Motif ID: HMX1.p2

Z-value: 1.935


Transcription factors associated with HMX1.p2:

Gene SymbolEntrez IDGene Name
HMX1 3166 H6 family homeobox 1



Activity profile for motif HMX1.p2.

activity profile for motif HMX1.p2


Sorted Z-values histogram for motif HMX1.p2

Sorted Z-values for motif HMX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_131286513 4.502 NTM
neurotrimin
chr19_+_58750305 3.472 NM_001079907
ZNF331
zinc finger protein 331
chr3_-_112796855 3.281 NM_024508
ZBED2
zinc finger, BED-type containing 2
chr12_-_47604930 2.922 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr11_+_69602055 2.753 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr21_-_31853160 2.428 NM_003253
TIAM1
T-cell lymphoma invasion and metastasis 1
chr4_-_11039600 2.320 NM_005114
HS3ST1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr19_-_11352850 2.223 EPOR
erythropoietin receptor
chr21_-_38954433 2.193 ERG
v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr13_+_24152548 2.165 NM_001185085
NM_001676
ATP12A

ATPase, H+/K+ transporting, nongastric, alpha polypeptide

chr13_+_42046182 2.128 NM_003701
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chr4_+_91267706 2.107 NM_001145065
FAM190A
family with sequence similarity 190, member A
chr18_-_44189625 2.085 ZBTB7C
zinc finger and BTB domain containing 7C
chr11_-_407324 2.083 NM_001135053
NM_021805
SIGIRR

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

chr1_-_58815415 2.047 TACSTD2
tumor-associated calcium signal transducer 2
chr19_+_58733144 1.965 NM_001079906
ZNF331
zinc finger protein 331
chr8_+_120497732 1.947 NM_002514
NOV
nephroblastoma overexpressed gene
chr17_-_40695216 1.817 NM_152343
C17orf46
chromosome 17 open reading frame 46
chr5_-_115938305 1.691 NM_020796
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr9_-_109290107 1.652 KLF4
Kruppel-like factor 4 (gut)
chr5_-_139992621 1.644 NM_000591
CD14
CD14 molecule
chr3_-_11736946 1.636 NM_014667
VGLL4
vestigial like 4 (Drosophila)
chr5_-_168660293 1.616 NM_003062
SLIT3
slit homolog 3 (Drosophila)
chr19_-_10558906 1.592 NM_005498
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr19_-_62912347 1.582 NM_001085384
ZNF154
zinc finger protein 154
chr1_-_86394695 1.577 NM_152890
COL24A1
collagen, type XXIV, alpha 1
chr1_+_154297588 1.571 NM_020387
RAB25
RAB25, member RAS oncogene family
chr19_+_43447262 1.547 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr15_+_82113813 1.536 NM_207517
ADAMTSL3
ADAMTS-like 3
chr19_-_63643400 1.525 NM_003433
ZNF132
zinc finger protein 132
chr8_+_102574012 1.513 GRHL2
grainyhead-like 2 (Drosophila)
chr7_-_143523582 1.507 NM_001003702
ARHGEF35
Rho guanine nucleotide exchange factor (GEF) 35
chr8_+_102573837 1.476 NM_024915
GRHL2
grainyhead-like 2 (Drosophila)
chr7_-_143622233 1.475 ARHGEF35
Rho guanine nucleotide exchange factor (GEF) 35
chr9_-_84867604 1.475 RASEF
RAS and EF-hand domain containing
chr17_-_7106497 1.466 CLDN7
claudin 7
chr7_+_143683365 1.438 NM_005435
ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr9_-_23811477 1.428 NM_001171197
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr17_-_45427565 1.426 NM_005220
DLX3
distal-less homeobox 3
chr18_+_12244317 1.425 NM_001279
CIDEA
cell death-inducing DFFA-like effector a
chr7_-_143622188 1.406 ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr20_-_21442663 1.388 NM_002509
NKX2-2
NK2 homeobox 2
chr8_-_75396016 1.383 NM_020647
JPH1
junctophilin 1
chr16_+_23101538 1.381 NM_001039
SCNN1G
sodium channel, nonvoltage-gated 1, gamma
chr19_+_43446937 1.372 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr8_+_24828359 1.347 NM_001105541
NEFM
neurofilament, medium polypeptide
chr5_-_9599157 1.346 NM_003966
SEMA5A
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr19_+_43447078 1.344 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr1_+_151917674 1.342 NM_000906
NPR1
natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
chr21_-_27261276 1.342 NM_007038
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr2_-_73350103 1.336 NM_001080410
FBXO41
F-box protein 41
chr16_-_85099941 1.327 LOC400550
hypothetical LOC400550
chr6_+_41714171 1.319 NM_005586
MDFI
MyoD family inhibitor
chr14_-_50631407 1.319 TRIM9
tripartite motif containing 9
chr17_-_8809656 1.306 NM_001142633
PIK3R5
phosphoinositide-3-kinase, regulatory subunit 5
chr1_-_55039458 1.296 NM_001114108
NM_017904
TTC22

