4
glycerophosphodiester phosphodiesterase domain containing 4
chr2_-_188021117 0.622 NM_005795
CALCRL
calcitonin receptor-like
chr3_-_152517204 0.619 NM_023915
GPR87
G protein-coupled receptor 87
chr22_+_25383392 0.619 MIAT
myocardial infarction associated transcript (non-protein coding)
chr1_+_195123766 0.617 NM_006684
CFHR4
complement factor H-related 4
chr5_+_38439399 0.612 NM_182798
NM_182799
EGFLAM

EGF-like, fibronectin type III and laminin G domains

chr22_-_39189369 0.608 MKL1
megakaryoblastic leukemia (translocation) 1
chr19_-_14750347 0.608 NM_013447
NM_152916
NM_152917
NM_152918
NM_152919
NM_152920
NM_152921
EMR2






egf-like module containing, mucin-like, hormone receptor-like 2






chr6_+_37511383 0.607


chr6_-_119137923 0.606 NM_001178035
C6orf204
chromosome 6 open reading frame 204
chr4_-_74307637 0.606 ANKRD17
ankyrin repeat domain 17
chr1_-_149004916 0.604 NM_004079
CTSS
cathepsin S
chr2_+_169637255 0.604 NM_001142270
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr4_+_187307320 0.603 NM_001006655
FAM149A
family with sequence similarity 149, member A
chr17_+_65582981 0.599 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr6_-_76259976 0.596 NM_015687
FILIP1
filamin A interacting protein 1
chr5_-_20024050 0.595 NM_001167667
NM_004934
CDH18

cadherin 18, type 2

chr4_+_75393053 0.595 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr3_+_138132006 0.592 NM_001190796
NCK1
NCK adaptor protein 1
chr8_-_38324809 0.589 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr1_+_46151845 0.589 MAST2
microtubule associated serine/threonine kinase 2
chr8_-_102005697 0.582 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr7_+_115650240 0.578 NM_152829
TES
testis derived transcript (3 LIM domains)
chr4_-_87500201 0.570 MAPK10
mitogen-activated protein kinase 10
chrX_-_135690770 0.569 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chrX_-_11194015 0.568 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr7_-_20223467 0.563 NM_182762
MACC1
metastasis associated in colon cancer 1
chr15_-_74091817 0.563 NM_138573
NRG4
neuregulin 4
chr1_-_23393808 0.559 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chr1_+_84402962 0.558 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr3_+_122769467 0.558 NM_001012659
ARGFX
arginine-fifty homeobox
chr6_-_139654807 0.557 NM_153235
TXLNB
taxilin beta
chr3_+_123779122 0.554 NM_001113523
PARP15
poly (ADP-ribose) polymerase family, member 15
chr11_+_110890719 0.551 NM_001100388
NM_207430
C11orf88

chromosome 11 open reading frame 88

chr1_+_239762179 0.549 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr1_+_171871283 0.545 NM_001195190
LOC730159
hypothetical protein LOC730159
chr5_-_88155360 0.545 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr4_-_53217513 0.542 NM_001134223
USP46
ubiquitin specific peptidase 46
chr3_-_145049853 0.541 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr8_-_95298706 0.540 NM_001144663
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr3_+_46386636 0.539 NM_000579
NM_001100168
CCR5

chemokine (C-C motif) receptor 5


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.72 2.09e-05 GO:0007606 sensory perception of chemical stimulus
1.70 2.20e-04 GO:0007608 sensory perception of smell
1.36 1.42e-03 GO:0002376 immune system process
1.44 1.18e-02 GO:0006955 immune response
1.40 2.74e-02 GO:0007600 sensory perception

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.75 1.99e-05 GO:0004984 olfactory receptor activity
1.39 5.86e-03 GO:0004930 G-protein coupled receptor activity
1.30 1.03e-02 GO:0004888 transmembrane receptor activity
1.25 1.36e-02 GO:0004872 receptor activity