tetratricopeptide repeat domain 22

chr2_+_109729176 1.285 NM_023016
ANKRD57
ankyrin repeat domain 57
chr7_+_838663 1.280 NM_001130965
SUN1
Sad1 and UNC84 domain containing 1
chr4_+_81325447 1.249 NM_020226
PRDM8
PR domain containing 8
chr14_+_62740878 1.247 NM_020663
RHOJ
ras homolog gene family, member J
chr5_+_176717553 1.246


chr8_-_24828134 1.244 NEFM
neurofilament, medium polypeptide
chr5_+_148186348 1.234 NM_000024
ADRB2
adrenergic, beta-2-, receptor, surface
chr3_+_54131613 1.227 CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr17_-_72045218 1.227 NM_134268
CYGB
cytoglobin
chr12_-_94708477 1.209 NTN4
netrin 4
chr5_+_68746694 1.200 NM_001038603
MARVELD2
MARVEL domain containing 2
chr1_+_35020425 1.199 NM_001005752
GJB3
gap junction protein, beta 3, 31kDa
chr1_+_45565126 1.196 NM_032756
HPDL
4-hydroxyphenylpyruvate dioxygenase-like
chr4_-_78038025 1.195 NM_001029870
ANKRD56
ankyrin repeat domain 56
chr8_+_31616809 1.187 NM_013962
NRG1
neuregulin 1
chr15_-_66511488 1.184 NM_001004439
ITGA11
integrin, alpha 11
chr8_+_32525269 1.170 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr15_-_80123935 1.168 MEX3B
mex-3 homolog B (C. elegans)
chr11_-_128399218 1.167 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr18_+_54682261 1.160 ZNF532
zinc finger protein 532
chr2_-_133144094 1.159 LYPD1
LY6/PLAUR domain containing 1
chr11_+_93394025 1.157 NM_001098672
HEPHL1
hephaestin-like 1
chr16_+_12902955 1.154 NM_001145204
NM_001145205
SHISA9

shisa homolog 9 (Xenopus laevis)

chr11_+_66580861 1.151 NM_014578
RHOD
ras homolog gene family, member D
chr16_-_66827449 1.144 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr12_-_15265490 1.142 NM_001190726
NM_032918
RERG

RAS-like, estrogen-regulated, growth inhibitor

chr11_+_66381451 1.139 NM_024036
LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr21_-_42060334 1.133 RIPK4
receptor-interacting serine-threonine kinase 4
chr8_+_95722448 1.129 ESRP1
epithelial splicing regulatory protein 1
chr19_+_40299058 1.126 FXYD3
FXYD domain containing ion transport regulator 3
chr4_+_177224142 1.116 WDR17
WD repeat domain 17
chr5_+_174084137 1.100 NM_002449
MSX2
msh homeobox 2
chr9_-_129656413 1.099 ENG
endoglin
chr21_-_42060266 1.097 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr22_-_35970133 1.096 RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr17_-_15185623 1.091 NM_031898
TEKT3
tektin 3
chr1_-_231498081 1.067 NM_014801
PCNXL2
pecanex-like 2 (Drosophila)
chr6_-_40663089 1.065 NM_020737
LRFN2
leucine rich repeat and fibronectin type III domain containing 2
chr12_-_29827952 1.053 NM_001193451
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr3_+_10832867 1.052 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr9_+_123501186 1.044 DAB2IP
DAB2 interacting protein
chr4_+_177223978 1.040 NM_170710
NM_181265
WDR17

WD repeat domain 17

chr15_+_31390454 1.039 NM_001036
RYR3
ryanodine receptor 3
chr17_+_21220260 1.035 NM_021012
KCNJ12
potassium inwardly-rectifying channel, subfamily J, member 12
chr1_+_82038669 1.035 NM_012302
LPHN2
latrophilin 2
chr4_+_156900053 1.028 GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr4_-_17392232 1.019 NM_015688
FAM184B
family with sequence similarity 184, member B
chr14_-_100104014 1.018 NM_001159531
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr2_-_53940571 1.016 NM_001164165
NM_006794
GPR75-ASB3
GPR75
GPR75-ASB3 read-through transcript
G protein-coupled receptor 75
chr8_+_26427378 1.011 NM_001197293
DPYSL2
dihydropyrimidinase-like 2
chr3_+_11171213 1.008 NM_001098212
HRH1
histamine receptor H1
chr4_-_142273881 1.006 NM_020724
RNF150
ring finger protein 150
chr22_-_35970230 1.000 NM_002872
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr5_+_96024434 0.993 CAST
calpastatin
chr14_+_61653827 0.990 FLJ43390
hypothetical LOC646113
chr7_+_129919330 0.989 MEST
mesoderm specific transcript homolog (mouse)
chr4_+_148621694 0.985 EDNRA
endothelin receptor type A
chr11_+_66827563 0.980 SSH3
slingshot homolog 3 (Drosophila)
chr3_-_150858274 0.962 NM_001168280
NM_015472
WWTR1

WW domain containing transcription regulator 1

chr6_+_3794620 0.957 NM_012135
FAM50B
family with sequence similarity 50, member B
chr15_+_45263517 0.957 NM_001198999
SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr12_-_26166485 0.948 BHLHE41
basic helix-loop-helix family, member e41
chr2_-_191723996 0.939 STAT4
signal transducer and activator of transcription 4
chr20_+_13150417 0.939 NM_080826
ISM1
isthmin 1 homolog (zebrafish)
chr3_-_126414252 0.935 NM_024628
SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr1_+_234372454 0.928 NM_003272
GPR137B
G protein-coupled receptor 137B
chrX_-_131918905 0.928 HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr9_-_129656581 0.927 ENG
endoglin
chrX_+_48915127 0.926 NM_002668
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chr6_-_56824371 0.924 DST
dystonin
chr2_-_191723951 0.923 STAT4
signal transducer and activator of transcription 4
chr13_-_83354474 0.921 NM_052910
SLITRK1
SLIT and NTRK-like family, member 1
chr1_+_15446354 0.917 NM_052929
FHAD1
forkhead-associated (FHA) phosphopeptide binding domain 1
chr10_-_105604942 0.913 NM_014631
SH3PXD2A
SH3 and PX domains 2A
chr9_-_10602722 0.912 NM_002839
PTPRD
protein tyrosine phosphatase, receptor type, D
chr2_-_191723978 0.911 STAT4
signal transducer and activator of transcription 4
chr8_-_72918697 0.903 MSC
musculin
chr11_-_118799058 0.893 THY1
Thy-1 cell surface antigen
chr1_+_63831479 0.888 NM_002633
PGM1
phosphoglucomutase 1
chr13_-_83354425 0.885 SLITRK1
SLIT and NTRK-like family, member 1
chr12_+_120840829 0.877 NM_001178003
NM_144668
WDR66

WD repeat domain 66

chr7_+_96473225 0.872 NM_005222
DLX6
distal-less homeobox 6
chr5_+_176717449 0.870 NM_006480
RGS14
regulator of G-protein signaling 14
chr1_-_115682374 0.864 NM_002506
NGF
nerve growth factor (beta polypeptide)
chr14_+_73073570 0.864 NM_001037161
ACOT1
acyl-CoA thioesterase 1
chr8_-_119703361 0.862 NM_001101676
NM_207506
SAMD12

sterile alpha motif domain containing 12

chr3_+_54131731 0.861 NM_018398
CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr10_-_113933457 0.861 NM_020918
GPAM
glycerol-3-phosphate acyltransferase, mitochondrial
chr12_+_52634950 0.860 NM_173860
HOXC12
homeobox C12
chr3_+_120496180 0.859 ARHGAP31
Rho GTPase activating protein 31
chr2_+_219453487 0.859 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr21_-_41140457 0.858 DSCAM
Down syndrome cell adhesion molecule
chr2_+_177210683 0.857


chr18_+_48120539 0.856 NM_005215
DCC
deleted in colorectal carcinoma
chr21_+_25856311 0.853 MIR155HG
MIR155 host gene (non-protein coding)
chr6_-_56824672 0.852 DST
dystonin
chr9_-_129656778 0.852 ENG
endoglin
chr3_+_128874458 0.846 NM_172027
ABTB1
ankyrin repeat and BTB (POZ) domain containing 1
chr19_+_39860398 0.843 NM_001012320
NM_018443
ZNF302

zinc finger protein 302

chr2_-_191724169 0.840 NM_003151
STAT4
signal transducer and activator of transcription 4
chr17_+_77582774 0.840 NM_005052
RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr6_-_89884324 0.836 NM_080743
SRSF12
serine/arginine-rich splicing factor 12
chr3_+_57517013 0.835 NM_177966
PDE12
phosphodiesterase 12
chr19_-_49644470 0.831 NM_014518
ZNF229
zinc finger protein 229
chr8_-_74167886 0.831 NM_153225
C8orf84
chromosome 8 open reading frame 84
chr17_-_6887965 0.829 NM_153357
SLC16A11
solute carrier family 16, member 11 (monocarboxylic acid transporter 11)
chr13_+_40929690 0.828 C13orf15
chromosome 13 open reading frame 15
chr15_+_39032927 0.825 NM_001142776
NM_024111
CHAC1

ChaC, cation transport regulator homolog 1 (E. coli)

chr15_+_30797466 0.825 NM_001191322
NM_001191323
NM_013372
GREM1


gremlin 1


chr17_-_76064842 0.821 NM_002522
NPTX1
neuronal pentraxin I
chr11_+_7574992 0.821 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr19_+_46575008 0.819 NM_001042595
TMEM91
transmembrane protein 91
chr1_-_53159991 0.819 NM_001198961
NM_001198962
NM_018281
ECHDC2


enoyl CoA hydratase domain containing 2


chr11_+_66381077 0.816 LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr12_-_94708641 0.814 NM_021229
NTN4
netrin 4
chr1_-_9111674 0.813 NM_024980
GPR157
G protein-coupled receptor 157
chr11_+_63463009 0.810 NM_024771
NAA40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr2_+_106048543 0.808 NM_032411
C2orf40
chromosome 2 open reading frame 40
chr1_+_32703225 0.806 NM_001145720
ZBTB8B
zinc finger and BTB domain containing 8B
chr8_-_119703297 0.800 SAMD12
sterile alpha motif domain containing 12
chr20_-_35586366 0.799 NM_001167823
BLCAP
bladder cancer associated protein
chr1_-_31942142 0.798 COL16A1
collagen, type XVI, alpha 1
chr13_-_40393804 0.795 SUGT1P3
suppressor of G2 allele of SKP1 (S. cerevisiae) pseudogene 3
chr7_+_129919134 0.793 MEST
mesoderm specific transcript homolog (mouse)
chr13_+_40929679 0.792 C13orf15
chromosome 13 open reading frame 15
chr4_-_90977149 0.789 NM_001146054
NM_007308
NM_000345
SNCA


synuclein, alpha (non A4 component of amyloid precursor)


chr16_-_17472238 0.785 NM_022166
XYLT1
xylosyltransferase I
chr6_+_36752244 0.785 NM_078467
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr7_+_129919157 0.783 NM_002402
MEST
mesoderm specific transcript homolog (mouse)
chr5_+_146594718 0.781 NM_001112724
NM_145001
STK32A

serine/threonine kinase 32A

chr6_+_30002084 0.779


chr11_+_66827494 0.779 NM_017857
SSH3
slingshot homolog 3 (Drosophila)
chr11_+_128751044 0.777 NM_003658
BARX2
BARX homeobox 2
chr1_-_53159927 0.771 ECHDC2
enoyl CoA hydratase domain containing 2
chr3_-_73756668 0.771 NM_015009
PDZRN3
PDZ domain containing ring finger 3
chr7_-_155297576 0.769 NM_000193
SHH
sonic hedgehog
chr9_-_129656830 0.767 NM_000118
NM_001114753
ENG

endoglin

chr5_-_115180221 0.766 NM_001801
CDO1
cysteine dioxygenase, type I
chr18_-_45975163 0.761 NM_001080467
MYO5B
myosin VB
chr20_+_13924263 0.760 MACROD2
MACRO domain containing 2
chr1_+_154478574 0.760 NM_199173
BGLAP
bone gamma-carboxyglutamate (gla) protein
chrX_-_139414890 0.756 NM_005634
SOX3
SRY (sex determining region Y)-box 3
chr1_-_197173159 0.754 LOC100131234
familial acute myelogenous leukemia related factor
chr1_-_215377718 0.750 NM_001134285
ESRRG
estrogen-related receptor gamma

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.46 2.15e-07 GO:0030154 cell differentiation
1.43 1.47e-06 GO:0048869 cellular developmental process
1.49 2.52e-06 GO:0023051 regulation of signaling
1.99 6.38e-06 GO:0051094 positive regulation of developmental process
1.49 4.61e-05 GO:0009966 regulation of signal transduction
1.61 7.77e-05 GO:0048468 cell development
1.59 2.52e-04 GO:0050793 regulation of developmental process
2.70 2.75e-04 GO:0042692 muscle cell differentiation
1.66 2.84e-04 GO:2000026 regulation of multicellular organismal development
1.58 4.16e-04 GO:0022008 neurogenesis
1.14 5.99e-04 GO:0065007 biological regulation
1.38 6.19e-04 GO:0048583 regulation of response to stimulus
1.87 8.95e-04 GO:0016477 cell migration
1.43 9.35e-04 GO:0007399 nervous system development
1.34 1.03e-03 GO:0048523 negative regulation of cellular process
1.51 1.47e-03 GO:0010646 regulation of cell communication
1.32 1.48e-03 GO:0048522 positive regulation of cellular process
1.57 1.50e-03 GO:0048699 generation of neurons
1.64 1.80e-03 GO:0045595 regulation of cell differentiation
1.94 2.12e-03 GO:0045597 positive regulation of cell differentiation
1.15 2.29e-03 GO:0050794 regulation of cellular process
1.75 2.59e-03 GO:0000904 cell morphogenesis involved in differentiation
1.14 3.83e-03 GO:0050789 regulation of biological process
2.96 4.18e-03 GO:0060485 mesenchyme development
3.09 5.58e-03 GO:0048762 mesenchymal cell differentiation
1.79 5.75e-03 GO:0007409 axonogenesis
1.30 5.84e-03 GO:0048519 negative regulation of biological process
1.28 6.18e-03 GO:0048518 positive regulation of biological process
3.17 6.30e-03 GO:0014031 mesenchymal cell development
1.92 9.31e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.79 9.38e-03 GO:0009968 negative regulation of signal transduction
1.76 1.02e-02 GO:0048667 cell morphogenesis involved in neuron differentiation
1.42 1.13e-02 GO:0051239 regulation of multicellular organismal process
1.73 1.59e-02 GO:0023057 negative regulation of signaling
1.73 1.89e-02 GO:0048812 neuron projection morphogenesis
1.22 1.89e-02 GO:0023052 signaling
1.25 2.51e-02 GO:0048731 system development
1.24 2.55e-02 GO:0048856 anatomical structure development
1.63 2.60e-02 GO:0006928 cellular component movement
1.22 2.82e-02 GO:0007275 multicellular organismal development
1.32 2.93e-02 GO:0048513 organ development
1.69 3.16e-02 GO:0048870 cell motility
1.69 3.16e-02 GO:0051674 localization of cell
1.60 3.16e-02 GO:0000902 cell morphogenesis
1.70 3.35e-02 GO:0010648 negative regulation of cell communication
1.21 3.92e-02 GO:0032502 developmental process
1.57 4.64e-02 GO:0032989 cellular component morphogenesis
1.65 4.78e-02 GO:0048858 cell projection morphogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.34 1.08e-04 GO:0044459 plasma membrane part
1.20 1.84e-03 GO:0005886 plasma membrane
1.20 2.30e-03 GO:0071944 cell periphery
1.12 8.84e-03 GO:0016020 membrane
1.71 1.09e-02 GO:0031012 extracellular matrix
1.64 3.64e-02 GO:0043005 neuron projection
1.13 3.78e-02 GO:0044425 membrane part
1.50 4.80e-02 GO:0030054 cell junction

Nothing significant found in function category.